LOCUS       NM_001010836            3123 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 13 like
            (Ppp1r13l), transcript variant 1, mRNA.
ACCESSION   NM_001010836
VERSION     NM_001010836.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3123)
  AUTHORS   Miller,P., Akama-Garren,E.H., Owen,R.P., Demetriou,C.,
            Carroll,T.M., Slee,E., Al Moussawi,K., Ellis,M., Goldin,R.,
            O'Neill,E. and Lu,X.
  TITLE     p53 inhibitor iASPP is an unexpected suppressor of KRAS and
            inflammation-driven pancreatic cancer
  JOURNAL   Cell Death Differ 30 (7), 1619-1635 (2023)
   PUBMED   37270580
  REMARK    GeneRIF: p53 inhibitor iASPP is an unexpected suppressor of KRAS
            and inflammation-driven pancreatic cancer.
REFERENCE   2  (bases 1 to 3123)
  AUTHORS   Wang,J., Jia,C., Gao,Q., Zhang,J. and Gu,X.
  TITLE     iASPP regulates neurite development by interacting with Spectrin
            proteins
  JOURNAL   Front Mol Neurosci 16, 1154770 (2023)
   PUBMED   37284462
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3123)
  AUTHORS   Al Moussawi,K., Chung,K., Carroll,T.M., Osterburg,C., Smirnov,A.,
            Lotz,R., Miller,P., Dedeic,Z., Zhong,S., Oti,M., Kouwenhoven,E.N.,
            Asher,R., Goldin,R., Tellier,M., Murphy,S., Zhou,H., Dotsch,V. and
            Lu,X.
  TITLE     Mutant Ras and inflammation-driven skin tumorigenesis is suppressed
            via a JNK-iASPP-AP1 axis
  JOURNAL   Cell Rep 41 (3), 111503 (2022)
   PUBMED   36261000
REFERENCE   4  (bases 1 to 3123)
  AUTHORS   Bai,B., Zeng,G., Chen,R., Ai,Y. and Qiang,H.
  TITLE     Upregulation of iASPP ameliorates hypoxia/reoxygenation-induced
            apoptosis and oxidative stress in cardiomyocytes by upregulating
            Nrf2 signaling
  JOURNAL   J Biochem Mol Toxicol 35 (3), e22686 (2021)
   PUBMED   33332723
  REMARK    GeneRIF: Upregulation of iASPP ameliorates
            hypoxia/reoxygenation-induced apoptosis and oxidative stress in
            cardiomyocytes by upregulating Nrf2 signaling.
REFERENCE   5  (bases 1 to 3123)
  AUTHORS   Yagudin,T., Zhao,Y., Gao,H., Zhang,Y., Yang,Y., Zhang,X., Ma,W.,
            Daba,T.M., Ishmetov,V., Kang,K., Yang,B. and Pan,Z.
  TITLE     iASPP protects the heart from ischemia injury by inhibiting p53
            expression and cardiomyocyte apoptosis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (1), 102-111 (2021)
   PUBMED   33128543
  REMARK    GeneRIF: iASPP protects the heart from ischemia injury by
            inhibiting p53 expression and cardiomyocyte apoptosis.
            Erratum:[Acta Biochim Biophys Sin (Shanghai). 2021 Dec
            8;53(12):1739. doi: 10.1093/abbs/gmaa168.. PMID: 33336692]
REFERENCE   6  (bases 1 to 3123)
  AUTHORS   Laska,M.J., Lowe,S.W., Zender,L., Hearn,S., Vogel,U., Jensen,U.B.,
            Bric,A. and Nexo,B.A.
  TITLE     Enforced expression of PPP1R13L increases tumorigenesis and
            invasion through p53-dependent and p53-independent mechanisms
  JOURNAL   Mol Carcinog 48 (9), 832-842 (2009)
   PUBMED   19263435
  REMARK    GeneRIF: Studies revealed that overexpression of PPP1R13L causes
            faster p53 degradation, a likely explanation for the depletion of
            p53.
