LOCUS       NM_029632               1696 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory inhibitor subunit 11
            (Ppp1r11), mRNA.
ACCESSION   NM_029632
VERSION     NM_029632.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1696)
  AUTHORS   Goswami,S., Korrodi-Gregorio,L., Sinha,N., Bhutada,S.,
            Bhattacharjee,R., Kline,D. and Vijayaraghavan,S.
  TITLE     Regulators of the protein phosphatase PP1gamma2, PPP1R2, PPP1R7,
            and PPP1R11 are involved in epididymal sperm maturation
  JOURNAL   J Cell Physiol 234 (3), 3105-3118 (2019)
   PUBMED   30144392
  REMARK    GeneRIF: The three regulators (PPP1R2, PPP1R7, and PPP1R11)share
            localization with PP1gamma2 in the head and the principal piece of
            sperm. We show that the association of inhibitors to PP1gamma2
            changes during epididymal sperm maturation. In immotile caput
            epididymal sperm, PPP1R2 and PPP1R7 are not bound to PP1gamma2,
            whereas in motile caudal sperm, all three inhibitors are bound as
            heterodimers or heterotrimers.
REFERENCE   2  (bases 1 to 1696)
  AUTHORS   McKelvey,A.C., Lear,T.B., Dunn,S.R., Evankovich,J., Londino,J.D.,
            Bednash,J.S., Zhang,Y., McVerry,B.J., Liu,Y. and Chen,B.B.
  TITLE     RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate
            immunity
  JOURNAL   Elife 5, e18496 (2016)
   PUBMED   27805901
  REMARK    GeneRIF: Lentiviral gene transfer or knockdown of PPP1R11 in mouse
            lungs significantly affects lung inflammation and the clearance of
            Staphylococcus aureus. There is a negative correlation between
            PPP1R11 and TLR2 levels in white blood cell samples isolated from
            patients with Staphylococcus aureus infections.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1696)
  AUTHORS   Cheng,L., Pilder,S., Nairn,A.C., Ramdas,S. and Vijayaraghavan,S.
  TITLE     PP1gamma2 and PPP1R11 are parts of a multimeric complex in
            developing testicular germ cells in which their steady state levels
            are reciprocally related
  JOURNAL   PLoS One 4 (3), e4861 (2009)
   PUBMED   19300506
  REMARK    GeneRIF: Data show a reciprocal relationship between protein
            phosphatase isoform PP1gamma2 and its regulator PPP1R11, and
            suggest that complex formation between them in testis may prevent
            proteolysis of PPP1R11 and germ cell apoptosis.
REFERENCE   4  (bases 1 to 1696)
  AUTHORS   Han,Y., Song,X.X., Feng,H.L., Cheung,C.K., Lam,P.M., Wang,C.C. and
            Haines,C.J.
  TITLE     Mutations of t-complex testis expressed gene 5 transcripts in the
            testis of sterile t-haplotype mutant mouse
  JOURNAL   Asian J Androl 10 (2), 219-226 (2008)
   PUBMED   18286210
REFERENCE   5  (bases 1 to 1696)
  AUTHORS   Han,Y.B., Feng,H.L., Cheung,C.K., Lam,P.M., Wang,C.C. and
            Haines,C.J.
  TITLE     Expression of a novel T-complex testis expressed 5 (Tctex5) in
            mouse testis, epididymis, and spermatozoa
  JOURNAL   Mol Reprod Dev 74 (9), 1132-1140 (2007)
   PUBMED   17342733
  REMARK    GeneRIF: Tctex5 might be a specific protein phosphatase-1 inhibitor
            in sperm; various Tctex5 transcripts and isoforms and cellular
            locations imply its different roles in spermatogenesis.
REFERENCE   6  (bases 1 to 1696)
  AUTHORS   Jones,E.P., Kumanovics,A., Yoshino,M. and Fischer Lindahl,K.
  TITLE     Mhc class I and non-class I gene organization in the proximal H2-M
            region of the mouse
  JOURNAL   Immunogenetics 49 (3), 183-195 (1999)
   PUBMED   9914332
REFERENCE   7  (bases 1 to 1696)
  AUTHORS   Zhang,J., Zhang,L., Zhao,S. and Lee,E.Y.
