LOCUS       NM_177167               6315 bp    mRNA    linear   ROD 01-FEB-2024
DEFINITION  Mus musculus protein phosphatase 1E (PP2C domain containing)
            (Ppm1e), mRNA.
ACCESSION   NM_177167 XM_484060
VERSION     NM_177167.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6315)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   2  (bases 1 to 6315)
  AUTHORS   Chida,T., Ando,M., Matsuki,T., Masu,Y., Nagaura,Y.,
            Takano-Yamamoto,T., Tamura,S. and Kobayashi,T.
  TITLE     N-Myristoylation is essential for protein phosphatases PPM1A and
            PPM1B to dephosphorylate their physiological substrates in cells
  JOURNAL   Biochem J 449 (3), 741-749 (2013)
   PUBMED   23088624
REFERENCE   3  (bases 1 to 6315)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596130.13.
            
            On Nov 17, 2006 this sequence version replaced NM_177167.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122434.1, AK036583.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-546               AL596130.13        173023-173568       c
            547-665             AL596130.13        63506-63624         c
            666-865             AL596130.13        58843-59042         c
            866-1054            AL596130.13        55177-55365         c
            1055-1198           AL596130.13        52006-52149         c
            1199-1292           AL596130.13        51704-51797         c
            1293-6315           AL596130.13        41480-46502         c
FEATURES             Location/Qualifiers
     source          1..6315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.99 cM"
     gene            1..6315
                     /gene="Ppm1e"
                     /gene_synonym="B930008A12Rik; mKIAA1072; POPX1; PP2CH"
                     /note="protein phosphatase 1E (PP2C domain containing)"
                     /db_xref="GeneID:320472"
                     /db_xref="MGI:MGI:2444096"
     exon            1..546
                     /gene="Ppm1e"
                     /gene_synonym="B930008A12Rik; mKIAA1072; POPX1; PP2CH"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2341
                     /gene="Ppm1e"
                     /gene_synonym="B930008A12Rik; mKIAA1072; POPX1; PP2CH"
                     /EC_number="3.1.3.16"
                     /note="caMKN; caMKP-N; caMKP-nucleus; partner of PIXA;
                     partner of PIX 1; partner of PIX-alpha;
                     ca(2+)/calmodulin-dependent protein kinase phosphatase N"
                     /codon_start=1
                     /product="protein phosphatase 1E"
                     /protein_id="NP_796141.2"
                     /db_xref="CCDS:CCDS25211.1"
                     /db_xref="GeneID:320472"
                     /db_xref="MGI:MGI:2444096"
                     /translation="MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPESEPEPEPE
                     AELVAAEAAEASGEEPGEDAATVEATEEGEQDQDPEPEDEAVEEETATEGEEEEEEEA
                     AAPGHSAVPPPPQPQLPPLPPLPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAA
                     ALARATSDEVLQSDLSAHCIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFP
                     LRRRPQIYYETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVD
