LOCUS       NM_008889                919 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory inhibitor subunit
            14B (Ppp1r14b), mRNA.
ACCESSION   NM_008889 XM_913032
VERSION     NM_008889.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 919)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 919)
  AUTHORS   Weng,Q., Wang,J., Wang,J., He,D., Cheng,Z., Zhang,F., Verma,R.,
            Xu,L., Dong,X., Liao,Y., He,X., Potter,A., Zhang,L., Zhao,C.,
            Xin,M., Zhou,Q., Aronow,B.J., Blackshear,P.J., Rich,J.N., He,Q.,
            Zhou,W., Suva,M.L., Waclaw,R.R., Potter,S.S., Yu,G. and Lu,Q.R.
  TITLE     Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and
            Cell Fate Determinants during Development and Gliomagenesis
  JOURNAL   Cell Stem Cell 24 (5), 707-723 (2019)
   PUBMED   30982771
REFERENCE   3  (bases 1 to 919)
  AUTHORS   Florea,S., Anjak,A., Cai,W.F., Qian,J., Vafiadaki,E., Figueria,S.,
            Haghighi,K., Rubinstein,J., Lorenz,J. and Kranias,E.G.
  TITLE     Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75
            depresses calcium cycling in cardiomyocytes and leads to remodeling
            upon aging
  JOURNAL   Basic Res Cardiol 107 (5), 279 (2012)
   PUBMED   22777184
  REMARK    GeneRIF: results indicate that phosphorylation of I-1 at Ser67 and
            Thr75 is associated with increased PP1 activity and depressed
            cardiomyocyte Ca(2+)-cycling, which manifests in geometrical
            alterations over the long term
REFERENCE   4  (bases 1 to 919)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   5  (bases 1 to 919)
  AUTHORS   Tountas,N.A., Mandell,J.W., Everett,A.D. and Brautigan,D.L.
  TITLE     Juxtamembrane localization of the protein phosphatase-1 inhibitor
            protein PHI-1 in smooth muscle cells
  JOURNAL   Histochem Cell Biol 121 (4), 343-350 (2004)
   PUBMED   15083373
  REMARK    GeneRIF: Whereas CPI-17 staining was diffuse, PHI-1 was
            concentrated along the cell membrane in distinct foci. The common
            tissue distribution but different cellular localization of PHI-1
            and CPI-17 suggest distinctive physiological roles for these PP1
            inhibitors.
REFERENCE   6  (bases 1 to 919)
  AUTHORS   Deng,J.T., Sutherland,C., Brautigan,D.L., Eto,M. and Walsh,M.P.
  TITLE     Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and
            PHI-1, by integrin-linked kinase
  JOURNAL   Biochem J 367 (Pt 2), 517-524 (2002)
   PUBMED   12144526
REFERENCE   7  (bases 1 to 919)
  AUTHORS   Eto,M., Karginov,A. and Brautigan,D.L.
  TITLE     A novel phosphoprotein inhibitor of protein type-1 phosphatase
            holoenzymes
  JOURNAL   Biochemistry 38 (51), 16952-16957 (1999)
   PUBMED   10606530
REFERENCE   8  (bases 1 to 919)
  AUTHORS   Lagercrantz,J., Kedra,D., Carson,E., Nordenskjold,M.,
            Dumanski,J.P., Weber,G. and Piehl,F.
  TITLE     Sequence and expression of the mouse homologue to human
            phospholipase C beta3 neighboring gene
  JOURNAL   Biochem Biophys Res Commun 223 (2), 335-340 (1996)
   PUBMED   8670283
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC082545.1 and CF739461.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_913032.1, NM_008889.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082545.1, X97490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-916               BC082545.1         1-916
            917-919             CF739461.1         521-523
FEATURES             Location/Qualifiers
     source          1..919
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.12 cM"
     gene            1..919
                     /gene="Ppp1r14b"
                     /gene_synonym="AOM172; PHI-1; PLCB3N; Png"
                     /note="protein phosphatase 1, regulatory inhibitor subunit
                     14B"
                     /db_xref="GeneID:18938"
                     /db_xref="MGI:MGI:107682"
     exon            1..459
                     /gene="Ppp1r14b"
                     /gene_synonym="AOM172; PHI-1; PLCB3N; Png"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..645
                     /gene="Ppp1r14b"
                     /gene_synonym="AOM172; PHI-1; PLCB3N; Png"
                     /note="phosphatase holoenzyme inhibitor 1; phospholipase
                     C-beta-3 neighbouring gene protein; phospholipase c
                     neighboring"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 14B"
                     /protein_id="NP_032915.2"
                     /db_xref="CCDS:CCDS29514.1"
                     /db_xref="GeneID:18938"
                     /db_xref="MGI:MGI:107682"
                     /translation="MADSGPAGGAALAAPAPGPGSGSTGPRVYFQSPPGAAGEGPGGA
                     DDDGPVRRQGKVTVKYDRKELRKRLNLEEWILEQLTRLYDCQEEEIPELEIDVDELLD
                     MESDDTRAARVKELLVDCYKPTEAFISGLLDKIRGMQKLSTPQKK"
     exon            460..543
                     /gene="Ppp1r14b"
                     /gene_synonym="AOM172; PHI-1; PLCB3N; Png"
                     /inference="alignment:Splign:2.1.0"
     exon            544..576
                     /gene="Ppp1r14b"
                     /gene_synonym="AOM172; PHI-1; PLCB3N; Png"
                     /inference="alignment:Splign:2.1.0"
     exon            577..919
                     /gene="Ppp1r14b"
                     /gene_synonym="AOM172; PHI-1; PLCB3N; Png"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggggcgcgg ccaggccaag cccgggggct ccgcatgctg cagctgcccc cgggcgcccc
       61 cgccgccgcc ctcgccgcgg agctgcgcgg aacggagccc gcgagctaac cggagccagc
      121 ggccgggagc cagccggcgg gcgtccggga ggcggcggcg cagggagggg cccgagcgcg
      181 cacgtggccc cggcggccgc catggcggac agcggccccg cggggggcgc ggcgttagct
      241 gccccggccc ccgggccggg cagtggcagc acagggcccc gagtctactt ccagagtccc
      301 cctggggccg caggcgaagg cccggggggc gctgatgacg atggcccggt gagacggcaa
      361 gggaaggtca ccgtcaagta cgaccgcaag gagctacgga agcgcctcaa cctggaggag
      421 tggattttag aacagctcac gcgactctac gactgccagg aggaggagat cccggagctc
      481 gagatagatg tggatgaact tttagacatg gagagtgatg atacccgggc tgctagggtc
      541 aaggagctgt tagttgactg ttacaaaccc actgaggcct tcatctctgg cctgctggac
      601 aagatccggg gcatgcagaa gctgagcaca ccccagaaga aatgagggtc ctgactcaga
      661 cggccgtggc tcccacagga caatcgctgc cccccaacct cgtagcaaca gcaataccgg
      721 gggaccctgc agccaggcct ggtgccatga gcagggatcc ccgtgcccct gcctaggggt
      781 catttccctt gccctcagtt ttccactttt ggggtttttt attgttatta aactgacggg
      841 actttttgtg tttttatatt gactctgcgg cgcaggccct ttaaaaataa agctaggata
      901 cagcctttgg agcagctaa
//
