LOCUS       NM_026447               1844 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protein phosphatase 1M (Ppm1m), transcript variant 1,
            mRNA.
ACCESSION   NM_026447 XM_979600
VERSION     NM_026447.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1844)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1844)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1844)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1844)
  AUTHORS   Chida,T., Ando,M., Matsuki,T., Masu,Y., Nagaura,Y.,
            Takano-Yamamoto,T., Tamura,S. and Kobayashi,T.
  TITLE     N-Myristoylation is essential for protein phosphatases PPM1A and
            PPM1B to dephosphorylate their physiological substrates in cells
  JOURNAL   Biochem J 449 (3), 741-749 (2013)
   PUBMED   23088624
REFERENCE   5  (bases 1 to 1844)
  AUTHORS   Taher,L., Collette,N.M., Murugesh,D., Maxwell,E., Ovcharenko,I. and
            Loots,G.G.
  TITLE     Global gene expression analysis of murine limb development
  JOURNAL   PLoS One 6 (12), e28358 (2011)
   PUBMED   22174793
REFERENCE   6  (bases 1 to 1844)
  AUTHORS   Henmi,T., Amano,K., Nagaura,Y., Matsumoto,K., Echigo,S., Tamura,S.
            and Kobayashi,T.
  TITLE     A mechanism for the suppression of interleukin-1-induced nuclear
            factor kappaB activation by protein phosphatase 2Ceta-2
  JOURNAL   Biochem J 423 (1), 71-78 (2009)
   PUBMED   19594441
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1844)
  AUTHORS   Komaki,K., Katsura,K., Ohnishi,M., Guang Li,M., Sasaki,M.,
            Watanabe,M., Kobayashi,T. and Tamura,S.
  TITLE     Molecular cloning of PP2Ceta, a novel member of the protein
            phosphatase 2C family
  JOURNAL   Biochim Biophys Acta 1630 (2-3), 130-137 (2003)
   PUBMED   14654243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY202563.1 and BC058248.1.
            
            On Mar 29, 2008 this sequence version replaced NM_026447.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058248.1, AB474373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BY202563.1         2-75
            75-1844             BC058248.1         1-1770
FEATURES             Location/Qualifiers
     source          1..1844
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.46 cM"
     gene            1..1844
                     /gene="Ppm1m"
                     /gene_synonym="2810423O19Rik; PP2Ceta"
                     /note="protein phosphatase 1M"
                     /db_xref="GeneID:67905"
                     /db_xref="MGI:MGI:1915155"
     exon            1..264
                     /gene="Ppm1m"
                     /gene_synonym="2810423O19Rik; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1429
                     /gene="Ppm1m"
                     /gene_synonym="2810423O19Rik; PP2Ceta"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein phosphatase 2C eta; protein phosphatase 2C eta-2;
                     PP2CE; PP2C-eta"
                     /codon_start=1
                     /product="protein phosphatase 1M isoform 1"
                     /protein_id="NP_080723.3"
                     /db_xref="CCDS:CCDS23472.2"
                     /db_xref="GeneID:67905"
                     /db_xref="MGI:MGI:1915155"
                     /translation="MSAGWFRRRFLPGGPLPEPRPAGPRSSPVPYHRPRFLRGSGSSP
                     GATDASRRPDARPVRSPARGRTLPWNAGYAEVINAEKSEFNEDQAACGKLCIRRCEFG
                     IEEHQEWLTVCPEEFLTGHYWALFDGHGGPAAAILAANTLHSCLRRQLEAVVEGMIAP
                     QPPMHLSGRCVCPSDPQFVEEKGIQAEDLVIGALENAFQECDDVIGRELEASGQVGGC
                     TALVAVFLQGKLYVANAGDSRAILVRRHEIRQLSSEFTPETERQRIQQLAFTYPELLA
                     GEFTRLEFPRRLKGDDLGQKVLFRDHHMRGWSYKRVEKSDLKYPLIHGQGRQARLLGT
                     LAVSRGLGDHQLRVLDTDIQLKPFLLSIPQVTVLDVHQLAVQEEDVVVMATDGLWDVL
                     SNEQVALLVRSFLTGNQKDDPHRFSELAKMLIHNTQGKDNGATGEGQVSYDDVSVFVI
                     PLHSQAQEGSGH"
     exon            265..388
                     /gene="Ppm1m"
