LOCUS       NM_028658               3151 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 21
            (Ppp1r21), mRNA.
ACCESSION   NM_028658
VERSION     NM_028658.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3151)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3151)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3151)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY205567.1, BC137673.1 and BQ176826.1.
            
            On Jul 30, 2009 this sequence version replaced NM_028658.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028185.1, SRR1660817.197180.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BY205567.1         1-60
            61-3013             BC137673.1         1-2953
            3014-3151           BQ176826.1         1-138               c
FEATURES             Location/Qualifiers
     source          1..3151
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 58.02 cM"
     gene            1..3151
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /note="protein phosphatase 1, regulatory subunit 21"
                     /db_xref="GeneID:73825"
                     /db_xref="MGI:MGI:1921075"
     exon            1..195
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2481
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /note="KLRAQ motif-containing protein 1; coiled-coil
                     domain-containing protein 128; coiled-coil domain
                     containing 128; KLRAQ motif containing 1; ferry endosomal
                     RAB5 effector complex subunit 2"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 21"
                     /protein_id="NP_082934.3"
                     /db_xref="CCDS:CCDS29023.1"
                     /db_xref="GeneID:73825"
                     /db_xref="MGI:MGI:1921075"
                     /translation="MASAELQGKYQKLAQEYSKLRAQNQVLKKGVVDEQASSAALKEQ
                     LKMKDQSLRKLQQEMDSLTFRNLQLAKRVELLQDELALSEPRGKKNKKSGESSSQLSQ
                     EQKSVFDEDLQKKIEENERLHIQFFEADEHHRHVEAELRSRLATLETEAAQHQAVIDG
                     LTRKYMETIEKLQSDKAKLEVKSQTLEKEAKECRLRTEECQLQLKNLHEDLSGRLEES
                     LSIINEKVPFNDTKCHLYNALNVPLHNRRHQLKMRDIAGQALAFVQDLVPALLNFHTY
                     TEQRIQIFPVDSAIDTISPLNQKFSQYLHENASYVRPLEEGMLHLFESITEDTVTVLE
                     TTVKLKMFSDHLTSYVRFLRKILPYQLKSLEEECESSLCTPALRARNLELSQDMKTMT
                     AVFEKLQTYVTLLALPSTEPDGLLRTNYTSVLTNVGAALHGFHDVMKDISKHYSQKAS
                     IEHEIPTATQKLVTTNDCILSSAVTLTNGAGKIASFFGNNVDYFIASLSYGPKTASGF
                     ISPLSAECMLQYKKKAAAYMKSLRTPLAESVPYGEAVANRRVLLSSTESREGLAQQVQ
                     QSLEKISKLEQEKEHWMLEAQLAKIKLEKENQRIADRLRGTTSAQLPGLAQENATVPI
                     ASSQEEAAAKVLTEPVQSTSLVGMLTRTPDSEAPDVESREDLIKSHYMARIAELTSQL
                     QLADSKSVHFYAECRALSKRLALAEKSKETLTEEMRLASQNISRLQDELMTTKRSYED
                     QLSMMSDHLCSMNETLSKQREEIDTLKMASKGNSKKTRNR"
     exon            196..264
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            265..411
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..513
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..678
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..737
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..832
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..885
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1035
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1137
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1226
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1363
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1456
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1584
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1737
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1830
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..2073
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2106
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2223
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2322
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2451
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..3135
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3114..3119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /note="hexamer: AATAAA"
