LOCUS       NM_027982               1733 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus protein phosphatase 1J (Ppm1j), mRNA.
ACCESSION   NM_027982
VERSION     NM_027982.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1733)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1733)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1733)
  AUTHORS   Awano,K., Amano,K., Nagaura,Y., Kanno,S., Echigo,S., Tamura,S. and
            Kobayashi,T.
  TITLE     Phosphorylation of protein phosphatase 2Czeta by c-Jun NH2-terminal
            kinase at Ser92 attenuates its phosphatase activity
  JOURNAL   Biochemistry 47 (27), 7248-7255 (2008)
   PUBMED   18553930
  REMARK    GeneRIF: These results suggest that specific phosphorylation of
            PP2Czeta at Ser (92) by stress-activated JNK attenuates its
            phosphatase activity in cells.
REFERENCE   4  (bases 1 to 1733)
  AUTHORS   Komaki,K., Katsura,K., Ohnishi,M., Guang Li,M., Sasaki,M.,
            Watanabe,M., Kobayashi,T. and Tamura,S.
  TITLE     Molecular cloning of PP2Ceta, a novel member of the protein
            phosphatase 2C family
  JOURNAL   Biochim Biophys Acta 1630 (2-3), 130-137 (2003)
   PUBMED   14654243
REFERENCE   5  (bases 1 to 1733)
  AUTHORS   Kashiwaba,M., Katsura,K., Ohnishi,M., Sasaki,M., Tanaka,H.,
            Nishimune,Y., Kobayashi,T. and Tamura,S.
  TITLE     A novel protein phosphatase 2C family member (PP2Czeta) is able to
            associate with ubiquitin conjugating enzyme 9
  JOURNAL   FEBS Lett 538 (1-3), 197-202 (2003)
   PUBMED   12633878
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122831.2, BC117498.1 and BX518856.1.
            
            On Sep 8, 2006 this sequence version replaced NM_027982.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY184802.1, AK009235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC122831.2         6626-6629           c
            5-1630              BC117498.1         1-1626
            1631-1733           BX518856.1         327-429
FEATURES             Location/Qualifiers
     source          1..1733
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.85 cM"
     gene            1..1733
                     /gene="Ppm1j"
                     /gene_synonym="2310008J22Rik; PP2Czeta; Ppp2cz"
                     /note="protein phosphatase 1J"
                     /db_xref="GeneID:71887"
                     /db_xref="MGI:MGI:1919137"
     exon            1..354
                     /gene="Ppm1j"
                     /gene_synonym="2310008J22Rik; PP2Czeta; Ppp2cz"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1555
                     /gene="Ppm1j"
                     /gene_synonym="2310008J22Rik; PP2Czeta; Ppp2cz"
                     /EC_number="3.1.3.16"
                     /note="protein phosphatase 2C zeta; PP2C-zeta"
                     /codon_start=1
                     /product="protein phosphatase 1J"
                     /protein_id="NP_082258.2"
                     /db_xref="CCDS:CCDS17703.1"
                     /db_xref="GeneID:71887"
                     /db_xref="MGI:MGI:1919137"
                     /translation="MLNRVRSAVAHLVSSGGTSSQRSKSPDLPNATSAPPAAQETPKS
                     SREKPGNQVGAPQKTAETTVSFSRPTFLQLSPGGLRRADDHAGRAVQSPPDTGRRLPW
                     STGYAEVINAGKSRHNEDQACCEVVYVESRRSRSVTGVSREPSHNQGFCFYYWGLFDG
                     HAGGGAAEMASRLLHRHIREQLKDLVEILKDPLPPPLCLPSTPGTPGAPSPSQLVSPQ
                     SCWSPQKEVTHDSLIVGAIENAFHLMDEQMARERRGHQVEGGCCALVVLYLLGKMYVA
                     NAGDSRAIIVRNGEIIPMSREFTPETERQRLQLLGFLKPELLGSEFTHLEFPRRVQPK
                     ELGQRMLYRDQNMTGWAYKKIEVEDLRFPLVCGEGKKARVMATIGVTRGLGDHNLKVC
                     SSTLSIKPFLSCFPEVRVYDLTQYEHCPDDVLVLGTDGLWDVTNDSEVAATVDRVLSS
                     YEPNDPSRYTALAQALVLGARGIPRDRGWRLPNNKLGSGDDISVFVIPLGGPGSSYS"
     exon            355..475
                     /gene="Ppm1j"
                     /gene_synonym="2310008J22Rik; PP2Czeta; Ppp2cz"
