LOCUS       NM_001418824            1206 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory inhibitor subunit
            14A (Ppp1r14a), transcript variant 3, mRNA.
ACCESSION   NM_001418824 XM_036153397
VERSION     NM_001418824.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1206)
  AUTHORS   Zhao,G., Zhong,Y., Su,W., Liu,S., Song,X., Hou,T., Mu,X., Gong,M.C.
            and Guo,Z.
  TITLE     Transcriptional Suppression of CPI-17 Gene Expression in Vascular
            Smooth Muscle Cells by Tumor Necrosis Factor, Kruppel-Like Factor
            4, and Sp1 Is Associated with Lipopolysaccharide-Induced Vascular
            Hypocontractility, Hypotension, and Mortality
  JOURNAL   Mol Cell Biol 39 (11), e00070-19 (2019)
   PUBMED   30936247
  REMARK    GeneRIF: These data provide a novel mechanism of the
            transcriptional control of CPI-17 in vascular smooth muscle cells
            under inflammatory conditions. Mechanistically, 2 GC boxes were
            identified as TNF response element in the CPI-17 promoter and KLF4
            was upregulated by TNF, competed with Sp1 for the binding to the GC
            boxes in the CPI-17 promoter, and repressed CPI-17 transcription
            through histone deacetylase.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1206)
  AUTHORS   Sun,J., Tao,T., Zhao,W., Wei,L., She,F., Wang,P., Li,Y., Zheng,Y.,
            Chen,X., Wang,W., Qiao,Y., Zhang,X.N. and Zhu,M.S.
  TITLE     CPI-17-mediated contraction of vascular smooth muscle is essential
            for the development of hypertension in obese mice
  JOURNAL   J Genet Genomics 46 (3), 109-118 (2019)
   PUBMED   30948334
  REMARK    GeneRIF: upregulation of CPI-17-mediated calcium-sensitized
            vasocontraction by obesity contributes to the development of
            obesity-related hypertension
REFERENCE   3  (bases 1 to 1206)
  AUTHORS   Yang,Q., Fujii,W., Kaji,N., Kakuta,S., Kada,K., Kuwahara,M.,
            Tsubone,H., Ozaki,H. and Hori,M.
  TITLE     The essential role of phospho-T38 CPI-17 in the maintenance of
            physiological blood pressure using genetically modified mice
  JOURNAL   FASEB J 32 (4), 2095-2109 (2018)
   PUBMED   29229685
  REMARK    GeneRIF: CPI-17 phosphorylation at T38 is essential for the
            maintenance of physiological blood pressure.
REFERENCE   4  (bases 1 to 1206)
  AUTHORS   Reho,J.J., Zheng,X., Asico,L.D. and Fisher,S.A.
  TITLE     Redox signaling and splicing dependent change in myosin phosphatase
            underlie early versus late changes in NO vasodilator reserve in a
            mouse LPS model of sepsis
  JOURNAL   Am J Physiol Heart Circ Physiol 308 (9), H1039-H1050 (2015)
   PUBMED   25724497
  REMARK    GeneRIF: Enhanced vasorelaxation in early endotoxemia is mediated
            by redox signaling through PKG-1alpha but in later endotoxemia by
            myosin phosphatase isoform shifts enhancing sensitivity to NO/cGMP
            as well as smooth muscle atrophy.
REFERENCE   5  (bases 1 to 1206)
  AUTHORS   Boopathi,E., Gomes,C., Zderic,S.A., Malkowicz,B., Chakrabarti,R.,
            Patel,D.P., Wein,A.J. and Chacko,S.
  TITLE     Mechanical stretch upregulates proteins involved in Ca2+
            sensitization in urinary bladder smooth muscle hypertrophy
  JOURNAL   Am J Physiol Cell Physiol 307 (6), C542-C553 (2014)
   PUBMED   25031021
REFERENCE   6  (bases 1 to 1206)
  AUTHORS   Bonnevier,J. and Arner,A.
  TITLE     Actions downstream of cyclic GMP/protein kinase G can reverse
            protein kinase C-mediated phosphorylation of CPI-17 and Ca(2)
            sensitization in smooth muscle
  JOURNAL   J Biol Chem 279 (28), 28998-29003 (2004)
   PUBMED   15123611
  REMARK    GeneRIF: concluded that actions downstream of cGMP/PKG can reverse
            PKC-mediated phosphorylation of CPI-17 and Ca(2+) sensitization in
            smooth muscle
REFERENCE   7  (bases 1 to 1206)
  AUTHORS   Tountas,N.A., Mandell,J.W., Everett,A.D. and Brautigan,D.L.
  TITLE     Juxtamembrane localization of the protein phosphatase-1 inhibitor
            protein PHI-1 in smooth muscle cells
  JOURNAL   Histochem Cell Biol 121 (4), 343-350 (2004)
   PUBMED   15083373
REFERENCE   8  (bases 1 to 1206)
  AUTHORS   Liu,Q.R., Zhang,P.W., Lin,Z., Li,Q.F., Woods,A.S., Troncoso,J. and
            Uhl,G.R.