  TITLE     Identification and characterization of the human HCG V gene product
            as a novel inhibitor of protein phosphatase-1
  JOURNAL   Biochemistry 37 (47), 16728-16734 (1998)
   PUBMED   9843442
REFERENCE   8  (bases 1 to 1696)
  AUTHORS   Yoshino,M., Xiao,H., Jones,E.P. and Fischer Lindahl,K.
  TITLE     BAC/YAC contigs from the H2-M region of mouse Chr 17 define gene
            order as Znf173-Tctex5-mog-D17Tu42-M3-M2
  JOURNAL   Immunogenetics 47 (5), 371-380 (1998)
   PUBMED   9510555
REFERENCE   9  (bases 1 to 1696)
  AUTHORS   Giffon,T., Lepourcelet,M., Pichon,L., Jezequel,P., Bouric,P.,
            Carn,G., Pontarotti,P., Gall,J.Y. and David,V.
  TITLE     Cloning of a human homologue of the mouse Tctex-5 gene within the
            MHC class I region
  JOURNAL   Immunogenetics 44 (5), 331-339 (1996)
   PUBMED   8781118
REFERENCE   10 (bases 1 to 1696)
  AUTHORS   Ha,H., Howard,C.A., Yeom,Y.I., Abe,K., Uehara,H., Artzt,K. and
            Bennett,D.
  TITLE     Several testis-expressed genes in the mouse t-complex have
            expression differences between wild-type and t-mutant mice
  JOURNAL   Dev Genet 12 (4), 318-332 (1991)
   PUBMED   1718647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR956641.9, BB842861.1, AK162607.1 and BQ032907.1.
            
            On Jun 15, 2010 this sequence version replaced NM_029632.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162607.1, AK077455.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 CR956641.9         66207-66209
            4-118               BB842861.1         2-116
            119-409             AK162607.1         2-292
            410-1061            AK162607.1         294-945
            1062-1196           AK162607.1         947-1081
            1197-1549           AK162607.1         1083-1435
            1550-1696           BQ032907.1         1-147               c
FEATURES             Location/Qualifiers
     source          1..1696
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.16 cM"
     gene            1..1696
                     /gene="Ppp1r11"
                     /gene_synonym="1500041B02Rik; Hcgv; Tcte5; Tctex-5;
                     Tctex5"
                     /note="protein phosphatase 1, regulatory inhibitor subunit
                     11"
                     /db_xref="GeneID:76497"
                     /db_xref="MGI:MGI:1923747"
     exon            1..370
                     /gene="Ppp1r11"
                     /gene_synonym="1500041B02Rik; Hcgv; Tcte5; Tctex-5;
                     Tctex5"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..682
                     /gene="Ppp1r11"
                     /gene_synonym="1500041B02Rik; Hcgv; Tcte5; Tctex-5;
                     Tctex5"
                     /EC_number="2.3.2.27"
                     /note="protein phosphatase 1 regulatory subunit 11;
                     T-complex testis expressed protein 5; t-complex
                     testis-expressed 5"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase PPP1R11"
                     /protein_id="NP_083908.1"
                     /db_xref="CCDS:CCDS28729.1"
                     /db_xref="GeneID:76497"
                     /db_xref="MGI:MGI:1923747"
                     /translation="MAETGAGISETVTETTVTETTVTETTEPENQSLTMKLRKRKPEK
                     KVEWSSDTVDNEHMGRRSSKCCCIYEKPRAFGESSTESDEDEEEGCSHKHCVRGHRKG
                     RRPTTPAPTPTTPPQPPDPSKPPPGPMQH"
