LOCUS       NM_025800               4098 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory inhibitor subunit 2
            (Ppp1r2), mRNA.
ACCESSION   NM_025800
VERSION     NM_025800.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4098)
  AUTHORS   Zhang,K., Da Silva,F., Seidl,C., Wilsch-Brauninger,M., Herbst,J.,
            Huttner,W.B. and Niehrs,C.
  TITLE     Primary cilia are WNT-transducing organelles whose biogenesis is
            controlled by a WNT-PP1 axis
  JOURNAL   Dev Cell 58 (2), 139-154 (2023)
   PUBMED   36693320
REFERENCE   2  (bases 1 to 4098)
  AUTHORS   Goswami,S., Korrodi-Gregorio,L., Sinha,N., Bhutada,S.,
            Bhattacharjee,R., Kline,D. and Vijayaraghavan,S.
  TITLE     Regulators of the protein phosphatase PP1gamma2, PPP1R2, PPP1R7,
            and PPP1R11 are involved in epididymal sperm maturation
  JOURNAL   J Cell Physiol 234 (3), 3105-3118 (2019)
   PUBMED   30144392
  REMARK    GeneRIF: The three regulators (PPP1R2, PPP1R7, and PPP1R11)share
            localization with PP1gamma2 in the head and the principal piece of
            sperm. We show that the association of inhibitors to PP1gamma2
            changes during epididymal sperm maturation. In immotile caput
            epididymal sperm, PPP1R2 and PPP1R7 are not bound to PP1gamma2,
            whereas in motile caudal sperm, all three inhibitors are bound as
            heterodimers or heterotrimers.
REFERENCE   3  (bases 1 to 4098)
  AUTHORS   Yang,H., Hou,H., Pahng,A., Gu,H., Nairn,A.C., Tang,Y.P.,
            Colombo,P.J. and Xia,H.
  TITLE     Protein Phosphatase-1 Inhibitor-2 Is a Novel Memory Suppressor
  JOURNAL   J Neurosci 35 (45), 15082-15087 (2015)
   PUBMED   26558779
  REMARK    GeneRIF: Protein phosphatase-1 inhibitor-2 acts as a memory
            suppressor through its positive functional influence on type I
            protein phosphatase.
REFERENCE   4  (bases 1 to 4098)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   5  (bases 1 to 4098)
  AUTHORS   Bruchert,N., Mavila,N., Boknik,P., Baba,H.A., Fabritz,L., Gergs,U.,
            Kirchhefer,U., Kirchhof,P., Matus,M., Schmitz,W.,
            DePaoli-Roach,A.A. and Neumann,J.
  TITLE     Inhibitor-2 prevents protein phosphatase 1-induced cardiac
            hypertrophy and mortality
  JOURNAL   Am J Physiol Heart Circ Physiol 295 (4), H1539-H1546 (2008)
   PUBMED   18689497
REFERENCE   6  (bases 1 to 4098)
  AUTHORS   Hurley,T.D., Yang,J., Zhang,L., Goodwin,K.D., Zou,Q., Cortese,M.,
            Dunker,A.K. and DePaoli-Roach,A.A.
  TITLE     Structural basis for regulation of protein phosphatase 1 by
            inhibitor-2
  JOURNAL   J Biol Chem 282 (39), 28874-28883 (2007)
   PUBMED   17636256
REFERENCE   7  (bases 1 to 4098)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
REFERENCE   8  (bases 1 to 4098)
  AUTHORS   Prescott,K., Ivins,S., Hubank,M., Lindsay,E., Baldini,A. and
            Scambler,P.
  TITLE     Microarray analysis of the Df1 mouse model of the 22q11 deletion
            syndrome
  JOURNAL   Hum Genet 116 (6), 486-496 (2005)
   PUBMED   15778864
REFERENCE   9  (bases 1 to 4098)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   10 (bases 1 to 4098)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK150281.1, AK053657.1 and AI573352.1.