  TITLE     GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory
            protein, is activated by PKC and inactivated by PKA
  JOURNAL   Biochem J 377 (Pt 1), 171-181 (2004)
   PUBMED   12974676
REFERENCE   9  (bases 1 to 1206)
  AUTHORS   Yamawaki,K., Ito,M., Machida,H., Moriki,N., Okamoto,R., Isaka,N.,
            Shimpo,H., Kohda,A., Okumura,K., Hartshorne,D.J. and Nakano,T.
  TITLE     Identification of human CPI-17, an inhibitory phosphoprotein for
            myosin phosphatase
  JOURNAL   Biochem Biophys Res Commun 285 (4), 1040-1045 (2001)
   PUBMED   11467857
REFERENCE   10 (bases 1 to 1206)
  AUTHORS   Li,Z., Yu,L., Zhang,Y., Gao,J., Zhang,P., Wan,B., Chen,C. and
            Zhao,S.
  TITLE     Identification of human, mouse and rat PPP1R14A, protein
            phosphatase-1 inhibitor subunit 14A, & mapping human PPP1R14A to
            chromosome 19q13.13-q13.2
  JOURNAL   Mol Biol Rep 28 (2), 91-101 (2001)
   PUBMED   11931393
  REMARK    GeneRIF: distribution of mouse and rat PPP1R14A was more specific
            and different from that of humans
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166079.2.
            
            On Mar 23, 2023 this sequence version replaced XM_036153397.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.23195.1, BY710881.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               AC166079.2         72686-72914
            230-310             AC166079.2         74889-74969
            311-343             AC166079.2         75430-75462
            344-1206            AC166079.2         75909-76771
FEATURES             Location/Qualifiers
     source          1..1206
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.94 cM"
     gene            1..1206
                     /gene="Ppp1r14a"
                     /gene_synonym="1110001M11Rik; CPI-17; Cpi17"
                     /note="protein phosphatase 1, regulatory inhibitor subunit
                     14A"
                     /db_xref="GeneID:68458"
                     /db_xref="MGI:MGI:1931139"
     exon            1..229
                     /gene="Ppp1r14a"
                     /gene_synonym="1110001M11Rik; CPI-17; Cpi17"
                     /inference="alignment:Splign:2.1.0"
     exon            230..310
                     /gene="Ppp1r14a"
                     /gene_synonym="1110001M11Rik; CPI-17; Cpi17"
                     /inference="alignment:Splign:2.1.0"
     exon            311..343
                     /gene="Ppp1r14a"
                     /gene_synonym="1110001M11Rik; CPI-17; Cpi17"
                     /inference="alignment:Splign:2.1.0"
     exon            344..1206
                     /gene="Ppp1r14a"
                     /gene_synonym="1110001M11Rik; CPI-17; Cpi17"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1206
                     /gene="Ppp1r14a"
                     /gene_synonym="1110001M11Rik; CPI-17; Cpi17"
                     /note="major polyA site"
ORIGIN      
        1 caaagtaggg gcagcgggtg acggtacgat ggctgcgcag cggctgggca agcgcgtgct
       61 gagcaagctg cagtccccgt cgcgggcccg cggcccgggg ggcagcccca gcgggctgca
      121 gaagcggcac gcgcgagtca cggtcaagta cgaccgacgg gagctgcagc gacggctgga
      181 cgtggagaag tggatcgacg gatgcttgga ggagctgtac cgcggcaggg agtcagacat
      241 gccggacgag gtcaacatcg atgagctatt ggaattggac agtgaagagg aaagatgccg
      301 gaaaatccag ggacttctgg aggcttgtgc aaatcccaca gagctcctag atgccagagg
      361 gacaaacgtc accgcctgtc agtcggcctg gagctggctc agacctggtc tctggggact
      421 gtctctcagc ctgagaaaca tctccctctt ccatctgagc ctgtgtctct ctcggatcag
      481 ggtctttgtc tctctccatc tctatttttt atttgacttt attttaagtg gataagtgtt
      541 ttgtctgcat gtatgcctgt gcaccacaca tgcctggtgc ccatgaaggc cagaagaggg
      601 ctcagatcca ttggagctgg tgttacagac agttgtgagc tgccatgtgg ctgctgggaa
      661 ccgaactcgg atcctctgga agagcagcca ctgctcttaa ccacagagca accacagagc
      721 tgccttttca cacccctccc cctttttctt gagataagta ctcagtgtgt aaattcatag
      781 caatcctcct gcctccagta gaactattga cccagggagt aatttcagct tcctccaatc
      841 tttctacctg cccctgccct tttctcttgc ctatcttagg ctccattccc gccctgtttg
      901 gccccagatc ccacttcgaa taagctgttg cccaaagaga cacaggcctt ggggtgggag
      961 gcctctctcc tgctctgttc tcagaatccc actctgtctg taggacttcg tccaggagct
     1021 actggccaag cttcggggcc tgcacaaaca gccgggcttc ccgcagccca gcccctcaga
     1081 tgaccccagc ctgagccccc gccaggaccg ggcccacact gccccaccct gactgcgccc
     1141 gcctctgcgc tccaccccca aagcccagat tgtttctaag ttgtatttaa tggttctgta
     1201 actgcc
//
