LOCUS       NM_011625               4355 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 13B
            (Ppp1r13b), mRNA.
ACCESSION   NM_011625 XM_127168
VERSION     NM_011625.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4355)
  AUTHORS   Yang,Y., Zhang,Y., Yang,J., Zhang,M., Tian,T., Jiang,Y., Liu,X.,
            Xue,G., Li,X., Zhang,X., Li,S., Huang,X., Li,Z., Guo,Y., Zhao,L.,
            Bao,H., Zhou,Z., Song,J., Yang,G., Xuan,L., Shan,H., Zhang,Z.,
            Lu,Y., Yang,B. and Pan,Z.
  TITLE     Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates
            Cardiac Ischemia/Reperfusion Injury
  JOURNAL   Circ Res 132 (2), 208-222 (2023)
   PUBMED   36656967
  REMARK    GeneRIF: Interdependent Nuclear Co-Trafficking of ASPP1 and p53
            Aggravates Cardiac Ischemia/Reperfusion Injury.
REFERENCE   2  (bases 1 to 4355)
  AUTHORS   Tsukiji,N., Inoue,O., Morimoto,M., Tatsumi,N., Nagatomo,H.,
            Ueta,K., Shirai,T., Sasaki,T., Otake,S., Tamura,S., Tachibana,T.,
            Okabe,M., Hirashima,M., Ozaki,Y. and Suzuki-Inoue,K.
  TITLE     Platelets play an essential role in murine lung development through
            Clec-2/podoplanin interaction
  JOURNAL   Blood 132 (11), 1167-1179 (2018)
   PUBMED   29853539
REFERENCE   3  (bases 1 to 4355)
  AUTHORS   Otowa,Y., Moriwaki,K., Sano,K., Shirakabe,M., Yonemura,S.,
            Shibuya,M., Rossant,J., Suda,T., Kakeji,Y. and Hirashima,M.
  TITLE     Flt1/VEGFR1 heterozygosity causes transient embryonic edema
  JOURNAL   Sci Rep 6, 27186 (2016)
   PUBMED   27251772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4355)
  AUTHORS   Yamashita,M., Nitta,E. and Suda,T.
  TITLE     Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents
            Malignant Transformation
  JOURNAL   Cell Stem Cell 17 (1), 23-34 (2015)
   PUBMED   26119234
  REMARK    GeneRIF: After genotoxic stress, Aspp1 promotes hematopoietic stem
            cell (HSC) cycling and induces p53-dependent apoptosis in cells
            with persistent DNA damage foci. Aspp1 also attenuates HSC
            self-renewal and accumulation of DNA damage in p53 null HSCs.
REFERENCE   5  (bases 1 to 4355)
  AUTHORS   Wilson,A.M., Morquette,B., Abdouh,M., Unsain,N., Barker,P.A.,
            Feinstein,E., Bernier,G. and Di Polo,A.
  TITLE     ASPP1/2 regulate p53-dependent death of retinal ganglion cells
            through PUMA and Fas/CD95 activation in vivo
  JOURNAL   J Neurosci 33 (5), 2205-2216 (2013)
   PUBMED   23365256
  REMARK    GeneRIF: Our study demonstrates a novel role for ASPP1 and ASPP2 in
            the death of retinal ganglion cells.
REFERENCE   6  (bases 1 to 4355)
  AUTHORS   Sullivan,A. and Lu,X.
  TITLE     ASPP: a new family of oncogenes and tumour suppressor genes
  JOURNAL   Br J Cancer 96 (2), 196-200 (2007)
   PUBMED   17211478
  REMARK    Review article
REFERENCE   7  (bases 1 to 4355)
  AUTHORS   Hirashima,M., Bernstein,A., Stanford,W.L. and Rossant,J.
  TITLE     Gene-trap expression screening to identify endothelial-specific
            genes
  JOURNAL   Blood 104 (3), 711-718 (2004)
   PUBMED   15090446
REFERENCE   8  (bases 1 to 4355)
  AUTHORS   Espanel,X. and Sudol,M.
