LOCUS       NM_172707               4024 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protein phosphatase 1 catalytic subunit beta (Ppp1cb),
            mRNA.
ACCESSION   NM_172707 XM_909256
VERSION     NM_172707.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4024)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4024)
  AUTHORS   Deneyer,N., Bridoux,L., Bombled,C., Pringels,T., Bergiers,I., Pyr
            Dit Ruys,S., Vertommen,D., Twizere,J.C. and Rezsohazy,R.
  TITLE     HOXA2 activity regulation by cytoplasmic relocation, protein
            stabilization and post-translational modification
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1862 (9), 194404 (2019)
   PUBMED   31323436
REFERENCE   3  (bases 1 to 4024)
  AUTHORS   Chang,A.N., Gao,N., Liu,Z., Huang,J., Nairn,A.C., Kamm,K.E. and
            Stull,J.T.
  TITLE     The dominant protein phosphatase PP1c isoform in smooth muscle
            cells, PP1cbeta, is essential for smooth muscle contraction
  JOURNAL   J Biol Chem 293 (43), 16677-16686 (2018)
   PUBMED   30185619
  REMARK    GeneRIF: Smooth muscle-specific conditional PP1cbeta knockout
            decreased contractile force development in bladder, ileal, and
            aortic tissues and reduced mouse survival.
REFERENCE   4  (bases 1 to 4024)
  AUTHORS   Bose,S.K., Hutson,I. and Harris,C.A.
  TITLE     Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose
            GR in Metabolic Syndrome Despite Renal Compensation
  JOURNAL   Endocrinology 157 (12), 4943-4960 (2016)
   PUBMED   27754788
REFERENCE   5  (bases 1 to 4024)
  AUTHORS   Cho,Y.L., Min,J.K., Roh,K.M., Kim,W.K., Han,B.S., Bae,K.H.,
            Lee,S.C., Chung,S.J. and Kang,H.J.
  TITLE     Phosphoprotein phosphatase 1CB (PPP1CB), a novel adipogenic
            activator, promotes 3T3-L1 adipogenesis
  JOURNAL   Biochem Biophys Res Commun 467 (2), 211-217 (2015)
   PUBMED   26449462
  REMARK    GeneRIF: PPP1CB is a novel adipogenic activator that promotes
            adipogenesis in vivo and in vitro.
REFERENCE   6  (bases 1 to 4024)
  AUTHORS   Llorian,M., Beullens,M., Andres,I., Ortiz,J.M. and Bollen,M.
  TITLE     SIPP1, a novel pre-mRNA splicing factor and interactor of protein
            phosphatase-1
  JOURNAL   Biochem J 378 (Pt 1), 229-238 (2004)
   PUBMED   14640981
REFERENCE   7  (bases 1 to 4024)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4024)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   9  (bases 1 to 4024)
  AUTHORS   Saadat,M., Kakinoki,Y., Mizuno,Y., Kikuchi,K. and Yoshida,M.C.
  TITLE     Chromosomal localization of human, rat, and mouse protein
            phosphatase type 1 beta catalytic subunit genes (PPP1CB) by
            fluorescence in situ hybridization
  JOURNAL   Jpn J Genet 69 (6), 697-700 (1994)
   PUBMED   7857673
REFERENCE   10 (bases 1 to 4024)
  AUTHORS   Ohkura,H., Kinoshita,N., Miyatani,S., Toda,T. and Yanagida,M.
  TITLE     The fission yeast dis2+ gene required for chromosome disjoining
            encodes one of two putative type 1 protein phosphatases
  JOURNAL   Cell 57 (6), 997-1007 (1989)
   PUBMED   2544298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102372.8, AK166623.1, AK160743.1 and AK017392.1.