                     /inference="alignment:Splign:2.1.0"
     exon            476..763
                     /gene="Ppm1j"
                     /gene_synonym="2310008J22Rik; PP2Czeta; Ppp2cz"
                     /inference="alignment:Splign:2.1.0"
     exon            764..876
                     /gene="Ppm1j"
                     /gene_synonym="2310008J22Rik; PP2Czeta; Ppp2cz"
                     /inference="alignment:Splign:2.1.0"
     exon            877..961
                     /gene="Ppm1j"
                     /gene_synonym="2310008J22Rik; PP2Czeta; Ppp2cz"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1080
                     /gene="Ppm1j"
                     /gene_synonym="2310008J22Rik; PP2Czeta; Ppp2cz"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1144
                     /gene="Ppm1j"
                     /gene_synonym="2310008J22Rik; PP2Czeta; Ppp2cz"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1252
                     /gene="Ppm1j"
                     /gene_synonym="2310008J22Rik; PP2Czeta; Ppp2cz"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1404
                     /gene="Ppm1j"
                     /gene_synonym="2310008J22Rik; PP2Czeta; Ppp2cz"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1721
                     /gene="Ppm1j"
                     /gene_synonym="2310008J22Rik; PP2Czeta; Ppp2cz"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1703..1708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1j"
                     /gene_synonym="2310008J22Rik; PP2Czeta; Ppp2cz"
                     /note="hexamer: AATAAA"
     polyA_site      1721
                     /gene="Ppm1j"
                     /gene_synonym="2310008J22Rik; PP2Czeta; Ppp2cz"
                     /note="major polyA site"
ORIGIN      
        1 cccacggtcg agggcggggc acggaggcag catgctaaac cgggtgcgct cagccgtggc
       61 gcacctggtg agctcgggtg gcacttcttc ccagcgctcc aagtccccag atctgcccaa
      121 cgctacctca gcgcctcccg ccgcccaaga aacacctaag agttcccggg agaagcctgg
      181 gaaccaggtc ggcgcgcccc agaagaccgc ggagactact gtgagcttct ctcgacccac
      241 ctttctgcag ctgagccccg gagggctgcg gcgcgccgac gaccacgcag gccgggctgt
      301 gcaaagcccc ccagacaccg gccgccgcct gccctggagc acaggctatg ccgaggtcat
      361 caatgctggc aagagcaggc acaatgagga tcaggcttgc tgcgaggttg tgtatgtgga
      421 aagtcggagg agcaggagcg ttacaggggt ctccagggag cctagccata accagggctt
      481 ctgcttttac tactggggcc tgtttgatgg gcacgctggt ggaggagcag ctgaaatggc
      541 ctcccggctc ctgcatcgcc acatccggga acagctcaag gatctagtag aaatacttaa
      601 ggatcccttg ccgcctcccc tctgtctccc atccactcct ggaaccccag gagcccccag
      661 tccttcacag ttggttagcc ctcaatcctg ctggtctcca cagaaggaag tgacccatga
      721 cagcctgata gtaggagcca ttgagaatgc cttccatctc atggatgagc agatggctcg
      781 ggagcggcgt ggccaccaag tggaaggggg ctgctgtgca ctagtggtgc tgtacctgct
      841 aggcaagatg tatgtggcta acgcaggtga cagcagggcc atcattgtcc gaaatgggga
      901 gatcattccg atgtcccggg agttcacacc agagacggag cgccagcgtc ttcagctgct
      961 tggcttcctg aaaccagaac tgctgggcag tgagttcacc caccttgaat ttccccgaag
     1021 agttcagccc aaggaactag ggcagaggat gctgtacagg gaccagaata tgactggctg
     1081 ggcctacaaa aagattgagg tggaggatct caggtttcct ctggtctgtg gggagggcaa
     1141 aaaggcccgg gtaatggcta ccattggggt gacacggggc ttgggagacc acaaccttaa
     1201 ggtctgcagc tctactctgt ccatcaagcc tttcctctcc tgctttcctg aagtacgagt
     1261 gtatgatctg acgcagtatg agcactgtcc agatgatgtg ctggtcctgg gaacagatgg
     1321 cttgtgggat gtgaccaatg actctgaggt agctgccact gtggacaggg tgctgtcatc
     1381 ctatgagccc aatgatccca gcaggtatac agctctggcc caagctctgg tcctgggggc
     1441 ccggggaatc ccccgggacc gtggctggcg tctcccaaac aacaagctgg gttccgggga
     1501 tgacatctcg gtcttcgtca tccccctggg cgggccaggc agcagttact cctgatgggc
     1561 tcagccccat ccctctcaat gccaccccag cctctccact atcacccttc tcctgcccaa
     1621 acacggaagt tgtgtccctg actcgagagt ggccatttga acaaagggat gcctgctaga
     1681 tccaaaatta cagcaactgg caaataaacc agatggataa aaaaaaaaaa aaa
//
