LOCUS       NM_144828               2017 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory inhibitor subunit 1B
            (Ppp1r1b), transcript variant 1, mRNA.
ACCESSION   NM_144828
VERSION     NM_144828.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2017)
  AUTHORS   Hwang,J., Kang,X., Wolf,C. and Touma,M.
  TITLE     Mapping Chromatin Occupancy of Ppp1r1b-lncRNA Genome-Wide Using
            Chromatin Isolation by RNA Purification (ChIRP)-seq
  JOURNAL   Cells 12 (24), 2805 (2023)
   PUBMED   38132125
  REMARK    GeneRIF: Mapping Chromatin Occupancy of Ppp1r1b-lncRNA Genome-Wide
            Using Chromatin Isolation by RNA Purification (ChIRP)-seq.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2017)
  AUTHORS   Biswas,S., Chan,C.S., Rubenstein,J.L.R. and Gan,L.
  TITLE     The transcription regulator Lmo3 is required for the development of
            medial ganglionic eminence derived neurons in the external globus
            pallidus
  JOURNAL   Dev Biol 503, 10-24 (2023)
   PUBMED   37532091
REFERENCE   3  (bases 1 to 2017)
  AUTHORS   Galazo,M.J., Sweetser,D.A. and Macklis,J.D.
  TITLE     Tle4 controls both developmental acquisition and early post-natal
            maturation of corticothalamic projection neuron identity
  JOURNAL   Cell Rep 42 (8), 112957 (2023)
   PUBMED   37561632
REFERENCE   4  (bases 1 to 2017)
  AUTHORS   Liu,W., Xie,H., Liu,X., Xu,S., Cheng,S., Wang,Z., Xie,T.,
            Zhang,Z.C. and Han,J.
  TITLE     PQBP1 regulates striatum development through balancing striatal
            progenitor proliferation and differentiation
  JOURNAL   Cell Rep 42 (3), 112277 (2023)
   PUBMED   36943865
REFERENCE   5  (bases 1 to 2017)
  AUTHORS   Dupuy,V., Prieur,M., Pizzoccaro,A., Margarido,C., Valjent,E.,
            Bockaert,J., Bouschet,T., Marin,P. and Chaumont-Dubel,S.
  TITLE     Spatiotemporal dynamics of 5-HT6 receptor ciliary localization
            during mouse brain development
  JOURNAL   Neurobiol Dis 176, 105949 (2023)
   PUBMED   36496200
REFERENCE   6  (bases 1 to 2017)
  AUTHORS   Fienberg,A.A., Hiroi,N., Mermelstein,P.G., Song,W., Snyder,G.L.,
            Nishi,A., Cheramy,A., O'Callaghan,J.P., Miller,D.B., Cole,D.G.,
            Corbett,R., Haile,C.N., Cooper,D.C., Onn,S.P., Grace,A.A.,
            Ouimet,C.C., White,F.J., Hyman,S.E., Surmeier,D.J., Girault,J.,
            Nestler,E.J. and Greengard,P.
  TITLE     DARPP-32: regulator of the efficacy of dopaminergic
            neurotransmission
  JOURNAL   Science 281 (5378), 838-842 (1998)
   PUBMED   9694658
REFERENCE   7  (bases 1 to 2017)
  AUTHORS   Anderson,S.A., Qiu,M., Bulfone,A., Eisenstat,D.D., Meneses,J.,
            Pedersen,R. and Rubenstein,J.L.
  TITLE     Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the
            striatal subventricular zone and differentiation of late born
            striatal neurons
  JOURNAL   Neuron 19 (1), 27-37 (1997)
   PUBMED   9247261
REFERENCE   8  (bases 1 to 2017)
  AUTHORS   Blau,S., Daly,L., Fienberg,A., Teitelman,G. and Ehrlich,M.E.
  TITLE     DARPP-32 promoter directs transgene expression to renal thick
            ascending limb of loop of Henle
  JOURNAL   Am J Physiol 269 (4 Pt 2), F564-F570 (1995)
   PUBMED   7485543
REFERENCE   9  (bases 1 to 2017)
  AUTHORS   Perez,R.G. and Lewis,R.M.
  TITLE     Regional distribution of DARPP-32 (dopamine- and adenosine
            3',5'-monophosphate-regulated phosphoprotein of Mr = 32,000) mRNA
            in mouse brain
  JOURNAL   J Comp Neurol 318 (3), 304-315 (1992)
   PUBMED   1533862
REFERENCE   10 (bases 1 to 2017)
  AUTHORS   Kurihara,T., Lewis,R.M., Eisler,J. and Greengard,P.
  TITLE     Cloning of cDNA for DARPP-32, a dopamine- and cyclic AMP-regulated
            neuronal phosphoprotein
  JOURNAL   J Neurosci 8 (2), 508-517 (1988)
   PUBMED   3339428
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CX239932.1, CX240293.1,
            AK141563.1 and BU700812.1.
            
            On Sep 17, 2015 this sequence version replaced NM_144828.1.
