LOCUS       NM_013636               2387 bp    mRNA    linear   ROD 27-AUG-2023
DEFINITION  Mus musculus protein phosphatase 1 catalytic subunit gamma
            (Ppp1cc), transcript variant 1, mRNA.
ACCESSION   NM_013636
VERSION     NM_013636.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2387)
  AUTHORS   Camlin NJ, Venkatachalam I and Evans JP.
  TITLE     Oscillations in PP1 activity are essential for accurate progression
            through mammalian oocyte meiosis
  JOURNAL   Cell Cycle 22 (13), 1614-1636 (2023)
   PUBMED   37340734
  REMARK    GeneRIF: Oscillations in PP1 activity are essential for accurate
            progression through mammalian oocyte meiosis.
REFERENCE   2  (bases 1 to 2387)
  AUTHORS   Yanagisawa M, Han H, Pradhan S, Khatlani T, Subramanyam D and
            Vijayan KV.
  TITLE     Protein Phosphatase 1 gamma Modulates Steady-State BAD
            Phosphorylation and Murine Platelet Survival
  JOURNAL   Thromb Haemost 123 (6), 645-648 (2023)
   PUBMED   36764308
  REMARK    GeneRIF: Protein Phosphatase 1 gamma Modulates Steady-State BAD
            Phosphorylation and Murine Platelet Survival.
REFERENCE   3  (bases 1 to 2387)
  AUTHORS   Yadav Y, Sharma M and Dey CS.
  TITLE     PP1gamma regulates neuronal insulin signaling and aggravates
            insulin resistance leading to AD-like phenotypes
  JOURNAL   Cell Commun Signal 21 (1), 82 (2023)
   PUBMED   37085815
  REMARK    GeneRIF: PP1gamma regulates neuronal insulin signaling and
            aggravates insulin resistance leading to AD-like phenotypes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2387)
  AUTHORS   Gnan S, Flyamer IM, Klein KN, Castelli E, Rapp A, Maiser A, Chen N,
            Weber P, Enervald E, Cardoso MC, Bickmore WA, Gilbert DM and
            Buonomo SCB.
  TITLE     Nuclear organisation and replication timing are coupled through
            RIF1-PP1 interaction
  JOURNAL   Nat Commun 12 (1), 2910 (2021)
   PUBMED   34006872
  REMARK    GeneRIF: Nuclear organisation and replication timing are coupled
            through RIF1-PP1 interaction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2387)
  AUTHORS   Dong W, Rasid O, Chevalier C, Connor M, Eldridge MJG and Hamon MA.
  TITLE     Streptococcus pneumoniae Infection Promotes Histone H3
            Dephosphorylation by Modulating Host PP1 Phosphatase
  JOURNAL   Cell Rep 30 (12), 4016-4026 (2020)
   PUBMED   32209465
  REMARK    GeneRIF: Streptococcus pneumoniae Infection Promotes Histone H3
            Dephosphorylation by Modulating Host PP1 Phosphatase.
REFERENCE   6  (bases 1 to 2387)
  AUTHORS   Saadat M, Nomoto K, Mizuno Y, Kikuchi K and Yoshida MC.
  TITLE     Assignment of the gene encoding type 1 gamma protein phosphatase
            catalytic subunit (PPP1CC) on human, rat, and mouse chromosomes
  JOURNAL   Jpn J Hum Genet 41 (1), 159-165 (1996)
   PUBMED   8914631
REFERENCE   7  (bases 1 to 2387)
  AUTHORS   Mann M, Latham KE and Varmuza S.
  TITLE     Identification of genes showing altered expression in
            preimplantation and early postimplantation parthenogenetic embryos
  JOURNAL   Dev Genet 17 (3), 223-232 (1995)
   PUBMED   8565329
REFERENCE   8  (bases 1 to 2387)
  AUTHORS   Saadat M, Kakinoki Y, Mizuno Y, Kikuchi K and Yoshida MC.
