LOCUS       NM_008911               1821 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protoporphyrinogen oxidase (Ppox), mRNA.
ACCESSION   NM_008911
VERSION     NM_008911.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1821)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1821)
  AUTHORS   Mattebo,A., Sen,T., Jassinskaja,M., Pimkova,K., Prieto
            Gonzalez-Albo,I., Alattar,A.G., Ramakrishnan,R., Lang,S., Jaras,M.,
            Hansson,J., Soneji,S., Singbrant,S., van den Akker,E. and
            Flygare,J.
  TITLE     Yippee like 4 (Ypel4) is essential for normal mouse red blood cell
            membrane integrity
  JOURNAL   Sci Rep 11 (1), 15898 (2021)
   PUBMED   34354145
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1821)
  AUTHORS   Shea,C.J., Carhuatanta,K.A., Wagner,J., Bechmann,N., Moore,R.,
            Herman,J.P. and Jankord,R.
  TITLE     Variable impact of chronic stress on spatial learning and memory in
            BXD mice
  JOURNAL   Physiol Behav 150, 69-77 (2015)
   PUBMED   26079812
REFERENCE   4  (bases 1 to 1821)
  AUTHORS   Tallack,M.R., Whitington,T., Yuen,W.S., Wainwright,E.N., Keys,J.R.,
            Gardiner,B.B., Nourbakhsh,E., Cloonan,N., Grimmond,S.M.,
            Bailey,T.L. and Perkins,A.C.
  TITLE     A global role for KLF1 in erythropoiesis revealed by ChIP-seq in
            primary erythroid cells
  JOURNAL   Genome Res 20 (8), 1052-1063 (2010)
   PUBMED   20508144
  REMARK    Erratum:[Genome Res. 2010 Dec;20(12):1748]
REFERENCE   5  (bases 1 to 1821)
  AUTHORS   Drissen,R., von Lindern,M., Kolbus,A., Driegen,S., Steinlein,P.,
            Beug,H., Grosveld,F. and Philipsen,S.
  TITLE     The erythroid phenotype of EKLF-null mice: defects in hemoglobin
            metabolism and membrane stability
  JOURNAL   Mol Cell Biol 25 (12), 5205-5214 (2005)
   PUBMED   15923635
REFERENCE   6  (bases 1 to 1821)
  AUTHORS   Taketani,S., Yoshinaga,T., Furukawa,T., Kohno,H., Tokunaga,R.,
            Nishimura,K. and Inokuchi,H.
  TITLE     Induction of terminal enzymes for heme biosynthesis during
            differentiation of mouse erythroleukemia cells
  JOURNAL   Eur J Biochem 230 (2), 760-765 (1995)
   PUBMED   7607249
REFERENCE   7  (bases 1 to 1821)
  AUTHORS   Matringe,M., Camadro,J.M., Labbe,P. and Scalla,R.
  TITLE     Protoporphyrinogen oxidase inhibition by three peroxidizing
            herbicides: oxadiazon, LS 82-556 and M&B 39279
  JOURNAL   FEBS Lett 245 (1-2), 35-38 (1989)
   PUBMED   2522396
REFERENCE   8  (bases 1 to 1821)
  AUTHORS   Ferreira,G.C., Andrew,T.L., Karr,S.W. and Dailey,H.A.
  TITLE     Organization of the terminal two enzymes of the heme biosynthetic
            pathway. Orientation of protoporphyrinogen oxidase and evidence for
            a membrane complex
  JOURNAL   J Biol Chem 263 (8), 3835-3839 (1988)
   PUBMED   3346226
REFERENCE   9  (bases 1 to 1821)
  AUTHORS   Ferreira,G.C. and Dailey,H.A.
  TITLE     Mouse protoporphyrinogen oxidase. Kinetic parameters and
            demonstration of inhibition by bilirubin
  JOURNAL   Biochem J 250 (2), 597-603 (1988)
   PUBMED   2451512
REFERENCE   10 (bases 1 to 1821)
  AUTHORS   Deybach,J.C., da Silva,V., Grandchamp,B. and Nordmann,Y.
  TITLE     The mitochondrial location of protoporphyrinogen oxidase
  JOURNAL   Eur J Biochem 149 (2), 431-435 (1985)
   PUBMED   3996415
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084821.26, AK142632.1 and U25114.1.
