LOCUS       NM_008014               2165 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1G (formerly 2C),
            magnesium-dependent, gamma isoform (Ppm1g), mRNA.
ACCESSION   NM_008014
VERSION     NM_008014.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2165)
  AUTHORS   Peng,D., Huang,Z., Yang,H., Luo,Y. and Wu,Z.
  TITLE     PPM1G regulates hepatic ischemia/reperfusion injury through
            STING-mediated inflammatory pathways in macrophages
  JOURNAL   Immun Inflamm Dis 12 (2), e1189 (2024)
   PUBMED   38372470
  REMARK    GeneRIF: PPM1G regulates hepatic ischemia/reperfusion injury
            through STING-mediated inflammatory pathways in macrophages.
REFERENCE   2  (bases 1 to 2165)
  AUTHORS   Foster,W.H., Langenbacher,A., Gao,C., Chen,J. and Wang,Y.
  TITLE     Nuclear phosphatase PPM1G in cellular survival and neural
            development
  JOURNAL   Dev Dyn 242 (9), 1101-1109 (2013)
   PUBMED   23723158
  REMARK    GeneRIF: Nuclear phosphatase PPM1G in cellular survival and neural
            development.
REFERENCE   3  (bases 1 to 2165)
  AUTHORS   Chida,T., Ando,M., Matsuki,T., Masu,Y., Nagaura,Y.,
            Takano-Yamamoto,T., Tamura,S. and Kobayashi,T.
  TITLE     N-Myristoylation is essential for protein phosphatases PPM1A and
            PPM1B to dephosphorylate their physiological substrates in cells
  JOURNAL   Biochem J 449 (3), 741-749 (2013)
   PUBMED   23088624
REFERENCE   4  (bases 1 to 2165)
  AUTHORS   Lo,J.C., Jamsai,D., O'Connor,A.E., Borg,C., Clark,B.J.,
            Whisstock,J.C., Field,M.C., Adams,V., Ishikawa,T., Aitken,R.J.,
            Whittle,B., Goodnow,C.C., Ormandy,C.J. and O'Bryan,M.K.
  TITLE     RAB-like 2 has an essential role in male fertility, sperm
            intra-flagellar transport, and tail assembly
  JOURNAL   PLoS Genet 8 (10), e1002969 (2012)
   PUBMED   23055941
REFERENCE   5  (bases 1 to 2165)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   6  (bases 1 to 2165)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2165)
  AUTHORS   Guthridge,M.A., Bellosta,P., Tavoloni,N. and Basilico,C.
  TITLE     FIN13, a novel growth factor-inducible serine-threonine phosphatase
            which can inhibit cell cycle progression
  JOURNAL   Mol Cell Biol 17 (9), 5485-5498 (1997)
   PUBMED   9271424
REFERENCE   8  (bases 1 to 2165)
  AUTHORS   Guthridge,M.A., Seldin,M. and Basilico,C.
  TITLE     Induction of expression of growth-related genes by FGF-4 in mouse
            fibroblasts
  JOURNAL   Oncogene 12 (6), 1267-1278 (1996)
   PUBMED   8649829
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC114619.9.
            
            On Nov 17, 2006 this sequence version replaced NM_008014.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009004.1, U42383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               AC114619.9         107798-108040
            244-313             AC114619.9         119887-119956
            314-399             AC114619.9         120245-120330
            400-532             AC114619.9         120648-120780
            533-948             AC114619.9         121890-122305
            949-1080            AC114619.9         123214-123345
            1081-1315           AC114619.9         123656-123890
            1316-1445           AC114619.9         124184-124313
            1446-1548           AC114619.9         124669-124771
            1549-2165           AC114619.9         125059-125675
FEATURES             Location/Qualifiers
     source          1..2165
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.27 cM"
     gene            1..2165
                     /gene="Ppm1g"
                     /gene_synonym="Fin13"
                     /note="protein phosphatase 1G (formerly 2C),
                     magnesium-dependent, gamma isoform"
                     /db_xref="GeneID:14208"
                     /db_xref="MGI:MGI:106065"
     exon            1..243
                     /gene="Ppm1g"
                     /gene_synonym="Fin13"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1752
                     /gene="Ppm1g"
                     /gene_synonym="Fin13"
                     /EC_number="3.1.3.16"
                     /note="PP2C-gamma; protein phosphatase 1C; fibroblast
                     growth factor-inducible protein 13; protein phosphatase
                     magnesium-dependent 1 gamma; fibroblast growth factor
                     inducible 13"
                     /codon_start=1
                     /product="protein phosphatase 1G"
                     /protein_id="NP_032040.1"
                     /db_xref="CCDS:CCDS19179.1"
                     /db_xref="GeneID:14208"
                     /db_xref="MGI:MGI:106065"
                     /translation="MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHN
                     CIPELDNETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALQDAFLAID
                     AKLTTEEVIKELAQIAGRPTEDEDDKDKVADEDDVDNEEAALLHEEATMTIEELLTRY
