LOCUS       NM_001159662            6392 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 16B
            (Ppp1r16b), transcript variant 1, mRNA.
ACCESSION   NM_001159662
VERSION     NM_001159662.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6392)
  AUTHORS   Wang,L., Lin,L., Qi,H., Chen,J. and Grossfeld,P.
  TITLE     Endothelial Loss of ETS1 Impairs Coronary Vascular Development and
            Leads to Ventricular Non-Compaction
  JOURNAL   Circ Res 131 (5), 371-387 (2022)
   PUBMED   35894043
REFERENCE   2  (bases 1 to 6392)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6392)
  AUTHORS   Wang,X., Obeidat,M., Li,L., Pasarj,P., Aburahess,S., Holmes,C.F.B.
            and Ballermann,B.J.
  TITLE     TIMAP inhibits endothelial myosin light chain phosphatase by
            competing with MYPT1 for the catalytic protein phosphatase 1
            subunit PP1cbeta
  JOURNAL   J Biol Chem 294 (36), 13280-13291 (2019)
   PUBMED   31315927
REFERENCE   4  (bases 1 to 6392)
  AUTHORS   Yang,J., Yin,S., Bi,F., Liu,L., Qin,T., Wang,H. and Cao,W.
  TITLE     TIMAP repression by TGFbeta and HDAC3-associated Smad signaling
            regulates macrophage M2 phenotypic phagocytosis
  JOURNAL   J Mol Med (Berl) 95 (3), 273-285 (2017)
   PUBMED   27709267
  REMARK    GeneRIF: TIMAP is suppressed by TGFbeta via HDAC3-associated Smad
            signaling.
REFERENCE   5  (bases 1 to 6392)
  AUTHORS   Poirier,C., Gorshkov,B.A., Zemskova,M.A., Bogatcheva,N.V. and
            Verin,A.D.
  TITLE     TIMAP protects endothelial barrier from LPS-induced vascular
            leakage and is down-regulated by LPS
  JOURNAL   Respir Physiol Neurobiol 179 (2-3), 334-337 (2011)
   PUBMED   21907835
  REMARK    GeneRIF: These data confirmed the barrier-protective role of TIMAP
REFERENCE   6  (bases 1 to 6392)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 6392)
  AUTHORS   Heinzel,K. and Bleul,C.C.
  TITLE     The Foxn1-dependent transcripts PCOLCE2 and mPPP1R16B are not
            required for normal thymopoiesis
  JOURNAL   Eur J Immunol 37 (9), 2562-2571 (2007)
   PUBMED   17683113
REFERENCE   8  (bases 1 to 6392)
  AUTHORS   Magdaleno,S., Northcutt,G.M., Curran,T. and Kurschner,C.
  TITLE     mPPP1R16B is a novel mouse protein phosphatase 1 targeting subunit
            whose mRNA is located in cell bodies and dendrites of neurons in
            four distinct regions of the brain
  JOURNAL   Brain Res Gene Expr Patterns 1 (3-4), 143-149 (2002)
   PUBMED   12638124
  REMARK    GeneRIF: mRNA is located in cell bodies and dendrites of neurons in
            four distinct regions of the brain.
REFERENCE   9  (bases 1 to 6392)
  AUTHORS   Cao,W., Mattagajasingh,S.N., Xu,H., Kim,K., Fierlbeck,W., Deng,J.,
            Lowenstein,C.J. and Ballermann,B.J.
  TITLE     TIMAP, a novel CAAX box protein regulated by TGF-beta1 and
            expressed in endothelial cells
  JOURNAL   Am J Physiol Cell Physiol 283 (1), C327-C337 (2002)
   PUBMED   12055102
REFERENCE   10 (bases 1 to 6392)
  AUTHORS   Bleul,C.C. and Boehm,T.