            
            On Jan 20, 2006 this sequence version replaced NM_025800.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053657.1, AK028603.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AK150281.1         4-102
            100-4064            AK053657.1         1-3965
            4065-4098           AI573352.1         360-393
FEATURES             Location/Qualifiers
     source          1..4098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 21.41 cM"
     gene            1..4098
                     /gene="Ppp1r2"
                     /gene_synonym="0610025N14Rik; 2310007G06Rik;
                     4930440J04Rik; 5430408E15Rik; D16Ertd248e; I-2; IPP-2"
                     /note="protein phosphatase 1, regulatory inhibitor subunit
                     2"
                     /db_xref="GeneID:66849"
                     /db_xref="MGI:MGI:1914099"
     exon            1..432
                     /gene="Ppp1r2"
                     /gene_synonym="0610025N14Rik; 2310007G06Rik;
                     4930440J04Rik; 5430408E15Rik; D16Ertd248e; I-2; IPP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             308..928
                     /gene="Ppp1r2"
                     /gene_synonym="0610025N14Rik; 2310007G06Rik;
                     4930440J04Rik; 5430408E15Rik; D16Ertd248e; I-2; IPP-2"
                     /EC_number="3.1.3.16"
                     /codon_start=1
                     /product="protein phosphatase inhibitor 2"
                     /protein_id="NP_080076.1"
                     /db_xref="CCDS:CCDS28104.1"
                     /db_xref="GeneID:66849"
                     /db_xref="MGI:MGI:1914099"
                     /translation="MAASTASHRPIKGILKNKTSAASPPVVPSAEQPRPIVEEELSKK
                     SQKWDEMNILATYHPADKDYGLMKIDEPNTPYHNMIGDDEDAYSDSEGNEVMTPDILA
                     KKLAAAEGSEPKYRTREQESSGEEDNDLSPEEREKKRQFEMKRKLHYNEGLNIKLARQ
                     LISKDLHDDDEDEEMAETADGDSMNVEESSQGSTTSDHLQHKSQSS"
     exon            433..540
                     /gene="Ppp1r2"
                     /gene_synonym="0610025N14Rik; 2310007G06Rik;
                     4930440J04Rik; 5430408E15Rik; D16Ertd248e; I-2; IPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            541..618
                     /gene="Ppp1r2"
                     /gene_synonym="0610025N14Rik; 2310007G06Rik;
                     4930440J04Rik; 5430408E15Rik; D16Ertd248e; I-2; IPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            619..713
                     /gene="Ppp1r2"
                     /gene_synonym="0610025N14Rik; 2310007G06Rik;
                     4930440J04Rik; 5430408E15Rik; D16Ertd248e; I-2; IPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            714..881
                     /gene="Ppp1r2"
                     /gene_synonym="0610025N14Rik; 2310007G06Rik;
                     4930440J04Rik; 5430408E15Rik; D16Ertd248e; I-2; IPP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            882..4074
                     /gene="Ppp1r2"
                     /gene_synonym="0610025N14Rik; 2310007G06Rik;
                     4930440J04Rik; 5430408E15Rik; D16Ertd248e; I-2; IPP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      961..966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r2"