  TITLE     Chromosomal localization of human, rat, and mouse protein
            phosphatase type 1 beta catalytic subunit genes (PPP1CB) by
            fluorescence in situ hybridization
  JOURNAL   Jpn J Genet 69 (6), 697-700 (1994)
   PUBMED   7857673
REFERENCE   9  (bases 1 to 2387)
  AUTHORS   Matsuzawa S, Tamura T, Mizuno Y, Kobayashi S, Okuyama H, Tsukitani
            Y, Uemura D and Kikuchi K.
  TITLE     Increase in potential activities of protein phosphatases PP1 and
            PP2A in lymphoid tissues of autoimmune MRL/MpJ-lpr/lpr mice
  JOURNAL   J Biochem 111 (4), 472-477 (1992)
   PUBMED   1319990
REFERENCE   10 (bases 1 to 2387)
  AUTHORS   Ohkura H, Kinoshita N, Miyatani S, Toda T and Yanagida M.
  TITLE     The fission yeast dis2+ gene required for chromosome disjoining
            encodes one of two putative type 1 protein phosphatases
  JOURNAL   Cell 57 (6), 997-1007 (1989)
   PUBMED   2544298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127266.4.
            
            [WARNING] On Sep 28, 2023 this sequence was replaced by
            NM_013636.5.
            
            On May 12, 2018 this sequence version replaced NM_013636.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147131.1, AK169336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               AC127266.4         128162-128502       c
            342-473             AC127266.4         118471-118602       c
            474-704             AC127266.4         117628-117858       c
            705-809             AC127266.4         114851-114955       c
            810-1033            AC127266.4         113822-114045       c
            1034-1168           AC127266.4         113497-113631       c
            1169-2387           AC127266.4         111504-112722       c
FEATURES             Location/Qualifiers
     source          1..2387
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.2 cM"
     gene            1..2387
                     /gene="Ppp1cc"
                     /gene_synonym="dis2m1; PP-1G; PP1"
                     /note="protein phosphatase 1 catalytic subunit gamma"
                     /db_xref="GeneID:19047"
                     /db_xref="MGI:MGI:104872"
     exon            1..341
                     /gene="Ppp1cc"
                     /gene_synonym="dis2m1; PP-1G; PP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1258
                     /gene="Ppp1cc"
                     /gene_synonym="dis2m1; PP-1G; PP1"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase 1C catalytic subunit; PP1C
                     gamma 1; PP1C gamma 2"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase PP1-gamma
                     catalytic subunit"
                     /protein_id="NP_038664.2"
                     /db_xref="CCDS:CCDS19643.1"
                     /db_xref="GeneID:19047"
                     /db_xref="MGI:MGI:104872"
                     /translation="MADIDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSRE
                     IFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLE
                     TICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLP
                     IAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGE
                     NDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEF
                     DNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRGMITKQAKK"
     exon            342..473
                     /gene="Ppp1cc"
                     /gene_synonym="dis2m1; PP-1G; PP1"
                     /inference="alignment:Splign:2.1.0"
     exon            474..704
                     /gene="Ppp1cc"