     exon            371..479
                     /gene="Ppp1r11"
                     /gene_synonym="1500041B02Rik; Hcgv; Tcte5; Tctex-5;
                     Tctex5"
                     /inference="alignment:Splign:2.1.0"
     exon            480..1679
                     /gene="Ppp1r11"
                     /gene_synonym="1500041B02Rik; Hcgv; Tcte5; Tctex-5;
                     Tctex5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      717..722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r11"
                     /gene_synonym="1500041B02Rik; Hcgv; Tcte5; Tctex-5;
                     Tctex5"
                     /note="hexamer: AATATA"
     polyA_site      744
                     /gene="Ppp1r11"
                     /gene_synonym="1500041B02Rik; Hcgv; Tcte5; Tctex-5;
                     Tctex5"
                     /note="major polyA site"
     regulatory      1659..1664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r11"
                     /gene_synonym="1500041B02Rik; Hcgv; Tcte5; Tctex-5;
                     Tctex5"
                     /note="hexamer: AATAAA"
     polyA_site      1679
                     /gene="Ppp1r11"
                     /gene_synonym="1500041B02Rik; Hcgv; Tcte5; Tctex-5;
                     Tctex5"
ORIGIN      
        1 attacggcgg aactattctg gcgacgcctg ctttgaccca ggcggtggtg gggaagggaa
       61 actgtgttct gcaggatgcg tcacaaccgg aagtgaaagg ccggaagtgg ggttggacag
      121 gttttcccca ggggtgggga agcagaggcc gtggaggagt aggggagatt aagaagctag
      181 agcatcctgg cctctactcc gagtcttgta ccggttctct tagatctctg aggctcagaa
      241 aaaggaaagg gtgtctcatc ccgctttctc gcttttcgct ttagccatgg cggagacagg
      301 ggccgggata agtgagaccg tcactgagac aacggttact gagacaacgg ttaccgagac
      361 aaccgagcca gagaatcaga gcctaactat gaaacttcgg aaacgcaagc cagagaagaa
      421 ggtggagtgg tccagtgaca ctgtggacaa tgagcatatg gggcgacgct cgtcgaaatg
      481 ctgctgtatt tatgagaagc ctcgggcctt tggcgagagc tccaccgaga gtgatgagga
      541 tgaagaagaa ggctgtagtc ataagcactg tgtacggggt caccgcaaag gacggcgtcc
      601 tacaacccca gcacccaccc caaccactcc tccacagcct cctgatccct ctaagccccc
      661 tccaggacct atgcagcact aaatccctct caccattcat gtgtctgcct gccccaaata
      721 tatccatctg acatggggac tccacccatt gcctccgttc tcctgccccc ttcttccgtc
      781 tcctgagtga tagagaagag gaagaggagg gtggatacag atcctggaat tctgacttgc
      841 tgctgttcca gaacccaggc ttctgggttc tcccagcccc tgcttcccta cagtttgctc
      901 ccatgcctgg gatccaggca tcttggtccc agtctatccc ttttgttctc actgccaaac
      961 tacctgtcct gggatccagt atcttggcca cctgcaccct cagcttgagt cccaagcact
     1021 tcaactgggt tttcaacggt cccagctttc actgccaggg ctccaatcag atgccaggca
     1081 atcttgcacc ccagttctgc gtattaatcc tggcttatgg ttcttctact gatgcagttt
     1141 tcctaaatct tagttcttgc ctgtgggatg taaggttgtg tggagactat agggttccct
     1201 ggcccttctg ctcctcttac cccttatggc tctccaaagg agttaggaga ggtctttgtc
     1261 attcacacct aatggaaagt ggaaccaaaa aaaaaaaaaa aatagccatg tcctgaatat
     1321 aacatttctg acaaagctgg ctgagaccac tgacttagag ccaatgattt tctcagcctt
     1381 taatctttga gcttcagcat tggtgtccta ggggcctggg tccctaaaag gaaagaggga
     1441 gaaagcaaag agatgagggg acaggcccct gcagtatgct cctacccttt cctgcctagg
     1501 ctttggtgtc tgccaaccca ggtgtcttgc tctctcagcc ctccccggct ggtgctagga
     1561 tctgggtact gccctccagg cctctggctg tgcacagtac agaaatcagc aaaacccatg
     1621 gcaccactta gatctcattt attgccacag atgcacaaaa taaataaccc aacattgcaa
     1681 aaaaaaaaaa aaaaaa
//
