LOCUS       NP_032937                477 aa            linear   ROD 30-APR-2024
DEFINITION  protoporphyrinogen oxidase [Mus musculus].
ACCESSION   NP_032937
VERSION     NP_032937.1
DBSOURCE    REFSEQ: accession NM_008911.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 477)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 477)
  AUTHORS   Mattebo,A., Sen,T., Jassinskaja,M., Pimkova,K., Prieto
            Gonzalez-Albo,I., Alattar,A.G., Ramakrishnan,R., Lang,S., Jaras,M.,
            Hansson,J., Soneji,S., Singbrant,S., van den Akker,E. and
            Flygare,J.
  TITLE     Yippee like 4 (Ypel4) is essential for normal mouse red blood cell
            membrane integrity
  JOURNAL   Sci Rep 11 (1), 15898 (2021)
   PUBMED   34354145
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 477)
  AUTHORS   Shea,C.J., Carhuatanta,K.A., Wagner,J., Bechmann,N., Moore,R.,
            Herman,J.P. and Jankord,R.
  TITLE     Variable impact of chronic stress on spatial learning and memory in
            BXD mice
  JOURNAL   Physiol Behav 150, 69-77 (2015)
   PUBMED   26079812
REFERENCE   4  (residues 1 to 477)
  AUTHORS   Tallack,M.R., Whitington,T., Yuen,W.S., Wainwright,E.N., Keys,J.R.,
            Gardiner,B.B., Nourbakhsh,E., Cloonan,N., Grimmond,S.M.,
            Bailey,T.L. and Perkins,A.C.
  TITLE     A global role for KLF1 in erythropoiesis revealed by ChIP-seq in
            primary erythroid cells
  JOURNAL   Genome Res 20 (8), 1052-1063 (2010)
   PUBMED   20508144
  REMARK    Erratum:[Genome Res. 2010 Dec;20(12):1748]
REFERENCE   5  (residues 1 to 477)
  AUTHORS   Drissen,R., von Lindern,M., Kolbus,A., Driegen,S., Steinlein,P.,
            Beug,H., Grosveld,F. and Philipsen,S.
  TITLE     The erythroid phenotype of EKLF-null mice: defects in hemoglobin
            metabolism and membrane stability
  JOURNAL   Mol Cell Biol 25 (12), 5205-5214 (2005)
   PUBMED   15923635
REFERENCE   6  (residues 1 to 477)
  AUTHORS   Taketani,S., Yoshinaga,T., Furukawa,T., Kohno,H., Tokunaga,R.,
            Nishimura,K. and Inokuchi,H.
  TITLE     Induction of terminal enzymes for heme biosynthesis during
            differentiation of mouse erythroleukemia cells
  JOURNAL   Eur J Biochem 230 (2), 760-765 (1995)
   PUBMED   7607249
REFERENCE   7  (residues 1 to 477)
  AUTHORS   Matringe,M., Camadro,J.M., Labbe,P. and Scalla,R.
  TITLE     Protoporphyrinogen oxidase inhibition by three peroxidizing
            herbicides: oxadiazon, LS 82-556 and M&B 39279
  JOURNAL   FEBS Lett 245 (1-2), 35-38 (1989)
   PUBMED   2522396
REFERENCE   8  (residues 1 to 477)
  AUTHORS   Ferreira,G.C., Andrew,T.L., Karr,S.W. and Dailey,H.A.
  TITLE     Organization of the terminal two enzymes of the heme biosynthetic
            pathway. Orientation of protoporphyrinogen oxidase and evidence for
            a membrane complex
  JOURNAL   J Biol Chem 263 (8), 3835-3839 (1988)
   PUBMED   3346226
REFERENCE   9  (residues 1 to 477)
  AUTHORS   Ferreira,G.C. and Dailey,H.A.
  TITLE     Mouse protoporphyrinogen oxidase. Kinetic parameters and
            demonstration of inhibition by bilirubin
  JOURNAL   Biochem J 250 (2), 597-603 (1988)
   PUBMED   2451512
REFERENCE   10 (residues 1 to 477)
  AUTHORS   Deybach,J.C., da Silva,V., Grandchamp,B. and Nordmann,Y.
  TITLE     The mitochondrial location of protoporphyrinogen oxidase
  JOURNAL   Eur J Biochem 149 (2), 431-435 (1985)
   PUBMED   3996415
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084821.26, AK142632.1 and U25114.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U25114.1, BC002047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.3 cM"
     Protein         1..477
                     /product="protoporphyrinogen oxidase"
                     /EC_number="1.3.3.4"
                     /note="protoporhyrinogen oxidase"
                     /calculated_mol_wt=50740
     Region          3..473
                     /region_name="HemY"
                     /note="Protoporphyrinogen oxidase HemY/PPOX [Coenzyme
                     transport and metabolism]; COG1232"
                     /db_xref="CDD:440845"
     CDS             1..477
                     /gene="Ppox"
                     /gene_synonym="Ppo"
                     /coded_by="NM_008911.2:323..1756"
                     /db_xref="CCDS:CCDS15487.1"
                     /db_xref="GeneID:19044"
                     /db_xref="MGI:MGI:104968"
ORIGIN      
        1 mgrtvivlgg gisglaasyh lirgpsppkv ilvegskrlg gwirsirgsd gaifelgprg
       61 irpagalgar tlllvselgl esevlpvrgd hpaaqnrfly vggtlhplps glrgllrpsp
      121 pfskplfwag lrellkprgk epdetvhsfa qrrlgpevas lamdslcrgv fagnsrelsi
      181 rscfpslfqa eqthrsillg lllgagqspq pdsslirqar aerwsqwslr gglevlpqal
      241 hnhlaskgvt vlsgqpvcgl slqpegrwkv slgdsslead hiisaipase lskllpaeaa
      301 plarilstik avsvavvnlq yrgaclpvqg fghlvpssed ptvlgivyds vafpeqdgnp
      361 pslrvtvmlg gywlqklkaa ghqlspelfq qqaqeaaatq lglkeppshc lvhlhkncip
      421 qytighwqkl dsamqfltaq rlpltlagas yegvavndci esgrqaavav lgtesns
//