  TITLE     Yes-associated protein and p53-binding protein-2 interact through
            their WW and SH3 domains
  JOURNAL   J Biol Chem 276 (17), 14514-14523 (2001)
   PUBMED   11278422
REFERENCE   9  (bases 1 to 4355)
  AUTHORS   Hoffman,N.G., Sparks,A.B., Carter,J.M. and Kay,B.K.
  TITLE     Binding properties of SH3 peptide ligands identified from
            phage-displayed random peptide libraries
  JOURNAL   Mol Divers 2 (1-2), 5-12 (1996)
   PUBMED   9238627
REFERENCE   10 (bases 1 to 4355)
  AUTHORS   Sparks,A.B., Hoffman,N.G., McConnell,S.J., Fowlkes,D.M. and
            Kay,B.K.
  TITLE     Cloning of ligand targets: systematic isolation of SH3
            domain-containing proteins
  JOURNAL   Nat Biotechnol 14 (6), 741-744 (1996)
   PUBMED   9630982
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC054788.1.
            
            On Mar 22, 2004 this sequence version replaced XM_127168.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054788.1, BC053092.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4355
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.14 cM"
     gene            1..4355
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /note="protein phosphatase 1, regulatory subunit 13B"
                     /db_xref="GeneID:21981"
                     /db_xref="MGI:MGI:1336199"
     exon            1..194
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..3449
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /note="transformation related protein 53 binding protein
                     2; tumor protein p53 binding protein, 2; protein
                     phosphatase 1, regulatory (inhibitor) subunit 13B"
                     /codon_start=1
                     /product="apoptosis-stimulating of p53 protein 1"
                     /protein_id="NP_035755.1"
                     /db_xref="CCDS:CCDS56866.1"
                     /db_xref="GeneID:21981"
                     /db_xref="MGI:MGI:1336199"
                     /translation="MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGGCH
                     LAEVWRGSERPIPYDHMMYEHLQKWGPRREEVKFFLRHEDSPTESSEQGARQTQEQRT
                     QRSVVNVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLK
                     QQERRQQQSVSENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFS
                     AMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQSYNGRLTGPAAVELKRLYQELQ
                     IRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQ
                     SPLSTSGRVAAVGPYIQVPSTGGFPLPGDPVKPQSLTIASSAAHGRSKSANDGNWPPL
                     KQNSASVKSTQMTGDWKDSGMEGTLKQGAISSQPLPLSALGATEKLGIEIGKGPPPIP
                     GVGKPLPPSYGTYPSSGPLGPGSTSSLERRKEGSLPRPGAGPPSRQKPAPLPPASNAP
                     QPGSSQQIQQRISVPPSPTYPPAGPPAFPTGDGKPELPLTVAIRPFLADKGSRPQSPR
                     KGPQTVNSSSIYSMYLQQATPPKNYQPPAHGTLNKSVKAVYGKPVLPSGSASPSPLPF
                     LHGSLGTGTAQPQPPSDSAEKEPEQEGPSVPGEGSTVESLPRPLSPTKLTPIVHSPLR
                     YQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPF
                     YQPSPSQDFVGTLADMDNGNTNANGNLDEPFPPRPTAPLPEELAPSSDANDNELPSPE
                     PEELICPQTTHQTAEPTEDNNNNVAPVPSTEQIPSPVAEAPSEEDQVPPAPLSPVIHP
                     PAASASKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKP
                     NDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVE
