LOCUS       NM_001403564            4242 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1, regulatory subunit 10
            (Ppp1r10), transcript variant 3, mRNA.
ACCESSION   NM_001403564 XM_006524616
VERSION     NM_001403564.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4242)
  AUTHORS   Lozano-Vidal,N., Stanicek,L., Bink,D.I., Juni,R.P., Hooglugt,A.,
            Kremer,V., Phelp,P., van Bergen,A., MacInnes,A.W., Dimmeler,S. and
            Boon,R.A.
  TITLE     Aging-regulated PNUTS maintains endothelial barrier function via
            SEMA3B suppression
  JOURNAL   Commun Biol 7 (1), 541 (2024)
   PUBMED   38714838
  REMARK    GeneRIF: Aging-regulated PNUTS maintains endothelial barrier
            function via SEMA3B suppression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4242)
  AUTHORS   Lee,J.H., You,J., Dobrota,E. and Skalnik,D.G.
  TITLE     Identification and characterization of a novel human PP1
            phosphatase complex
  JOURNAL   J Biol Chem 285 (32), 24466-24476 (2010)
   PUBMED   20516061
REFERENCE   3  (bases 1 to 4242)
  AUTHORS   De Leon,G., Cavino,M., D'Angelo,M. and Krucher,N.A.
  TITLE     PNUTS knockdown potentiates the apoptotic effect of Roscovitine in
            breast and colon cancer cells
  JOURNAL   Int J Oncol 36 (5), 1269-1275 (2010)
   PUBMED   20372802
  REMARK    GeneRIF: stimulation of PP1 activity via siRNA mediated knockdown
            of its interacting protein PNUTS (Phosphatase Nuclear Targeting
            Subunit) leads to Rb dephosphorylation and apoptosis in cancer
            cells
REFERENCE   4  (bases 1 to 4242)
  AUTHORS   Hutchins,J.R., Toyoda,Y., Hegemann,B., Poser,I., Heriche,J.K.,
            Sykora,M.M., Augsburg,M., Hudecz,O., Buschhorn,B.A., Bulkescher,J.,
            Conrad,C., Comartin,D., Schleiffer,A., Sarov,M., Pozniakovsky,A.,
            Slabicki,M.M., Schloissnig,S., Steinmacher,I., Leuschner,M.,
            Ssykor,A., Lawo,S., Pelletier,L., Stark,H., Nasmyth,K.,
            Ellenberg,J., Durbin,R., Buchholz,F., Mechtler,K., Hyman,A.A. and
            Peters,J.M.
  TITLE     Systematic analysis of human protein complexes identifies
            chromosome segregation proteins
  JOURNAL   Science 328 (5978), 593-599 (2010)
   PUBMED   20360068
REFERENCE   5  (bases 1 to 4242)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   6  (bases 1 to 4242)
  AUTHORS   Kim,H., Lee,O.H., Xin,H., Chen,L.Y., Qin,J., Chae,H.K., Lin,S.Y.,
            Safari,A., Liu,D. and Songyang,Z.
  TITLE     TRF2 functions as a protein hub and regulates telomere maintenance
            by recognizing specific peptide motifs
  JOURNAL   Nat Struct Mol Biol 16 (4), 372-379 (2009)
   PUBMED   19287395
REFERENCE   7  (bases 1 to 4242)
  AUTHORS   Rose,M., Dutting,E., Schroder,N., Sticht,H., Brandstatter,J.H. and
            Enz,R.
  TITLE     PNUTS forms a trimeric protein complex with GABA(C) receptors and
            protein phosphatase 1
  JOURNAL   Mol Cell Neurosci 37 (4), 808-819 (2008)
   PUBMED   18325784
  REMARK    GeneRIF: Protein phosphatase 1 (PP1) and GABA(C) receptors
            simultaneously bind to different domains of PNUTS, demonstrating
            that PNUTS crosslinks PP1 and GABA(C) receptors.
REFERENCE   8  (bases 1 to 4242)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 4242)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974451.9.