     polyA_site      3135
                     /gene="Ppp1r21"
                     /gene_synonym="1110018J12Rik; Ccdc128; Fy-2; Klraq1"
                     /note="major polyA site"
ORIGIN      
        1 ggaggaggag gcgcggcggc ggcggcggtg ctgcagaagc tggctgagcc ctgcccggga
       61 ggagcaagtg tggggttggg ggcggggggc ggggctcggc agcccgggcg gccaggcctg
      121 gacggggcgg gggaggccat ggcctccgca gagttgcagg ggaagtacca gaagctggct
      181 caggagtact cgaagcttcg agctcagaat caggttctga agaaaggtgt tgtggatgag
      241 caggccagct ctgctgctct gaaggaacaa ctgaaaatga aggaccagtc cttgaggaaa
      301 ctgcagcagg aaatggacag tttgacattt cgaaatctgc agcttgccaa gagggtggaa
      361 ctccttcaag atgagctagc actaagtgaa cctcgaggca agaaaaacaa gaaaagtggt
      421 gaatcttctt ctcagttgag ccaagagcag aagagcgtct ttgatgaaga cctgcaaaag
      481 aaaatcgagg agaacgaacg gctgcacata cagttcttcg aagcggacga gcatcacagg
      541 cacgtggaag cggagctgag gagtcggctg gccactcttg aaacagaagc tgctcagcac
      601 caagctgtga tcgacggcct gacccggaag tacatggaga ccattgagaa actccagagc
      661 gacaaggcaa agctagaagt aaaatctcag actctagaaa aggaggccaa ggaatgtcga
      721 ctgcgaacag aagaatgtca attacagtta aagaatcttc atgaagattt gtcaggtaga
      781 ttagaggaat ccttatcaat catcaatgaa aaagtccctt ttaatgatac aaagtgtcat
      841 ctgtacaacg ctctcaatgt tcccctgcac aataggcgac accagctgaa gatgcgagat
      901 atagctgggc aggccctggc ttttgttcag gatcttgtac cggctcttct gaactttcac
      961 acctatacag aacagaggat tcaaattttc cctgttgatt ctgccataga cactatatca
     1021 ccattgaatc agaagttctc ccaatacctt catgaaaacg catcgtatgt ccgccccctt
     1081 gaggaaggaa tgctgcactt attcgagagc attacagagg atactgtgac tgtcctggag
     1141 acaactgtga aattgaaaat gttttcagat catctaactt cctacgtacg cttcctgagg
     1201 aagatccttc cttatcagtt aaaaagttta gaagaagagt gtgaatcttc cctctgcaca
     1261 cctgcactga gagccaggaa cctggagctg tcccaggaca tgaagacgat gacagccgtg
     1321 tttgagaagc tgcagacgta tgtcactctc ctcgccttgc caagtacaga gccagatgga
     1381 ctccttcgaa caaactacac ttccgtctta acaaatgttg gtgctgctct gcatggattt
     1441 catgatgtca tgaaagatat ttccaaacac tatagtcaga aggcttccat agagcatgaa
     1501 attccaacag caacacagaa gctagtaacg actaacgact gcatcttgtc ctcagcggtg
     1561 acgttaacaa acggagcggg caagattgcg tctttcttcg gcaacaacgt ggactacttc
     1621 attgcttcac tgagctatgg gcccaagaca gccagcggat tcattagtcc cctttcggct
     1681 gagtgcatgc tgcagtacaa gaagaaggct gctgcctata tgaagtcttt gagaacgccc
     1741 ctcgcagagt ctgtgcctta cggggaagct gtggccaacc gccgggttct cctcagctct
     1801 acagagagtc gggaaggcct tgcacagcag gttcagcaga gtttggaaaa gatttctaag
     1861 ctggagcagg agaaagaaca ttggatgcta gaagcacagt tagccaaaat caagctggag
     1921 aaagaaaacc aacggattgc agacaggctg cggggcacca ccagtgccca gctgcctggg
     1981 ctggcccagg agaatgcgac tgtgcccatt gcttccagcc aggaggaggc tgcagccaag
     2041 gtcctgacag agcctgtgca gagcaccagt ctggttggga tgttaaccag gacgccagac
     2101 agtgaggctc cggatgttga gtcccgtgaa gacctaatta agagtcacta catggccagg
     2161 atagcggagc tcacatctca gctgcagctg gctgacagta agtcagtgca cttctacgcc
     2221 gagtgccgtg cgctctctaa gagactagcc ctggcggaga agtcgaagga gacactgaca
     2281 gaggagatga ggctagccag tcagaacatc agcaggcttc aggacgagct gatgaccacc
     2341 aagcggagct acgaggatca gctgagcatg atgagcgacc acctatgcag catgaacgag
     2401 accctgtcca aacagaggga ggagattgac acgctcaaga tggccagtaa ggggaattct
     2461 aagaagaccc ggaatcggta gttgatgacc taggctgcca ccgcagtgac tgttctgccc
     2521 tgagactcga gccagactcc acagccagtg ctggtgaccg ctgggaagcc gtgtgccctt
     2581 ggacttggta gatgagccag tgctgtctgt gacctggaga cctttgaaga atatttgtga
     2641 acagaagcaa atacagagcc ccatgttgac agtcagatgg aaagcagtac acatacccgt
     2701 ggacattgta ggtttcctta cgctgttttt actgtgcact ttttaaaatt aggatttaat
     2761 ttcagtatgt aagaacaaca aatattttgt atattttcaa actcaattat atggtaatgg
     2821 atttggtatc tatggaatag atatatgttt ctggataaaa tgcttaaatt gtcagatgtc
     2881 attacttcct gtattgtcat ttcttcctat aattgaaaac tgaaagacat ctcagattcc
     2941 ttttaaaaga gtctctccct tgccatgtct ctccatccct ttccctcccc ttcccccttg
     3001 tcccttgaag gtgacaagcc ttacagcctt ctagagccta tgggttcgct gtcatgtctg
     3061 cagctgtaca gtacactctc tgtgttcaaa taattgctaa aggaaattct gtcaataaat
     3121 tcgtacccac gtgaaaaaaa aaaaaaaaaa a
//
