LOCUS       NM_172420               3071 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory inhibitor subunit 1C
            (Ppp1r1c), transcript variant 1, mRNA.
ACCESSION   NM_172420 XM_912600 XM_922427 XM_922438
VERSION     NM_172420.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3071)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3071)
  AUTHORS   Dykes,I.M., Tempest,L., Lee,S.I. and Turner,E.E.
  TITLE     Brn3a and Islet1 act epistatically to regulate the gene expression
            program of sensory differentiation
  JOURNAL   J Neurosci 31 (27), 9789-9799 (2011)
   PUBMED   21734270
REFERENCE   3  (bases 1 to 3071)
  AUTHORS   Chen,G., Zhou,X., Florea,S., Qian,J., Cai,W., Zhang,Z., Fan,G.C.,
            Lorenz,J., Hajjar,R.J. and Kranias,E.G.
  TITLE     Expression of active protein phosphatase 1 inhibitor-1 attenuates
            chronic beta-agonist-induced cardiac apoptosis
  JOURNAL   Basic Res Cardiol 105 (5), 573-581 (2010)
   PUBMED   20512582
  REMARK    GeneRIF: mitochondrial signaling and ERK activation may be involved
            in the I-1c cardioprotective effects against apoptosis induced by
            prolonged beta-adrenergic stimulation
REFERENCE   4  (bases 1 to 3071)
  AUTHORS   Coulpier,F., Le Crom,S., Maro,G.S., Manent,J., Giovannini,M.,
            Maciorowski,Z., Fischer,A., Gessler,M., Charnay,P. and Topilko,P.
  TITLE     Novel features of boundary cap cells revealed by the analysis of
            newly identified molecular markers
  JOURNAL   Glia 57 (13), 1450-1457 (2009)
   PUBMED   19243017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK051670.1 and AK051449.1.
            
            On Mar 19, 2014 this sequence version replaced NM_172420.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051670.1, BC132149.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164136 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2644              AK051670.1         2-2645
            2645-3071           AK051449.1         2407-2833
FEATURES             Location/Qualifiers
     source          1..3071
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 47.58 cM"
     gene            1..3071
                     /gene="Ppp1r1c"
                     /gene_synonym="4930565M23Rik; 4930579P15Rik"
                     /note="protein phosphatase 1, regulatory inhibitor subunit
                     1C"
                     /db_xref="GeneID:75276"
                     /db_xref="MGI:MGI:1923185"
     exon            1..475
                     /gene="Ppp1r1c"
                     /gene_synonym="4930565M23Rik; 4930579P15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..721
                     /gene="Ppp1r1c"
                     /gene_synonym="4930565M23Rik; 4930579P15Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     protein phosphatase 1 regulatory subunit 1C"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 1C
                     isoform a"
                     /protein_id="NP_766008.2"
                     /db_xref="CCDS:CCDS16171.1"
                     /db_xref="GeneID:75276"
                     /db_xref="MGI:MGI:1923185"
                     /translation="MEPNSPKKIQFAVPLFQSQIAPEAAEQIRKRRPTPASLVILNEH
                     NSPEIDEKRVTNTQESQNASPKQRKQSVYTPPAMKGVKHLKDQNGSAFPEEEESASER
                     EEKWNH"
     exon            476..536
                     /gene="Ppp1r1c"
                     /gene_synonym="4930565M23Rik; 4930579P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            537..571
                     /gene="Ppp1r1c"
                     /gene_synonym="4930565M23Rik; 4930579P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            572..632
                     /gene="Ppp1r1c"
                     /gene_synonym="4930565M23Rik; 4930579P15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            633..3071
                     /gene="Ppp1r1c"
                     /gene_synonym="4930565M23Rik; 4930579P15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r1c"
                     /gene_synonym="4930565M23Rik; 4930579P15Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      1760