                     /gene_synonym="0610025N14Rik; 2310007G06Rik;
                     4930440J04Rik; 5430408E15Rik; D16Ertd248e; I-2; IPP-2"
                     /note="hexamer: AATACA"
     polyA_site      981
                     /gene="Ppp1r2"
                     /gene_synonym="0610025N14Rik; 2310007G06Rik;
                     4930440J04Rik; 5430408E15Rik; D16Ertd248e; I-2; IPP-2"
                     /note="major polyA site"
     regulatory      2365..2370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r2"
                     /gene_synonym="0610025N14Rik; 2310007G06Rik;
                     4930440J04Rik; 5430408E15Rik; D16Ertd248e; I-2; IPP-2"
                     /note="hexamer: AATAAA"
     polyA_site      2395
                     /gene="Ppp1r2"
                     /gene_synonym="0610025N14Rik; 2310007G06Rik;
                     4930440J04Rik; 5430408E15Rik; D16Ertd248e; I-2; IPP-2"
                     /note="major polyA site"
     polyA_site      2609
                     /gene="Ppp1r2"
                     /gene_synonym="0610025N14Rik; 2310007G06Rik;
                     4930440J04Rik; 5430408E15Rik; D16Ertd248e; I-2; IPP-2"
ORIGIN      
        1 gggagggccg ggcttggctt cggcatccgc gtcgctcccg cgctggggca ctaggcgggc
       61 ctcctccgcg ggccgcgggc tactttgccg gcggcgaagg gccgcccgcc gcgcggcgtc
      121 ggctgtggcg ttgcggtcat tgtgtcgtga cggagacgcc ggtcgtggtt tccgcggcag
      181 cgggtgtggc tgctttagcc tggcctgggc tccacggctg cctggagggt ctctgcagcg
      241 cccatccctt ctcctccgga accccacgcc agcagcgacc ctgagtcggc agccggagcg
      301 accggccatg gcggcctcaa cggcctcgca ccggcccatc aaaggaatcc tgaagaacaa
      361 gacctctgcg gcttcccccc cggtggtgcc ctcggccgaa cagccccgcc cgatcgtgga
      421 agaggaactg agtaagaagt ctcagaagtg ggatgaaatg aatatcctgg caacatatca
      481 tcccgctgac aaagactatg gcttgatgaa aatagacgag ccaaacaccc catatcacaa
      541 tatgataggt gacgatgaag acgcctatag tgattcagaa ggcaatgaag tcatgactcc
      601 agatatctta gctaagaaat tagctgctgc tgaaggctca gagccaaagt atcggactcg
      661 ggagcaagaa agtagtggag aggaagataa tgacctctcc cctgaggagc gagaaaagaa
      721 gcgacagttt gaaatgaaaa ggaagcttca ttacaatgaa ggactcaata ttaagttagc
      781 cagacagtta atttcaaaag acctacatga tgatgatgaa gatgaagaaa tggcagagac
      841 tgcagatgga gacagcatga atgttgaaga gtcaagtcaa ggatctacta caagtgacca
      901 tctgcaacac aaatcacaaa gttcataaaa gaaacatgtt caacaatgcg gtcgttgtca
      961 aatacaaacc ttgttactat actacactgt ttcttgttct ctacaattca tgacttatgt
     1021 accagagtac acaccagtta tatattgcca agaattaaga ccatagagac tgagtagatg
     1081 gaaaatgcct aattaataca tatattcttg tgcctcatat ttcaccacaa gtacagtgta
     1141 ctgttagtag tccaaaactg ctttactttt gtaaaaacac tggttaattt gtataagata
     1201 ttatatagct ttttatgctt tagagattaa atatcatggg ggaaactaat ttatttttgt
     1261 cacttctaga tggtggtacc tcttataaaa tgtttggggg tagtttgatg tcatttcttc
     1321 ttttaatcaa aagcctattc acaaagtggg atatatagat ggataaatat ttaggctgaa
     1381 agaatttaac ttttatcttt accttgtttt ggctaattga aaaggtttct aagaagtttt
     1441 gttcattttc tgatcattta aaattcctgt tgattttctt tgtgcttgaa aggaataaaa
     1501 tctttttatc caaactggtt tcccccattc ccaccccaaa taaatacaca aataaatgtc
