LOCUS       NM_178726               3962 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1 (formerly 2C)-like (Ppm1l),
            mRNA.
ACCESSION   NM_178726
VERSION     NM_178726.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3962)
  AUTHORS   Firulli,B.A., George,R.M., Harkin,J., Toolan,K.P., Gao,H., Liu,Y.,
            Zhang,W., Field,L.J., Liu,Y., Shou,W., Payne,R.M., Rubart-von der
            Lohe,M. and Firulli,A.B.
  TITLE     HAND1 loss-of-function within the embryonic myocardium reveals
            survivable congenital cardiac defects and adult heart failure
  JOURNAL   Cardiovasc Res 116 (3), 605-618 (2020)
   PUBMED   31286141
REFERENCE   2  (bases 1 to 3962)
  AUTHORS   Kusano,R., Fujita,K., Shinoda,Y., Nagaura,Y., Kiyonari,H., Abe,T.,
            Watanabe,T., Matsui,Y., Fukaya,M., Sakagami,H., Sato,T.,
            Funahashi,J.I., Ohnishi,M., Tamura,S. and Kobayashi,T.
  TITLE     Targeted disruption of the mouse protein phosphatase ppm1l gene
            leads to structural abnormalities in the brain
  JOURNAL   FEBS Lett 590 (20), 3606-3615 (2016)
   PUBMED   27680501
  REMARK    GeneRIF: Study provided evidence that PPM1L is involved in the
            development of the central nervous system.
REFERENCE   3  (bases 1 to 3962)
  AUTHORS   Ren,S., Lu,G., Ota,A., Zhou,Z.H., Vondriska,T.M., Lane,T.F. and
            Wang,Y.
  TITLE     IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the
            postpartum mammary gland
  JOURNAL   PLoS One 9 (11), e111606 (2014)
   PUBMED   25369058
  REMARK    GeneRIF: This study provides the first in vivo evidence that PP2Ce
            is an essential regulator of normal lactation, possibly involving
            IRE1 signaling and endoplasmic reticulum stress regulation in
            mammary epithelium.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3962)
  AUTHORS   Chida,T., Ando,M., Matsuki,T., Masu,Y., Nagaura,Y.,
            Takano-Yamamoto,T., Tamura,S. and Kobayashi,T.
  TITLE     N-Myristoylation is essential for protein phosphatases PPM1A and
            PPM1B to dephosphorylate their physiological substrates in cells
  JOURNAL   Biochem J 449 (3), 741-749 (2013)
   PUBMED   23088624
REFERENCE   5  (bases 1 to 3962)
  AUTHORS   Shinoda,Y., Fujita,K., Saito,S., Matsui,H., Kanto,Y., Nagaura,Y.,
            Fukunaga,K., Tamura,S. and Kobayashi,T.
  TITLE     Acyl-CoA binding domain containing 3 (ACBD3) recruits the protein
            phosphatase PPM1L to ER-Golgi membrane contact sites
  JOURNAL   FEBS Lett 586 (19), 3024-3029 (2012)
   PUBMED   22796112
REFERENCE   6  (bases 1 to 3962)
  AUTHORS   Chen,Y., Zhu,J., Lum,P.Y., Yang,X., Pinto,S., MacNeil,D.J.,
            Zhang,C., Lamb,J., Edwards,S., Sieberts,S.K., Leonardson,A.,
            Castellini,L.W., Wang,S., Champy,M.F., Zhang,B., Emilsson,V.,
            Doss,S., Ghazalpour,A., Horvath,S., Drake,T.A., Lusis,A.J. and
            Schadt,E.E.
  TITLE     Variations in DNA elucidate molecular networks that cause disease
  JOURNAL   Nature 452 (7186), 429-435 (2008)
   PUBMED   18344982
REFERENCE   7  (bases 1 to 3962)
  AUTHORS   Saito,S., Matsui,H., Kawano,M., Kumagai,K., Tomishige,N.,
            Hanada,K., Echigo,S., Tamura,S. and Kobayashi,T.
  TITLE     Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral
            membrane protein that dephosphorylates the ceramide transport
            protein CERT to enhance its association with organelle membranes
  JOURNAL   J Biol Chem 283 (10), 6584-6593 (2008)
   PUBMED   18165232
  REMARK    GeneRIF: CERT is a physiological substrate of PP2Cepsilon and that
            dephosphorylation of CERT by PP2Cepsilon may play an important role
            in the regulation of ceramide trafficking from the ER to the Golgi
            apparatus.
