LOCUS       NM_175242               3185 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 18
            (Ppp1r18), transcript variant 1, mRNA.
ACCESSION   NM_175242 XM_001003622 XM_001474189
VERSION     NM_175242.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3185)
  AUTHORS   Lee,H.S., Sun,H., Lagarrigue,F., Kim,S.H.J., Fox,J.W.,
            Sherman,N.E., Gingras,A.R. and Ginsberg,M.H.
  TITLE     Phostensin enables lymphocyte integrin activation and population of
            peripheral lymphoid organs
  JOURNAL   J Exp Med 219 (8) (2022)
   PUBMED   35766979
  REMARK    GeneRIF: Phostensin enables lymphocyte integrin activation and
            population of peripheral lymphoid organs.
REFERENCE   2  (bases 1 to 3185)
  AUTHORS   Matsubara,T., Kokabu,S., Nakatomi,C., Kinbara,M., Maeda,T.,
            Yoshizawa,M., Yasuda,H., Takano-Yamamoto,T., Baron,R. and Jimi,E.
  TITLE     The Actin-Binding Protein PPP1r18 Regulates Maturation, Actin
            Organization, and Bone Resorption Activity of Osteoclasts
  JOURNAL   Mol Cell Biol 38 (4), e00425-17 (2018)
   PUBMED   29158294
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY198945.1, AK051656.1 and CR974451.9.
            
            On or before Apr 10, 2009 this sequence version replaced
            XM_001474189.1, XM_001003622.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051656.1, AK009340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BY198945.1         5-49
            46-2507             AK051656.1         2-2463
            2508-2586           AK051656.1         2465-2543
            2587-3185           CR974451.9         99393-99991
FEATURES             Location/Qualifiers
     source          1..3185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.72 cM"
     gene            1..3185
                     /gene="Ppp1r18"
                     /gene_synonym="2310014H01Rik"
                     /note="protein phosphatase 1, regulatory subunit 18"
                     /db_xref="GeneID:76448"
                     /db_xref="MGI:MGI:1923698"
     exon            1..2171
                     /gene="Ppp1r18"
                     /gene_synonym="2310014H01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             621..2405
                     /gene="Ppp1r18"
                     /gene_synonym="2310014H01Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phostensin; protein phosphatase 1 F-actin
                     cytoskeleton-targeting subunit"
                     /codon_start=1
                     /product="phostensin isoform 1"
                     /protein_id="NP_780451.1"
                     /db_xref="CCDS:CCDS50094.1"
                     /db_xref="GeneID:76448"
                     /db_xref="MGI:MGI:1923698"
                     /translation="MTAIPDWKLQLLARRRQEEAAVRGREKAERDRLSQMPAWKRGIL
                     ERRRAKLGLPPGEGSPVPGNAEAGPPDPDESAVLLEAIGPVHQNRFIQQERQRQQQQQ
                     QQQRNEVLGDRKAGPLEVLERRSSPGNLRDQSPKGRESREERLSPRESRDRRLVIGGA
                     QESSSRSLRDWRQSPAEARDLSSRPAEAQKWRLSPGETPEESLRLAGSGDDSPKRKEV
                     LESILSPGEPGDQKASPTDVHKWNLDSREPQKQSLIQLEATEWRLKSGEERKDYLEGC
                     GREEEKLSSGIVPVTKEVQDITSSEVETAEQRPTESWKWTLNSGKARERTTWDIDTQT
                     QKPDPPASSEKHPGPSGMEAEEEAEKEEAEAQSRPLRAQQNLCSGPSPLPPEHSGTEG
                     SRQQEEEAAEPRPPTPAPLSPPPSAPTAPQPSGDPLMSRLFYGVKPGPGVGAPRRSGH
                     TFTVNPRRCAPPASPAPPVNPATADAAGSGSGKKRYPTAEEILVLGGYLRLSRSCLVK
                     GSPERHHKQLKISFSETALETTYQYPSESSVLEDLGPEPETPIAPLATQPDEEEEEEE
                     EEEELLLQPGLQGGLRTKALIVDESCRR"
     exon            2172..2385
                     /gene="Ppp1r18"
                     /gene_synonym="2310014H01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..3185
                     /gene="Ppp1r18"
                     /gene_synonym="2310014H01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3159..3164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r18"
                     /gene_synonym="2310014H01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3185
                     /gene="Ppp1r18"