            
            On Mar 31, 2022 this sequence version replaced XM_006524616.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.1497010.1,
                                           SRR13422600.831540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                CR974451.9         141381-141400
            21-539              CR974451.9         141593-142111
            540-657             CR974451.9         147703-147820
            658-744             CR974451.9         148432-148518
            745-880             CR974451.9         148640-148775
            881-932             CR974451.9         149253-149304
            933-1010            CR974451.9         150597-150674
            1011-1184           CR974451.9         150795-150968
            1185-1290           CR974451.9         151167-151272
            1291-1403           CR974451.9         151369-151481
            1404-1504           CR974451.9         152305-152405
            1505-1652           CR974451.9         152577-152724
            1653-1811           CR974451.9         152798-152956
            1812-2058           CR974451.9         153047-153293
            2059-2122           CR974451.9         153616-153679
            2123-2317           CR974451.9         153787-153981
            2318-2393           CR974451.9         154168-154243
            2394-2507           CR974451.9         154446-154559
            2508-3107           CR974451.9         154687-155286
            3108-4242           CR974451.9         155544-156678
FEATURES             Location/Qualifiers
     source          1..4242
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.77 cM"
     gene            1..4242
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /note="protein phosphatase 1, regulatory subunit 10"
                     /db_xref="GeneID:52040"
                     /db_xref="MGI:MGI:1289273"
     exon            1..20
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            21..539
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            540..657
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     CDS             551..3217
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /note="protein phosphatase I; HLA-C adjacent transcript
                     53; MHC class I region proline-rich protein CAT53"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase 1
                     regulatory subunit 10"
                     /protein_id="NP_001390493.1"
                     /db_xref="GeneID:52040"
                     /db_xref="MGI:MGI:1289273"
                     /translation="MGSGPIDPKELLKGLDSFLTRDGEVKSVDGISKIFSLMKEARKM
                     VSRCTYLNIILQTRAPEVLVKFIDVGGYKLLNNWLTYSKTTNNIPLLQQILLTLQHLP
                     LTVDHLKQNNTAKLVKQLSKSSEDEELRKLASVLVSDWMAVIRSQSSTQPAEKDKKKR
                     KEEGKSRTTLPERPLTEVKAETRAEEAPEKKKEKPKSLRTTAPSHAKFRSTGLELDTP
                     SLVPVKKNSSTVVVSDKYNLKPIPLKRQSATAAPGDAAPPAEKKYKPLNTAPNTTKEI
                     KVKIIPPQPMEGLGFLDALNSAPVPGIKIKKKKKVLSPTAAKPSPFEGKTSTEQSTAK
                     PSSPEPAPPAEPMDTDRPGTPVPPVEVPELMDAASSEPGALDAKPVDSPGDPNQLTRK
                     GRKRKTVTWPEEGKLREYFYFELDETERVNVNKIKDFGEAAKREILSDRHAFETARRL
                     SHDNMEEKVPWVCPRPLVLPSPLVIPGSNSQERYIQAEREKGILQELFLNKESPHEPD
                     PEPYEPIPPKLIPLDEECAMDETPYVETLEPGGSGGSPDGAGGSKLPPVLANLMGSMG
                     AGKSPQGPGGGGINVQEILTSIMGSPNSHPSEELLKQPDYSDKLKQMLVPHGLLGPGP
                     VANGFPPGGPGGPKGMQHFPPGPGGPMPGPHGGPGGPVGPRLLGPPPPSRGGDPFWDG
