LOCUS       NM_001110218            6413 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1H (PP2C domain containing)
            (Ppm1h), transcript variant 1, mRNA.
ACCESSION   NM_001110218
VERSION     NM_001110218.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6413)
  AUTHORS   Khan,S.S., Sobu,Y., Dhekne,H.S., Tonelli,F., Berndsen,K.,
            Alessi,D.R. and Pfeffer,S.R.
  TITLE     Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in
            neurons and astrocytes of mouse brain
  JOURNAL   Elife 10, e67900 (2021)
   PUBMED   34658337
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6413)
  AUTHORS   Osawa,J., Akizuki,K., Kashimura,A., Ueta,S., Nakatani,M., Inui,Y.,
            Shigeri,Y., Ishida,A., Kameshita,I. and Sueyoshi,N.
  TITLE     Dual phosphorylation of protein phosphatase PPM1H promotes
            dephosphorylation of Smad1 in cellulo
  JOURNAL   Biochem Biophys Res Commun 530 (3), 513-519 (2020)
   PUBMED   32600616
  REMARK    GeneRIF: Dual phosphorylation of protein phosphatase PPM1H promotes
            dephosphorylation of Smad1 in cellulo.
REFERENCE   3  (bases 1 to 6413)
  AUTHORS   Biesemann,C., Gronborg,M., Luquet,E., Wichert,S.P., Bernard,V.,
            Bungers,S.R., Cooper,B., Varoqueaux,F., Li,L., Byrne,J.A.,
            Urlaub,H., Jahn,O., Brose,N. and Herzog,E.
  TITLE     Proteomic screening of glutamatergic mouse brain synaptosomes
            isolated by fluorescence activated sorting
  JOURNAL   EMBO J 33 (2), 157-170 (2014)
   PUBMED   24413018
REFERENCE   4  (bases 1 to 6413)
  AUTHORS   Chida,T., Ando,M., Matsuki,T., Masu,Y., Nagaura,Y.,
            Takano-Yamamoto,T., Tamura,S. and Kobayashi,T.
  TITLE     N-Myristoylation is essential for protein phosphatases PPM1A and
            PPM1B to dephosphorylate their physiological substrates in cells
  JOURNAL   Biochem J 449 (3), 741-749 (2013)
   PUBMED   23088624
REFERENCE   5  (bases 1 to 6413)
  AUTHORS   Coulpier,F., Le Crom,S., Maro,G.S., Manent,J., Giovannini,M.,
            Maciorowski,Z., Fischer,A., Gessler,M., Charnay,P. and Topilko,P.
  TITLE     Novel features of boundary cap cells revealed by the analysis of
            newly identified molecular markers
  JOURNAL   Glia 57 (13), 1450-1457 (2009)
   PUBMED   19243017
REFERENCE   6  (bases 1 to 6413)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK043121.1, AK220260.1, AK134804.1, CK622851.1, AC159503.10 and
            BP769253.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220260.1, AK134804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AK043121.1         2-44
            44-189              AK220260.1         1-146
            190-2569            AK134804.1         170-2549
            2570-3133           AK220260.1         2527-3090
            3134-3397           CK622851.1         352-615
            3398-5754           AC159503.10        168392-170748
            5755-6413           BP769253.1         1-659               c
FEATURES             Location/Qualifiers
     source          1..6413
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 70.44 cM"
     gene            1..6413
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /note="protein phosphatase 1H (PP2C domain containing)"
                     /db_xref="GeneID:319468"
                     /db_xref="MGI:MGI:2442087"
     exon            1..669
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1966