                     /gene_synonym="2310014H01Rik"
                     /note="major polyA site"
ORIGIN      
        1 gccgagcgca gccgggaagg cagccgggag ctgcgggggc cccgtgcgaa gaggcgccgg
       61 cgcccttgcc tgtttcccgg tctccccttc taccctggac ctctgccctc tacatctgtc
      121 ctcacctcct cacctcctgc ccgatctcct cgcccttcgc cgtctggttc cctgttcttc
      181 ccgtttatct ccccctgcgt accgggggag gcagtcttga ctgaatccgc tcacttctca
      241 gccccggctc ctccggctcc tctctctctc ctgcttttcc tctctcccct ttcttatatc
      301 ttagggacgg tctggtgccc acaaacccca atctagctct gcctctgccc ggaatctcga
      361 ctcttcctct cccactatcc ccacccccaa cttggcaccc agcttttctc ttcagttttt
      421 cagttcctga ctcttttgct gtccttcctt tcacggcctt cctctatctt cattcttaat
      481 tccactgtcc cctcctgccc ttcttcgtcc cttcccgcat cacttcctcc cccaaccccc
      541 attctcagtc tccgggctcc tctgaagctt acccttcctg ttcctgtccc ccaatactct
      601 ctccttcact tccagtgacc atgaccgcta tcccagattg gaagctacag ttgctagccc
      661 ggcggaggca ggaggaggca gcggttcgtg gccgcgagaa agcagaacgg gatcgcttgt
      721 cccagatgcc agcctggaag aggggaatcc tggaacgacg cagagccaag ttgggcctgc
      781 ctcctggaga ggggagccct gtgcctggga atgctgaggc tggacctcca gacccagatg
      841 aatctgctgt ccttttggag gctattggac cagtacatca gaatcgattc atccaacagg
      901 agcgacagcg gcagcagcaa cagcagcagc agcagagaaa cgaggtgctt ggtgatagga
      961 aggctgggcc tctggaggtt ctagaaagga gatcaagtcc tggtaattta agagatcaga
     1021 gtcctaaggg aagagagtcc agagaagaga ggctaagtcc ccgggagtcc agagatagga
     1081 ggctggtgat agggggagcc caagagtcaa gttcgaggtc tcttcgagac tggaggcaga
     1141 gcccagcaga ggccagagac ctgagttcca gaccagcaga ggctcagaaa tggaggctga
     1201 gccctggaga aactccagag gagagtctga gattagcggg ttctggagat gacagtccca
     1261 agagaaagga ggtgttggaa agcattctga gccctgggga gcctggtgac cagaaggcca
     1321 gcccgacaga tgtccataaa tggaatcttg actcaagaga accccagaaa cagagcttga
     1381 tacagctgga ggccacagag tggaggctga agtccggtga agagaggaaa gactacttgg
     1441 aagggtgtgg gagagaggaa gagaaattga gttcagggat tgttccggtg acaaaggagg
     1501 ttcaagacat cacctcgagc gaagtggaga ctgctgagca gagacccact gaaagctgga
     1561 aatggaccct aaactctggg aaggctcgag aacggacgac ctgggacata gatacacaaa
     1621 ctcagaagcc agatcctcca gcatcttcag agaagcaccc aggaccttct ggtatggagg
     1681 ctgaagagga ggctgagaag gaggaggcgg aggctcagag caggcctctg agagcccagc
     1741 agaacctctg ctctgggccc tcccccctcc caccagagca ctctgggacg gaaggctcca
     1801 gacagcagga agaggaagcg gcagaacccc ggcccccaac accagcccct ctgtctcccc
     1861 caccctcggc cccaactgcc ccccaaccct ctggggatcc cctcatgagc cgtctgttct
     1921 atggggtgaa accaggaccg ggggtggggg ccccccgccg cagtggacac accttcactg
     1981 tcaacccacg gaggtgtgcg ccccctgcca gcccagcccc tccagtcaac cctgctacag
     2041 ctgatgctgc agggtctgga tctgggaaga agcggtaccc aactgcagag gagatcttgg
     2101 tgctgggggg ctacctccgt ctcagccgca gctgccttgt caaggggtcc cctgaaagac
     2161 atcacaaaca gctcaagatc tcctttagtg agacagccct ggagaccaca taccaatacc
     2221 cttctgagag ctcggtactg gaggatctag gcccggagcc tgagaccccc attgccccct
     2281 tagcaaccca gcctgacgag gaggaggagg aggaggagga agaggaggag ttgcttctgc
     2341 agcctgggct ccagggcggg ctgcgcacca aggccctaat cgtggatgag tcctgccggc
     2401 ggtgaccatc ttccagtttg ggcgcatacc tccttccttc cttccttccc gtacctgaag
     2461 cttctggagt ctggatgatt cagagccgac agacctggca gggagcctgc ctggcaggga
     2521 agggggttga gcatattctg acttgctttt cccatcccat ttctggggca gagccagtag
     2581 cctaaattta cccctaactc agggtgtttc ccgtgggtga cctaagagtg agcatcaagt
     2641 cctgggttgg aactcagaag tgatctggaa ttgagatgga gcacccccta gccctgcagc
     2701 cttccttaac tcccagcaac tcccggggac ctacagacac ccctttttct aggtcactac
     2761 cccttcgttt acagcttcct tctctcttga tcacagcctg gtttacatta cccccccccc
     2821 ccagctccca gtcccacctg cgaagtccca ggtttacaag ccatgcctac ccacggagag
     2881 cccccgtggg accctccacc ttcccaccgt ttcattgaga gtgacttggg aaggtgtgtg
     2941 gccttcttca actttgctca gtattactgt gcctcggttt cccccaagag ggaaggctgg
     3001 ggatcctaac cctgaacccc atgaaagtta tttaattctg tttctctgtg tggttcatat
     3061 tgaattgaac tgcagcgtgg gggtgctaag gaagtgcttc gcttccctgg cgctcctttg
     3121 tcagctgcct gatttgtatc gtttttgtaa ctttccataa taaaatggag ctcttttcaa
     3181 ctctc
//