                     SGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMNKGTVYALWDYEAQ
                     NSDELSFHEGDAITILRRKDENETEWWWARLGDREGYVPKNLLGLYPRIKPRQRTLA"
     exon            195..342
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..462
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..539
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..641
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            642..816
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1013
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1154
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1335
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1499
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..2001
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2768
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2906
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3040
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3207
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3407
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..4333
                     /gene="Ppp1r13b"
                     /gene_synonym="ASPP1; p85; Tp53bp2; Trp53bp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggctga gggacggcga cgcggcacgc ggggcggcgc gacaggacga gcgagggctg
       61 cgcggctctc cgcagctgcc gcctcgccgc agccgggccg cagggcgccg cagcgggtgc
      121 gaggcctgtg aggcggccgg agcggcgtcc tgtcaggcgg cgcgggcgcg gcggacggcg
      181 ccgcgatgat gccgatgata ttaaccgtgt tcttgagcaa caatgaacag attttaacag
      241 aagttcctat aacaccagaa accacctgtc gagatgtcgt agaattctgc aaggaacctg
      301 gagagggcgg ttgccacctg gctgaagtgt ggagaggaag tgagcgtccc atcccctatg
      361 accacatgat gtatgagcac ctgcagaagt gggggcctcg cagagaagaa gtaaaatttt
      421 ttcttcgtca tgaggattct ccaactgaga gcagtgaaca aggtgcccgt cagacccaag
      481 agcagagaac tcagaggagt gtagtaaatg tacctggaga aaagcgcact gaaaatgggg
      541 ttgggaatcc acgtgttgaa cttaccctct cagaacttca agatatggca gccaggcagc
      601 agcagcaaat tgaaaaccag cagcaaatgt tggttgccaa ggaacagcgt ttacattttc
      661 taaagcaaca ggagcgccgc cagcagcagt ccgtttctga aaatgaaaag cttcagaaac
      721 tgaaagagcg agttgaagcc caggaaaaca agctgaagaa gatccgggcc atgagaggac
      781 aagttgacta cagcaagatc atgaatggca atctgtctgc tgagatagaa aggttcagtg
      841 ccatgttcca ggagaagaaa caggaagttc agactgcaat cttacgagtt gatcagctta
      901 gtcagcaact agaagattta aagaaaggaa aactgaatgg gttccagtca tacaatggca
      961 ggttgacagg gccagcagca gtggagttga aacgactcta ccaagagctg cagattcgta
     1021 accagcttaa tcaggagcag aattccaagc tccagcagca gaaggagctc ttgaacaagc
     1081 gcaacatgga agtggccatg atggataagc ggatcagtga gctgcgggag cgcctgtatg
     1141 gcaagaagat ccagctgaac cgtgtgaatg gcacatcgtc accacagtca cccctgagca
     1201 catctggccg ggtcgctgct gtgggtcctt atatccaggt tcccagtact ggggggtttc
     1261 ctctcccagg ggaccctgtg aagccccagt ctctcaccat cgcctcaagt gctgcccatg
     1321 gaagatccaa atctgctaat gatggaaact ggccaccatt aaagcagaat tctgcttcag
     1381 tgaagtcaac tcagatgact ggagactgga aggactcagg catggagggg accctaaagc
     1441 aaggtgccat ctcaagccag cctttgcctt tgtcagcact gggagctaca gaaaagctgg
     1501 gcatcgagat tggcaaaggg ccacctccca tacctggtgt gggcaagcca ctgcccccaa
     1561 gttatgggac atatccaagt tctgggccct tgggcccggg atcaacaagc tctctggaga
     1621 ggaggaaaga aggaagcttg cccagacctg gtgcaggccc accgagtcgg cagaaacctg