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="protein phosphatase 1H isoform 1"
                     /protein_id="NP_001103688.1"
                     /db_xref="CCDS:CCDS48705.1"
                     /db_xref="GeneID:319468"
                     /db_xref="MGI:MGI:2442087"
                     /translation="MLTRVKSAVANFMGGIMAGSSGSEHGGSGCGGSDLPLRFPYGRP
                     EFLGLSQDEVECSADHIARPILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLT
                     VKKKAGTITSTPNRNSKRRSSLPNGEGLQLKENSESEGISCHYWSLFDGHAGSGAAVV
                     ASRLLQHHITQQLQDIVEILKNSAILPPTCLGEEPESTPAHGRTLTRAASLRGGVGAP
                     GSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIERERSAYNISGGCTALIVVCL
                     LGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFMQPHLLGNEFTHLEF
                     PRRVQRKELGKKMLYRDFNMTGWAYKTIEDDDLKFPLIYGEGKKARVMATIGVTRGLG
                     DHDLKVHDSNIYIKPFLSSAPEVRVYDLSRYEHGADDVLILATDGLWDVLSNEEVAEA
                     ITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIH
                     GNKLS"
     exon            670..832
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1177
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1290
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1375
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1494
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1558
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1666
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1818
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..6389
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3113..3118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3134
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /note="major polyA site"
     regulatory      6335..6340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /note="hexamer: AATAAA"
     regulatory      6357..6362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
                     /note="hexamer: TATAAA"
     polyA_site      6362
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
     polyA_site      6389
                     /gene="Ppm1h"
                     /gene_synonym="A430075L18Rik; ARHCL1; C030002B11Rik"
ORIGIN      
        1 gtgcagcctg atcatcacat gactccacgg ccgtagccgc ggcagcagga gcggcgggtc
       61 cgtgggctcg ccgggtgggc tccgctcggc gcaagcagga accaggcgca aggggcgggg
      121 aagggacccg tcgcagccgc cgcccgccag ccgctcccgg ggctctcgct gtccctcccc
      181 aggcgcccgc ccgctccatg tcgcccggtt gcggaagtgt cgccgagaga ggtggcggcg
      241 gcggcgtcag ggagcacagg aggccggggc tcggccccct gcagcactga gctcacggag
      301 ccgcgcgtcc cagcgtcccc accgcccgta caccccgcgc ccgccgcagc ctgcatgccc
      361 cgcgctgcgc ctcggccggc cgccgcctcc tgctcgctca gcggctgccc ggcgccggag
      421 taatatgctc actcgagtga aatctgccgt ggccaatttc atgggcggca tcatggctgg
      481 cagctccggc tccgagcacg gcgggagcgg ctgcggaggc tcggacctgc ccctgcgctt
      541 cccgtacggg cggccggagt tcctcgggct gtctcaggat gaggtggagt gcagcgcaga
      601 ccacatcgcc cgccccatcc tcatcctcaa ggagacccgg cggctgccct gggccactgg
      661 ctacgcagag gttattaatg ctgggaagag cacacacaat gaggaccaag ccagctgcga
      721 ggtgctcaca gtgaagaaga aagccggaac cattacttcc accccgaaca gaaactccaa
      781 gagaaggtca tcacttccca acggggaagg cctgcagtta aaggagaact ctgagtccga
      841 aggcatctcc tgccactact ggtccctgtt tgacggtcac gcaggctcgg gggctgccgt
      901 ggtggcatcg cgcctgctgc agcaccacat cacgcaacag ctgcaggaca tcgtggagat