            
            On Sep 15, 2006 this sequence version replaced NM_008911.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U25114.1, BC002047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               AC084821.26        64342-64604
            264-1055            AK142632.1         216-1007
            1056-1530           U25114.1           1031-1505
            1531-1821           AK142632.1         1483-1773
FEATURES             Location/Qualifiers
     source          1..1821
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.3 cM"
     gene            1..1821
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /note="protoporphyrinogen oxidase"
                     /db_xref="GeneID:19044"
                     /db_xref="MGI:MGI:104968"
     exon            1..314
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /inference="alignment:Splign:2.1.0"
     exon            315..409
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..1756
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /EC_number="1.3.3.4"
                     /note="protoporhyrinogen oxidase"
                     /codon_start=1
                     /product="protoporphyrinogen oxidase"
                     /protein_id="NP_032937.1"
                     /db_xref="CCDS:CCDS15487.1"
                     /db_xref="GeneID:19044"
                     /db_xref="MGI:MGI:104968"
                     /translation="MGRTVIVLGGGISGLAASYHLIRGPSPPKVILVEGSKRLGGWIR
                     SIRGSDGAIFELGPRGIRPAGALGARTLLLVSELGLESEVLPVRGDHPAAQNRFLYVG
                     GTLHPLPSGLRGLLRPSPPFSKPLFWAGLRELLKPRGKEPDETVHSFAQRRLGPEVAS
                     LAMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLLGAGQSPQPDSSLIRQ
                     ARAERWSQWSLRGGLEVLPQALHNHLASKGVTVLSGQPVCGLSLQPEGRWKVSLGDSS
                     LEADHIISAIPASELSKLLPAEAAPLARILSTIKAVSVAVVNLQYRGACLPVQGFGHL
                     VPSSEDPTVLGIVYDSVAFPEQDGNPPSLRVTVMLGGYWLQKLKAAGHQLSPELFQQQ
                     AQEAAATQLGLKEPPSHCLVHLHKNCIPQYTIGHWQKLDSAMQFLTAQRLPLTLAGAS
                     YEGVAVNDCIESGRQAAVAVLGTESNS"
     exon            410..544
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /inference="alignment:Splign:2.1.0"
     exon            545..660
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /inference="alignment:Splign:2.1.0"
     exon            661..793
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /inference="alignment:Splign:2.1.0"
     exon            794..938
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1129
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1190
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1309
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1420
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1570
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1613
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1821
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1801..1806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /note="hexamer: AGTAAA"
     polyA_site      1821
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /note="major polyA site"
ORIGIN      
        1 gaaaggaatc gacggagagt cggagggacc ctaaaagtta ggggcgggga taccagactt
       61 gaacctgctc acccctgagg ctggaaaaac cgagtgctgt agaattctgg cctccgaagg
      121 gtttgtgctg gggagatagc gtgggcgtgg cccttatctg cacacggaca ggatggactg
      181 ctcctagggc ctctatcagt cactcacttt ctcgggttcc ccctatctcg tgggtaagtt
      241 ctggcttcag aacgaagacc ttactcttcc accagcacgt acacgcgcgc cctgcattag
      301 ttgctcataa atcagcctta cgatgggccg gactgtgata gtacttggcg gaggtatcag
      361 tggattggcc gcaagttatc atctgatccg aggccccagt cctcctaagg tgatcttagt
      421 ggagggcagc aagcgtttgg gaggatggat ccgctcaatc cgaggatcag atggtgcgat
      481 ctttgaactt ggacctcgag ggattaggcc ggctggagcc ctgggagccc ggaccctgct
      541 cctggtttct gaacttggct tggagtctga agtcttgcct gtccgagggg atcacccagc
      601 tgcccagaac aggttcctgt atgtaggcgg taccctgcac cctctaccct ccggcctcag
      661 ggggctactc cgtccttcac cccccttctc aaaacctctg ttttgggctg ggctgaggga
      721 gttgctgaag cccaggggca aagagcctga tgaaactgtg cacagttttg cccagcgccg
      781 ccttggacct gaggtggcat ctttagccat ggacagtctt tgccgaggag tatttgctgg
      841 caacagccgg gagctcagca tccggtcctg ctttcccagt ctcttccaag ctgaacaaac
      901 ccaccggtcc atattgctgg ggctgctgct gggcgcagga cagagtcccc agccggattc
      961 ctcactaatt cgtcaggccc gggctgagcg atggagccag tggtcactcc gtggagggct
     1021 ggaggtgttg ccccaggctc ttcacaatca cctagcaagt aaaggggtca ctgtcctcag
     1081 tgggcagcca gtctgtgggc tcagccttca gccagaaggg cgctggaagg tgtctctagg
     1141 ggacagcagt ctggaggctg accacattat aagtgccatt ccagcttcag agctcagcaa
     1201 gctgctccct gccgaggctg cacctctagc tcgaatcctg agtaccatca aggcagtgtc
     1261 tgttgctgtg gtgaatctgc agtaccgagg agcttgtctg cctgtccagg gatttggaca
     1321 tttggtgcca tcgtcagaag acccgactgt cctgggaatt gtgtacgact cggtggcttt
     1381 tcctgaacag gatgggaacc ccccaagcct cagagtgact gtgatgttgg gaggttactg
     1441 gctacagaag ctaaaagctg cgggccacca actgtctcca gagctgttcc agcaacaagc
     1501 ccaggaggca gccgccacac agttaggact gaaagaacca ccgagtcact gcctggtcca
     1561 tctacacaag aactgtatcc ctcagtatac aataggccac tggcaaaaac tagactcagc
     1621 tatgcaattc ctgacggccc agaggttgcc cctgactttg gctggagcct cctatgaggg
     1681 ggttgctgtc aatgactgta tagagagtgg gcgccaggca gcagttgctg tcctgggcac
     1741 agaatctaac agctgacaag ccccctgtcc cgtccccacc cccactttcc tactcatgaa
     1801 agtaaaagtt ggtagagctt g
//