            
            On Dec 1, 2007 this sequence version replaced NM_172707.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147112.1, SRR1660811.252690.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               AC102372.8         202089-202446
            359-978             AK166623.1         262-881
            979-3066            AK160743.1         688-2775
            3067-4024           AK017392.1         444-1401
FEATURES             Location/Qualifiers
     source          1..4024
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.33 cM"
     gene            1..4024
                     /gene="Ppp1cb"
                     /gene_synonym="1200010B19"
                     /note="protein phosphatase 1 catalytic subunit beta"
                     /db_xref="GeneID:19046"
                     /db_xref="MGI:MGI:104871"
     exon            1..438
                     /gene="Ppp1cb"
                     /gene_synonym="1200010B19"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..1370
                     /gene="Ppp1cb"
                     /gene_synonym="1200010B19"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.53"
                     /note="PP-1B"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase PP1-beta
                     catalytic subunit"
                     /protein_id="NP_766295.2"
                     /db_xref="CCDS:CCDS19193.1"
                     /db_xref="GeneID:19046"
                     /db_xref="MGI:MGI:104871"
                     /translation="MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREI
                     FLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLET
                     ICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPI
                     AAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGEN
                     DRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFD
                     NAGGMMSVDETLMCSFQILKPSEKKAKYQYGGLNSGRPVTPPRTANPPKKR"
     exon            439..570
                     /gene="Ppp1cb"
                     /gene_synonym="1200010B19"
                     /inference="alignment:Splign:2.1.0"
     exon            571..801
                     /gene="Ppp1cb"
                     /gene_synonym="1200010B19"
                     /inference="alignment:Splign:2.1.0"
     exon            802..906
                     /gene="Ppp1cb"
                     /gene_synonym="1200010B19"
                     /inference="alignment:Splign:2.1.0"
     exon            907..978
                     /gene="Ppp1cb"
                     /gene_synonym="1200010B19"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1130
                     /gene="Ppp1cb"
                     /gene_synonym="1200010B19"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1265
                     /gene="Ppp1cb"
                     /gene_synonym="1200010B19"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..4024
                     /gene="Ppp1cb"
                     /gene_synonym="1200010B19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3044..3049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppp1cb"
                     /gene_synonym="1200010B19"
                     /note="hexamer: AGTAAA"
     polyA_site      3063
                     /gene="Ppp1cb"
                     /gene_synonym="1200010B19"
                     /note="major polyA site"
ORIGIN      
        1 gcggctaggc ggcccgcaag ggcggagggg agggagtgac gctgagggcg gggctgtccg
       61 tggcgctgcc gagctttgcg gagctgggcg gtgccgagga ggaggtggag gaggcggtgg
      121 cggctggggt ctgacgcggc ccggttcctg acgcggcccg gttcctgggg gcctgcttgt
      181 ttatttattt atttccagtg ggcgccgcca gcgtgtgcgc gcgctgtcgc tgctcggcgg
      241 ggagggggtg gggggagggc ccgcgcccgg ggggagttgg agccggggtc gaaacgccgc
      301 gtgactcgta ggtgagaacg ccgagccgcc gccgccgccg agaagccctg ttaacgcttt
      361 agggaggaga gtctggtgcc gacaagatgg cggacgggga gctgaacgtg gacagcctca
      421 tcacccgcct gctggaggta cgaggatgtc gtccaggaaa gattgtacaa atgactgaag
      481 cagaagtccg agggttgtgt atcaagtctc gtgaaatctt tctcagccag cctattcttt
      541 tggaattgga agcaccactg aagatttgtg gagacattca tggacaatat acagacttac
      601 taagattatt tgaatatgga ggttttccac cagaagccaa ctatcttttc ttaggagatt
