LOCUS       NM_001419228            2996 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 12C
            (Ppp1r12c), transcript variant 2, mRNA.
ACCESSION   NM_001419228 XM_006539767
VERSION     NM_001419228.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2996)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2996)
  AUTHORS   Acharya,D., Reis,R., Volcic,M., Liu,G., Wang,M.K., Chia,B.S.,
            Nchioua,R., Gross,R., Munch,J., Kirchhoff,F., Sparrer,K.M.J. and
            Gack,M.U.
  TITLE     Actin cytoskeleton remodeling primes RIG-I-like receptor activation
  JOURNAL   Cell 185 (19), 3588-3602 (2022)
   PUBMED   36113429
REFERENCE   3  (bases 1 to 2996)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 2996)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161218.10.
            
            On Mar 29, 2023 this sequence version replaced XM_006539767.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422600.1943810.1,
                                           SRR13422592.355674.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-425               AC161218.10        116622-117046       c
            426-556             AC161218.10        112772-112902       c
            557-675             AC161218.10        112573-112691       c
            676-835             AC161218.10        105089-105248       c
            836-980             AC161218.10        101867-102011       c
            981-1055            AC161218.10        101714-101788       c
            1056-1129           AC161218.10        100745-100818       c
            1130-1257           AC161218.10        100545-100672       c
            1258-1331           AC161218.10        100367-100440       c
            1332-1484           AC161218.10        99975-100127        c
            1485-1552           AC161218.10        99806-99873         c
            1553-1684           AC161218.10        99297-99428         c
            1685-1775           AC161218.10        98999-99089         c
            1776-1859           AC161218.10        98830-98913         c
            1860-1920           AC161218.10        98697-98757         c
            1921-2006           AC161218.10        98459-98544         c
            2007-2047           AC161218.10        98329-98369         c
            2048-2150           AC161218.10        98147-98249         c
            2151-2255           AC161218.10        97940-98044         c
            2256-2306           AC161218.10        97735-97785         c
            2307-2357           AC161218.10        97593-97643         c
            2358-2996           AC161218.10        96876-97514         c
FEATURES             Location/Qualifiers
     source          1..2996
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.59 cM"
     gene            1..2996
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /note="protein phosphatase 1, regulatory subunit 12C"
                     /db_xref="GeneID:232807"
                     /db_xref="MGI:MGI:1924258"
     exon            1..425
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2444
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /note="isoform 2 is encoded by transcript variant 2;
                     myosin-binding subunit 85; protein phosphatase 1
                     myosin-binding subunit p85; protein phosphatase 1
                     myosin-binding subunit of 85 kDa; protein phosphatase 1,
                     regulatory (inhibitor) subunit 12C"
                     /codon_start=1
                     /product="protein phosphatase 1 regulatory subunit 12C
                     isoform 2"
                     /protein_id="NP_001406157.1"
                     /db_xref="GeneID:232807"
                     /db_xref="MGI:MGI:1924258"
                     /translation="MSGEDGPAAGPGAAAAAAAARERRQEQLRQWGARAGADPGPGER
                     RARTVRFERAAEFLAACAGGDLDEARLMLRAADPGPGSGAASDPAVPPPARAVLDSTN
                     ADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSH
                     GANIAAVNSDGDLPLDLAESDAMEGLLKAEITRRGVDVEAAKRAEEELLLHDTRCWLN
                     GGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDTELRDGDGWTPLHAAAHWGV
                     EDACRLLAEHGGGMDSLTHAGQRPCDLADEDVMNLLEELAQKQEDLRNQKEGSQGRGQ
                     ESQVPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIGDEDEGGEASAEHPA
                     VEPRALNGVSSPVSSNPKSPVLPEEAPFSRRFGLQKTGSTGALGPSERRATEGVLGLQ
                     RSASSSLLEKASTQAREPRLARITPTPAQKVPEPFTLYEAATPPSLDHSVPPSRREPG
                     SIVKPNVLTASAAPLADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLT
                     DLKEAEKVAGKVPEPEQPALPSLDPSRRPRVPGVENAEGPAQRAEAPEGQGQGPQAAR
                     EHRKAGHERRGPAEGEEAGPAERSPECSTVDGGSQVRRQHSQRDLVLESKQEHEEPDG
                     GFRKMYTELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFER
                     RALERKAAELEEELKALSDLRADNQRLKDENAALIRVISKLSK"
     exon            426..556
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            557..675
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            676..835