                     PGDPMRGGPMRGGPGPAPGPYHRGRGGRGGNEPPPPPPFRGARGGRSGGGPPNGRGGP
                     GGGGMVGGGGHRPHEGPGGSMGSGHRSHDGPGGNMGSGHRSHDGPGGNMGGSGGHRSH
                     EGPGHGGPHGHRPHDVPSHRGHDHRGPPPHEHRGHDGHGGGGHRGHDGGHSHGGDMSN
                     RPVCRHFMMKGNCRYENNCAFYHPGVNGPPLP"
     exon            658..744
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            745..880
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            881..932
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1010
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1184
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1290
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1403
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1504
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1652
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1811
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2058
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2122
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2317
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2393
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2507
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..3107
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..4242
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4210..4215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /note="hexamer: AATAAA"
     polyA_site      4229
                     /gene="Ppp1r10"
                     /gene_synonym="2610025H06Rik; Cat53; D17Ertd808e; Fb19;
                     Pnuts"
                     /note="major polyA site"
ORIGIN      
        1 attctggggt tcgtttagag gttgaatttt ctcggagaaa gacaggccgg ccatcaggaa
       61 aacaaacaag cctcagcaac atctaaaccc ttgaaaggat cctgagaggg gggaaaggga
      121 aatcagccac cagcccaacc actcgtgtct tctgcccctc cccacctatc ttgcccaccc
      181 caccagccca cgctgcttgg gacttgagat ctgtggccga aggaccgtca ccacataact
      241 tcaaaaataa tcaaccacct tccctgccca aacctaccca atctcactca tccagcattt
      301 ccgttttgga atccactcag actttttttt tcaacgaccc cctctcccta aatggagttg
      361 ggcggggggg aaatgaaaac tgagttggtc tttacttttt ttaaaagaga ctttttgatc
      421 caatgaggcc ccacaagtaa ctgagtttgg gtcctggttg gttgctttat tttttttcct
      481 ccaaaatttt acccctcccc cctgagcccg aggtgctgac gtcgcaaaaa aattggataa
      541 agccaccatc atgggttcag gtcccataga ccccaaagaa ctgctcaagg gcctggatag
      601 cttccttacc cgggacggag aagtgaagag tgtggatgga atttccaaga tcttcagtct
      661 aatgaaggag gcacgaaaga tggtgagtcg gtgcacgtac ttgaacataa tcctgcagac
      721 ccgcgctcca gaagtgctcg tcaagtttat tgatgtcggt ggctacaagc ttctgaacaa
      781 ctggctaaca tattcaaaga ccaccaacaa cattcctctc ctacagcaga ttctgctgac
      841 tctgcagcac ctcccgctca ctgtggacca tctcaagcag aacaacacag caaaactagt
      901 gaagcagctc agcaagtcaa gtgaggatga agagctccgg aaattggcat cagtccttgt
      961 cagtgactgg atggctgtca tccgctccca gagtagcacc cagcctgcag agaaagataa
     1021 gaagaaaagg aaggaagagg ggaaaagtcg aaccacgctt cctgagcggc ctttgactga
     1081 agtgaaggct gagacccggg ctgaggaagc cccagagaag aagaaagaga agcccaagtc
     1141 acttagaact acggcaccca gtcatgccaa gttccgttct actggactgg agctggacac
     1201 cccatctttg gtgcctgtga agaagaactc cagcactgtg gttgtgtcag acaagtacaa
     1261 cctgaagccc atccccctga agcggcagag tgccacagct gctccaggtg acgctgcccc
     1321 acctgcagag aagaaataca agcctctcaa cacagccccc aataccacca aagaaatcaa
     1381 agtgaagatc atccctccac agcctatgga gggcctgggt tttctggatg ctctcaattc