                     AAIYASVHLHVNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFI
                     RGNMLHVAWVGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNG
                     SLSVSRAIGDAEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDH
                     LKENNGDSSMVAHKLVASARDAGSSDNITVIVVFLRDMNKAVNVSEESEWTENSFQGG
                     QEDGGDDKETHGECKRPWPQHQCSAPADLGYEGRVDSFTDRTSLSPGPQINVLEDPDY
                     LDLTQIEASKPHSTQFLPPVEMIGPGAPKKDLNELIMEERSVKSSLPERSGAGEPRVS
                     FNLGSTGQQICRMENLSPVSSGLENEQFKSRGKTASRLYHLRHHYSKRQRGFRFNPKF
                     YSFLSAREPSHKIGISLSSLTRSGKRNKMLRSSLPWRENSWEGYSGNVKIRKRNDIPC
                     PDFPWSYKI"
     exon            547..665
                     /gene="Ppm1e"
                     /gene_synonym="B930008A12Rik; mKIAA1072; POPX1; PP2CH"
                     /inference="alignment:Splign:2.1.0"
     exon            666..865
                     /gene="Ppm1e"
                     /gene_synonym="B930008A12Rik; mKIAA1072; POPX1; PP2CH"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1054
                     /gene="Ppm1e"
                     /gene_synonym="B930008A12Rik; mKIAA1072; POPX1; PP2CH"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1198
                     /gene="Ppm1e"
                     /gene_synonym="B930008A12Rik; mKIAA1072; POPX1; PP2CH"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1292
                     /gene="Ppm1e"
                     /gene_synonym="B930008A12Rik; mKIAA1072; POPX1; PP2CH"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..6315
                     /gene="Ppm1e"
                     /gene_synonym="B930008A12Rik; mKIAA1072; POPX1; PP2CH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagcgggag gcgaggctcc gaagcagccc cctcctcctc ctgggctcac ctcccacccc
       61 cttcccggtg gacctcgggg catgagcaac gatggcgggc tgcatccctg aggagaaaac
      121 ttaccggcgc ttcctggagc tgttcctggg cgagttccgc ggaccgtgcg gtggcggcga
      181 gccagagccc gaacccgaat ccgagcccga gcccgagccc gaagccgagc tagtcgcggc
      241 tgaggcggcc gaggcttcgg gggaggaacc gggggaggac gctgcgacgg tagaggcgac
      301 cgaggagggg gagcaggacc aagaccccga gcccgaagac gaggcggtgg aggaggagac
      361 ggcgacggag ggcgaggagg aggaagagga ggaagcggct gccccggggc actcggccgt
      421 gccgccaccg ccgcagcccc agctgccacc gctgcccccg ctcccacggc cgctgtcgga
      481 gcgcatcacc cgagaggagg tggagggcga gagcctggac ctgtgcctgc agcagctcta
      541 caaatataac tgcccttcct ttctggctgc tgctttagcc agagccacat cagatgaagt
      601 cctccagagt gacctttctg ctcactgtat cccaaaggaa acggacggca cagaagggac
      661 tgtggaaatt gagacagtga aattggcccg ttctgtcttc agcaaactac atgagatctg
      721 ctgcagttgg gtgaaggact tccctctgcg caggaggcct cagatttatt atgagacgtc
      781 aattcatgcc atcaagaaca tgcgaaggaa aatggaggac aaacacgtct gcattcctga
      841 ctttaacatg ctcttcaacc tagaggacca ggaggaacaa gcatactttg cagtgtttga
      901 tggccatggg ggagtggacg ctgctattta tgcctccgtt cacctacacg ttaacttagt
      961 gcgccaggag atgtttcccc atgatcctgc tgaggctctc tgccgggcct tccgtgtcac
     1021 agatgagcgg tttgtgcaga aggcagccag ggagagctta cggtgtggga ccacaggagt
     1081 agtgactttt atcagaggca acatgctcca cgtggcatgg gtgggcgatt cccaggtcat
     1141 gctggtaaga aaggggcaag ctgttgaact aatgaaacca cacaagccag acagagagga
