LOCUS       NM_176833               4933 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus protein phosphatase 1F (PP2C domain containing)
            (Ppm1f), mRNA.
ACCESSION   NM_176833
VERSION     NM_176833.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4933)
  AUTHORS   Liu,J., Meng,F., Wang,W., Wu,M., Zhang,Y., Cui,M., Qiu,C., Hu,F.,
            Zhao,D., Wang,D., Liu,C., Liu,D., Xu,Z., Wang,Y., Li,W. and Li,C.
  TITLE     Medial prefrontal cortical PPM1F alters depression-related
            behaviors by modifying p300 activity via the AMPK signaling pathway
  JOURNAL   CNS Neurosci Ther 29 (11), 3624-3643 (2023)
   PUBMED   37309288
  REMARK    GeneRIF: Medial prefrontal cortical PPM1F alters depression-related
            behaviors by modifying p300 activity via the AMPK signaling
            pathway.
REFERENCE   2  (bases 1 to 4933)
  AUTHORS   Meng,F., Liu,J., Dai,J., Lian,H., Jiang,S., Li,Q., Wu,M., Wang,W.,
            Wang,D., Zhao,D., Liu,C., Qiu,C. and Li,C.
  TITLE     PPM1F in Dentate Gyrus Modulates Anxiety-Related Behaviors by
            Regulating BDNF Expression via AKT/JNK/p-H3S10 Pathway
  JOURNAL   Mol Neurobiol 58 (7), 3529-3544 (2021)
   PUBMED   33745117
  REMARK    GeneRIF: PPM1F in Dentate Gyrus Modulates Anxiety-Related Behaviors
            by Regulating BDNF Expression via AKT/JNK/p-H3S10 Pathway.
REFERENCE   3  (bases 1 to 4933)
  AUTHORS   Liu,J., Meng,F., Wang,W., Cui,M., Wu,M., Jiang,S., Dai,J., Lian,H.,
            Li,Q., Xu,Z., Wang,Y., Zhang,J. and Li,C.
  TITLE     PPM1F in hippocampal dentate gyrus regulates the depression-related
            behaviors by modulating neuronal excitability
  JOURNAL   Exp Neurol 340, 113657 (2021)
   PUBMED   33639208
  REMARK    GeneRIF: PPM1F in hippocampal dentate gyrus regulates the
            depression-related behaviors by modulating neuronal excitability.
REFERENCE   4  (bases 1 to 4933)
  AUTHORS   Grimm,T.M., Dierdorf,N.I., Betz,K., Paone,C. and Hauck,C.R.
  TITLE     PPM1F controls integrin activity via a conserved phospho-switch
  JOURNAL   J Cell Biol 219 (12) (2020)
   PUBMED   33119040
  REMARK    GeneRIF: PPM1F controls integrin activity via a conserved
            phospho-switch.
REFERENCE   5  (bases 1 to 4933)
  AUTHORS   Wingo,A.P., Velasco,E.R., Florido,A., Lori,A., Choi,D.C.,
            Jovanovic,T., Ressler,K.J. and Andero,R.
  TITLE     Expression of the PPM1F Gene Is Regulated by Stress and Associated
            With Anxiety and Depression
  JOURNAL   Biol Psychiatry 83 (3), 284-295 (2018)
   PUBMED   29054677
  REMARK    GeneRIF: Ppm1f is involved in stress- and trauma-related
            manifestation of anxiety and depression.
REFERENCE   6  (bases 1 to 4933)
  AUTHORS   Onouchi,T., Kishino-Kaneko,Y., Kameshita,I., Ishida,A. and
            Sueyoshi,N.
  TITLE     Regulation of Ca(2+)/calmodulin-dependent protein kinase
            phosphatase (CaMKP/PPM1F) by protocadherin-gammaC5 (Pcdh-gammaC5)
  JOURNAL   Arch Biochem Biophys 585, 109-120 (2015)
   PUBMED   26386307
  REMARK    GeneRIF: C-terminal cytoplasmic fragment of PcdhgC5 acts as a
            scaffold for CaMKP and CaMKI to regulate CaMKP activity.
REFERENCE   7  (bases 1 to 4933)
  AUTHORS   Susila,A., Chan,H., Loh,A.X., Phang,H.Q., Wong,E.T., Tergaonkar,V.
            and Koh,C.G.
  TITLE     The POPX2 phosphatase regulates cancer cell motility and
            invasiveness
  JOURNAL   Cell Cycle 9 (1), 179-187 (2010)
   PUBMED   20016286
  REMARK    GeneRIF: The POPX2 phosphatase regulates cancer cell motility and
            invasiveness.
REFERENCE   8  (bases 1 to 4933)
  AUTHORS   Xie,Y., Tan,E.J., Wee,S., Manser,E., Lim,L. and Koh,C.G.