                     /gene_synonym="dis2m1; PP-1G; PP1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..809
                     /gene="Ppp1cc"
                     /gene_synonym="dis2m1; PP-1G; PP1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1033
                     /gene="Ppp1cc"
                     /gene_synonym="dis2m1; PP-1G; PP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1168
                     /gene="Ppp1cc"
                     /gene_synonym="dis2m1; PP-1G; PP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..2387
                     /gene="Ppp1cc"
                     /gene_synonym="dis2m1; PP-1G; PP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcccgcgc gcgcatccgt gcgccgcccg aggctggcct gaggagtcgg cggccatctt
       61 gttcttctcg tggttcccag tggcgagagg aggaggaagc ccggagcgga gcggggcggc
      121 tggggggggt ggacccgccg cggctgctgc tgccaccgcc gccgccgcca ccaccgctcg
      181 tggggctcgt ggcgtgagga aggaggacga gtgagacccc ggggcgagcg ggcggcggcg
      241 ccgctgctgc tgctgctgct gcgggagggt cggcggcggg acggcgatgg cggatatcga
      301 caaactcaac atcgacagca tcatccaacg gctgctggaa gtgagagggt ccaagccagg
      361 caagaatgtc cagctccagg agaacgagat ccgaggactc tgcctgaagt ctcgggagat
      421 cttcctcagt cagcctatcc ttttagaact tgaagcacca ctcaagatat gtggtgacat
      481 ccacgggcag tactatgatt tgctccgtct gtttgaatac ggtggctttc ctccagagag
      541 caactatttg tttctcgggg actatgtgga caggggcaag cagtccctgg agacaatctg
      601 cctcttgctg gcctacaaaa tcaagtatcc ggagaacttc tttcttctca gagggaacca
      661 cgagtgcgcc agcatcaata ggatctacgg attttatgat gagtgtaaaa gaagatacaa
      721 cattaagctg tggaaaacgt tcacagactg ttttaactgc ttgccgatag cagccatcgt
      781 ggacgagaag atattctgct gtcatggagg tttatcacca gatcttcaat ctatggagca
      841 gattcggcga attatgagac caactgatgt accagatcaa ggtcttcttt gtgatctttt
      901 gtggtctgac cccgataaag atgtcttagg ctggggtgaa aatgacagag gagtgtcctt
      961 cacatttggt gcagaagtgg ttgcaaaatt tctccataag catgatttgg atcttatatg
     1021 tagagcccat caggtggttg aagatggcta tgagtttttt gcaaagaggc agttagtcac
     1081 tctgttttct gcacccaact actgtggcga gtttgacaat gcaggcgcca tgatgagtgt
     1141 ggatgagacc ctcatgtgtt ccttccagat tttaaagcct gcagagaaaa agaagcccaa
     1201 cgccacgaga cctgtcacac caccacgggg tatgatcaca aagcaagcaa agaaatagat
     1261 gtcacttgac actgcctggt tgggacttgt aacatagcgt tcataacctt cctttttaaa
     1321 ctgtgatgtg ctggtcagct tgcccaggta gacctgtctg tcgggccctc ctccatttga
     1381 ttactgctgg cacttgctgg ttatagcagc aagccaagca cttcattctc aagagagcat
     1441 tttgttttga acctctgttc cctttgtgga cagctctgat gatggtgtta agctgtacac
     1501 cctggcaggt tatcctgtct gaggagaaag tgtacaattg atcttttttt aatttagtat
     1561 aagtcatgaa taatgtaaat gcctgttttc tttaggatat aaagagagcc ttagagtgcg
     1621 tgagtctcta catgtaattg tcataaatgc attctgttga tacaaaccac tgtgaacaat
     1681 tttttttcca gtttgtttga aagggactgc tttccctcat tgtcttgtca tgtacaaact
     1741 agtgtctgca gctgtggcag caggagtgac ctgcctgccg ccagccctgc ccagactatc
     1801 tgaagcacac tccttcccac tgcacattta ataatgatta aagccattct tttcaatgtc
     1861 tgtgattcct tcctaaagcc aaagtttctg ttggactgta tggcacgccc tggggatgag
     1921 gtggccaggg catcgaggct gcgtgcacag gccgcctccc tccgtggggc ctcagaagca
     1981 ggttatttta actagcaata gtggtatagt gctgagtaag ctattaatga tggaagttaa
     2041 tgacactttg tacagttccc atatagtcta ttcactgagt gatcttttta cagttggatc
     2101 aggcctgaac ccgtccattc agaaagcttc aaattataga aacaacactg tcctatacga
     2161 gtgaccgata atgctttctt tggctacatt ctttattctg cggtgacatt gaggcttata
     2221 aatcaaaagg aactaacttg ccgtccaccg gtttatacag aactcacagt atctatgact
     2281 tttttaaact acgacctgtt aaatgaatct gtttgcacag atgcccgtgt acaatgccat
     2341 gtgctgagaa tggtttcaga cttattaaat gcaagcttgt taacttg
//