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            836..980
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1055
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1129
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1257
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1331
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1484
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1552
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1684
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1775
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1859
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1920
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2006
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2047
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2150
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2255
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2306
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2357
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2996
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2975..2980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /note="hexamer: AATAAA"
     polyA_site      2996
                     /gene="Ppp1r12c"
                     /gene_synonym="2410197A17Rik; B430101M08; Mbs85"
                     /note="major polyA site"
ORIGIN      
        1 ggttcccggc ggcccccggg gcgggcgggt ggcggctgtt cgtcgcccgg tgctcgctcg
       61 ctcgcttagt aggcgggcga gcggccggcg cgatgtccgg cgaggatggt ccggcagcgg
      121 gcccgggggc ggcggcggct gctgcggccg cccgtgagcg gcggcaggag cagctgcggc
      181 agtggggggc tcgggcgggc gccgacccgg gccccgggga gcggcgagcc cgcacggtcc
      241 gcttcgagcg cgccgctgag ttcctggcgg cctgcgcggg gggcgatctg gacgaggctc
      301 gcctgatgct gcgcgcagcg gatcccggtc ccggctccgg cgctgcgtcc gaccccgccg
      361 tccctccgcc tgcccgtgcc gtgctcgact ccaccaacgc ggatggcatc agcgccctgc
      421 accaggcctg catagatgag aacctggaag tcgttcgctt cctggtggag cagggtgcta
      481 ctgtgaacca ggcagacaac gagggctgga cgcctctgca tgtggctgcc tcctgtgggt
      541 acctggacat tgccaggtac ctcctgagcc atggggccaa cattgctgct gtcaacagtg
      601 acggggacct gcctttggac ctggctgagt cagatgccat ggaggggctg ctgaaggcag
      661 agatcactcg ccgaggtgtg gatgtcgagg cagccaagcg ggctgaagaa gaattgctgc
      721 ttcatgacac aaggtgctgg ctgaatgggg gtgctatgcc agaggccagg cacccccgga
      781 ctggggcctc tgccctgcat gtggctgctg ccaagggcta catcgaggtg atgaggttgc
      841 tactccaagc tggctatgac acagagctcc gggatggaga tggctggaca cccttgcatg
      901 cagcagccca ctggggtgtg gaggatgcct gccgtctgct ggctgagcat ggcgggggca
      961 tggattcgct gacccacgcg gggcagcgtc cctgtgacct ggctgacgag gacgtgatga
     1021 accttttgga ggaactggct cagaaacagg aggaccttcg gaaccaaaag gaaggctccc
     1081 agggccgagg ccaggagtca caggtccctt caagtagtaa gcacagaagg agctccgtgt
     1141 gccgtttgag cagccgagag aagatctcct tgcaggatct atcaaaggag cgccggcctg
     1201 gtggggcagg agggcctcct attggagatg aggatgaggg aggtgaagcg tcagctgagc
     1261 acccagctgt ggaaccaaga gccctcaatg gtgtgtcttc ccctgtgtcc tccaacccta
     1321 agagccctgt gctgccagaa gaggctccct tttccaggcg ctttggtctc cagaagacag
     1381 ggagcactgg tgccttgggt ccttcagaaa ggagggctac agagggcgtt ctcggtctgc
     1441 agcgctcagc ctcctcctcc ctccttgaga aggcctccac tcaggccagg gagccccgtc
     1501 ttgccagaat aacccctacc cctgcccaga aagtgccaga gcccttcacc ctgtatgagg
     1561 ctgccacgcc tccttctttg gatcactctg ttccaccctc caggagggag cctggatcga
     1621 tagtgaagcc aaatgtcctc acagcctctg cagcgcccct ggccgactcc agggaccgtc
     1681 ggaggtccta ccagatgcct gtgcgtgatg aggagtccga gtctcagcgg aaggcccgct
     1741 cccgccttat gcgacagtct cggaggtcca cacagggtgt aactctaaca gacttgaagg
     1801 aagcagaaaa ggtggctggg aaggtcccag agccagagca gcctgcccta cccagcctgg
     1861 acccttctcg gagacctcgg gtccctggag tggagaacgc tgagggccct gcccagagag
     1921 cagaggcgcc cgaagggcag ggccagggac cacaggcggc cagggagcat cgaaaagctg
     1981 gccatgagcg gagggggcca gcagaggggg aagaggcggg gcctgcggaa cggagcccag
     2041 agtgcagcac tgtggatggt ggatcccagg tccgcaggca gcactcacag agagacctcg
     2101 ttctagaatc caagcaggag cacgaggagc ctgatggagg cttccggaag atgtacacgg
     2161 agctccgcag ggagaatgag cgacttcgtg aggccctgac agagaccacc ctgcgtctgg
     2221 cacagctcaa ggtggagctg gagcgggcca cgcagcggca ggaacgcttt gctgagaggc
     2281 ccgccctcct tgaactggag agatttgagc gcagggctct ggagcgcaag gcagcagagc
     2341 tggaagagga gctgaaggcc ctctctgatc tccgggctga caaccagcgg ctcaaggatg
     2401 agaatgcagc attgatccga gtcatcagca aactatccaa gtgactctgg aggagttccc
     2461 gcaccatatt tatactgctg cttctgacac acgcaccctt tccccccgcg tgaacatgag
     2521 tgacagggct ctgggggaaa ttgctgagaa gccataacct ctcgggacct cagaaccggg
     2581 aggaaagcac agagtcccca ggaaccaagg gggactctct gagatcagga tagagatggg
     2641 aggctgagcc aagtagggag acgttgctga gagtggacag gcaccagaga tgggaccaag
     2701 aaggaagcaa ggaccaagag acacaaagat cagtatccag aagcagagtg gttgccccag
     2761 gatcccacct cacgtgtgat gctacccagc actcctcctc ctccccagca gggatgcagg
     2821 aatgtgccaa gagtcccact ggcctctgcc aggtgggcct gtagataggt ccatgtgcaa
     2881 tagggaggga tgtcttctat ttttgctgcc tcctccctac ccattgtctg gggaggggga
     2941 gaaggtattt ttgagacaaa gcacaggcac cataaataaa gtgacattgc cactca
//