     1681 ccccgctgcc cccagcaagc aacgctcccc agcctggctc ctcacagcag attcagcaga
     1741 ggatctcagt gccaccaagt cccacatacc cgccagcggg gccacctgcc tttccaactg
     1801 gagatggaaa acctgagctt ccactcacag tggccattag gccttttctg gctgataaag
     1861 ggtcaaggcc acaatctccc aggaaaggac ctcagacagt aaattcaagt tctatatact
     1921 ccatgtacct ccagcaagcc acaccaccta agaactacca gccaccagcg catggcacct
     1981 taaataagtc agttaaagca gtgtacggta agcctgtcct gccgtcaggg tcagcatcgc
     2041 catcaccctt accgtttctt catgggtcac tgggcacagg cacggcacag cctcagccac
     2101 cttcagactc tgctgagaaa gagccagagc aggaaggccc cagtgtacct ggagaaggca
     2161 gcacagtgga aagcctgcca cggccgctca gtcccaccaa actcacaccc atcgtacact
     2221 ccccactccg ttatcagagt gatgcagacc tggaagctct ccgcaggaag ctggccaatg
     2281 caccccgacc cctgaagaag cgcagctcta tcacagagcc agagggccct ggagggccca
     2341 acattcaaaa gttgctttac caacgtttca acaccttggc tggtggaatg gagggtaccc
     2401 ctttctacca gcccagccct tcccaggact ttgtgggcac cttagctgac atggacaacg
     2461 gaaacaccaa tgccaatggc aacttggacg agcctttccc tccccggccc acggccccac
     2521 ttcctgagga gcttgcccct tcctcagatg ccaatgataa tgagttacct tcccctgagc
     2581 cagaggagct catttgtccc caaacaactc atcaaactgc tgagcccact gaagacaata
     2641 acaacaatgt ggccccagta ccctccacag aacagatccc aagtcctgtg gctgaggctc
     2701 cttcagagga ggatcaagtc cctccagcac ctctttcccc cgtcatccat cctccagcag
     2761 catccgcgag caaacgcacc aacctgaaga agcctaactc tgaacggaca gggcacgggc
     2821 tgagagtgcg cttcaacccc ctagccctgc ttctggacgc ttctctcgaa ggagagtttg
     2881 atctagtgca gaggatcatc tatgaggtgg aggaccctag caaacccaat gacgaaggga
     2941 tcacccccct acacaatgct gtctgtgctg gccaccacca tatcgtgaag tttctgctgg
     3001 actttggtgt caatgtgaat gctgcagaca gtgacggatg gacaccactg cattgtgctg
     3061 cctcttgcaa cagtgtccac ctctgcaagc agctggtgga aagtggagcc gctatctttg
     3121 cctccaccat cagtgacatt gagactgctg cagacaagtg tgaagagatg gaagagggat
     3181 acatccagtg ttcccagttt ctgtatgggg tacaagagaa gctgggagtg atgaacaaag
     3241 gcaccgtgta tgctttgtgg gactacgagg cccagaacag cgatgagctg tccttccatg
     3301 aaggggatgc catcaccatc ctgaggcgca aagatgaaaa cgagaccgag tggtggtggg
     3361 ctcgtcttgg ggaccgggag ggctacgtgc ccaaaaactt gctggggttg tatccacgga
     3421 tcaaaccccg gcagcgaaca cttgcctgaa ccccctggag taccacagtc tcgtttgctc
     3481 ccaggagcta ctggaggaga tcccagctgc cctgggaaaa ctgaagctag gatggtctcc
     3541 tggtgctcac tttagcagac agtgtccaca atgtgaatcc cacttcccag gtgaggccct
     3601 ctccaggttg caggagctgg gagaggtagt gcttttgcca attactgtaa atccacataa
     3661 atacccagct tccaaaacat ccagcccttc caccagtaag aagtcatgac tctgatcccc
     3721 gaccgctgcc agtgaagaca aaagccctga cgtggcccaa aggccccttc tcatgttaaa
     3781 tgtctcagac cttgaacaag agcaaggtgg ctttggctcc cccttcttgg aaagcctcaa
     3841 accatcatac tttctcacat tgcctctcac taccaaagga gcccattcgg aaactgcgtt
     3901 tcattaccta tggcgttctg ctgtggctgg acatgcacgc ctcagcacat gggggtctgc
     3961 gcaatgatga gtcaaagtca agtcggtggt gggctgggca aagccacctg gcagccctcg
     4021 aggctgtcac tggctgcatc ctgagcaagg caagtccgtt ctggagcttg acctctgtag
     4081 acaggctttt tctacaccag gattgttttt cagccaggcc actggaactg tgtttcttct
     4141 gtcggaacac aggccctgcc tgaggcttta tttttcatgt gagtcttgtg tagaactacg
     4201 tgtaaatcct gtaggctctg ggagcagtgc tgtgggcagc cgccatgtgc tgatcgcacc
     4261 cgtgagcagc cactgccatc ccagtgccac cgatgctgtg tgacgtgcac aataaactgc
     4321 tgtctcacac ctgaaaaaaa aaaaaaaaaa aaaaa
//