  TITLE     Laser capture microdissection-based expression profiling identifies
            PD1-ligand as a target of the nude locus gene product
  JOURNAL   Eur J Immunol 31 (8), 2497-2503 (2001)
   PUBMED   11500834
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY718617.1, AK037627.1 and AL663077.8.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042123.1, BC057542.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-602               BY718617.1         1-602
            603-2402            AK037627.1         898-2697
            2403-6392           AL663077.8         81607-85596
FEATURES             Location/Qualifiers
     source          1..6392
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 78.72 cM"
     gene            1..6392
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /note="protein phosphatase 1, regulatory subunit 16B"
                     /db_xref="GeneID:228852"
                     /db_xref="MGI:MGI:2151841"
     exon            1..115
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /inference="alignment:Splign:2.1.0"
     exon            116..464
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1921
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /note="whn-dependent transcript 4; CAAX box protein TIMAP;
                     TGF-beta-inhibited membrane-associated protein; protein
                     phosphatase 1, regulatory (inhibitor) subunit 16B"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory inhibitor
                     subunit 16B"
                     /protein_id="NP_001153134.1"
                     /db_xref="CCDS:CCDS16991.1"
                     /db_xref="GeneID:228852"
                     /db_xref="MGI:MGI:2151841"
                     /translation="MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDL
                     LHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGL
                     TALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADL
                     LAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRAAPEQKMISDIHCMIAA
                     GQDLDWIDGQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMP
                     MAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSR
                     RTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQQRSAAEDQRTSTYNGDIRETRT
                     DQENKDPNPRLEKPVLLSEFSTKISRGELDGPVENGLRAPVSTYQYALANGDIWKMHE
                     MPDYSMAYGNPGVADVPPPWSGFKEQSPQTLLELKRQRAAAKLLSHPFLSTHLGSSVA
                     RSGESSSEGKAPLIGGRTSPYSSNGTSVYYTVTSGDPPLLKFKAPMEEMEEKVHGCCR
                     IS"
     exon            465..535
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /inference="alignment:Splign:2.1.0"
     exon            536..681
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /inference="alignment:Splign:2.1.0"
     exon            682..785
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /inference="alignment:Splign:2.1.0"
     exon            786..910
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1036
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1112
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1242
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1411
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..6392
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6372..6377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /note="hexamer: ATTAAA"
     polyA_site      6392
                     /gene="Ppp1r16b"
                     /gene_synonym="ANKRD4; C130078N17Rik; TIMAP; Wdt4"
                     /note="major polyA site"
ORIGIN      
        1 acggtggctc gctacccagc cgagctggct ctgtcgccgc accaccagct gcggctctgg
       61 gacctgcgga tcgagccggg gccggagccg cccggggtag ggctcgagag agcgggcccc
      121 accatgaggc tccagcccct tgggagcccc tgtgctcccc tggccccggg ctcaccgcgc
      181 tagccccagg cagagcaagg gcaggcgcgg ggccatggcc agccacgtgg acctgctcac
