LOCUS       NM_027242                953 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 35
            (Ppp1r35), transcript variant 1, mRNA.
ACCESSION   NM_027242
VERSION     NM_027242.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 953)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 953)
  AUTHORS   Archambault,D., Cheong,A., Iverson,E., Tremblay,K.D. and Mager,J.
  TITLE     Protein phosphatase 1 regulatory subunit 35 is required for
            ciliogenesis, notochord morphogenesis, and cell-cycle progression
            during murine development
  JOURNAL   Dev Biol 465 (1), 1-10 (2020)
   PUBMED   32628936
  REMARK    GeneRIF: Protein phosphatase 1 regulatory subunit 35 is required
            for ciliogenesis, notochord morphogenesis, and cell-cycle
            progression during murine development.
REFERENCE   3  (bases 1 to 953)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 953)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125063.4 and AK008148.1.
            
            On Oct 14, 2017 this sequence version replaced NM_027242.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052497.1, AK008148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC125063.4         107091-107104       c
            15-882              AK008148.1         2-869
            883-883             AC125063.4         105971-105971       c
            884-925             AK008148.1         871-912
            926-926             AC125063.4         105928-105928       c
            927-953             AK008148.1         913-939
FEATURES             Location/Qualifiers
     source          1..953
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.7 cM"
     gene            1..953
                     /gene="Ppp1r35"
                     /gene_synonym="2010007H12Rik; 2010011D20Rik"
                     /note="protein phosphatase 1, regulatory subunit 35"
                     /db_xref="GeneID:69871"
                     /db_xref="MGI:MGI:1922853"
     exon            1..318
                     /gene="Ppp1r35"
                     /gene_synonym="2010007H12Rik; 2010011D20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..873
                     /gene="Ppp1r35"
                     /gene_synonym="2010007H12Rik; 2010011D20Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0683 protein C7orf47 homolog"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 35
                     isoform 1"
                     /protein_id="NP_081518.1"
                     /db_xref="CCDS:CCDS19777.1"
                     /db_xref="GeneID:69871"
                     /db_xref="MGI:MGI:1922853"
                     /translation="MMGFGASALESIEGEEALEVPGPPPEPRAPEPRAPEPEPGLDLS
                     LSPSPLPESPKARKSSPGQRKGRRGGSRRGRQVRFQLAPPSPVRSEPLLVAGAPGDDH
                     ELEAPALQSSLALSLELQNARAAVASGQFDASKAVEEQLRKSFRTRCALEETVAEGLN
                     VPRSKRLYRDLVSLQVPEEQVLNAALREKLAMLPPQPRAPPLKEVLGPGPDMTMLCNP
                     DSLWSESPHLTVDGLPPLRLQARPRPSEDTFLMHRMLRRWEA"
     exon            319..562
                     /gene="Ppp1r35"
                     /gene_synonym="2010007H12Rik; 2010011D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            563..699
                     /gene="Ppp1r35"
                     /gene_synonym="2010007H12Rik; 2010011D20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            700..953
                     /gene="Ppp1r35"
                     /gene_synonym="2010007H12Rik; 2010011D20Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagggctaac ggtttccggt agtggtagcc ccggagggtg ggagaaaaga ggagaccccg
       61 cgtcctgaaa ccccgagcct ttagaacaag atgatgggct tcggggcgtc tgcgttagag
      121 tccattgaag gcgaagaggc cctggaggtc ccggggccac ccccggagcc gcgagccccg
      181 gaaccccgag ccccagagcc cgagccgggc ttggacttga gccttagccc gagcccgctg
      241 cccgaaagtc cgaaggcgcg gaagagcagc ccgggtcagc ggaaggggcg gcggggcggt
      301 agccggaggg ggcggcaggt tcgttttcaa ctggcgccgc cctccccggt gcggtccgag
      361 ccgctgctgg tggccggtgc accgggcgac gatcatgagc tggaggcacc ggccctgcag
      421 agcagcctgg ctttgagtct ggagctgcag aacgcgcgcg ccgctgtcgc cagcggccag
      481 tttgatgcct ccaaggcggt agaggagcag ctgagaaagt cgttccggac ccgctgtgcc
      541 ctggaggaga ccgtggcgga ggggttgaac gtgccgcgct ctaagcgact ctaccgagac
      601 ctggtgagtc tgcaggtgcc cgaggagcag gtactgaacg cggcgctgag ggagaagctg
      661 gcgatgctgc caccgcagcc ccgagccccg cccctgaagg aggtgctcgg gccgggccca
      721 gacatgacca tgctgtgcaa cccagattct ctgtggtccg aatctccgca cttgacagtg
      781 gatgggctgc ccccactaag gcttcaagcc cggccccgcc cttcagaaga tacctttctc
      841 atgcatcgga tgctgaggcg ctgggaagcg tagccctcat aactctggaa tgctagtctg
      901 taattttgtt agtttttttt ttttttataa tagaataaaa tgtttccccc cct
//
