LOCUS       NM_016910               2911 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus protein phosphatase 1D magnesium-dependent, delta
            isoform (Ppm1d), mRNA.
ACCESSION   NM_016910 XM_914218
VERSION     NM_016910.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2911)
  AUTHORS   Wang,Y., Cui,C., Zhao,W., Tian,X., Liu,P., Wei,L., Zhu,Z., Liu,M.,
            Fu,R. and Jia,L.
  TITLE     WIP1-mediated regulation of p38 MAPK signaling attenuates
            pyroptosis in sepsis-associated acute kidney injury
  JOURNAL   Immunobiology 229 (5), 152832 (2024)
   PUBMED   38943814
  REMARK    GeneRIF: WIP1-mediated regulation of p38 MAPK signaling attenuates
            pyroptosis in sepsis-associated acute kidney injury.
REFERENCE   2  (bases 1 to 2911)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2911)
  AUTHORS   Miller,P.G., Sperling,A.S., Mayerhofer,C., McConkey,M.E.,
            Ellegast,J.M., Da Silva,C., Cohen,D.N., Wang,C., Sharda,A., Yan,N.,
            Saha,S., Schluter,C., Schechter,I., Slabicki,M., Sandoval,B.,
            Kahn,J., Boettcher,S., Gibson,C.J., Scadden,D.T., Stegmaier,K.,
            Bhatt,S., Lindsley,R.C. and Ebert,B.L.
  TITLE     PPM1D modulates hematopoietic cell fitness and response to DNA
            damage and is a therapeutic target in myeloid malignancy
  JOURNAL   Blood 142 (24), 2079-2091 (2023)
   PUBMED   37595362
  REMARK    GeneRIF: PPM1D modulates hematopoietic cell fitness and response to
            DNA damage and is a therapeutic target in myeloid malignancy.
REFERENCE   4  (bases 1 to 2911)
  AUTHORS   Burocziova,M., Danek,P., Oravetzova,A., Chalupova,Z.,
            Alberich-Jorda,M. and Macurek,L.
  TITLE     Ppm1d truncating mutations promote the development of genotoxic
            stress-induced AML
  JOURNAL   Leukemia 37 (11), 2209-2220 (2023)
   PUBMED   37709843
  REMARK    GeneRIF: Ppm1d truncating mutations promote the development of
            genotoxic stress-induced AML.
REFERENCE   5  (bases 1 to 2911)
  AUTHORS   Apaydin,T., Zonis,S., Zhou,C., Valencia,C.W., Barrett,R.,
            Strous,G.J., Mol,J.A., Chesnokova,V. and Melmed,S.
  TITLE     WIP1 is a novel specific target for growth hormone action
  JOURNAL   iScience 26 (11), 108117 (2023)
   PUBMED   37876819
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2911)
  AUTHORS   Lu,X., Bocangel,D., Nannenga,B., Yamaguchi,H., Appella,E. and
            Donehower,L.A.
  TITLE     The p53-induced oncogenic phosphatase PPM1D interacts with uracil
            DNA glycosylase and suppresses base excision repair
  JOURNAL   Mol Cell 15 (4), 621-634 (2004)
   PUBMED   15327777
  REMARK    GeneRIF: Data demonstrate that p53-induced phosphatase PPM1D
            interacts with the nuclear isoform of uracil DNA glycosylase, UNG2,
            and suppresses base excision repair.
REFERENCE   7  (bases 1 to 2911)
  AUTHORS   Harrison,M., Li,J., Degenhardt,Y., Hoey,T. and Powers,S.
  TITLE     Wip1-deficient mice are resistant to common cancer genes
  JOURNAL   Trends Mol Med 10 (8), 359-361 (2004)
   PUBMED   15310454
  REMARK    Review article
REFERENCE   8  (bases 1 to 2911)
  AUTHORS   Bulavin,D.V., Phillips,C., Nannenga,B., Timofeev,O.,
            Donehower,L.A., Anderson,C.W., Appella,E. and Fornace,A.J. Jr.
