LOCUS       NM_031868               1363 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus protein phosphatase 1 catalytic subunit alpha
            (Ppp1ca), mRNA.
ACCESSION   NM_031868
VERSION     NM_031868.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1363)
  AUTHORS   Zhang,L., Jiao,G., You,Y., Li,X., Liu,J., Sun,Z., Li,Q., Dai,Z.,
            Ma,J., Zhou,H., Li,G., Meng,C. and Chen,Y.
  TITLE     Arginine methylation of PPP1CA by CARM1 regulates glucose
            metabolism and affects osteogenic differentiation and osteoclastic
            differentiation
  JOURNAL   Clin Transl Med 13 (9), e1369 (2023)
   PUBMED   37649137
  REMARK    GeneRIF: Arginine methylation of PPP1CA by CARM1 regulates glucose
            metabolism and affects osteogenic differentiation and osteoclastic
            differentiation.
REFERENCE   2  (bases 1 to 1363)
  AUTHORS   Park,E.J., Kim,H.S., Lee,D.H., Kim,S.M., Yoon,J.S., Lee,J.M.,
            Im,S.J., Lee,H., Lee,M.W. and Lee,C.W.
  TITLE     Ssu72 phosphatase is essential for thermogenic adaptation by
            regulating cytosolic translation
  JOURNAL   Nat Commun 14 (1), 1097 (2023)
   PUBMED   36841836
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1363)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   4  (bases 1 to 1363)
  AUTHORS   Chen,Y., Che,M., Li,C., Li,Y., Zhang,T., Li,X. and Sun,C.
  TITLE     PP1A prevents ROS-induced pyroptosis by inhibiting MAPK/caspase-3
            in mouse adipose tissue
  JOURNAL   FEBS J 289 (13), 3839-3853 (2022)
   PUBMED   35080339
  REMARK    GeneRIF: PP1A prevents ROS-induced pyroptosis by inhibiting
            MAPK/caspase-3 in mouse adipose tissue.
REFERENCE   5  (bases 1 to 1363)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1363)
  AUTHORS   Smith,G.D., Sadhu,A., Mathies,S. and Wolf,D.P.
  TITLE     Characterization of protein phosphatases in mouse oocytes
  JOURNAL   Dev Biol 204 (2), 537-549 (1998)
   PUBMED   9882488
REFERENCE   7  (bases 1 to 1363)
  AUTHORS   Fernandes,M., Lespinasse,F., Rotomondo,F., Poirier,C., Guenet,J.L.,
            Gaudray,P. and Carle,G.F.
  TITLE     Comparative mapping of two adjacent regions of MMU19 with their
            human counterpart on HSA11q13
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 237-246 (1998)
   PUBMED   9730611
REFERENCE   8  (bases 1 to 1363)
  AUTHORS   Saadat,M., Mizuno,Y., Kikuchi,K. and Yoshida,M.C.
  TITLE     Comparative mapping of the gene encoding the catalytic subunit of
            protein phosphatase type 1 alpha (PPP1CA) to human, rat, and mouse
            chromosomes
  JOURNAL   Cytogenet Cell Genet 70 (1-2), 55-57 (1995)
   PUBMED   7736790
REFERENCE   9  (bases 1 to 1363)
  AUTHORS   Saadat,M., Kakinoki,Y., Mizuno,Y., Kikuchi,K. and Yoshida,M.C.
  TITLE     Chromosomal localization of human, rat, and mouse protein
            phosphatase type 1 beta catalytic subunit genes (PPP1CB) by
            fluorescence in situ hybridization
  JOURNAL   Jpn J Genet 69 (6), 697-700 (1994)
   PUBMED   7857673
REFERENCE   10 (bases 1 to 1363)
  AUTHORS   Becker,W., Kentrup,H., Klumpp,S., Schultz,J.E. and Joost,H.G.
  TITLE     Molecular cloning of a protein serine/threonine phosphatase
            containing a putative regulatory tetratricopeptide repeat domain
  JOURNAL   J Biol Chem 269 (36), 22586-22592 (1994)
   PUBMED   8077208
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC140073.4.