     1201 tgaaaagcag cgaattgagg cccttggagg ctgtgtggtt tggtttggcg cctggagggt
     1261 gaatggaagc ctgtccgtct ccagagccat cggagatgct gagcacaagc cgtatatctg
     1321 tggagacgca gactcggcct ccactgtttt ggatgggact gaagactacc tcattctggc
     1381 ctgtgacggc ttctatgaca ccgtgaaccc tgacgaggca gtgaaggttg tgtctgacca
     1441 cttgaaagag aataacggag acagcagcat ggttgcccac aaattagtag cgtcggctcg
     1501 tgatgcgggg tcaagtgata acatcactgt tattgtggta ttcctgaggg acatgaacaa
     1561 ggctgtaaat gttagtgagg agtcagagtg gacagagaac tcttttcaag gagggcaaga
     1621 agatggtggg gatgataagg agactcatgg agagtgcaag cgcccttggc cacagcacca
     1681 gtgctcagca cccgccgatc taggctatga ggggcgagtg gattcattca ctgatagaac
     1741 tagcctcagc ccagggcccc aaatcaacgt gctggaagat ccagactacc tagatctcac
     1801 acaaatagaa gcaagcaaac ctcacagtac ccaatttttg ccaccagttg agatgattgg
     1861 tcctggtgca ccaaagaaag atcttaatga gctaataatg gaggagagat cagtcaagtc
     1921 atcattgcct gaacggagtg gtgctggaga gcctcgggtt tcttttaatt tgggttcaac
     1981 agggcaacag atatgcagaa tggagaactt gtctcctgtc agttctgggt tggaaaatga
     2041 acagttcaaa tcccggggga agacagcgtc taggttgtat catttacgcc accactactc
     2101 caaaaggcag cgtggattca ggtttaatcc aaagttttac tcgtttctgt ctgctcgaga
     2161 gccttctcac aaaataggca ttagcctctc ctcacttact cgaagtggga agagaaacaa
     2221 gatgttaaga agttctttgc catggaggga aaatagttgg gaaggatata gtggaaatgt
     2281 gaagatcaga aagcgtaatg atattccatg cccagacttt ccctggagct ataaaattta
     2341 agactttttc ttcaacatag gctagctagt tctctcagaa atataactat cagagtagaa
     2401 acaaggtaga catttttaac gtacatgtgc ttcattatga atccacggat ggctcaaccc
     2461 ttaaatgtac atagattgtt aggaaattca aaatagcatt ttcaatctaa tcaaaagtat
     2521 tggcggtttc actagagaaa ttattcaact ggtccctgtg atgtgtctct ataccacaga
     2581 cagcccctct ccaccatccc ttcacgtcac tagtggaagc ttgaaagtta ttcgagtcag
     2641 aatatatggt atggaaatcg caactatctg gtctgatgtg cctactctaa aggaaacaat
     2701 gcagaattaa attttgttgg gaaatgtccc tcaagatctt ggggactatg gagcatctct
     2761 tcccaattgt gtgggtaggt gaaagcctaa aagccacacg ggcctaaact gctgatgaga
     2821 cgcagtaagc cggtaccaaa gtgtcatgtt ctcagacttg ggaggcagga tacagtaaga
     2881 tcattcactt ttcatagaaa atgaaaggca actatgacat ttttaattaa aatacttcat
     2941 aaggttttag ttatttgaac gttttataac ctgttatggt gcttttgatg ggattttgtt
     3001 acttggcatt ttaggagacc accatcagct ggttgtaacc tatgatgcta atgtttttca
     3061 cagtaccttc atctcaggaa taaagtggtt tagcagagat gatgtgaggt acaatataag
     3121 aatcatgcca tttaaaaaga gttgtgaaat agcatttcta tattttctgc ttttttttat
     3181 gtttacagac agcaaaggca tatattatta taatataaaa cgtagtttgg agaatgaaaa
     3241 aaatgatagt tttaacttct ctaaaattgt tttccccaag ggaatgaagt aattggtatg
     3301 aaggaggctg agtgtgaacc cagaggccaa gtgcaaagga gaatgcagat tactgagagc
     3361 cagggctgtt tagttataac tggaagacaa gccagagtcc agctacttgc ttcagactac
     3421 agtgacaggt catgtgcttc tcatttcaat acttaagtta tagtttatat agttttaaat
     3481 cctttcaata cttaaggtat atagttttaa atcaaccacc ttctgccatt tcaaagtttc
     3541 aaagcataaa gacagcaagt acgcgatcgt atctgttcag tgaggcagcc tggtttctct
     3601 cagccatgaa tgcatccatg tcctcatgtt ccccaccctc acccccaccc tgggccagtc
     3661 aggccaacag gcaagagtag ctgctagagc cattgctccc agtgcaggca ctgctaaatg
     3721 ttcttgctga ggcactgctg ctcctatcca cggtctacgt aacacaattc atgctgcatt