  TITLE     Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis
            through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf)
            pathway
  JOURNAL   Nat Genet 36 (4), 343-350 (2004)
   PUBMED   14991053
  REMARK    GeneRIF: inactivation or depletion of the Wip1 phosphatase with
            resultant p38 MAPK activation suppresses tumor appearance by
            modulating the Cdkn2a tumor-suppressor locus
REFERENCE   9  (bases 1 to 2911)
  AUTHORS   Choi,J., Nannenga,B., Demidov,O.N., Bulavin,D.V., Cooney,A.,
            Brayton,C., Zhang,Y., Mbawuike,I.N., Bradley,A., Appella,E. and
            Donehower,L.A.
  TITLE     Mice deficient for the wild-type p53-induced phosphatase gene
            (Wip1) exhibit defects in reproductive organs, immune function, and
            cell cycle control
  JOURNAL   Mol Cell Biol 22 (4), 1094-1105 (2002)
   PUBMED   11809801
REFERENCE   10 (bases 1 to 2911)
  AUTHORS   Choi,J., Appella,E. and Donehower,L.A.
  TITLE     The structure and expression of the murine wildtype p53-induced
            phosphatase 1 (Wip1) gene
  JOURNAL   Genomics 64 (3), 298-306 (2000)
   PUBMED   10756097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC051966.1, AK157818.1 and AW488397.1.
            
            On Jul 30, 2009 this sequence version replaced NM_016910.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051966.1, AK157818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-414               BC051966.1         1-414
            415-2888            AK157818.1         403-2876
            2889-2911           AW488397.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..2911
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.34 cM"
     gene            1..2911
                     /gene="Ppm1d"
                     /gene_synonym="Wip1"
                     /note="protein phosphatase 1D magnesium-dependent, delta
                     isoform"
                     /db_xref="GeneID:53892"
                     /db_xref="MGI:MGI:1858214"
     exon            1..670
                     /gene="Ppm1d"
                     /gene_synonym="Wip1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..899
                     /gene="Ppm1d"
                     /gene_synonym="Wip1"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1024
                     /gene="Ppm1d"
                     /gene_synonym="Wip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1215
                     /gene="Ppm1d"
                     /gene_synonym="Wip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1458
                     /gene="Ppm1d"
                     /gene_synonym="Wip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..2894
                     /gene="Ppm1d"
                     /gene_synonym="Wip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2103..2108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1d"
                     /gene_synonym="Wip1"
                     /note="hexamer: AATAAA"
     regulatory      2112..2117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1d"
                     /gene_synonym="Wip1"
                     /note="hexamer: AATACA"
     polyA_site      2123
                     /gene="Ppm1d"
                     /gene_synonym="Wip1"
                     /note="major polyA site"
     polyA_site      2138
                     /gene="Ppm1d"
                     /gene_synonym="Wip1"
                     /note="major polyA site"
     regulatory      2872..2877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1d"
                     /gene_synonym="Wip1"
                     /note="hexamer: AATAAA"
     polyA_site      2889
                     /gene="Ppm1d"
