LOCUS       NM_011153               1757 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 17
            (Ppp1r17), mRNA.
ACCESSION   NM_011153
VERSION     NM_011153.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1757)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1757)
  AUTHORS   Tokizane,K., Brace,C.S. and Imai,S.I.
  TITLE     DMHPpp1r17 neurons regulate aging and lifespan in mice through
            hypothalamic-adipose inter-tissue communication
  JOURNAL   Cell Metab 36 (2), 377-392 (2024)
   PUBMED   38194970
  REMARK    GeneRIF: DMH[Ppp1r17] neurons regulate aging and lifespan in mice
            through hypothalamic-adipose inter-tissue communication.
REFERENCE   3  (bases 1 to 1757)
  AUTHORS   Liu,Y., Wei,D., Deguchi,Y., Xu,W., Tian,R., Liu,F., Xu,M., Mao,F.,
            Li,D., Chen,W., Valentin,L.A., Deguchi,E., Yao,J.C., Shureiqi,I.
            and Zuo,X.
  TITLE     PPARdelta dysregulation of CCL20/CCR6 axis promotes gastric
            adenocarcinoma carcinogenesis by remodeling gastric tumor
            microenvironment
  JOURNAL   Gastric Cancer 26 (6), 904-917 (2023)
   PUBMED   37572185
  REMARK    GeneRIF: PPARdelta dysregulation of CCL20/CCR6 axis promotes
            gastric adenocarcinoma carcinogenesis by remodeling gastric tumor
            microenvironment.
REFERENCE   4  (bases 1 to 1757)
  AUTHORS   Galdos,F.X., Xu,S., Goodyer,W.R., Duan,L., Huang,Y.V., Lee,S.,
            Zhu,H., Lee,C., Wei,N., Lee,D. and Wu,S.M.
  TITLE     devCellPy is a machine learning-enabled pipeline for automated
            annotation of complex multilayered single-cell transcriptomic data
  JOURNAL   Nat Commun 13 (1), 5271 (2022)
   PUBMED   36071107
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1757)
  AUTHORS   Girskis,K.M., Stergachis,A.B., DeGennaro,E.M., Doan,R.N., Qian,X.,
            Johnson,M.B., Wang,P.P., Sejourne,G.M., Nagy,M.A., Pollina,E.A.,
            Sousa,A.M.M., Shin,T., Kenny,C.J., Scotellaro,J.L., Debo,B.M.,
            Gonzalez,D.M., Rento,L.M., Yeh,R.C., Song,J.H.T., Beaudin,M.,
            Fan,J., Kharchenko,P.V., Sestan,N., Greenberg,M.E. and Walsh,C.A.
  TITLE     Rewiring of human neurodevelopmental gene regulatory programs by
            human accelerated regions
  JOURNAL   Neuron 109 (20), 3239-3251 (2021)
   PUBMED   34478631
REFERENCE   6  (bases 1 to 1757)
  AUTHORS   Nakazawa,T., Endo,S., Shimura,M., Kondo,M., Ueno,S. and Tamai,M.
  TITLE     Retinal G-substrate, potential downstream component of NO/cGMP/PKG
            pathway, is located in subtype of retinal ganglion cells and
            amacrine cells with protein phosphatases
  JOURNAL   Brain Res Mol Brain Res 135 (1-2), 58-68 (2005)
   PUBMED   15857669
  REMARK    GeneRIF: retinal G-substrate plays a role as a downstream component
            of the NO-cGMP-PKG pathway. The co-localization of retinal
            G-substrate with protein Ser/Thr phosphatases suggests that it acts
            as an endogenous protein phosphatase inhibitor.
REFERENCE   7  (bases 1 to 1757)
  AUTHORS   Mukhopadhyay,P., Greene,R.M., Zacharias,W., Weinrich,M.C.,
            Singh,S., Young,W.W. Jr. and Pisano,M.M.
  TITLE     Developmental gene expression profiling of mammalian, fetal
            orofacial tissue
  JOURNAL   Birth Defects Res A Clin Mol Teratol 70 (12), 912-926 (2004)
   PUBMED   15578713
REFERENCE   8  (bases 1 to 1757)
  AUTHORS   Iida,R., Yasuda,T., Tsubota,E., Takatsuka,H., Masuyama,M.,
            Matsuki,T. and Kishi,K.
  TITLE     Five age-dependently expressed genes in mouse brain revealed by the
            fluorescence differential display-PCR technique
  JOURNAL   Exp Gerontol 37 (8-9), 1121-1126 (2002)
   PUBMED   12213562
REFERENCE   9  (bases 1 to 1757)
  AUTHORS   Hall,K.U., Collins,S.P., Gamm,D.M., Massa,E., DePaoli-Roach,A.A.
            and Uhler,M.D.
  TITLE     Phosphorylation-dependent inhibition of protein phosphatase-1 by
            G-substrate. A Purkinje cell substrate of the cyclic GMP-dependent
            protein kinase
  JOURNAL   J Biol Chem 274 (6), 3485-3495 (1999)
   PUBMED   9920894
REFERENCE   10 (bases 1 to 1757)
  AUTHORS   Sowden,J.C., Morrison,K., Putt,W., Beddington,R. and Edwards,Y.H.
