LOCUS       NM_028292               2361 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein phosphatase methylesterase 1 (Ppme1), mRNA.
ACCESSION   NM_028292
VERSION     NM_028292.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2361)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2361)
  AUTHORS   Ikeda,S., Sato,K. and Ohama,T.
  TITLE     Transcriptome analysis revealed that PME-1 suppresses inflammatory
            signaling, activates PI3K/Akt signaling, and promotes
            epithelial-mesenchymal transition
  JOURNAL   Biochem Biophys Res Commun 692, 149148 (2024)
   PUBMED   38043157
  REMARK    GeneRIF: Transcriptome analysis revealed that PME-1 suppresses
            inflammatory signaling, activates PI3K/Akt signaling, and promotes
            epithelial-mesenchymal transition.
REFERENCE   3  (bases 1 to 2361)
  AUTHORS   Zhao,H., Feng,L., Zhong,W., Zhen,H., Chi,Q. and Wang,X.
  TITLE     Hyperphosphorylation of Tau Due to the Interference of Protein
            Phosphatase Methylesterase-1 Overexpression by MiR-125b-5p in
            Melatonin Receptor Knockout Mice
  JOURNAL   Int J Mol Sci 22 (21), 11850 (2021)
   PUBMED   34769281
  REMARK    GeneRIF: Hyperphosphorylation of Tau Due to the Interference of
            Protein Phosphatase Methylesterase-1 Overexpression by MiR-125b-5p
            in Melatonin Receptor Knockout Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2361)
  AUTHORS   Staniszewski,A., Zhang,H., Asam,K., Pitstick,R., Kavanaugh,M.P.,
            Arancio,O. and Nicholls,R.E.
  TITLE     Reduced Expression of the PP2A Methylesterase, PME-1, or the PP2A
            Methyltransferase, LCMT-1, Alters Sensitivity to
            Beta-Amyloid-Induced Cognitive and Electrophysiological Impairments
            in Mice
  JOURNAL   J Neurosci 40 (23), 4596-4608 (2020)
   PUBMED   32341098
  REMARK    GeneRIF: Reduced Expression of the PP2A Methylesterase, PME-1, or
            the PP2A Methyltransferase, LCMT-1, Alters Sensitivity to
            Beta-Amyloid-Induced Cognitive and Electrophysiological Impairments
            in Mice.
REFERENCE   5  (bases 1 to 2361)
  AUTHORS   Zhou,Y., Li,M., Xue,Y., Li,Z., Wen,W., Liu,X., Ma,Y., Zhang,L.,
            Shen,Z. and Cao,X.
  TITLE     Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral
            innate responses by strengthening IRF3 phosphorylation
  JOURNAL   Cell Res 29 (8), 641-654 (2019)
   PUBMED   31213650
REFERENCE   6  (bases 1 to 2361)
  AUTHORS   Bachovchin,D.A., Mohr,J.T., Speers,A.E., Wang,C., Berlin,J.M.,
            Spicer,T.P., Fernandez-Vega,V., Chase,P., Hodder,P.S.,
            Schurer,S.C., Nomura,D.K., Rosen,H., Fu,G.C. and Cravatt,B.F.
  TITLE     Academic cross-fertilization by public screening yields a
            remarkable class of protein phosphatase methylesterase-1 inhibitors
  JOURNAL   Proc Natl Acad Sci U S A 108 (17), 6811-6816 (2011)
   PUBMED   21398589
  REMARK    GeneRIF: Academic cross-fertilization by public screening yields a
            remarkable class of protein phosphatase methylesterase-1
            inhibitors.
REFERENCE   7  (bases 1 to 2361)
  AUTHORS   Sontag,J.M., Nunbhakdi-Craig,V., Mitterhuber,M., Ogris,E. and
            Sontag,E.
  TITLE     Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1
            plays a critical role in differentiation of neuroblastoma cells
  JOURNAL   J Neurochem 115 (6), 1455-1465 (2010)
   PUBMED   21044074
  REMARK    GeneRIF: PME-1 plays a critical role in differentiation of
            neuroblastoma cells.
