LOCUS       NM_133485               2524 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory inhibitor subunit
            14C (Ppp1r14c), mRNA.
ACCESSION   NM_133485 XM_001471789
VERSION     NM_133485.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Moreau,M.X., Saillour,Y., Cwetsch,A.W., Pierani,A. and Causeret,F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   McDermott,J.E., Mitchell,H.D., Gralinski,L.E., Eisfeld,A.J.,
            Josset,L., Bankhead,A. 3rd, Neumann,G., Tilton,S.C., Schafer,A.,
            Li,C., Fan,S., McWeeney,S., Baric,R.S., Katze,M.G. and Waters,K.M.
  TITLE     The effect of inhibition of PP1 and TNFalpha signaling on
            pathogenesis of SARS coronavirus
  JOURNAL   BMC Syst Biol 10 (1), 93 (2016)
   PUBMED   27663205
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Xiong,L., Xia,W.F., Tang,F.L., Pan,J.X., Mei,L. and Xiong,W.C.
  TITLE     Retromer in Osteoblasts Interacts With Protein Phosphatase 1
            Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling,
            and Promotes Its Catabolic Response
  JOURNAL   EBioMedicine 9, 45-60 (2016)
   PUBMED   27333042
  REMARK    GeneRIF: the data presented in this manuscript demonstrate a
            critical function of VPS35 in regulating PTH1R trafficking. This
            event and VPS35-interaction with PPP1R14C appear to be essential
            for turning off PTH1R's endosomal signaling, and promoting
            PTH1R-mediated catabolic response and bone remodeling.
REFERENCE   4  (bases 1 to 2524)
  AUTHORS   Drgonova,J., Zimonjic,D.B., Hall,F.S. and Uhl,G.R.
  TITLE     Effect of KEPI (Ppp1r14c) deletion on morphine analgesia and
            tolerance in mice of different genetic backgrounds: when a knockout
            is near a relevant quantitative trait locus
  JOURNAL   Neuroscience 165 (3), 882-895 (2010)
   PUBMED   19819304
REFERENCE   5  (bases 1 to 2524)
  AUTHORS   Terami,H., Hidaka,K., Shirai,M., Narumiya,H., Kuroyanagi,T.,
            Arai,Y., Aburatani,H. and Morisaki,T.
  TITLE     Efficient capture of cardiogenesis-associated genes expressed in ES
            cells
  JOURNAL   Biochem Biophys Res Commun 355 (1), 47-53 (2007)
   PUBMED   17286962
REFERENCE   6  (bases 1 to 2524)
  AUTHORS   Gong,J.P., Liu,Q.R., Zhang,P.W., Wang,Y. and Uhl,G.R.
  TITLE     Mouse brain localization of the protein kinase C-enhanced
            phosphatase 1 inhibitor KEPI (kinase C-enhanced PP1 inhibitor)
  JOURNAL   Neuroscience 132 (3), 713-727 (2005)
   PUBMED   15837133
  REMARK    GeneRIF: The expression patterns point to possible roles for KEPI
            in regulating protein dephosphorylation by inhibiting PP1
            activities in a number of brain pathways.
REFERENCE   7  (bases 1 to 2524)
  AUTHORS   Liu,Q.R., Zhang,P.W., Zhen,Q., Walther,D., Wang,X.B. and Uhl,G.R.
  TITLE     KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by
            morphine
  JOURNAL   J Biol Chem 277 (15), 13312-13320 (2002)
   PUBMED   11812771
  REMARK    GeneRIF: regulation by morphine
            GeneRIF: PPP1R14C gene encodes a PKC-potentiated inhibitory
            protein, KEPI, for type-1 Ser/Thr protein phosphatase (PP1). KEPI
            mRNA and protein are enriched in brain, heart and skeletal muscle.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162384.6 and AC155833.10.
            
            On or before Aug 8, 2008 this sequence version replaced
            XM_001471789.1, NM_133485.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF407167.2, BC055717.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-820               AC162384.6         87568-88387         c
            821-904             AC155833.10        52751-52834
            905-937             AC155833.10        54991-55023
            938-2524            AC155833.10        92646-94232
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.06 cM"
     gene            1..2524
                     /gene="Ppp1r14c"
                     /gene_synonym="6330514J04Rik; KEPI"
                     /note="protein phosphatase 1, regulatory inhibitor subunit
                     14C"
                     /db_xref="GeneID:76142"
                     /db_xref="MGI:MGI:1923392"
     exon            1..820
                     /gene="Ppp1r14c"
                     /gene_synonym="6330514J04Rik; KEPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             518..1012
                     /gene="Ppp1r14c"
                     /gene_synonym="6330514J04Rik; KEPI"