REFERENCE   8  (bases 1 to 3962)
  AUTHORS   Saito,J., Toriumi,S., Awano,K., Ichijo,H., Sasaki,K., Kobayashi,T.
            and Tamura,S.
  TITLE     Regulation of apoptosis signal-regulating kinase 1 by protein
            phosphatase 2Cepsilon
  JOURNAL   Biochem J 405 (3), 591-596 (2007)
   PUBMED   17456047
REFERENCE   9  (bases 1 to 3962)
  AUTHORS   Imanaka-Yoshida,K., Matsumoto,K., Hara,M., Sakakura,T. and
            Yoshida,T.
  TITLE     The dynamic expression of tenascin-C and tenascin-X during early
            heart development in the mouse
  JOURNAL   Differentiation 71 (4-5), 291-298 (2003)
   PUBMED   12823230
REFERENCE   10 (bases 1 to 3962)
  AUTHORS   Li,M.G., Katsura,K., Nomiyama,H., Komaki,K., Ninomiya-Tsuji,J.,
            Matsumoto,K., Kobayashi,T. and Tamura,S.
  TITLE     Regulation of the interleukin-1-induced signaling pathways by a
            novel member of the protein phosphatase 2C family (PP2Cepsilon)
  JOURNAL   J Biol Chem 278 (14), 12013-12021 (2003)
   PUBMED   12556533
  REMARK    GeneRIF: in the absence of IL-1-induced signal, PP2Cepsilon
            contributes to keeping the TAK1 signaling pathway in an inactive
            state by associating with and dephosphorylating TAK1.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC112685.16
            and AC111096.15.
            
            On Nov 17, 2006 this sequence version replaced NM_178726.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096031.1, AK131646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1048              AC112685.16        126982-128029       c
            1049-1223           AC111096.15        125173-125347       c
            1224-1385           AC111096.15        73631-73792         c
            1386-3962           AC111096.15        67714-70290         c
FEATURES             Location/Qualifiers
     source          1..3962
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 32.21 cM"
     gene            1..3962
                     /gene="Ppm1l"
                     /gene_synonym="3222401G13; 5930404J21Rik; mKIAA4175; PP2C;
                     Pp2ce; PP2Cepsilon; Ppp2ce"
                     /note="protein phosphatase 1 (formerly 2C)-like"
                     /db_xref="GeneID:242083"
                     /db_xref="MGI:MGI:2139740"
     exon            1..1048
                     /gene="Ppm1l"
                     /gene_synonym="3222401G13; 5930404J21Rik; mKIAA4175; PP2C;
                     Pp2ce; PP2Cepsilon; Ppp2ce"
                     /inference="alignment:Splign:2.1.0"
     CDS             650..1732
                     /gene="Ppm1l"
                     /gene_synonym="3222401G13; 5930404J21Rik; mKIAA4175; PP2C;
                     Pp2ce; PP2Cepsilon; Ppp2ce"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase 2C epsilon; protein phosphatase
                     1-like; PP2C-epsilon"
                     /codon_start=1
                     /product="protein phosphatase 1L"
                     /protein_id="NP_848841.2"
                     /db_xref="CCDS:CCDS17405.1"
                     /db_xref="GeneID:242083"
                     /db_xref="MGI:MGI:2139740"
                     /translation="MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDE
                     VKTIVKSSRDAVKMVKGKVAEIMQNDRLGGLDVLEAEFSKTWEFKSHNVAVYSIQGRR
                     DHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKEN
                     SVLTYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLC
                     DKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLN
                     VVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQ
                     SFYRGCPDNITVMVVKFRNSSKTEEH"
     exon            1049..1223
                     /gene="Ppm1l"
                     /gene_synonym="3222401G13; 5930404J21Rik; mKIAA4175; PP2C;
                     Pp2ce; PP2Cepsilon; Ppp2ce"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1385
                     /gene="Ppm1l"
                     /gene_synonym="3222401G13; 5930404J21Rik; mKIAA4175; PP2C;
                     Pp2ce; PP2Cepsilon; Ppp2ce"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..3962
                     /gene="Ppm1l"
                     /gene_synonym="3222401G13; 5930404J21Rik; mKIAA4175; PP2C;
                     Pp2ce; PP2Cepsilon; Ppp2ce"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3353..3358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1l"
                     /gene_synonym="3222401G13; 5930404J21Rik; mKIAA4175; PP2C;
                     Pp2ce; PP2Cepsilon; Ppp2ce"
                     /note="hexamer: AATAAT"
     polyA_site      3372
                     /gene="Ppm1l"
                     /gene_synonym="3222401G13; 5930404J21Rik; mKIAA4175; PP2C;
                     Pp2ce; PP2Cepsilon; Ppp2ce"
     regulatory      3715..3720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1l"
                     /gene_synonym="3222401G13; 5930404J21Rik; mKIAA4175; PP2C;
                     Pp2ce; PP2Cepsilon; Ppp2ce"
                     /note="hexamer: AATAAA"
     polyA_site      3733
                     /gene="Ppm1l"
                     /gene_synonym="3222401G13; 5930404J21Rik; mKIAA4175; PP2C;
                     Pp2ce; PP2Cepsilon; Ppp2ce"
                     /note="major polyA site"
ORIGIN      
        1 ggagaggcag gcagagcctg ccggcggctc cgcacccatc gtgctgcgtt tcccagctcg
       61 gtgtccccct gcctttgccc aggcaccggc aaaactttta ttgtttcggg gaccccccct
      121 ggatgtgtga cgaaatcgca acgctccgct gtctcgtccc ccaagctcgc ctgcagcggc
      181 gatcgaggga acgtgcaacc ctcgccgccg ggctcttgcg ccctgcgctt cctcacctgc
      241 cgatcgctcc cgggaaccgc gaggggggac ccctaaaggg accgcgcggg catcggcacc
      301 ccgaaatcct cttcaccgtt gcggaccggc tcggcgcaac tttaacttga ttcctgtcgc
      361 ccacccgggg cacccgcggc ggccgccgcc gccgccgtcg ctgcggtctc acaaagagcg
      421 cggggaggga aggcggcgca ggcggcaggc acgggccttc gggctgccca gacaaaaggg
      481 aaactgccat cgttctggac gactgttccg agcggccgtg ggttcgttca ccctgtcggc
      541 ccgggctgcc tctccgcctt ggtccccgcg ggcagtgccc gcagtactcg gaccccgcga
      601 gttgcggggc acgcgtcgct gctgctggtc cgggctctag ggataataaa tgatagagga
      661 tacaatgact ttgctgtctc tgctgggtcg catcatgcgc tacttcttac tgagacccga
      721 gacgcttttc ctgctgtgca tcagcttggc tctctggagt tacttcttcc acacggacga
      781 agtgaagacc atcgttaagt ctagccggga cgcggtgaag atggtgaagg gcaaggtggc
      841 cgagattatg cagaacgatc gtcttggagg acttgatgtg ctggaggccg agttttccaa
      901 gacctgggaa ttcaagagcc ataatgtggc ggtgtactcc atccagggcc ggagagacca
      961 catggaagat cgcttcgaag ttctcaccga tctagccaac aagacgcacc cgtccatctt
     1021 cggaatcttt gatgggcacg gcggcgagac tgcagcggaa tatgtaaaat ctcgactccc
     1081 agaggctctt aagcagcacc ttcaggatta tgagaaggac aaagaaaaca gtgttctgac
     1141 ctaccagacc atcctcgagc agcagatctt gtcaattgac cgggaaatgc tggaaaagtt
     1201 gacagtctcc tatgatgaag caggcacaac gtgtttgatc gctctactct cagataaaga