     3781 ctccagaccc acagagggct aagattccca aatttcaaga catagatgac taacatatat
     3841 catggttaca tcaagttgtt aaagagacca aaactcagct tctcttcagc aatggttaca
     3901 ctgttaatct atagctttta tttttcaaaa cttgagagta agcggagatt ctcagtgttt
     3961 tctgttgacc ttggagtcgg tctacccctc tccgacagta cctgtgatac acaggtggag
     4021 aggaataccc gcggctcctc ctcagcagtg ttaatttcat cctcctctct ctcatgctct
     4081 gcctacacat ggccctcaca catggttgtt gttttttgaa gcccaggtct tgttgacaac
     4141 ccatcaggta cagggtcact ttcaaaccaa aatttctaag aaaacaaggc agcagaacac
     4201 agatgaacat tcatatccca aagtagctaa gatcatctgt ggttacctgt tggcaatgat
     4261 tttgatcaga atgaggagaa aagaaaaatt ttgaggtgat ataggcttat cagtggggta
     4321 aaaaaactgg gtggatgaaa ccgggacaaa cagacccatt tgaaaggtct ggattttgta
     4381 ggtctgacta cacagcagtg ttaactccat ttctcatatc actagctctc tagaaaatag
     4441 agaaaagtat ttctagtgtg gtcaagttaa taaaccaata atgtaaaaac taacttcatt
     4501 tgttcacaat gtgcgtattt ataaggtagt taggtaccat ttgtaaggta agtcctttaa
     4561 cattctataa tattaaagta gtggttattg gcctgataaa tgctgctgtt ggttctataa
     4621 accagacaag aagcagtgct ttgtgaaatg cagtgttaaa tcttaatgcc actggtgata
     4681 ggaagtagtt cccttcagtt caaatcctct gcccttattt gctgcttgct aatgtaagca
     4741 ataagtaacc ctctaactaa cggtatctat acatttctgt aacttatact taatgatggt
     4801 gtatctggtg attgtacaat tattagacag atataaaagt atctatacaa tatatattaa
     4861 ctgtaaatgc tgaggtatag tctgtgaatt atgtgttttg tacctctatt tctttgtgca
     4921 atttagtggt ggtgaaagtt ctacactcga tccttaaaga gtggcagtat cactttttca
     4981 attaacatga tctgcatcaa tttgtttgct tgctaaaaca gttttgttaa agtaggaaat
     5041 agcaaaacaa atataaacaa gaaagtgtag tatctgatag gaaagtagac aagtcaccaa
     5101 ccgagattac tactccttgt acattcactg tgagtctcaa agggcatcag tcccgaattt
     5161 caaaggtttc tttttttcac tttttgagac atgtatattg ggaaggataa ctgagattgg
     5221 caacattaca gcaccaaata ctggggctat tagtaatatt tatgtctgta caacagaggt
     5281 cagacagaaa aacatgtata taccttttct ttacctataa gtgccatcca ttgtccttga
     5341 agtaatacaa ttaaagtcca tgttgcattt aacagaagga gccttgaaag gatcatcatt
     5401 tcaaaggaca atgttagtaa tgtcaacact aagtctagtc ctgaccacag tcgcctggta
     5461 cagcagcacc gctccatttc catgacacca cactccattg ctagaacact gtgccagtaa
     5521 gaggccggca tccaaggggc agatggacat gatgcgtgac gcagctcagg gttgcggaca
     5581 agtaaactgc tgtgcttcaa gttcttcctc cccaccaaag gcttcctgag gctttgtgag
     5641 aaaaggtcta aattatttta atttttaaac tcaatttgtt caatgtgctt ttccccctaa
     5701 gtacaagagg atactatagt tttgttcaaa cctttgtttg gggaaatttt ctttggatta
     5761 taagttacta aaagattttt ttcacctttt aaaaccagga taaaaaaaca aagccccaac
     5821 actctcctgt tttgatctat gaaaagatgg ttgtttcttc aaaaccaatg acactgccag
     5881 tattctaaca gccaaatcgt actgactgaa ggggaacccc actgctgcac ctgccagcag
     5941 cacttgaaca gctcaggcct gttcattata ctgagtagaa acctgaagga gggcaggggg
     6001 ttccaccctg gcgcagcagt catgcttgaa aaggaagtct ttaactctga cgtctgaggt
     6061 aacgcagata cagcactgta atctctctag gtgctctttg gtgagagacg agctttctct
     6121 tgttcaggac atttctctgc aaagaattct ctctggagtg aagtgagtga cgttacgatt
     6181 tacaaaccca ctctacagat cacttttgag ttgagttgta atcataagtg atccttattt
     6241 ttatttatta aaactgttta ttcaggtaag gagtatgttg aaattttgcc aatatcttaa
     6301 taaaactcag caatt
//