                     /note="kinase-enhanced PP1 inhibitor; PKC-potentiated PP1
                     inhibitory protein"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 14C"
                     /protein_id="NP_597844.1"
                     /db_xref="CCDS:CCDS56669.1"
                     /db_xref="GeneID:76142"
                     /db_xref="MGI:MGI:1923392"
                     /translation="MSVVTGGGEAAGGGGGGGARVFFQSPRGGTGGSPGSSSSSGSSR
                     EDSAPVTTVAAAGQVQQQQRRHQQGKVTVKYDRKELRKRLVLEEWIVEQLGQLYGCEE
                     EEMPDVEIDIDDLLDANSEEERASKLQEALVDCYKPTEEFIRELLSRIRGMRKLSPPQ
                     KKSV"
     exon            821..904
                     /gene="Ppp1r14c"
                     /gene_synonym="6330514J04Rik; KEPI"
                     /inference="alignment:Splign:2.1.0"
     exon            905..937
                     /gene="Ppp1r14c"
                     /gene_synonym="6330514J04Rik; KEPI"
                     /inference="alignment:Splign:2.1.0"
     exon            938..2524
                     /gene="Ppp1r14c"
                     /gene_synonym="6330514J04Rik; KEPI"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1125
                     /gene="Ppp1r14c"
                     /gene_synonym="6330514J04Rik; KEPI"
ORIGIN      
        1 taggagagct gaggcgagag gaccccacag cacggtcttt tcccacgacc tttacccggt
       61 gggacagagc ttatccagac agagggagtc gacatatttc gtgcgcccca agattgctcg
      121 agaagcgcag ttcgcgtctg cagggcaaaa aacgaggacg cccaattaga ggaccgactg
      181 tctcctgcct cccagacgat ccacgccagt ctcctccttg gactacacag cccctcgagg
      241 ccctgtcgct gggcacagat tctccacctc ggacgacttc ctagccgggg gcggtctctg
      301 gggcaggagc accagggtcc ttggaggcgt ctttaaggct ttggtccccg ccctcatcgc
      361 ccgccctctt cccgcctccc tccgcaagga tccagcgtct aggcgcgcgg agcaggtgcg
      421 ggccaccgta tgcggctgtt ggggctgctg tggtagcggc gcggggcgct cgcccacccc
      481 ttctccgggc cactctcagg ctctggcgcg cggggacatg tcggtggtga ctggcggcgg
      541 tgaggcggcc ggtggcggcg gcggcggcgg tgcgcgtgtc ttcttccaga gtccccgcgg
      601 tggaaccggc ggcagcccag gatccagcag cagctccggc tcctcaaggg aggactcggc
      661 gccggtgact acggtggccg ccgccgggca agtgcaacag caacaacgac gccaccagca
      721 gggaaaagtg acagtgaaat acgaccgtaa ggagcttcgt aagcggttgg tgctggaaga
      781 atggatcgtg gagcagctgg gtcagctgta cggctgcgag gaagaagaaa tgccagatgt
      841 agaaattgac attgatgatc ttcttgatgc caacagcgag gaggaaagag cttcgaaatt
      901 acaggaagct ctcgtagact gctataaacc aacagaggaa ttcatcagag agctgctctc
      961 ccggataaga ggcatgagga agctgagccc tccgcagaag aagagcgtat gatttcacta
     1021 cagggtaaaa ttctctcggc gatgaagaaa gcaacctggg atttggaccc cacagatact
     1081 tttcttaaaa aaaaaaaata accatagttg tcttttacaa caacattttt tggtgtgtat
     1141 gtgtgtgtgt tggggggtag acatttattc aaaagtgttt cttcttttgt tgtttttaaa
     1201 gggttttcat tactgtaata ttttaatggc aaagctacta caacttggac tgtagcccaa
     1261 ccaagaacta tcaaagcagg tacatccaca aggatggaca aggccaggtg tgttttctgt
     1321 caggactcgg ctgtaattta ggatctcaca atacagggaa gatggttttc ttatggtcag
     1381 tttggtaaga cgttttaagt tgtaaatttg acttcaatgt caaagctatc tcatgcttgt
     1441 atatatctac agacactaag ttaaaactag agatgtgagc tttgtatcag gttcatgaaa
     1501 taagcctgtg cttccctatt agatgtggtc acaacacacg tgctttcaaa aggtctccag
     1561 acattcttca gacaaatgtc gtccaccttc agcatccact ttctgcaaca aagtgaaaga
     1621 attcagtgtg tttgtcatta caatgagcca tactgcatat gtgttgagtt ggtcaagggc
     1681 ttaattcata aattttatta tttcattggt tgagatgctt tgccaggtca tgtacttatt
     1741 gcctcattgt ggttttttaa agttgtatga actcttaatt ttgaaaacca gcctgattga
     1801 taaagaaata cctacacttt ttgaacacag ttttgcaatc agaaaaggaa gccccaggta
     1861 gcaacatgtt ctctgctttc agtgtaatac actgtattag ctttgtccat gaaagcaggt
     1921 caaaaggaaa ccaatgggtt gagcttcctt tttagaagca gattctggcc tcttctgtgc
     1981 cagtaccatc agtccagaag tgtgaactga gtgttgcgaa atgtagagat ggaagacccc
     2041 tcaagacctt tgttggttta gaagtctggt ttcatctctg gtttctctca gtggttcatg
     2101 gtcctgattg tgaccttgat ttccatgtta ggagctaggt ctgatgacct accctaaccc
     2161 tacagctaca taccagctct ttgagtagaa ttaaaattca tatgggatgt aggcagggta
     2221 aaagttgagt aaaagcccta ccttccttcc ttccttcctt ccttccttcc ttccttccag
     2281 gaagcccctg ctgcctcccc ctggaaaccc tgcctgccgt gagaagtctc caggtggccc
     2341 tgtctgaaaa cagggaccag gcaatttata tcaagggtgc tttgaacata ttttattttt
     2401 taaaagaact atgtttgtga attttccgta tactggcaag cttttgaaaa tgtatttaat
     2461 tttgtaatgt ttaccaatga tttatttaca agctatttac tcaaataaag ggagctgctt
     2521 acaa
//