  TITLE     The identification of novel sequences expressed in the mouse
            notochord
  JOURNAL   Mamm Genome 8 (1), 42-44 (1997)
   PUBMED   9021147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079365.5.
            
            On May 30, 2018 this sequence version replaced NM_011153.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078335.1, AF500906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC079365.5         122595-122673
            80-238              AC079365.5         127417-127575
            239-391             AC079365.5         131119-131271
            392-544             AC079365.5         131549-131701
            545-1757            AC079365.5         136575-137787
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.65 cM"
     gene            1..1757
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs; Ppp1r2"
                     /note="protein phosphatase 1, regulatory subunit 17"
                     /db_xref="GeneID:19051"
                     /db_xref="MGI:MGI:1333876"
     exon            1..79
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs; Ppp1r2"
                     /inference="alignment:Splign:2.1.0"
     exon            80..238
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs; Ppp1r2"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..624
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs; Ppp1r2"
                     /note="protein phosphatase 1, regulatory (inhibitor) 2; G
                     substrate"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 17"
                     /protein_id="NP_035283.1"
                     /db_xref="CCDS:CCDS20169.1"
                     /db_xref="GeneID:19051"
                     /db_xref="MGI:MGI:1333876"
                     /translation="MSTEMMTTEPVPPLELSDDILGKLDPQCSPSDDLSDQFIKDCDL
                     KKKPRKGKNVQATLNVESDQKKPRRKDTPAVHIPPFIPGVISEHLIKRYDVQERIPKA
                     KSGPALHNSDMEQKRPRRKDTPALHMPPFVAGLTLLRDESAGVILEDEEMDGDKLAI"
     exon            239..391
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs; Ppp1r2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..544
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs; Ppp1r2"
                     /inference="alignment:Splign:2.1.0"
     exon            545..1757
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs; Ppp1r2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1735..1740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs; Ppp1r2"
                     /note="hexamer: AATAAA"
     polyA_site      1756
                     /gene="Ppp1r17"
                     /gene_synonym="Gsbs; Ppp1r2"
                     /note="major polyA site"
ORIGIN      
        1 agccagtgca gccgagtaga gccccagcgc ggtgagaaga actgccttta ccttctcggc
       61 tcaacgcctg cactgattga aaagactctc tctctctctc tctctctctc tctctctctc
      121 tctctctctc tctgtcaact gaggatgtcc actgagatga tgaccaccga gccagtgccg
      181 cctctggagc tttcagacga catactaggc aagctggatc ctcagtgcag cccctcagat
      241 gacctttcag accagttcat taaggactgt gacctcaaaa agaagccaag gaaggggaag
      301 aatgtacagg ccactctgaa tgttgagtca gatcaaaaga aacccaggag gaaagacaca
      361 ccagcagtgc acatcccacc tttcatccca ggtgtgattt cggaacactt aatcaaaaga
      421 tatgatgttc aagagagaat tccaaaggcc aaatcaggcc cagctcttca taactctgat
      481 atggaacaaa aaaggccaag gagaaaagac acgcctgcct tgcacatgcc tccctttgtt
      541 gcaggtctga ctctgctccg ggatgagagt gcaggagtga ttctagagga tgaagaaatg
      601 gatggtgaca agctagctat ttaaagacat ctcccctgag attgcgtgta aatagattac
      661 actggttccc tatggtgatc tagagggaaa aaatagattt gtctctgctc tcattttgtc
      721 ctagtcgact ctaagatcta gacgcctcct ccccaggaga cctactactc agattgctgg
      781 tcaggtcacc tctttgtctt tcctttcttg ctttttaacc ccacctccta aactttcatt
      841 tttctatact gtgcaaagga aagtgatttt tttcttccaa agtaagagag gtgagacctc
      901 agtgcttcat gtctgcaagc aaaaatcctg gataaaagat ggggaggggg gaggggaggc
      961 ggtcctttcc acctggttta gtagcagggc agtccgattc agcatcaaac actcaggagt
     1021 acagcaaggc cacagctgct ggttagactg taagaacatt tggactctaa ctcatggact
     1081 gctatgatga aatgtttttt tctttcttcc ttcctatctt gagagtccaa ctctgatcat
     1141 cctctcctct gaagaccctc attacagatg ttataatggt tcaagaagag gaagccagcc
     1201 cattatgcaa gaataaaaga catcaaaggc agaggatgct ggtctatgta gggaggtctt
     1261 atacttaatc tattgttaaa aaaaaagaga gttcttaact atattggttg tcgtgatatt
     1321 tgtgaattat gtcataatgg gaggtaaata aataccaatg taaggaattt atttttttaa
     1381 atctaaggcc agttgaaggt tgttctgata tttttgccat ctcacttatt tagactctga
     1441 tacgttttct tatataagag gtggtgttgt ctagtgaaca cagatgtgca tttggctcct
     1501 gtgcagctgg caatctccaa gtgcctgtgg ggactctttg catctgtact tcatcagcca
     1561 aacagcagac agagaggagg tgaggactaa aagggtgaaa agcagagtat ctagtgttca
     1621 gaccaaggca ggaggcatgg gacagctctg tacatactga ggtccagctg tttgttatcc
     1681 tttctgtctt tctgttcccc ttacaaagat gtgaaagatg caatacattt cagaaataaa
     1741 gatacttccg cacacat
//