REFERENCE   8  (bases 1 to 2361)
  AUTHORS   Ortega-Gutierrez,S., Leung,D., Ficarro,S., Peters,E.C. and
            Cravatt,B.F.
  TITLE     Targeted disruption of the PME-1 gene causes loss of demethylated
            PP2A and perinatal lethality in mice
  JOURNAL   PLoS One 3 (7), e2486 (2008)
   PUBMED   18596935
  REMARK    GeneRIF: targeted disruption of the PME-1 gene causes perinatal
            lethality in mice, a phenotype that correlates with a virtually
            complete loss of the demethylated form of PP2A in the nervous
            system and peripheral tissues
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2361)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2361)
  AUTHORS   Ogris,E., Du,X., Nelson,K.C., Mak,E.K., Yu,X.X., Lane,W.S. and
            Pallas,D.C.
  TITLE     A protein phosphatase methylesterase (PME-1) is one of several
            novel proteins stably associating with two inactive mutants of
            protein phosphatase 2A
  JOURNAL   J Biol Chem 274 (20), 14382-14391 (1999)
   PUBMED   10318862
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC122269.4.
            
            On Nov 17, 2006 this sequence version replaced NM_028292.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014867.1, AK154876.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AC122269.4         150151-150324       c
            175-268             AC122269.4         133696-133789       c
            269-361             AC122269.4         133137-133229       c
            362-419             AC122269.4         126550-126607       c
            420-471             AC122269.4         126233-126284       c
            472-626             AC122269.4         123380-123534       c
            627-717             AC122269.4         120274-120364       c
            718-783             AC122269.4         119459-119524       c
            784-907             AC122269.4         116798-116921       c
            908-1037            AC122269.4         113476-113605       c
            1038-1082           AC122269.4         112356-112400       c
            1083-1147           AC122269.4         110286-110350       c
            1148-1215           AC122269.4         107463-107530       c
            1216-2361           AC122269.4         105165-106310       c
FEATURES             Location/Qualifiers
     source          1..2361
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.35 cM"
     gene            1..2361
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /note="protein phosphatase methylesterase 1"
                     /db_xref="GeneID:72590"
                     /db_xref="MGI:MGI:1919840"
     exon            1..174
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1234
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /EC_number="3.1.1.89"
                     /codon_start=1
                     /product="protein phosphatase methylesterase 1"
                     /protein_id="NP_082568.1"
                     /db_xref="CCDS:CCDS40036.1"
                     /db_xref="GeneID:72590"
                     /db_xref="MGI:MGI:1919840"
                     /translation="MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFTPV
                     PWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISR
                     VQCRIVALDLRGHGETKVKNSEDLSAETMAKDVGNVVEAMYGDLPPPVMLIGHSMGGA
                     IAVHTAAANLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKS
                     GQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESVNKRKKEDD
                     METKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQ
                     MQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC"
     exon            175..268
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /inference="alignment:Splign:2.1.0"
     exon            269..361