REFERENCE   7  (bases 1 to 3123)
  AUTHORS   Sullivan,A. and Lu,X.
  TITLE     ASPP: a new family of oncogenes and tumour suppressor genes
  JOURNAL   Br J Cancer 96 (2), 196-200 (2007)
   PUBMED   17211478
  REMARK    Review article
REFERENCE   8  (bases 1 to 3123)
  AUTHORS   Chang,B., Hawes,N.L., Hurd,R.E., Wang,J., Howell,D., Davisson,M.T.,
            Roderick,T.H., Nusinowitz,S. and Heckenlively,J.R.
  TITLE     Mouse models of ocular diseases
  JOURNAL   Vis Neurosci 22 (5), 587-593 (2005)
   PUBMED   16332269
REFERENCE   9  (bases 1 to 3123)
  AUTHORS   Herron,B.J., Rao,C., Liu,S., Laprade,L., Richardson,J.A.,
            Olivieri,E., Semsarian,C., Millar,S.E., Stubbs,L. and Beier,D.R.
  TITLE     A mutation in NFkB interacting protein 1 results in cardiomyopathy
            and abnormal skin development in wa3 mice
  JOURNAL   Hum Mol Genet 14 (5), 667-677 (2005)
   PUBMED   15661756
  REMARK    GeneRIF: Mice with mutation in Nkip1 (Ppp1r13l) represent a
            potentially important model for the analysis of the role of
            inflammatory processes in heart disease.
REFERENCE   10 (bases 1 to 3123)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC148988.5 and AC118017.15.
            
            On Mar 30, 2023 this sequence version replaced NM_001010836.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170535.1, AY869711.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC148988.5         153181-153271
            92-172              AC118017.15        85893-85973         c
            173-315             AC118017.15        85656-85798         c
            316-826             AC118017.15        84211-84721         c
            827-925             AC118017.15        84028-84126         c
            926-1017            AC118017.15        83858-83949         c
            1018-1459           AC118017.15        82869-83310         c
            1460-1920           AC118017.15        81131-81591         c
            1921-2052           AC118017.15        79134-79265         c
            2053-2186           AC118017.15        78897-79030         c
            2187-2353           AC118017.15        78624-78790         c
            2354-2553           AC118017.15        76828-77027         c
            2554-3123           AC118017.15        75979-76548         c
FEATURES             Location/Qualifiers
     source          1..3123
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.62 cM"
     gene            1..3123
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /note="protein phosphatase 1, regulatory subunit 13 like"
                     /db_xref="GeneID:333654"
                     /db_xref="MGI:MGI:3525053"
     exon            1..91
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /inference="alignment:Splign:2.1.0"
     exon            92..172
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..2592
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /note="NFkB interacting protein 1; protein iASPP;
                     PPP1R13B-like protein; inhibitor of ASPP protein; protein
                     phosphatase 1, regulatory (inhibitor) subunit 13 like"
                     /codon_start=1