                     /gene="Ppp1r1c"
                     /gene_synonym="4930565M23Rik; 4930579P15Rik"
                     /note="major polyA site"
ORIGIN      
        1 agccggttag taatgtacag tagatagagc ctttctttta aatcccaggg cagcaggtcc
       61 ttcagggcta gcattgcaat ttcaattagc tcctgagtga aagcttggca tgtgtattag
      121 caagcaggga cacaattagc ttattcctcc tttccgtgtt gtgttgagag gatccaaaag
      181 attggtggtg gatcgggcaa gccaggcatc actggatttt taagaaggga gttgctcaga
      241 cctcgacatc ttcacttgct cacgctggaa ttacagagat ttattacaaa gcactgtgtg
      301 gcttggtgaa gggtgcctct ggagacactc cggatagcat ttgagctttg tctgtttgag
      361 tgcttcaccg ctctgtcttg gtctcatcat tagcatggag cccaatagcc ccaaaaagat
      421 acaatttgct gtgcctttat tccagagtca gattgcccca gaggcagcag agcagatcag
      481 gaaaagaaga cctacaccag catcccttgt gattctcaat gaacataatt ccccagaaat
      541 tgatgagaag agagtgacta acacacaaga atcgcagaat gcatcgccta agcaaaggaa
      601 gcagagtgtg tacacaccac cggccatgaa aggcgttaag catctgaaag accagaatgg
      661 atcagcgttc ccggaagaag aagaaagtgc aagtgaaaga gaagagaagt ggaaccatta
      721 attacccatc ggtagcaaga gggcttcttg gaaataactg gactgtgtac tcttctgaat
      781 atccattggt actccaaagc tccgcctcca gcatcctctt ctgtctcacc ccccaccccc
      841 acagcagtgt gatccccatg gaagccccct tgactgaact gtgaaaccga gtgcagattg
      901 ctgtgtacca cttgcagtaa agaataggca cttactttac cccaactttt cttttcaact
      961 catcacacct aggaatctgc tgccacatga atgttctcac tttgatactg ccaaagctta
     1021 agtcctcctg gcctacgaca taatttacat tctaaggtca aatgtagaga gcattacaaa
     1081 ataaatagca aatgtgtgtg ggacgagtgt gagtggggat taatggaaga cgggcatctg
     1141 cggaggctcc taagtaataa ccgcacttag caagcttctg tgccctacat cagaccccag
     1201 tttacctcaa ggagacagtg ataggcagac atctgttgtc tggcttcaaa acaccacatc
     1261 agatgttaca tgatttccat ccagcagtta cttaaagaaa caaatgtccc tttattttct
     1321 aagccattca atgttggctt ctcagcatca tctagttatt ggaaaggaaa tgttaaattt
     1381 gtaagtaaac atagccattc tcttctgcct tttctttatt attatttttt aactatttaa
     1441 aacgaagcca tctatattgt atcacttttg tttgtctggg tttttcattg tttctttctg
     1501 ttttattggt gctagagaat gaacccaggg ctttgtatat gcaaatattc ctcagtctta
     1561 ttgcagttta atatatcctg actgttttat tcttcttctc tgtgatagaa taaaaagaaa
     1621 tatctcaaaa actcagccat agactcaccc attaattcga caactacttt ttgtggagtt
     1681 aaaaaaaaat cgctgttatt tggagattag tattacaaca ttccatcttt ccctttctca
     1741 gtaaaccttt ctacccctca gcccttttca aagttgtcgc ctctcttttc attaactgtt
     1801 gtaacataca tatcaaaaat gattttaaat gttttttcct aggaaattac tcttttggaa
     1861 gccataaaga taaaggaaag cttattttct ctctggagat agggctacag caaggttttg
     1921 tatgacaatg ggtatttgtc agtatgactt taacttagat ttctggccat tgggtaattt
     1981 taattattca tgatatagga atgcacaatt tagtggagat agatagtttt gtttctacac
     2041 tgttggtttt aatgagattc aaatatttca tagatgtaaa gaaatatcca tccaaagcca
     2101 ttaaagcaag gggttggtga taggtcagtg ggtaagaacg cctgtcacca actgataggt
     2161 tagtagatcc ctgaaaccca caggcaggag gagagaatca attgtttctt acttcatgag
     2221 atgtattgta tgcctctcac ttttactaca caccttagaa tgtgggacac acacacacac
     2281 acacacacac acacacacac acactaaata atcataaaaa atccactaag agaaaattaa
     2341 gaagggaagg aaaaattaaa atgtgaaatt tactataaaa tcttaaagtg caaatccaaa
     2401 agaataagat ttttttttaa tttaaaattt tataatgtag caaataagag tttatgtgaa
     2461 attattaaca aatgcagtag aaatgagttt cactcagtga gaagcatccc aagactggat
     2521 gttattgccc agtgtctatc ctgtcctcta tctgtcttcc tcttcctcct ctttttcctc
     2581 cttgtttcct ctttctctct tttctctatg ttgtccttga taaatcaata aaccattaga
     2641 gtctattgcc acctgccgtg actatttttc ttcccaaatt cttctctact gtgaacatca
     2701 ttaaggttca tatttcttgt aaatgtgttt gagttttttg tttcaaaaca ttcctgacac
     2761 cctttgagag tgtttgagac tccctggggt gcaaacaaaa taatagtcac cttttccctt
     2821 tccttgaata tacactttta taagtgcacc cctcccccac cttaggtaaa caggaaggat
     2881 ccaaagctcc ccctgatatc atattatcat tttaggacat gtgcagcctg acttttgagc
     2941 tgctttcttt tcctctctgt tgttaatggt atcaaaccat gagatgcatg ttttcctggg
     3001 ggaatgttgt ttcttctgtt ccttggtcca ctctcaaaac aaatcaatta cagtttaaag
     3061 tttttcttgg g
//