     1561 caggttaaag ttgcactgac acctgctctg cttgtcttcg tgcgctatgc aagcttcagg
     1621 caaggtttaa ataccatggg ctatcttcgt ttccctttat ttatatacct gtcttaacct
     1681 gctctgattt cctgctcccg ctgctgatac acatgcagtt gtaatattgt attgtaggat
     1741 ggcaaaggct attggacgtg aggaactctt cttgcatatt ctgtcatctg ctgcagtagt
     1801 gaattctcac ttggcacctg ctagttctaa tgcatgaagg aaacagatct agtagtggcc
     1861 atactgtggc aggaaggact gcttagcagc ttgatcgctg tccttctctg attgacagct
     1921 tggtcagtaa atgcctgata ttagttcatt tgacattaga ccttagaaaa caattaacta
     1981 aggcattttt gcacgatgaa agcattgtat gtaatcagaa tatgattgtt cttgagtgta
     2041 cagacagaat tatacctgga cagttttaaa cttaaagatt ctgcggagtc tgctttaaag
     2101 ggactacgat aatgcacact gtggcagatg gacacggttc ctctaacatg atagagatta
     2161 tgtgggtttc ctagttcctg tgtgtcttag tttagtgatg gttccctttg tagttgttta
     2221 tttgtatcgt aagtttttgg tagcaccaaa tgaatctgtt atatgacaga cttttaaaat
     2281 aatttctgta tattatatat atgaaatggc ttttattgaa cagctatctt ccactttaaa
     2341 tttctggaac tatcatgatg tcaaaataaa aaagtaggaa gagtctttgc tgttagaaga
     2401 atgtgcttat tttgaatgtc tttctttttt tatgggactt taccagagta gctctgaatg
     2461 ttagtgcagt attctaacca aacgttttag ccagtgaacc gctcatgtac acactaagca
     2521 atgtatacct catctttgta aagtaagcct gtttgtggga tgtggaaatt gactgtatat
     2581 atgtatgtgg atatgttcat gtacccagat ctctgctttt agttttctta ttttgtgttc
     2641 ttttcaaatt gtttttatca ttgtgtgtgt atgggggttt gcctacagtg tgtgtctgtt
     2701 cactgcttgt atgcaaaacc tgtggaaacc aaaggaaggt gaccatcaga tgccctgaag
     2761 ctagagttat agacagttgt gatctcccct ctgggtaata ggagttgaac gcaggtcctc
     2821 tggaagagca gccagagctt tcacatgctg agccatccct ccagcccctc ctctgattgt
     2881 atactcggaa agttccacct actctttata tatgtagaag tggcctattg tacagtgggg
     2941 aaaaagtaag acttaaatgt ctgattcttc gtgttttctt taagttcgtt cctaaaactt
     3001 aaaatctcaa gtaagacttt tggtttcaca aagttgatac ttacttcaga ggaatgttct
     3061 aggcctaata gcatgtcggt aggattttag gtagtcaaat gcaactaaat aaaaagtatt
     3121 tcctccaggg cattgggaag atggctctct cagttgagtg cttgctatgc aagcatgagg
     3181 gcctgagtgt ggaatcctag tacccagaaa accacatatg gtcatacatg tctgtaatta
     3241 gagaggtaga gaccgctaga tccctggacc gtgctggcca gccagccttg ctgaatcagt
     3301 gagaccctgt ctcaaagtag gcctgagagt aattggaggg gaaacagcat gcttctgtgg
     3361 actccccaag agcatgaaga cagagcataa aatattttca acagattgtt ctaattgacc
     3421 ttgtgccaga ctgctgaaaa caagatgggt ttttttaaat tgtaaccatg gaggtgggtg
     3481 ctaaacctgt aaaatggctc tagtgggtca aaaggtttgc tctccagaaa catggtggga
     3541 ggagggaacc aactctacat gtactccatg gcatgaagtc tgtctgctgg tgtgtgtgtg
     3601 tgtgtgtgtg tgtgtgtgat gagtggttag tggatgtgca cttttgtaaa tgttttttaa
     3661 attttccccc ctttggagaa agttatctat tactggtctg ttctagccac agtagatgaa
     3721 ttcttacttt caacttttaa attacatccc ctgcttaaca ctattatatc acttccattt
     3781 actcattaac ccatcacaaa atcagtaggg ataataattt aaagcatggg ccaccttagt
     3841 gtaaatggaa tgataatgta agagcaactt ttaagttgaa gggtagagca aaatgctatt
     3901 tccccttaaa cttccatttt taaatatttc ccttttgttg gcatgcacta agcatagtat
     3961 catgtacata atctgaaatt ggcctctctc tctttctcat ttttcaaaac aatgtttcta
     4021 gaactcttga gatccaagta ttgagattaa agatgtgggc caccactgcc tgtcaaaaaa
     4081 aaaaaaaaaa aaaaaaaa
//