  TITLE     Functional interactions between phosphatase POPX2 and mDia modulate
            RhoA pathways
  JOURNAL   J Cell Sci 121 (Pt 4), 514-521 (2008)
   PUBMED   18230650
  REMARK    GeneRIF: The binding of POPX2 (PPM1F) to mDia1 or to an
            mDia-containing complex greatly decreases the ability of mDia1 to
            activate transcription from the serum response element (SRE).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK016942.1, AK164964.1 and AC166832.2.
            
            On Aug 21, 2010 this sequence version replaced NM_176833.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164964.1, AK154192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AK016942.1         2-120
            120-1697            AK164964.1         1-1578
            1698-4933           AC166832.2         91497-94732
FEATURES             Location/Qualifiers
     source          1..4933
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.48 cM"
     gene            1..4933
                     /gene="Ppm1f"
                     /gene_synonym="1110021B16Rik; 4933427B07Rik; CaMKPase;
                     mKIAA0015; Popx2"
                     /note="protein phosphatase 1F (PP2C domain containing)"
                     /db_xref="GeneID:68606"
                     /db_xref="MGI:MGI:1918464"
     exon            1..156
                     /gene="Ppm1f"
                     /gene_synonym="1110021B16Rik; 4933427B07Rik; CaMKPase;
                     mKIAA0015; Popx2"
                     /inference="alignment:Splign:2.1.0"
     exon            157..424
                     /gene="Ppm1f"
                     /gene_synonym="1110021B16Rik; 4933427B07Rik; CaMKPase;
                     mKIAA0015; Popx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1580
                     /gene="Ppm1f"
                     /gene_synonym="1110021B16Rik; 4933427B07Rik; CaMKPase;
                     mKIAA0015; Popx2"
                     /EC_number="3.1.3.16"
                     /note="calcium/calmodulin-dependent protein kinase
                     phosphatase; partner of PIX2; caM-kinase phosphatase;
                     ca(2+)/calmodulin-dependent protein kinase phosphatase"
                     /codon_start=1
                     /product="protein phosphatase 1F"
                     /protein_id="NP_789803.1"
                     /db_xref="CCDS:CCDS27991.1"
                     /db_xref="GeneID:68606"
                     /db_xref="MGI:MGI:1918464"
                     /translation="MASGAAQNSSQMACDSEIPGFLDAFLQDFPAPLSLESPLPWKVP
                     GTVLSQEEVEAELIELALGFLGSRNAPPSFAVAVTHEAISQLLQTDLSEFKRLPEQEE
                     EEEEEEEEKALVTLLDAKGLARSFFNCLWKVCSQWQKQVPLTAQAPQWQWLVSIHAIR
                     NTRRKMEDRHVSLPAFNHLFGLSDSVHRAYFAVFDGHGGVDAARYASVHVHTNASHQP
                     ELRTNPAAALKEAFRLTDEMFLQKAKRERLQSGTTGVCALIAGAALHVAWLGDSQVIL
                     VQQGRVVKLMEPHKPERQDEKARIEALGGFVSLMDCWRVNGTLAVSRAIGDVFQKPYV
                     SGEADAASRELTGSEDYLLLACDGFFDVVPHHEVTGLVHGHLLRHKGNGMRIAEELVA
                     VARDRGSHDNITVMVVFLREPLELLEGGVQGTGDAQADVGSQDLSTGLSELEISNTSQ
                     RS"
     exon            425..567
                     /gene="Ppm1f"
                     /gene_synonym="1110021B16Rik; 4933427B07Rik; CaMKPase;
                     mKIAA0015; Popx2"
                     /inference="alignment:Splign:2.1.0"
     exon            568..770
                     /gene="Ppm1f"
                     /gene_synonym="1110021B16Rik; 4933427B07Rik; CaMKPase;
                     mKIAA0015; Popx2"
                     /inference="alignment:Splign:2.1.0"
     exon            771..959
                     /gene="Ppm1f"
                     /gene_synonym="1110021B16Rik; 4933427B07Rik; CaMKPase;