      961 cctgaagaac tcggccatcc ttcccccgac ctgcctgggg gaggagccag agagcacgcc
     1021 agcccacggc aggaccctaa cccgcgcggc ctcactgcgt ggaggtgtgg gtgccccggg
     1081 ctcccccagt acgccaccca cgcgcttctt cactgagaag aagatcccgc acgagtgtct
     1141 ggtcatcggg gccctggaga gcgctttcaa ggaaatggac cttcaaatcg aacgcgagag
     1201 gagtgcgtat aatatatctg gcggctgcac ggccctcatc gtggtttgcc tcttggggaa
     1261 gctctatgtg gcgaatgctg gcgacagcag ggccataatc atcagaaatg gagaaatcat
     1321 ccccatgtct tccgaattca cccctgagac tgagcgccag agacttcagt acctggcgtt
     1381 catgcagccc cacttgctgg gaaatgagtt cacacatttg gagtttccaa ggagagtgca
     1441 gaggaaggaa ctcgggaaga agatgctgta ccgggacttt aatatgacag gctgggcata
     1501 caaaaccatt gaggatgatg acttgaagtt cccccttata tatggagaag gcaagaaggc
     1561 ccgagtaatg gcaactattg gagtgacgag gggacttggg gaccatgact taaaggttca
     1621 tgactccaac atctacataa aaccattcct gtcttcagct ccagaggtca gagtctacga
     1681 tctctccaga tatgagcacg gagcagatga cgtgctgatc ctggctactg atggactctg
     1741 ggatgtctta tccaacgaag aagtagcgga agcaatcact cagtttcttc ctaactgtga
     1801 tccagacgac cctcacagat acacactggc ggctcaggac ctggtgatgc gtgcccgagg
     1861 cgtcctgaag gaccgagggt ggcggatatc gaatgaccga ctgggctcag gagatgacat
     1921 ttctgtatat gtcattcctt taatacacgg aaacaaactg tcatgaaagt gacccagggg
     1981 actaggagga cagaagggaa gaaaactggg gtgcctacga gcagggcggg accggggagt
     2041 gcctgggctg gattccaggt gatgcatatt tttcccagcc cagatgggga gtttgctgcc
     2101 caaaggcctc tctggttttg cttccaggtg acccttaggt ttccacttct tctttggtaa
     2161 caagtctgga cactgaataa gagccaaaca caaagcctgc tactgagtgt tatatttctc
     2221 ttggtttcta tggtaggggc tcctaggcag cgattgccta tttggggcac aggcatacat
     2281 ttatttattt tatctagaat agcagcaggg acagccattt caggtgtaac tggtgaaagc
     2341 ccctcctcag cccgacaagc tgccagcatc tctctgggag aagagccaca ttgaaaagtt
     2401 gaggaccacg gctcagaatg tctgagcagc catcttattg tgcgttccag ttatttcagg
     2461 gatcctgcct gtcctgtctc attcctcccc ctctttcctg cccccctctg tttctctaaa
     2521 gtcttttgtg gtaatggtgg tgtgaggcag agacttgttt tttttttttt ggacactcct
     2581 cctatcgttc tcattcccct ccaatggaac tttccaaatt gccactggac agtgtccaga
     2641 tcagagacta gacccatctg gctagtccca tgttccgtgc cccatacaca cctatagttt
     2701 tgtccagagc aatgtcccag gtgacagttt gtctttgttg tgttttctcc ccaaatagat
     2761 atgtttgctt caaaatgtgg gtgtttcatt ggaccaacag ttcctgtgct atctctaagg
     2821 tcccatctgg aggtttagct gtgagaggct gggttttatt tctggaatgg gtggtgctcc
     2881 ctcaccttct gtgtcctgga gacacatagg aagcagcatc cagtgccgta gctcagcaag
     2941 ttcttgtacc catcagctaa ccgtgcttca ttagggaaga gtgtggggct caggctcctt
     3001 ggtcgctgtt ctccaggcca caccacagga ggtttgagtg tcacagctca gctaagcagt
     3061 gactactctc ttcctgtcac ctttgtgcaa gggtatctgg gatgacactt gaattaaagt
     3121 gaatttgaat tgcagttggt cattgtgatg ttcccccatt cctcaaggga atcgcagtgt
     3181 agaaacttaa gagctgagac ccccttccta ctatgcatcc actggtgtgc atgcctcagt
     3241 ggcacgcaca tgggcacatg ggcacatggg catagtatct acctactgct tccttgccgg
     3301 gaagaacagc aaagtccagt ttaaagatca ctgcacagct gctctgccca ggggccttca
     3361 gagctgcatc cagttgctta gtcctgttcc cgtagtcttc caggatatcg gctttctgac
     3421 aacttggtat aattcagaca tttccaaccc aaggaaggaa ccaatggtgt catttccccc
     3481 aagatgcaat cccagctctt gtgtttacga gaattccttc ccaggggaga agggaggggc
     3541 acttcttcca ggctggtaag ccatccacat tcctagaatt gtagatattt tcttaggaaa
     3601 ggtctggtgc cttcctactc aggaacaaag tcaccccact gtttagagcc agggtccagc
     3661 ccggcaggtg acacactgtg cgagtgtgcc agctcactgc ggcgggaaga ctgggcatct