      241 agagctgcag ctgctggaga aggtgcctac gctggagcgc ctgcgcgcag cccagaagcg
      301 ccgggctcag cagctgaaga agtgggcaca gtacgagcag gacctgcttc atcgcaagcg
      361 caagcatgag cggaagcgca gcacgggtgg acgtcgcaag aaggtgtcct tcgaggccag
      421 tgtagcgttg ctggaagcct cactgaggaa tgacgccgaa gaagttcgct acttcctgaa
      481 gaacaaggtt agccctgatt tgtgcaatga ggatggactt acagccttgc accagtgctg
      541 cattgacaac tttgaagaga ttgtcaagct gctgctgtcc cacggtgcga acgtgaatgc
      601 caaggacaac gagctgtgga cgcccttgca cgcggcagcc acctgcggcc acatcaacct
      661 ggtgaagatc ctcgttcagt atggggctga cttgcttgct gtcaactctg atggaaacat
      721 gccatatgac ctctgcgagg atgaacccac cctggatgtc atcgagacct gcatggcata
      781 ccaaggcatc acacaggaga aaatcaacga gatgcgagca gcccctgagc agaagatgat
      841 ttcagacatc cactgcatga tagcagcggg ccaggatctc gactggatcg atggccaggg
      901 tgccacactg ctacacatag ctggagccaa tggatatctg cgagcagccg agctcctcct
      961 ggaccatgga gtgcgtgtgg atgtgaagga ctgggatggc tgggagcctc tgcatgcagc
     1021 agccttctgg ggacagatgc caatggcaga gctgctggtg tcccatggag ctagtctcag
     1081 tgccaggaca tccatggatg agatgccaat agacctgtgt gaggaggagg aattcaaggt
     1141 cctgctgttg gagctgaaac acaagcatga tgtgatcatg aagtcgcagc tgaggcacaa
     1201 gtcgtccctg agccggagga catccagcgc gggcagccgt gggaaggtgg tgcgtcgagc
     1261 cagcctgtca gacagaacca acctataccg gaaagaatat gagggcgagg ccatcttgtg
     1321 gcagcagcgg agtgcagctg aggaccagcg gacttcaacc tacaatggag acatcaggga
     1381 gaccaggaca gaccaggaga acaaggaccc gaaccccagg ctggagaagc ccgtgctgct
     1441 ctcagaattc tctaccaaga tctcacgggg agaactggat gggcctgtgg agaatggcct
     1501 ccgggctcct gtcagcactt accagtatgc gctggccaat ggggacatat ggaagatgca
     1561 cgagatgcct gactacagca tggcctacgg caaccctggc gtggctgatg tccccccacc
     1621 ctggagtggc ttcaaggagc agagccccca aacgctcctg gagctgaaga ggcagagggc
     1681 cgcagccaag ctgctcagtc acccattctt aagcacccac ctgggcagca gcgtggccag
     1741 gtcgggggag agcagcagcg aaggcaaggc ccccttgatt ggaggcagaa cttcccccta
     1801 cagcagcaac gggacctcgg tgtattatac agtcaccagc ggagatcccc cgctcttgaa
     1861 gttcaaggcc cccatggagg agatggagga gaaagttcac ggctgctgcc ggatctccta
     1921 gtgtccttga actggaggag agagctgcct cggagagggg cccctggaat ccaaagccgg
     1981 tccaacagct ctggctggcg aggtgtcggg gcagccgggg agaggtggga tctgctttct
     2041 agaggaatgc tgaccttacc tcatgcccag ccgcccatag catctccact cccttctgtg
     2101 ctgcttcctt gcctcactca atgcctgcac ctgaagtata gcaggccgac tcactctgca
     2161 gtctgattca ggaagggtgg gcctgggatc tcacttctgc acttggtaaa ggcttcttag
     2221 gaccaggaat atcaactccc tacacacaca cacacacaca cacacacaca cacacacaca
     2281 cacacacaca cacatactca atttagtgta taaggatgtt acacctgagc tcttgggaaa
     2341 caaatgaggc taagaacttg tgggttatcc ccagaaaatg aatgagttca agacagtctt
     2401 ggcaccactg ccaactggct tccactgggg agaggcctgc tcagcggaga cccacagctc
     2461 tgaagtcata ccaggctggg tcactagcac acctagcaag agacaggaag tcctatgggt
     2521 tcagggaatc cgggaatcca tacggatcag gttagtgggc ccaggcctgc tccccacagc
     2581 cttgctgaga gctgttctca tacatatgtc aataagaaag tggagagtgt tcaaaggtca
     2641 aacaggaaag ccaggccatc catgcttctg tgggagcaca ggagtcgggt tgggtgcagc
     2701 acattggtat tttccaaact gtgtttggta aaagcgttct ttcaggctgt aagatcccag
     2761 gtgggaggtt cctgaatttg ccttctccca agatagtgtc acacttgggt tttattgtct
     2821 ggtatttgag aaatgaattt catcaggagc ttccgtgggg ctagggctcc cagggagaag
     2881 gtgaacgcat tgctgagaac accatggtta acattgacat aacagcatcc tagccggtct
     2941 ttgtggtttt cctgctgttt tgggccagcc catctcagcc tggccttctc agcctgagcc
     3001 atcccatctt tcggttgagg cttgcaccct gccctcccac ctaacaggat tgagtctgca
     3061 gagtgaatgc tcaggcccac gccccttcaa gctttgcctt ttctgtaatg ttgtgtaaga
     3121 catgtttgcc aagtgtcact tgtcggctct tgccaggagg tctcaaagct cccagcctgc
     3181 tgcttctgga gtggtcatgc ccaaagctgc aaactgaggt gcccgcggcc accatcctgt
     3241 gctgcattca ggagagcatg gcgtggctgg agttggctat catcccagct gtacagcttt