                     /product="relA-associated inhibitor"
                     /protein_id="NP_001010836.1"
                     /db_xref="CCDS:CCDS20899.1"
                     /db_xref="GeneID:333654"
                     /db_xref="MGI:MGI:3525053"
                     /translation="MDSEAFQHARDLLDLNFQSLAMKHMDLKQMELDTAAAKVDELTK
                     QLESLWSDSPAPPGAQAGVPSRMARYSTSPVPEHFGSRGSPQKIATDGIEARFGRSES
                     APSLHPYSPLSPKGRPSSPRTPIYLQPDTYSSLDRAPSPRPRAFDGAGSPHGRAPSPR
                     PGIGPVRQPGPSTPFDYLGRAGSPRGSPLAEGPQAFFPERGPSPRPPAAAYDTAGTFG
                     SPLLGAGGSAFTPPLRAQDDSTLRRRPPKAWNESDLDVAYEKKSSQTASYERLDVFTR
                     PASPGLQLLPWRESSLDGLGASGKDHLTSATLPRNYKVSPLASDRRSDVGSYRRSLGS
                     AGPSGTLPRSWQPVSRIPMPPSSPQPRSTPRQRPIPLSMIFKLQNAFWEHGAGRAVLP
                     GSPIFSRAPPPKLPPQPPPQPQMQPQPQPQPQMQPQSQAQPQTPAPQQTWSPMNEGLL
                     KSPAELEPEPELEVLLAPVEEAGDADEGTVTRPLSPTRLQPALPPEAQTVPELEEVAR
                     VLAEIPRPLKRRGSMEQSPAVALPPTHKKQYQQIINRLFHRHGGPGPGGPEPELSTIT
                     EGSEARAGPPAPAPPAPIPPPAPPQSSPPEQPQSMEMRSVLRKVGSPRKARRARLNPL
                     VLLLDAALTGELDVVQQAVKEMNDPSQPNEEGITALHNAICGANYPIVDFLIAAGANV
                     NSPDSHGWTPLHCAASCNDTAICTALVQHGAAIFATTLSDGATAIEKCDPYREGYADC
                     ATYLADVEQSMGLMHNGVVYALWDYSAEFGDELSFREGESVTVLRRDGPEETDWWWAS
                     LHGQEGYVPRNYFGLFPRVKSQRSKI"
     exon            173..315
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /inference="alignment:Splign:2.1.0"
     exon            316..826
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /inference="alignment:Splign:2.1.0"
     exon            827..925
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1017
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1459
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1920
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2052
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2186
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2353
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2553
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..3123
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3101..3106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /note="hexamer: AATAAA"
     polyA_site      3123
                     /gene="Ppp1r13l"
                     /gene_synonym="IASPP; Nkip1; wa3"
                     /note="major polyA site"
ORIGIN      
        1 gactgccccg ccccgtcctc cgctccccgc cgctggagcc ggagccggag cccgaggaaa
       61 agccccccgg tgccaggatc tgccccgacg cacaggcacc ctgctccggc cggcaccatg
      121 gacagcgaag cattccagca tgcgagggac cttctggacc tgaacttcca gtcactggcc
      181 atgaagcaca tggatctgaa acagatggag ctggacaccg ctgccgccaa agtggacgaa
      241 ttaaccaagc agttagagtc gttgtggtca gactcgccag ctcctcctgg cgctcaggct
      301 ggagtcccct ctaggatggc ccggtacagc accagcccgg tccccgagca ttttggcagc
      361 agagggtcac ctcagaagat agccaccgat ggcatagagg cccgttttgg acgctcggag
      421 agtgccccgt ccctgcaccc ttacagccct ctgtctccca agggccgtcc gtcttcaccg
      481 cgcaccccta tctacctgca gcctgacacc tacagcagcc tagatcgggc gccatcgccc
      541 agaccccgcg ccttcgatgg agcgggcagc ccccatggtc gggcaccgtc cccgaggccg