     3721 gaccatggat gcctctcctt caggaagtct tcaccacccc agacgccttg gtggggagtg
     3781 ttctgtggta accatttgct tcccgggaag aatatgacgc tgtaaaaaac tgtccaagca
     3841 tgctacagtc gcatggtggt cttcccacca tcgcccagtt ctcaaagtca cacacaaatg
     3901 ggaaatttga gaaagtgttg aattctatgg aggacacaaa ctgccttcct tgggggagca
     3961 tttccaggtt cccgatgcct ttcgaatttt ttgcttttct gatctcccag agtctcacct
     4021 tgaccttctc caatcatatt taagccacca gagtcagaac tggagtgtaa atatcctgta
     4081 ggtgccagtg gcaacattct cccaattctt ccattgtcaa accaaatctg aaagactcca
     4141 attaccctaa aacctggagt cctgctggtc ttagctggaa aggaatccag gagttctctt
     4201 catgagaagc tgggtggaaa gatctaagtc acaagctaaa gctctgtgtg tgttgggggg
     4261 cagggggggg ggggaagact acaaatgaat cggataaatc aaaaagtgga aaagtgattc
     4321 gttaatgccc atggcagatc tgcccagcac tgatattgct ctgtgctttg ggtttaactc
     4381 tgtgtgggcc ttattgttac cccagactcc aagtcaccct gtcccagaat aggatgggtc
     4441 tgtgtagcaa gttggccctt ggagaattcc tgggaaggcc aaagaaacaa cacactcaga
     4501 attctgcaaa atgtatttcg gtgtgtgtct agaaatcatg cctgtctgac ttccagctgg
     4561 acttgcttgc cctaatagcc tcagaggaag ccttgagtga tgaagtgcgt ttgatttcca
     4621 agtctagtct ttacgggcgt cttgggggtt gtgtggctac ttcctttaat gaaaggctca
     4681 ctcaacccta aatctcttct tcgctcagcc tgcatctgct cttctgactc ctggcacttc
     4741 cctgaagagt gtgaaccctg aagcgtcttc ctaagtgaca actaaagctt tgttcctcta
     4801 acaccaacag tcaccacaca aaggtgcggg agggacctgc tggggttgtg tatgcccagt
     4861 gactgccctt tgtggctggg aaggaaggtg acagttaggc tggaccaata ggcagctgtc
     4921 tgactgggac aagccaaaga agttagtgtt tcagctagtt ttcacagtat tcgattttga
     4981 cagatttggg atgttgagtt tttttttaat tcttagcatc ttacctccat ggggctacat
     5041 gaagccagtc atgtcttccc accactcgcc cctgaaagtc actttcttga aggaaatcat
     5101 gcccctagat ggatattgat gatcaagaat acttagagac tcaggagcca aatttcactc
     5161 gagaccttgg ccatttgggt agggagtcca gtactcccag gacactagtt tggaatcctt
     5221 ttgggaaagt gtctgatttg ttctcatctc cccctccccc gtgccctttc ctcatctgcc
     5281 cgtttgcttt tttttttttt tttttttttt ttttttttga gggagcaagt ggcggatgct
     5341 gttgtgtgca attgtttgaa ggtttttact ttttcctaag tgagccaaga tctctgatgc
     5401 tttcagagca cgttatgctg tgatgagatt ctaatttcag tgagtcagta cctccagggc
     5461 agctggagaa agcaatgaaa ttgtctatgc aaggaacaaa cagcctgacc ctaccagatc
     5521 taatagagtc gtagggcaga cttcagccac aggacaggat tttgtgttgg gagcttatga
     5581 atgtcagggc tcatgaatac agagaagtat tacagcctgc agaccacagc ccacctctct
     5641 gggcaatctt cgggtgctat gtggcaatgt ggcgtcatgt gtgtgagtgt gtgtgtgtgt
     5701 gcactggaac tttcagagga tgctacatgg gcagcctgac ttcctctctg agcctcgtgg
     5761 cccctgtcag atgtgattgc cactgctctt tcaaattcaa aatgttatct gtgtaaatag
     5821 ctttggtatt tcttttccat gtcttaggtg aagttttgtt catgtaacaa ccaggtacga
     5881 ggtgaccgaa taaagctata aacatactgt tcagttgtcg tgtgctgaag atggagaacc
     5941 tgggtcctcc atctctcctc tctctcatta gatgagtatc ttgtgcgtgt ttagggggtc
     6001 ctgccgttac ttcttcattc ctgattcgcc tctaattttc tttgtttctt tggaaacccc
     6061 aggaggcgcc tactaaggat caattgtaag aatatgtata tggtgatctg ggtttccaaa
     6121 aattacccta tatatagtga actgagaaga atctgcctgg agattggttt tcgaaccacg
     6181 tacctttatg cctcgtgatt gtgaaacatt gacttttgta aacccccaaa tgaaaacctg
     6241 tttagtaaag gggatatatt ttgtgtgttt tgaaatttag gtgcaatgtc ccctggaaaa
     6301 agctcaagaa ctgtatatgc tcaatggcat tttaaataaa atactatata tgtatatata
     6361 aatatgtata taggaaatct ttaacaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