                     GQNCQKVPPHTKSGIGTGDEPGPQGLNGEAGPEDPSRETPSQENGPTAKGHTGFSSNS
                     EHGTEAGQISEPGTATGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEVEEEEDDSEE
                     CSEDEDGYSSEEAENEEDEDDTEEAEEDDDEEMMVPGMEGKEEPGSDSGTTAVVALIR
                     GKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLN
                     LSRAIGDHFYKRNKNLPPQEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVV
                     DFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICFKPRNTV
                     ELQAESGKRKLEEALSTEGAEDTGNSDKKKAKRD"
     exon            244..313
                     /gene="Ppm1g"
                     /gene_synonym="Fin13"
                     /inference="alignment:Splign:2.1.0"
     exon            314..399
                     /gene="Ppm1g"
                     /gene_synonym="Fin13"
                     /inference="alignment:Splign:2.1.0"
     exon            400..532
                     /gene="Ppm1g"
                     /gene_synonym="Fin13"
                     /inference="alignment:Splign:2.1.0"
     exon            533..948
                     /gene="Ppm1g"
                     /gene_synonym="Fin13"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1080
                     /gene="Ppm1g"
                     /gene_synonym="Fin13"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1315
                     /gene="Ppm1g"
                     /gene_synonym="Fin13"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1445
                     /gene="Ppm1g"
                     /gene_synonym="Fin13"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1548
                     /gene="Ppm1g"
                     /gene_synonym="Fin13"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..2165
                     /gene="Ppm1g"
                     /gene_synonym="Fin13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2154..2159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1g"
                     /gene_synonym="Fin13"
                     /note="hexamer: AACAAA"
     polyA_site      2165
                     /gene="Ppm1g"
                     /gene_synonym="Fin13"
                     /note="major polyA site"
ORIGIN      
        1 cttgcgtcga ctgcgcagcc gggcccgctc cttgccacgc gcgcccccag gggccccggc
       61 tccggcgccg gcaagggtcg cgtcccgctt acctgttcct caggtagcca gccatccgcc
      121 gccatgggtg cctacctctc tcagcccaac acggtgaagt gctccgggga cggggttggc
      181 gccccgcggc tcccgctgcc ctacggcttc tccgccatgc aaggctggcg cgtctccatg
      241 gaggatgctc acaactgtat tcctgagctg gacaatgaga cagccatgtt ttctgtctac
      301 gatggacatg gaggggaaga ggttgccttg tactgtgcca aatatcttcc tgatattatc
      361 aaagatcaga aggcctacaa ggaaggcaag cttcagaagg ctttacaaga tgccttcttg
      421 gctattgatg ccaagctgac cacagaggaa gtcattaagg aactggccca gattgcaggg
      481 agacccactg aagatgagga tgataaagac aaagtagcag atgaggatga tgtggacaat
      541 gaggaggctg cattgttgca tgaagaggct accatgacta ttgaagagct gctgacgcga
      601 tatgggcaga actgtcagaa ggtccctccc cacaccaaat ctggaattgg gacaggcgat
      661 gaaccagggc cccagggcct caatggggag gctggacctg aggacccatc tagggaaact
      721 ccttcccagg aaaatggccc cacagccaaa ggccacacag gcttttcctc caactcggaa
      781 catgggactg aggcaggcca aattagtgag cccggtactg ctaccggtga ggctggacct
      841 tcctgctctt cagcctctga caagctgcct cgagttgcta agtccaagtt ctttgaggac
      901 agtgaagatg aatcagatga ggtggaggaa gaggaggatg acagtgagga atgtagtgag
      961 gacgaggacg gctacagcag tgaggaggca gagaacgagg aagacgagga tgacacggag
     1021 gaggctgaag aggatgatga tgaagagatg atggtccctg gaatggaagg caaagaagag
     1081 cctggttctg acagtggcac aacagcggtg gtggctctga tcagagggaa gcagttgatt
     1141 gtggccaatg caggagactc tcgctgtgtg gtgtccgagg ctggcaaagc tttagatatg
     1201 tcctatgacc acaaaccaga ggatgaagtg gagctggcac gcatcaagaa tgctggtggc
     1261 aaggtcacca tggatggacg agtcaatgga ggcctcaacc tctccagggc cattggagac
     1321 cacttctaca agagaaacaa aaacttgcca ccccaggaac agatgatttc tgcccttcct
     1381 gacatcaagg tgctgactct cactgatgac catgaattca tggtcattgc ttgtgacggc
     1441 atctggaatg tgatgagcag ccaggaggtt gtagacttta ttcaatcaaa gatcagtcaa
     1501 cgtgatgaaa acggggagct tcggttattg tcatccattg tggaagagct gctggatcag
     1561 tgcctggcgc cagacacttc tggggatggt acagggtgtg acaacatgac gtgcatcatc
     1621 atttgcttca agccccgaaa cacagtagag cttcaggcag agagtggcaa gaggaaactg
     1681 gaggaggcac tgtccacgga gggggctgaa gacaccggca acagtgacaa aaagaaggcc
     1741 aagagggact agtggtcaac cggaccctgc ccatgtggac tgttttctga gcccttggac
     1801 ccgagactga gttttgtcct tgtcctttag ccttagcagt gggtatgagg tgtgcagggg
     1861 gctgggtggc tttcctcagc ccattacaaa gagggccccc cacccccccc acgcggcagc
     1921 ctgggaggct ctgctgtcct cttaagcctc cttactctcc ttgggctcat cgactatcgg
     1981 ttctgtgcct gtgctctgtt gtgttggagg gaaggactgg tagttctgat ttttactctg
     2041 tgaacacttt atttaaggac attctttttt attggcggct ctgtgacccc tagccgcttg
     2101 cacccgctct ctgttgtaca ctttcaagca acactttttc agactaaagg ccaaacaaaa
     2161 gctaa
//