     3301 gctgcccctg tcttcttgat gctgggaaag gaagcccaca ccacatcacc accatgctat
     3361 cccacaaaac cgttgaaatt gtgccccgta ccttgagtgc gacacactgg ctctgccaaa
     3421 accttctggt gtaactggca agctacgagt tggttccttg ctccgtgctc tttttatttg
     3481 tcctcaaact acctccttag agccccaaga gggtccccac gtcattcgga tgtatgggac
     3541 agatacttct ttacagcccc ctatgccata cccttagtag gtaggcttgc cacttgttgg
     3601 tctctgtctc cactgtggcc tcagggcctc agtagactag agatgaatca ggacctgact
     3661 agatctgcaa gatgctttat tagaaccagg agtgtgggcc agagagcacc ctgaaggctg
     3721 ctggatgcag aaggaggtgc acaacactag gtcatctcca ccccaactcc aggacagatg
     3781 gaatccggca tggtgcaata acataagaga ctaaagacag tttctgggat ccctgggggc
     3841 tcagctaggc tctgtagccc atagctgaaa gaggagatgg tcaaaacaca cacctgtggc
     3901 tttaaacatt tagctctgac agacactgaa atgcctctgg agatgatttt agccacaagg
     3961 tgggcagttg cccaggcagc cagctacata ctcttaggag tcagctgccc agggtttctg
     4021 agctctgtgc tcaggggcca gagaatgaag gcatttattg ccatctctga gccattcagg
     4081 ccatctcttc acacccagca cttcttcctg cctcctggac cgttcttctc tacctgaggg
     4141 gtgggaaact cggctgcctc ctgcatggga gctagtccca gacggtgtgg actcatgggc
     4201 ttttgttcat gttttccact agggataaac aaatgttccc tgttcaggct ccaagtcccc
     4261 agggcacttt gtgactcttt ggaatattga gagtcacaat gaggaacagt ctccagcgca
     4321 tgagccaggg ccacccaccc attcactcat gtgatcgatc tattgaggtg ctgagacaca
     4381 cccgatgcgc tgttagtttc agcagataat ggactaacct ggcagtgaag actttgatct
     4441 cttgaggacc gtgggcatcc ccggactcat ctattattct aatcagagtg cctccatgcc
     4501 agaccagtgt cccccgtgct ttgccgcacc tgcagttctt aagagtgtga atctctttat
     4561 ctgggagaca gctttctgac cactcctaga taacatttgc cactaagtgc agaggctaga
     4621 tctcaggtac caggcagaca ttatacaggt ccatctagat agagccttca gaggtagcct
     4681 tcaggccagc atccatggag aacaatacaa cagcagtcta aggtcagtgc ctggaagaac
     4741 cagaagtctg caatttgctg tcaaatacat ccctagcatt tacagtcctc tcctgcttgt
     4801 tttttgctca tgaatcatac agtcttctcc cctacaccac caatgggtgt tgggagggag
     4861 aacaactact tctcttcttt tttttttttt tttttttttt ttttttttaa agatttattt
     4921 atttatttat tatatgtaag tacactgtag ctgtcttcag acactccaga agagggagtc
     4981 agatctcatt atgggtggtt gtaagccacc atgtggttgc tgggatttga acttcgaacc
     5041 ttcggaagag cagtcgggtg ctcttaccca ctgagccatc tcaccagccc actacttctc
     5101 ttcaaattaa acatttccat gtgtgtcagc ctctctccct ggaagatgtg gatccaaggg
     5161 ctaggagaag cctggcaagg ttgaccagat ggctcactcc tactgaagac atctatttcc
     5221 aaaccaggtg ccctgcagtt ccctgtgagc tgtggttcct tgcacccacc tatgctcccc
     5281 aaactattag aaattggtag ctatcaccag attgtgaatt tctggccagt agctcaggga
     5341 attggaatga atcctaaacc caggtctact gaagactttg gggacataat tctttatcaa
     5401 atatacagca ttaatgaagc ttctctgtac tatttgatta acttgtagac ttttgagaag
     5461 cttgccagag tgtgtccctc agccaggtgt agtggcacac atctttaatc ccagcacata
     5521 ggcggcagag gcaagtggtt gtatttctga gttccaagcc agcctggtct acagagtgag
     5581 ttctaggcta gccagggcta ctcagagaaa ccttgtctcc aaaaaaccaa ataaaaaata
     5641 aaataaaata tggcctctgg gttgggttaa cacagtctag ctttgtaaca atgtgagact
     5701 cttggttctt agtgttctat accctctggt tctgggcgtt gtctcccacc tgttcttcta
     5761 aagcaggata ttgggatatt ttccagaggg gccatcctta cacgatgttg ggactgtctg
     5821 aactgtcgct atttgtagcc tggtgatatc cccttcttcc ccagggcaca gaaaagccaa
     5881 gggtcatatg gccagggcca acagctccac taaagtgacc caccactttt ctagaaagcc
     5941 cgagacctct cccttgttga ccagagggcc tgcttctcat gggcacttca aatgccactg
     6001 tgcggggcct ggctctgcat acctaggaaa agtctgcaga cacccagccc tccgcaataa
     6061 ttcaccagac cagaagccac tgatgtacag agaacactta agaaaaaaaa atgtatttta
     6121 tgtgaaaaaa aagttaaaac tctgtatact gtatcagcag ctttgtgtaa aaaatggcaa
     6181 tcaaaagagt ctaatatatt taaaactttt ttaaaaaaat attctcatgg atctttgata
     6241 tcgttctgaa gcagctccat gcctccaaga tggggtctga ccatgtcacc aaggggcctg
     6301 tgcctctgga gttacttcca gctgccaagg cctgtgacgg aattcattgc tatggatttt
     6361 taattaagat tattaaattc cttttaataa ca
//