            
            On Mar 21, 2007 this sequence version replaced NM_031868.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167244.1, AK167981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC140073.4         231168-231265       c
            99-230              AC140073.4         230563-230694       c
            231-461             AC140073.4         230187-230417       c
            462-566             AC140073.4         229568-229672       c
            567-790             AC140073.4         228749-228972       c
            791-925             AC140073.4         228533-228667       c
            926-1363            AC140073.4         228020-228457       c
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.89 cM"
     gene            1..1363
                     /gene="Ppp1ca"
                     /gene_synonym="dism2; Ppp1c"
                     /note="protein phosphatase 1 catalytic subunit alpha"
                     /db_xref="GeneID:19045"
                     /db_xref="MGI:MGI:103016"
     exon            1..98
                     /gene="Ppp1ca"
                     /gene_synonym="dism2; Ppp1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1036
                     /gene="Ppp1ca"
                     /gene_synonym="dism2; Ppp1c"
                     /EC_number="3.1.3.16"
                     /note="PP-1A"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase PP1-alpha
                     catalytic subunit"
                     /protein_id="NP_114074.1"
                     /db_xref="CCDS:CCDS29421.1"
                     /db_xref="GeneID:19045"
                     /db_xref="MGI:MGI:103016"
                     /translation="MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSRE
                     IFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLE
                     TICLLLAYKIRYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLP
                     IAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGE
                     NDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEF
                     DNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK"
     exon            99..230
                     /gene="Ppp1ca"
                     /gene_synonym="dism2; Ppp1c"
                     /inference="alignment:Splign:2.1.0"
     exon            231..461
                     /gene="Ppp1ca"
                     /gene_synonym="dism2; Ppp1c"
                     /inference="alignment:Splign:2.1.0"
     exon            462..566
                     /gene="Ppp1ca"
                     /gene_synonym="dism2; Ppp1c"
                     /inference="alignment:Splign:2.1.0"
     exon            567..790
                     /gene="Ppp1ca"
                     /gene_synonym="dism2; Ppp1c"
                     /inference="alignment:Splign:2.1.0"
     exon            791..925
                     /gene="Ppp1ca"
                     /gene_synonym="dism2; Ppp1c"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1363
                     /gene="Ppp1ca"
                     /gene_synonym="dism2; Ppp1c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagagggc ccggagctgg tgggccggag cggcggcgcc gccatgtccg acagcgagaa
       61 gctcaacctg gactccatca tcgggcgcct gctggaagtg cagggctcac ggcctgggaa
      121 gaacgtgcag ctgacagaga acgagatccg tggtctgtgc ctcaaatccc gggagatttt
      181 cctgagccag cccattcttc tggagcttga ggcgcccctc aagatctgtg gtgacatcca
      241 tggccagtac tatgaccttc tacggctgtt tgagtatggt ggcttccctc cagagagcaa
      301 ctacctcttc ttgggggatt atgtagatcg gggcaagcag tctttggaga ccatctgcct
      361 gttgctggcc tataagatca gatacccgga gaatttcttt ctacttcgtg ggaaccatga
      421 gtgtgccagc atcaaccgca tttatggctt ctatgatgaa tgcaagagaa gatacaacat
      481 caaactgtgg aagacgttca ctgactgctt caactgcctg cccattgcag ccattgtgga
      541 tgagaagatc ttctgctgcc acgggggcct gtctccagac ttgcaatcca tggagcagat
      601 taggcgtatt atgcggccca cagacgtgcc tgaccagggc ctactgtgtg atctcctgtg
      661 gtctgaccct gacaaggatg ttcaaggctg gggcgagaat gaccgtggtg tctcctttac
      721 ctttggggct gaggtggtag ccaagttcct gcacaagcat gatttggacc tcatctgcag
      781 agcacatcag gttgtagaag atggctatga gttctttgcc aagagacagt tggtgacact
      841 cttctcagct cccaactact gtggagagtt tgacaatgct ggtgccatga tgagtgtgga
      901 tgagaccctc atgtgttcct tccagatcct caagcccgct gataagaata agggcaagta
      961 tgggcagttc agcggcctga accccggagg ccggcccatc actccacccc gcaattctgc
     1021 caaagccaag aaatagcctc catgtgctgc ccttctgccc cagatcgttt gtacagaaat
     1081 catgctgcca tgggtcacac tggcctctca ggcccacccg tcacggggaa cacacagcgt
     1141 taagtgtctt tcctttattt tttaaagaat caatagcagc atctaatctc ccagggctcc
     1201 ctcccaccag cacctgtggt ggctgcaagt ggaatcctgg ggccaaggct gcagctcagg
     1261 gcaatggcag accagattgt gggtctccag ccttgcatgg ctggcagcca gatcctgggg
     1321 caacccatct ggtctcttga ataaaggtca aagctggatt ctc
//