                     /gene_synonym="2810423O19Rik; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            389..643
                     /gene="Ppm1m"
                     /gene_synonym="2810423O19Rik; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            644..756
                     /gene="Ppm1m"
                     /gene_synonym="2810423O19Rik; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            757..841
                     /gene="Ppm1m"
                     /gene_synonym="2810423O19Rik; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            842..960
                     /gene="Ppm1m"
                     /gene_synonym="2810423O19Rik; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1024
                     /gene="Ppm1m"
                     /gene_synonym="2810423O19Rik; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1132
                     /gene="Ppm1m"
                     /gene_synonym="2810423O19Rik; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1284
                     /gene="Ppm1m"
                     /gene_synonym="2810423O19Rik; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1802
                     /gene="Ppm1m"
                     /gene_synonym="2810423O19Rik; PP2Ceta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1781..1786
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1m"
                     /gene_synonym="2810423O19Rik; PP2Ceta"
                     /note="hexamer: ATTAAA"
     polyA_site      1801
                     /gene="Ppm1m"
                     /gene_synonym="2810423O19Rik; PP2Ceta"
                     /note="major polyA site"
ORIGIN      
        1 ggtgtcccgc cgtgcgcggg cagcccccgg ccgccacgca atgtccgccg gctggttccg
       61 gcgccgcttc ctacccgggg gtccacttcc agagccgcgg ccagccgggc cgcgctccag
      121 cccggtgccc tatcaccggc cccgctttct acgcggctcc ggctccagcc cgggcgccac
      181 tgacgcctcg cgccgccccg atgcccggcc ggtgcgcagc ccagcacggg gccgcacact
      241 gccttggaac gcaggctacg cagaggttat caatgcagaa aaatctgaat tcaacgaaga
      301 ccaggctgct tgcgggaagc tatgcatccg gcgatgtgag tttgggatcg aagaacatca
      361 agagtggctg acggtgtgcc cagaggagtt cctgacgggt cactactggg cactgtttga
      421 tgggcatggt ggccctgctg cagctatctt ggctgccaac accctgcact cttgccttcg
      481 ccggcagctg gaggctgtgg ttgaaggcat gatagcccct cagcccccca tgcacctcag
      541 tggccgctgt gtctgcccca gtgaccccca gttcgtggag gaaaagggga tccaggcaga
      601 agacttggtg atcggggctc tggagaacgc cttccaggaa tgtgatgatg tgattgggag
      661 agagctggag gcctcaggac aggtgggtgg ctgtacagcc ctggtggcgg tgttcctgca
      721 agggaagctg tatgtggcca atgctgggga cagcagggcc atcttggtgc ggagacatga
      781 gatacggcag ctgagttctg agttcacccc agaaacagag cggcagcgga tccagcagct
      841 ggcctttacc taccctgagc ttctggctgg agagttcacc cgactggagt tcccacggcg
      901 gctaaagggg gatgacttag ggcagaaggt tttgttcagg gatcatcaca tgagaggctg
      961 gagctacaaa cgggtggaaa agtctgatct caagtatcca ctgattcatg gacagggtag
     1021 gcaggcgcgg ttactgggaa cactggctgt ctctagaggg ctgggcgacc atcagcttag
     1081 agtcctggac accgacatcc agctgaagcc cttcctactc tccatccctc aggtgactgt
     1141 gctggatgtc caccagctgg cagtgcagga ggaggatgtg gttgtcatgg caactgatgg
     1201 gctctgggat gtcctgtcca atgagcaggt ggcactgctt gtgcggagct tcctcaccgg
     1261 gaaccaaaag gatgacccac acaggttctc agagttggcc aaaatgctga tacacaacac
     1321 tcaaggaaag gacaatggtg ccaccggaga ggggcaggta tcctacgacg atgtctccgt
     1381 gtttgtgatt cctttgcaca gccaggccca agaaggcagt ggccactgag ggctcacata
     1441 ctgcgttcta gaacttcctc aggaccagtg cagactcagc atatgtccac tgtggccaag
     1501 gcaggcccct gcctggcctg ttcaaagcca cagcccaatg cttaccaggt cccaccttct
     1561 gcaatggtaa cattcccctg gcagaggtac ttgatagcac atggcatctg tgttagcgcc
     1621 tctgcaggat aaatggttaa gggcactatg aagtctcggg gagcaggaac tctgggtcca
     1681 actcgtgaaa tctcaagtta ttattcattt aaccatccat ccacacaagg taccttcttg
     1741 aaacctctgg gcagtctcac atttgcttaa tttaattaag attaaagcga tcttaatttt
     1801 ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