                     /gene_synonym="Wip1"
ORIGIN      
        1 cgcagctgct cggctcctct cgcccgcgac tcgaccggcc cagctctcgc ggacaagtcc
       61 cgacatcacg cgcccccccc caccgccgcg gggaccgcct cctcttcact ctcggcttcg
      121 tcgaagataa acaatagttg gccggcgagc ggcgagtgtg tctcccgcct cggaattcgg
      181 cgggctgcgt gggaacggcg ggatcccggg cagccggcca tggcggggct gtactcgctg
      241 ggagtgagcg tcttctcgga ccagggcggg aggaagtaca tggaggacgt aactcagatc
      301 gtggtggagc ccgagccggc tgcggaggac aagccggcgc cggtaccgcg gcgggcgctc
      361 gggttgccgg cgacccccac tctcgccggc gtcgggccat cggaaaaagg cccggcggcg
      421 gcccgcgacc ctgccccgga cgccgcggcc tcgctacccg ctggccgctg ctgtcgccgc
      481 cgctcttcgg tggccttctt tgcagtgtgc gacgggcacg gcggtcggga ggcggcacag
      541 tttgcccggg agcacttgtg gggtttcatc aagaagcaga aaggcttcac ctcgtccgag
      601 cccgccaagg tgtgcgctgc catccgcaaa ggtttcctcg cctgtcacct cgccatgtgg
      661 aagaaactgg cagaatggcc aaagactatg acaggtcttc ccagcacgtc cgggacaact
      721 gccagtgtgg ttataatacg gggcatgaag atgtatgtag cgcatgtagg tgactctggg
      781 gtggtccttg gaattcagga tgacccaaag gatgattttg tgagagctgt ggaggtgaca
      841 caagatcaca agccagaact tcccaaggaa agagaaagaa tcgaaggact tggcggcagt
      901 gtgatgaaca agtctggagt gaaccgagta gtttggaaaa ggccccggct cactcacagt
      961 ggacctgtca gaaggagcac agtcattgac cagattcctt ttctggctgt agcaagagcg
     1021 cttggtgact tgtggagcta tgatttcttc agtggtaagt ttgtggtgtc acctgaacca
     1081 gacaccagtg tccacactct tgacccccgg aagcacaagt atattatcct gggaagtgat
     1141 ggactttgga atatggttcc acctcaagat gccatctcca tgtgccaaga ccaagaggag
     1201 aaaaaatact tgatgggtga gcaaggacag tcctgtgcca aaatgcttgt gaatcgagca
     1261 cttggccgct ggaggcagcg tatgcttcgg gcagataaca caagtgccat cgtaatctgc
     1321 atctctccag aagtagacaa ccaagggaac ttcaccaatg aagatgagct ctttctgaac
     1381 ctgactgata gccctactta caacagccag gagacctgtg tgatgacttc ttctccaagt
     1441 tctacaccac caatcaagtc accggaagaa gatgcatggc caaggctgag ctctaaggac
     1501 catatacctg cccttgttcg cagtaatgcc ttctcagaga agtttttaga ggtcccagct
     1561 gagatagcta gagggaatat ccagactgta gtgatgacct caaaagactc agagacactt
     1621 gaagaaaatt gccccaaagc cctgacttta aggattcatg attctttgaa taatactctg
     1681 tcagttggcc tcattccaac caattcaaca aatactatca tggaccaaaa aaacttaaag
     1741 atgtcaactc caggtcaaat gaaagctcaa gaagttgaaa gaacccctcc agccaatttt
     1801 aaaaggacat tagaagaatc caactctggc ccccttatga agaagcaccg acgaaatggc
     1861 ttaagtcgaa gtagcggggc ccaggcttcc agtctcccta cagcatccca gcgcaggcac
     1921 tctgtcaaac tgaccctgag gcgcagactc aggggccaga ggaagatggg aaatcctctt
     1981 ctccaccagc accggaaaac agtgtgtgtg tgctgagatg ggcctgggaa gtgggggtct
     2041 ccctacctac gactgagggc tttttaaact tggtgcgaag ttgaactttt ttaaggggat
     2101 aaaataaaga gaatacagtt tgactttttg gaatttaaca gttttatttt ggccttgtac
     2161 ttgcctgtat tataatgtga attttgtaga tgtagggaat aagttgctgt aaaatgtgtg
     2221 taaatttgta tcctttacac aagtttagtc tcttactctg acacatagta attgtgacag
     2281 cagggctaat gttgaagaaa agtcagaaga atctttaaga ttttaaaaat gtctttaaag
     2341 tttttaaaat gcttactaca tacttatata caccccttgt gaagaacaca tgacttttta
     2401 aagaaaatta ctaagcaaac tggaaaagtg aagtattttc atagtgatct gtgctccact
     2461 taatgtttcc cagggaccat tagtgtcttt ttaaaattac attttatttc acatttcata
     2521 attcagaagt aaacctttca taggaaaaat actgagctgt gctaatgtag ctgattttag
     2581 tctccttgtc ccacttacac tatgcagtat ctcctaactt cagtgcactc tgctagaaca
     2641 gtacatttgc tgtatttact gaaatctctg gcacagaagg aagtgtgttt gcctcacaca
     2701 ccatttgtcc cagaccagtg gcattaggcc atatattctc ttctagtgtt tgcttaaaat
     2761 atgtgaagtt tttcttgcta tttcaataac aaatggtgct gctaacaccc aacatttcct
     2821 aaattatttt ctatcataca gttttcattg gttatatgag tatgtctacc caataaatca
     2881 ctgaatttat gttgaaaaaa aaaaaaaaaa a
//