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..419
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..471
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..626
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..717
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..783
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..907
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1037
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1082
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1147
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1215
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..2361
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /note="hexamer: AATAAA"
     polyA_site      2361
                     /gene="Ppme1"
                     /gene_synonym="1110069N17Rik; 2700017M01Rik; PME-1; Pme1"
                     /note="major polyA site"
ORIGIN      
        1 ctgtgaccgg ttgtactgca cgtatcgtgg gacggacctt gggccactgt tgtcgacgtg
       61 cggcctccct ttgatgtcgg cccttgaaaa aagcatgcac ctcggccgcc taccttctcg
      121 ccctcctcta cccggcagcg ggggcagtca gagcggagcc aagatgcgga tgggccctgg
      181 acggaagcgg gactttaccc ctgtcccatg gagtcagtac tttgagtcaa tggaagatgt
      241 ggaagtggag aatgaaactg gcaaggatac ttttcgagtt tacaagagtg gttctgaggg
      301 tccagtcctg ctgctgcttc atggaggagg ccattccgcc ctttcctggg cagtgttcac
      361 ggcagcaatc atcagtagag tacagtgtag gattgtggct ctggatctgc gaggtcacgg
      421 agaaactaaa gtcaagaatt ctgaagacct gtcagcagaa acaatggcaa aagatgttgg
      481 caatgtggtg gaagccatgt atggagacct ccctcctcca gtcatgctga ttgggcacag
      541 catgggtggc gccattgcag tgcacacagc cgcagctaac ctggtaccaa gcctcttggg
      601 cctttgcatg attgatgttg tagaaggtac cgccatggat gcacttaata gcatgcagaa
      661 tttcttgcgt ggtcgaccta aaaccttcaa gtctttggag aatgctattg aatggagtgt
      721 gaagagtggc cagattcgaa accttgagtc tgcccgtgta tccatggtcg gccaagtcaa
      781 acagtgtgaa ggaattacaa gtccagaagg ttccaaatcc atagtggaag gaatcataga
      841 ggaggaggaa gaagatgagg aaggaagtga gtcagttaac aagaggaaaa aggaagacga
      901 catggaaacc aagaaggatc acccatacac ctggagaatt gagctggcaa aaacagaaaa
      961 gtactgggat ggctggttcc ggggcttatc caatctcttt cttagctgtc ctattcctaa
     1021 actgctgctc ttggcaggtg ttgacagatt ggataaagat ctgaccatag gccagatgca
     1081 ggggaagttc cagatgcagg tcttacccca gtgtggccat gcagtccatg aggatgcccc
     1141 tgacaaggta gctgaagctg ttgccacttt cctgatccgg cacaggtttg cagagcccat
     1201 tggaggattc cagtgtgtgt ttcctggctg ctagtgacct gctgtctact cctccctcta
     1261 cattgagctc tgttgtaaat acatcgcacc agaggccact gtgacgccgc tgtctcctcc
     1321 tctccatccc gcccagccat gtgacaccgg ctcttgtaga gggcatcccc agatgtccaa
     1381 accctttcct gtgtactgtt gaaagcattg ttcttcaggg cccttgtcca acagtggccc
     1441 gtgcagtctg gggtccacag ctcttcctct ccttcctgtg ctccctgcct tgcctaggat
     1501 gaagcctcca gcgctgctcc ctggccctgt tcctggcata tggcaatgta ccccaggctc
     1561 agggatctcc cttccttgag gatgttcttg gcatggtcct gccctacctc atgggatggg
     1621 caatgcacac actggccctt atttttccct ttcaaataaa acaccagtca ggtaccttta
     1681 tcccagtctt aactgtccca aatctggaag gtccagagta agcaggattc agggagaggg
     1741 agtggatagc aagtatccca agaaaccaac ctgtaagtca ggtccagcca gtccaagcac
     1801 atggcttccc atctgggtga gcccactgtc ccactcccac atgtctgggc acctgccctg
     1861 ggctgaggcc aggctgctcc aagggccgca tgagccctaa tctgccacag agcaacccag
     1921 gttaaacaca gcccatgcac aaagccacag gctaaatcct gtggaattgt ttttaatgac
     1981 tgaatttaac cattttcata gttggttcct ggaggtgtgc caagtgcccg cttgcctctt
     2041 ctagacccac agcttcttga tccacttgtg gtttccatgt cactaatgta gaaacatcat
     2101 ggactagcat ccccagtctt tgccctcatc cagctgtcgc agcgcagcac tggggcctcc
     2161 ccctgctgcc cagggggggg ggggtgggca gcctcctgaa acccatcttt ctgtgactgt
     2221 cttaggtgac gtgtagccct cttccgtttt ttcacccaac aacttcctct gtcctgctgc
     2281 acggtccaga gtctgggacc gactttgttt ctttgttatt tatgatcttg tttaaagaaa
     2341 ataaatatct cccaaccttt a
//