            
            Summary: This gene encodes a bifunctional signal transduction
            molecule. Dopaminergic and glutamatergic receptor stimulation
            regulates its phosphorylation and function as a kinase or
            phosphatase inhibitor. As a target for dopamine, this gene may
            serve as a therapeutic target for neurologic and psychiatric
            disorders in humans. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.135321.1, BC026568.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               CX239932.1         1-284
            285-987             CX240293.1         1-703
            988-1991            AK141563.1         181-1184
            1992-2017           BU700812.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..2017
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.75 cM"
     gene            1..2017
                     /gene="Ppp1r1b"
                     /gene_synonym="DARPP-32; Darpp32"
                     /note="protein phosphatase 1, regulatory inhibitor subunit
                     1B"
                     /db_xref="GeneID:19049"
                     /db_xref="MGI:MGI:94860"
     exon            1..769
                     /gene="Ppp1r1b"
                     /gene_synonym="DARPP-32; Darpp32"
                     /inference="alignment:Splign:2.1.0"
     exon            770..830
                     /gene="Ppp1r1b"
                     /gene_synonym="DARPP-32; Darpp32"
                     /inference="alignment:Splign:2.1.0"
     exon            831..853
                     /gene="Ppp1r1b"
                     /gene_synonym="DARPP-32; Darpp32"
                     /inference="alignment:Splign:2.1.0"
     exon            854..929
                     /gene="Ppp1r1b"
                     /gene_synonym="DARPP-32; Darpp32"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1112
                     /gene="Ppp1r1b"
                     /gene_synonym="DARPP-32; Darpp32"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1235
                     /gene="Ppp1r1b"
                     /gene_synonym="DARPP-32; Darpp32"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1999
                     /gene="Ppp1r1b"
                     /gene_synonym="DARPP-32; Darpp32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1979..1984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r1b"
                     /gene_synonym="DARPP-32; Darpp32"
                     /note="hexamer: AATAAA"
     polyA_site      1999
                     /gene="Ppp1r1b"
                     /gene_synonym="DARPP-32; Darpp32"
                     /note="major polyA site"
ORIGIN      
        1 aagtccacgt cccgaggggg ggtgggcgaa gaggttaaag ccagagtccc ggctgcagct
       61 gcccctgccc cctcccctta gcgtcaccgc tggacttcat taataataca acgccgagtt
      121 ctggggatac tgcagggggc ccccgggccg ctcccctagc cctggctccc actccgcacc
      181 ctcctcccag cccgggagaa cacgcttctc gatgctcatt ggccgctttc ccctaagccc
      241 tccctccaaa cgcctgggcg ccagtccctg gcagagagga cgggctggga ccccagggtt
      301 gggacctgtg gggtgcagcc agtagcggca gaggcgcgga gaggaagaag gcagagtggg
      361 ggatagacag aagctggtag agcaaggccg agggcagccc gccgagatag ctcaggccgg
      421 cagccagagc cccgcgcccc aaaccggtgg cgcgcagcta aggcgcgggg atcctgagct
      481 ctgacctggg gacgctgagc ccggcgctgc aggcgagccc cgctgttcag tcctcccgac
      541 cgtcgcgcgt tctcctcgtg gagcgcggga ttttcctggg tgcggggaca gtgctcctcc
      601 tcctcctccg cgcagcacgc gccacccgca gctccggaca gccgagcagg gctcagccag
      661 acaccccaag aacgctcagc cgcccgccat ggaccccaag gaccgcaaga agattcagtt
      721 ctctgtgccc gcgcccccga gccagctcga cccccgacag gtggagatga tccggcgccg
      781 gagaccaacc cctgccatgc ttttccgggt ctcagagcac tcctcaccag aggaggaggc
      841 ctctccacat cagagaacct ctggagaggg gcaccaccca aagtcgaaga gacccaaccc
      901 ctgtgcctat acgcccccat cactgaaagc tgtgcagcac ctgcagacca ttagcaactt
      961 gagtgagaac caggcctcgg aggaagagga tgagttaggg gagcttcggg agcttgggta
     1021 cccacaggag gatgatgagg aggatgagga tgaagaggag gacgaagaag aagacagcca
     1081 ggcggaggtc ctgaaaggca gcaggggcac tgtggggcag aagcctactt gtggccgggg
     1141 tctggagggg ccctgggagc gcccacctcc tctggatgag ccccagagag atggaaactc
     1201 tgaggaccaa gtggaaggca gagcaacact aagtgagcct ggagaggaac ctcagcatcc
     1261 cagccccccc tgagcctggc acataagctc agagccctgt atctcccagg aggaagtgtt
     1321 ccccagaaac ccactctgtc cccaccctcc tttgtaccct gtctttcacc tgctagggct
     1381 gcggcttctg acttttagaa gactaaggct ggtctctgtt tgctttggct gaagcccaga
     1441 gtccccaatg cctttccctg ccagtcattc ttctatttac ccggtgggag tagggaggtg
     1501 agagagccca cactggaaac cccagaaggc cataaacaac catttattct ccacaagtcc
     1561 cctccctctc cagattctct cccctgggca caggagaccc acagggcagg tcctaagatc
     1621 tggggaaagg aggtactgag agcctacagg tgccctgaga tctcctcctt cccctaccag
     1681 tggtgggcgt tgagtcccca accctctcat agacttcaac cagggctcag gtctcacgca
     1741 ttctttgcag agcctcaaca tgtccctccc ttagtatccc attcctgctg ggtgcctgca
     1801 agatggactg gcagaggctg cttgctgcgt tttgtttgtg ctttggtgcc aggaatgcac
     1861 ttactatctg tccttagggg gccacacagt ggggggagcc tggttctcct tgtcctccag
     1921 caacttggtt cccttcccct tcttccctta ctctaggcct gaacccctcc tacgctgtaa
     1981 taaatctttg taaataatta aaaaaaaaaa aaaaaaa
//