                     mKIAA0015; Popx2"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1103
                     /gene="Ppm1f"
                     /gene_synonym="1110021B16Rik; 4933427B07Rik; CaMKPase;
                     mKIAA0015; Popx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1197
                     /gene="Ppm1f"
                     /gene_synonym="1110021B16Rik; 4933427B07Rik; CaMKPase;
                     mKIAA0015; Popx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..4933
                     /gene="Ppm1f"
                     /gene_synonym="1110021B16Rik; 4933427B07Rik; CaMKPase;
                     mKIAA0015; Popx2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4901..4906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1f"
                     /gene_synonym="1110021B16Rik; 4933427B07Rik; CaMKPase;
                     mKIAA0015; Popx2"
                     /note="hexamer: AATAAA"
     polyA_site      4920
                     /gene="Ppm1f"
                     /gene_synonym="1110021B16Rik; 4933427B07Rik; CaMKPase;
                     mKIAA0015; Popx2"
                     /note="major polyA site"
ORIGIN      
        1 gtcgtccctg aaacaagaga gcagagggac cagcaggagg cagcagaggt gcgcccgagg
       61 cccgactgcg cttgcgcaga gcctgcggcg cctaggacgg gaagtaggcg gggctgccca
      121 gagcagctcg tggggagcac tgcggcaggc tggcagagtg aagacttgac tggagactgt
      181 ctcaccccag cctagctgca aacccccgga atgcactggg catggcctct ggagccgcac
      241 agaacagcag ccagatggcc tgtgacagtg agatcccagg cttcctggac gcattcctcc
      301 aagacttccc agccccactg agcctggaga gccctttgcc atggaaggtc ccagggacag
      361 tcctgagcca ggaagaagtg gaggctgagc tgattgagct ggcattgggc ttcctgggca
      421 gcaggaacgc tcccccatcg tttgctgtgg ctgtgaccca cgaggcaatt tcccagctgc
      481 tgcagacaga cctttctgaa tttaagaggt tgcctgaaca agaggaggag gaggaagagg
      541 aggaagaaga gaaagccctc gtgaccttac tagatgccaa aggcctggca cggagcttct
      601 tcaactgcct ttggaaagta tgtagccagt ggcagaagca ggtgccgttg actgcccagg
      661 cccctcagtg gcagtggctg gtctctatcc atgccatccg gaacacacga cgcaagatgg
      721 aggaccgaca cgtgtccctt cctgctttca accatctctt cggcttgtct gactctgtgc
      781 accgtgccta ctttgctgtg tttgatggtc atggaggcgt ggatgcagca aggtatgcct
      841 ctgtccacgt gcataccaat gcttctcacc agccagagct gcgcacaaac cctgcagcag
      901 ctctcaaaga agccttccgg ctcaccgatg agatgtttct ccagaaagcc aagcgagagc
      961 gactgcagag cggtaccacg ggtgtgtgtg cactcatcgc gggagcagcc ctgcatgttg
     1021 cctggcttgg agactcccag gtcatcctgg tacagcaagg acgggtagtg aagctgatgg
     1081 agccgcacaa accggagcga caggatgaga aagcacgaat tgaagccctg ggtggctttg
     1141 tttctctcat ggactgttgg agagtcaacg ggaccctggc agtgtctaga gccattgggg
     1201 atgtcttcca gaagccctat gtgtctgggg aggccgatgc agcatccaga gagctaacgg
     1261 gctcagagga ctacctgttg cttgcttgtg atggtttctt cgatgttgtc ccccaccatg
     1321 aagtcacggg tctcgtccat ggccacttgc tcaggcacaa gggcaatggg atgcgtattg
     1381 ctgaggagct ggtggctgtg gcccgtgacc ggggctccca tgacaacatt acagtcatgg
     1441 tggtcttcct tagggagccc ctggagctgc tagagggtgg agtccagggg acaggggatg
     1501 cccaggcaga tgtaggaagc caggacttgt ccactggcct ctcagaactt gagatcagta
     1561 atacctcaca gagaagctaa gtggtccagg cctccaggcc ccatccggac tctccctctg
     1621 ccctcgtgat cctccccttc aaagacctta gatccaaaag gtatagtggg caggggtgca
     1681 cactctcaca gcattccctt agcaccccag cccttcatgt tgcctaccac agcctgtcct
     1741 catggctgca gaactgcagt aggcagctag tggatctcag aaggaaacat aggaaaatgg
     1801 cctcaccgaa gagcagatgg ctgaggtgat cagggccgga caggtctggg aacagaaacc
     1861 acaggcacct gctggtagcc taaccaaaaa cacaggtcag gtcttggagg accctcacac
     1921 agatcctgga atgagatctg cagccaggtg tccagcccag gcttgtggct tctcattgta