      601 gggattggcc cggtgcggca gcctggtccc tcgaccccct ttgactatct gggccgcgca
      661 gggtcccccc ggggcagccc tctagctgag gggccccagg ccttcttccc ggagcgagga
      721 ccttccccac gtccgcctgc tgcagcctac gacacagcgg gcacgttcgg gagccctctg
      781 ctgggcgcgg gtggcagtgc cttcaccccg ccgcttcgtg cacaagatga ctcgacgctg
      841 cgccggaggc ccccgaaggc ctggaacgag tctgacttgg atgtagccta cgagaaaaag
      901 tcttcacaga cagcaagcta cgaacggctg gatgtcttca cacggcctgc ctctccgggc
      961 ctgcagctct taccctggag agagagcagc ctggatgggc tgggggccag tggcaaggac
     1021 cacctcacca gcgccactct gccacgcaat tacaaggtgt ctcctctggc cagtgacagg
     1081 cgttctgacg ttggcagcta ccgccgctct ttgggctctg cagggccctc aggcactttg
     1141 ccccgcagct ggcagcccgt cagccgcatc cccatgcccc cctctagccc acagccccgc
     1201 agcaccccac gccagcgccc catccccctc agtatgatct ttaaactcca gaatgctttc
     1261 tgggaacatg gagccggcag ggctgtgctc ccgggatccc ccatcttctc ccgagcaccc
     1321 ccacctaagc tgcctcccca gccaccccct cagccacaga tgcaacccca accccaaccc
     1381 caacctcaga tgcagcccca gtcccaggcc cagcctcaga ctccagcacc tcaacagact
     1441 tggtctccca tgaatgaagg cctcctcaaa tcccctgccg agctggagcc cgagcccgag
     1501 ctggaggtgc tactggctcc tgtggaggag gccggggatg cagatgaagg cacggtcacg
     1561 cggcccctca gccctaccag gctgcagcca gcgctgccac cggaagcaca gactgtaccc
     1621 gagctggagg aggtggcccg agtgctggca gagattcctc gacccctcaa acgcagaggc
     1681 tccatggagc agagccctgc agtggcgctg cctcccaccc acaagaaaca ataccaacag
     1741 atcatcaata gactcttcca tcggcacggc ggcccagggc ctggagggcc tgagccggag
     1801 ctgtccacaa ttacagaggg atctgaagcc agggcagggc cccctgctcc cgccccacca
     1861 gctcctatcc cacccccagc cccaccccag agcagccctc cagagcagcc tcagagcatg
     1921 gagatgcgct cagtactgcg caaagtgggg tccccgcgca aggcccggcg tgctcgcctc
     1981 aatccactgg tgctgctgtt ggatgcagcg ctgactggag agttggacgt ggtacagcag
     2041 gcggtgaagg agatgaacga cccaagccag cccaacgagg agggcatcac cgccctgcac
     2101 aatgccatct gcggtgccaa ctaccccatc gtggacttcc tcatcgctgc gggcgccaac
     2161 gtcaactccc ctgacagcca cggctggacg ccactgcatt gtgccgcttc ctgcaatgac
     2221 actgccatct gcacagcatt ggtgcaacat ggtgcggcca tcttcgccac cactctcagt
     2281 gacggcgcca ccgccatcga aaagtgcgac ccttaccgcg agggctatgc agactgtgcc
     2341 acctacctgg cagacgtgga acaaagcatg ggactgatgc acaatggcgt tgtgtatgca
     2401 ctctgggact acagcgcaga gtttggggat gagctgtctt tccgagaggg cgagtcagtc
     2461 actgtgctgc ggagagatgg gccagaggag actgattggt ggtgggcctc actgcacggc
     2521 caggaaggct atgtgccgcg caactacttc gggctcttcc ctagagtgaa gtctcagcgg
     2581 agcaaaatct agtaggcatg aaggatgatt gtaaaggaga aaagtacaag ccagcccgcc
     2641 ttccacccgg acctgcccga tccagctagc taatctgcgc cgctgctctc cagagggcac
     2701 cggaaattct ctgctccctg agaggctcaa gggagggcgg ccccagactg aagattagga
     2761 agctgcctta agcattgggg tgaggtgggg ctggggaccc ttgcaggcaa gatctcccac
     2821 cctgccccca acatacccac gtgcccagtc agatctggtt ttaagtgcct cctactggca
     2881 gcaagccact gcactatcct agctgagcca gggaggctac ccaccccttc atttctctct
     2941 gagtcctttc ctcctctctc ccagaagtcc ccattctgct cagcagcccc cattcttccc
     3001 agaagcttag ggcctgtgtg aggaccccat gtccccaacc aagtgccttc ataccatgtg
     3061 gcttaatgtt tataatgaca tgggaaacat ttcctttata aataaaggtt gtttacccag
     3121 aaa
//