      661 atgtggacag aggaaagcag tctttggaaa ccatctgttt gctattggct tacaaaatca
      721 aatacccgga gaacttcttt cttctaagag gaaaccatga gtgtgctagc atcaatcgca
      781 tttatggatt ctacgatgag tgtaaacgaa gatttaatat taaattgtgg aagacattca
      841 ctgattgttt taactgtctg cctatagctg ctattgttga tgagaaaatc ttctgttgtc
      901 atggaggact gtcaccagac ctacaatcta tggaacagat tcggagaatt atgagaccca
      961 ctgacgtacc tgatacaggt ttgctttgtg acttactgtg gtccgaccca gataaggatg
     1021 tgcaaggctg gggagaaaat gaccgtggtg tttcttttac ttttggagct gatgtagtca
     1081 gtaaatttct gaatcgtcat gatttagact tgatttgtcg agctcatcag gtggtggaag
     1141 acggatatga attttttgct aaacgacagt tggtaacctt attttctgcc ccaaattact
     1201 gtggcgagtt tgacaatgct ggtggtatga tgagtgtgga tgagactttg atgtgttcat
     1261 tccagatatt gaaaccatct gaaaagaaag ctaagtacca gtatggtggg ctgaattctg
     1321 gacgtcctgt cactccgcct cgaacagcta atccaccgaa gaaaaggtga agacaggaat
     1381 tctagaaaga gaaaccatca gatttgttaa ggacatactt cataatatat aagtgtgcac
     1441 tgtaaaacca tccagccatt cgacaccctt tatgatgtca cacctttaac ttaaggagac
     1501 ggtaaaggat cttaaatttt tttctaatag aaagatgtgc tacactgtat tgtaataagt
     1561 atactctgtt ataatattca acaaaattaa atccaaattc aaaagtatcc attaaagttc
     1621 tatcttctca tatcacagtt tttaaagttg aaaagcatcc cagttaaact agccctgtta
     1681 gtgacccaga tgaaagcatg aagatccatc tgtgtaatgt ggttttagtg gtgcttggtt
     1741 gtttcattat tttgagcttg ttttgttttg tttgtttttg ctagaataat ggcatctact
     1801 tttcctattt ttccctaaac atttttaaaa gtgaaaatgg gaagagcttt aaagacattc
     1861 accaactatt cttttccttt acttatctac ttaagtaact gttggatctt actaagaaaa
     1921 cttacccctc attacagtaa aaaggaactt tagaggtcga taggttttaa aaatatacaa
     1981 actatctgat ccattgattt taatcaaaca gtttgactgg gcaaactttg cagctgataa
     2041 tgagtatttc gctttttaca aaattgccac tgatttggat ttgtgcactc taatctttaa
     2101 tttattgatg ctctattgtg cagtagcatt tcatttaaga taaggctcat atagtaatat
     2161 ccaaaactag ttggtaatgt gattatgtgg tactttggct ttgggttcta attcgcacga
     2221 aacacctttt ggcatgctta actttctggt attaccctca cctgcattgg ttttgttttt
     2281 tggggttttt gttgtttgtt tgtttttaga ttcacagaac atgagaatcc tttttgacaa
     2341 gccttggata gctggctctc ttctttccct ctctctatgt gaaggatgta tttaaatgaa
     2401 cgctggtcag tgggacattt gtcagctctg aatattgggt gcttcactaa taattgccat
     2461 gtgaatgttg ttttgactgt aaggctatgt cactaaagat ttttactctg cgttttcata
     2521 atcaaaggtc atgatgtgta tagacatgct ttgtagtgaa gtatagtagc aataatttct
     2581 gtatgtgatc aagagtttat tgcattattt ctttccctgt tctctttttt ttttttttaa
     2641 gggttagcat taacaaatgt caaggagtag caaagtcaac aaagatttta gaaggaggag
     2701 gaactaagag catacacaga cttatgattc tttggatgtg acacttattg gatgtgattc
     2761 taaagtcttt tattgaacat tgtcaaattc gtacgcttca taggatggac ataatgttta
     2821 tataatgccc ttcttatgtg ttaccataga tgtgtgaaac cttatagcgt ccttgaaagt
     2881 gttaaattga gaactctgtt aacattttat ggattgacac attatattac tgcaagtaac
     2941 atttgatttt cagcacagtg caaaagttct ttaaaatgca tatgtctttt tttttctaat
     3001 tccattttgt ttaaagcaca ttttaaatgt agttttctca tttagtaaaa gttgtctaat
     3061 tgatacaacg tctgagtgat tattctgtgt tgttttgttt tacagtgaga tatgtaagca
     3121 caagttgaca tagactgaag catagacagt ctctgagctg tagccatgtt ctattaggtc
     3181 acacatgctt ttatttaatg cgattggata acttacatac tagagtaaac gaacaattgt
     3241 ttactcaaac aattgctaat aggattttag atgttatctc tgagtaatca atacttaagg
     3301 tagctcaaga aaataagcct tagtctcaat attagttaat gtacactaat ttgtatctta
     3361 aactgttttg ttttttgtaa atgttcattc aaattaaaac taggggcgaa aagtaagcaa
     3421 attagtattg gttgttaaag gatagacatt taccatgttg gaaaattatt cagacctctt
     3481 aaaactactt tacagcttct catatataag tactcagtac atcatgtgct cctaagaatg
     3541 ataacacaga ttattaatta tactagttta ctgacaaagt cacaaagaca aacagtaaaa
     3601 tacaggctac ctttaacccc atgattggtg aggcagacag agacaggtga atctatgact
     3661 tgaagcctag actacatgtt acagtgtctg tttactagat gaaaagctac aagcaattgc
     3721 agagaatttg ggttcaattc tttttttttt tttttacacg tattttcctc aaattacatt
     3781 tccaatgcta tctcaaaagt cccccacacc ctgggttcta ttcttaacac tcagaaggct
     3841 gtctgtatgg ctaagccaag gggatctgct gttttatgcc ctctgagggc accaggcaca
     3901 cacatggcac acatggtggg tacatagaca tacatatagg caaaatcctc atacacataa
     3961 aaataaaatg tttaaaggat ttttttatta agtgttgagc aaataaaatg agttttttga
     4021 ttgg
//