     1441 agcccctgtc ccaggcatca aaattaagaa gaagaagaag gtactatcgc cgactgctgc
     1501 caagcccagc ccttttgaag ggaaaacaag caccgagcag agcacagcca aaccttcctc
     1561 cccagagcct gcaccacctg ctgagcccat ggacacggac cgccctggca cccctgttcc
     1621 ccctgttgaa gttccagagc tcatggatgc agcctcttca gagccaggag ctctggatgc
     1681 aaagcctgtg gacagccctg gagatcccaa ccagctgact cgcaagggca gaaagaggaa
     1741 aactgtgact tggcctgagg agggcaagct gagagagtat ttctactttg aactggacga
     1801 aactgagcga gtgaatgtga acaagatcaa agacttcggg gaggctgcta agcgtgagat
     1861 actgtctgac cgacatgctt tcgagacagc tcggcgacta agccatgaca atatggagga
     1921 gaaagtgcct tgggtgtgtc ccaggcctct ggttctgccc tcacctcttg tcatccctgg
     1981 aagcaacagc caggagcgat acatccaggc agagcgggag aagggcatcc ttcaggaact
     2041 cttcctgaac aaggagagtc cacatgaacc tgatcctgag ccatatgaac ccattccccc
     2101 aaaactcatc cccttggatg aggaatgtgc catggatgag actccatatg tcgagaccct
     2161 ggagcctgga gggtctggtg gctcacctga tggagcagga ggctccaagc tgcctccagt
     2221 tctggccaat cttatgggaa gcatgggagc tggaaagagc ccccagggcc ctggaggagg
     2281 cggcatcaat gttcaggaga tcctcacttc cataatgggc agtccaaaca gccacccttc
     2341 agaggagctg ctgaagcagc ctgactactc agacaagctc aagcagatgc tggtgcctca
     2401 tgggctccta ggtcctggtc ctgtggccaa tggctttcca ccaggaggcc ctgggggccc
     2461 gaagggtatg cagcatttcc cccctggtcc tggagggccc atgccaggtc cccatggagg
     2521 ccctggtgga ccagtgggtc cacgtctctt aggtccccca ccaccttctc ggggaggtga
     2581 tccattctgg gatggcccag gtgatccaat gcgaggtggc ccaatgcgtg ggggtccagg
     2641 acctgctccc ggaccatacc acagaggccg agggggtcga ggaggaaatg agccaccgcc
     2701 accacctcca ttccgaggag ccagaggagg tcgttccgga ggaggaccac caaatggccg
     2761 agggggtcct ggtggaggag gcatggttgg aggtggtggg caccgccccc atgaaggccc
     2821 tggagggagc atgggcagtg gacatcgttc ccatgatggc cctggaggga acatgggcag
     2881 tggacatcgt tctcatgatg gccctggagg gaacatgggt ggaagtggtg gacatcgttc
     2941 ccatgaaggc cctggacacg gaggacccca tggacaccga ccacatgatg tccctagcca
     3001 tcgaggccac gaccatcgag ggccaccacc tcatgaacac cgtggtcatg atggccatgg
     3061 gggaggcggc caccgagggc atgatggagg ccacagtcat ggaggagaca tgtcaaaccg
     3121 ccctgtctgc cgacacttca tgatgaaggg caactgccgc tatgagaaca actgtgcctt
     3181 ctaccaccca ggggtcaatg ggcccccact gccctagcct gcctgcccta cccgcacccc
     3241 tgtggactgc agccttgctc cttccacttg gttatggctt ctgtgaggcc cactgtcctt
     3301 ttccccagct gatgaggagc cggccccctc agttcccacc tggttgggtt tctgggggtt
     3361 tctgattcct ggtgtgcatt gatgtacata gtcccctcca gtctggagag gagagagact
     3421 ggacacactc tagatgctgg actgctgaga cggctggctt cactctgtga ggagatttgc
     3481 cctgtgcccc aaaccctttc cagtattagc cccgctgcct gagaacctaa agctggtcac
     3541 tctggagacc tctgctctcc acatgcacac agaactaagt gggtcagctg cacttaggaa
     3601 accatctaag ctaagctcat tatcctcaca gggcgagggg gtggtgaggg gtaccatcta
     3661 tcccactgca ctgcactgca ctgcactgag ggctcaagct ggctgaagct gagttctgga
     3721 accaccccca cttgtgcccc acatgggcca gtcactgttg agtcctttct caagaaagac
     3781 tgcaactgtt acttcccagg tcatcgtggg tctgctaggt tcagtgatgg cacgttcaca
     3841 tctgtatcca aggaagttgt tatctggcag aggggcatcc tgtagtgttg ggccactcct
     3901 gcctacagcg gtattagaga ctccgtgaga ccagctttca ttaactttag ccgggtacag
     3961 cgggcctgaa acactacatg cactgccttt gggagtgggc ctgctccttc cttaccccat
     4021 gaggagccct gtctgaggct tcctgggcag actcagcagt aggggccctt cccagtcgtc
     4081 tcctcccctt gtcttggcat cagttgtttt ctatgaaaac agtgggttgg ttttgtgaag
     4141 ggtcttgggt tagaaccaca atggatttga ggagtttttc ttttggtttt gtatattttg
     4201 tacattaata ataaacagtg gaaagagaag cagctcattt aa
//