     1261 cctcaccgtg gccaacgttg gtgactctcg gggagtcttg tgtgacaaag atggcaatgc
     1321 catccccttg tctcacgatc acaagcctta ccagctgaag gaaaggaaga ggataaagag
     1381 agctggtggg ttcatcagct ttaatggctc ctggagggtc cagggaatcc tagccatgtc
     1441 tcgatccctg ggagactatc cactgaaaaa tctcaacgtg gtcatcccag acccagacat
     1501 cttgaccttt gacctggaca agctgcagcc ggagttcatg atcttggcct cagatggcct
     1561 gtgggatgct ttcagcaatg aagaagcggt tcgattcatc aaggagcgct tggatgagcc
     1621 ccactttggg gccaaaagca tcgtcctgca gtccttttac agaggctgcc ctgacaacat
     1681 cactgtcatg gtggtgaagt tcaggaatag tagcaaaaca gaagagcact gaaccctgcc
     1741 agatctcagc tgccccaaac tagaggactc tcaacatact gttctcttca tgtagtaaaa
     1801 ggtgtgggta taattaggat catgcgtccc aacacagaac ccccttccct gatggccttg
     1861 aatccctttg gagtactgag cagagggttc ccttgctgac accgcagagg ctgctaagtt
     1921 tgtgtccccc cagcccttct atcagtgttt gaaacacata cataggtagc cacagatccc
     1981 acatatgagg caaaggaaag gcaggccata tgttttcctt cttaataatg tacttttcat
     2041 gatctcttct gtggtccttc agggacctga cttggcgtcc tctctgaacc tgggcagggc
     2101 aagctggtga tgccaacact tcaccatgac aatgaggtgg ccatgccctc tgccttgaag
     2161 cagtttcctc agaaatgctc tccccttctg agtcttggtc ttcagtactc cagcatcctg
     2221 gaaggagaca tgcaacactt tgtaatttgt tgcctgctct tagagacttg agagttggga
     2281 agccagtgca gcttcctgca cgccagacct ccccgcttcc gctcgcttcc ttcattagtt
     2341 cagtagagtc gggatgcagt tagccagccc ttacgcctct catggagtgc agcctcgcca
     2401 tttgttcaca ccttacgatg catcgagggc tgccgctgac ctcaccgtga gacgtgagtt
     2461 tttgtctccc ctcaccaaga ctccccagag aggggaggaa gcaggacgga aagcacatcg
     2521 cagtacagta tgcccttcca tcttcaagga ggaattaggc tgggatggtt ctccatgacc
     2581 ttttgaaaat tgctgtctgc actggagagg aaggcaggag tcctggggtc accagtcaca
     2641 ctcaccaact gctggtttct gcacagccct tcccaagccc accctaccta gtagctttca
     2701 tgcctttcaa acagaggtgg gagaaacagc aacctagaat cacccacggg tgctgttccc
     2761 agctaccacc acaagttggt atcggggcgc aaactactgg gacgtgcttc ctggcaagag
     2821 aaagaccttt catggtcaat tgcaaatctc tgtccatacc caggcaaata ggaactgtct
     2881 gctgtgacct ggagggaaag agcagactgg ctcctgggga cctgtgtgca ctggttggga
     2941 gttcaagcag gaaccctcag agataagcag cagagttatt tggggcctag attactgctc
     3001 ttcccttact aacaccaaag ttgtgggggt ttttttccca gtctctgtac tttgtaagtt
     3061 aatttatagg acatattaga ttgtcctgtt tgctgattga accagcccca aagagccacg
     3121 attttcattg cagacctaca ccagagccgg ccttgttttg ttctctcaga gaggctgtgt
     3181 gtcggcatga cttctcaagc cctgctcatt agctctccct accccggccc tctccttcag
     3241 ctgcagagct tgtaggaagc cgagtctgga gaatgaaaga cttggactct gaggactgca
     3301 aactgtctgg attcctctgg gaacttgctt tcctttggct gcatcaagaa ttaataatgg
     3361 cttcccagga aatctgctta cttttgtatc ttgtgttttc aacattggaa ttagggtctt
     3421 ttctgcttct cagaatgttt tagtacaaaa cacattctat catgttagac agaagcattg
     3481 attgtggaga gacgtgcact gatgggtgtg tattatgggt taggtgggtg gggaacagag
     3541 aagtcaggtg tgggtttaac cagtgatggg atgagcttgt tggcttagga tgctcttacc
     3601 agagagtacc caaaacccat cttctaacta aaggtccaga ctcaacagcc tatacagtca
     3661 acttcccttc tgtatttgct taacacaaaa gtatataaca agaggaaaaa aataaataaa
     3721 tttgagacac aaatgtttgg gtgaagaaaa aaagaaaact gccaagttag ttggttggta
     3781 ctccttgagc aagcagggtt tcttaaccag cattgctgaa cccccctagt tccagagcct
     3841 tctaactgag gtttatagat atagatatta tagatcgatc ttgtacattt gatcttgatt
     3901 tatagatctt gtacattttg ctttgcagaa gtaacttatt taaccaaata ggaaaaaaaa
     3961 aa
//