     1981 cccaaggctg ggagggtttg gtctgtacta acacacaagc tcgcagtcct gcttgactgc
     2041 tggcttccca aagaggagac attggtcttg ctgggaggca cagcaggaga gtgacccact
     2101 gccactgcac tctaactgag tactaaggcc actagggctt tctagacctc gctttcccct
     2161 tgagcttcct ggggaggtga agtgaggtgt gtgtgtgtgt gtgtgtcttt gtgtgcttag
     2221 atttattgca gggaaaggtc taatccagaa tcagtattca ggctttgtca tgttgtatca
     2281 gtgccaaggt gaccctcaag gtcatgtaac ttaagcaaag cttagcattt attttattcc
     2341 tgaaaactta agtattttac ttttttgtgt gttcgtggag acatttgcag tattaatgat
     2401 tttatttttc ctaaatcggg atggaaacaa acttttccag gttatgttaa taagccactt
     2461 aagtgcctta aacagctttg gtgtagatga gaattgctgg gtccgtcatg gatcctgata
     2521 ggcagacgtg ttgaggttct caaagaggct gcatttgttg tgggaaggca cactttcagc
     2581 cagcactctt tctgggaaag tccttttgtg cgtctgggca cctcagaact tccttgaagt
     2641 gatgggtaaa ggctgtgact atgggcacct ggggtgacac tggcctcctt gtccaccttg
     2701 gagtctggct ggttcccagc tgagagaacc ttactgctct tggctagaag attgacacac
     2761 tcaatctctc ttgaaactct cttaagtgtg tttgcagtta tgttgattga gttgttgaag
     2821 acagtgctta ggtgaggaac ttgggcaagc ccagcagtcc accatctttc tcctgtgact
     2881 tgtgtcctaa cctgctagac tctgtcctga cctgagcagc atgaaagacc tccacatccc
     2941 tagagcagtg atggatacag tcaggcaagg aaaccaagtg agggttgggg gggataccaa
     3001 gaatagaagg actaggaggc cctcaacaag ggccaagcga gtcaaggctg ctctctgcag
     3061 acactggcag gtccagagaa taatggtggc ttagcagagg ctcagggaag gatcagtagg
     3121 aagaagggtg gctgtgaggt aggtccccat gaaggagaca tagttcacct gtagagtgaa
     3181 agccctagca agacttgcag agctttgttc attgcaccta agccctcttt gaaaagaagc
     3241 aagggagctc atacttattc ctctgaggca agttcacttc cagcagtagg agagcgagcc
     3301 agccaaatgc agctgggcac ccacctgtat gcttgccatt tacccattcc cacagcaggg
     3361 atggaagagc tggggccatg tagttgattc cttgatcaag tctcctgata ggaacgtgat
     3421 cactcagatg gctgcccacc taatagctag gtattgctta acttgaaggc ctgctgcctt
     3481 ccgggggggg ggggggtgtc agaatccagc atcctcagtg ccatctcaac acagggtgtg
     3541 gttgttggtc cagcctgcct gtagcagtga ccttcataga gggagataaa ttgattttgg
     3601 ttttctccca tttttgctaa cctgatcatt gctggtaaga gtggaatttg ggcctccttg
     3661 gtggtctgga ttcatactcg catgtaaaga tgtgccaaat atcaaggcct cagtgtaaag
     3721 ggaagcccct ttcccaggct tgtctgagtg cctcccccac ccttccccct gtctggcaat
     3781 ggtctgggac caacatcagg cactgctcca tcctgatcta gtggccaagg aagaccacat
     3841 tctcctactg ttgagggctg gccttgagcg agttcctagg tacagagaac tctttttgtc
     3901 tggactggag ttgccagtac caagcctaca agacttgttg gccacctcct cctcagagtc
     3961 tcttcccaaa agaatcccct agccaggata atgggtggct tagtagaggc tcagggaagg
     4021 aacagggaga agggtggctg tgagctcaag tccccctctt tgccaccatc acattgtgtg
     4081 agcggaacca gtcactgcac ctctcaggcc tcagggaaag gcatggaggg catgcatagc
     4141 attaccagga gctgccagag cacgggagcc catcctccac cagcagcaga gaggggttaa
     4201 gtattattag tgtctattct taaaattaag tgggctggaa cagagctgag ttacaggcgc
     4261 cagtgtctta cacagataca aaagctgaag ccgtcagcct gcctttgcag gtacagctgc
     4321 ctcccaacca aggcctggag gcgttaagag gtgggagggc acaagcaggc tttcaggagt
     4381 gttgaagcaa gggatctgca gcatagcttt gggcgtctcc agaactcatg gtgagggagg
     4441 caccaacacc tagaggtctt aaaagccctg cattcaccat gatctgtctg cccctgccct
     4501 tttgggttct tctgcatgca gtgcccccct ctcctgatgc taagttttgg catgggtgtc
     4561 ctggctacct caactgtatt ctcaaggcca ggaggatggc tctggccata cttacggaag
     4621 ccaggccaat ttgtgtgaag caagctgggc ttctggtttg attcagcttc tgtagcctcc
     4681 agggaccatc ctctggagtc ttgtgctttc actggactct tcagcttcac caaacacacc
     4741 aagctttgcc atttacatgc catgtgggcc ttgccaaggg ttatttcagg ggtcttcctg
     4801 ggagtcttgt tctaagacac cgtgtttctt tagtcttagg gacaactccc aaggtgatga
     4861 gctcatagga cgtcttccca tggggccctg tactggtgtc aataaaccat atattcaaga
     4921 ttcctgagtg cca
//
