LOCUS       NM_008910               2789 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protein phosphatase 1A, magnesium dependent, alpha
            isoform (Ppm1a), mRNA.
ACCESSION   NM_008910
VERSION     NM_008910.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2789)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2789)
  AUTHORS   Ge,Q., Shi,Z., Zou,K.A., Ying,J., Chen,J., Yuan,W., Wang,W.,
            Xiao,L., Lin,X., Chen,D., Feng,X.H., Wang,P.E., Tong,P. and Jin,H.
  TITLE     Protein phosphatase PPM1A inhibition attenuates osteoarthritis via
            regulating TGF-beta/Smad2 signaling in chondrocytes
  JOURNAL   JCI Insight 8 (3), e166688 (2023)
   PUBMED   36752205
  REMARK    GeneRIF: Protein phosphatase PPM1A inhibition attenuates
            osteoarthritis via regulating TGF-beta/Smad2 signaling in
            chondrocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2789)
  AUTHORS   Zhou,R., Wu,Q., Wang,M., Irani,S., Li,X., Zhang,Q., Meng,F.,
            Liu,S., Zhang,F., Wu,L., Lin,X., Wang,X., Zou,J., Song,H., Qin,J.,
            Liang,T., Feng,X.H., Zhang,Y.J. and Xu,P.
  TITLE     The protein phosphatase PPM1A dephosphorylates and activates YAP to
            govern mammalian intestinal and liver regeneration
  JOURNAL   PLoS Biol 19 (2), e3001122 (2021)
   PUBMED   33630828
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2789)
  AUTHORS   Lee,B., Song,Y.S., Rhodes,C., Goh,T.S., Roh,J.S., Jeong,H.,
            Park,J., Lee,H.N., Lee,S.G., Kim,S., Kim,M., Lee,S.I., Sohn,D.H.
            and Robinson,W.H.
  TITLE     Protein phosphatase magnesium-dependent 1A induces inflammation in
            rheumatoid arthritis
  JOURNAL   Biochem Biophys Res Commun 522 (3), 731-735 (2020)
   PUBMED   31791585
  REMARK    GeneRIF: Protein phosphatase magnesium-dependent 1A induces
            inflammation in rheumatoid arthritis.
REFERENCE   5  (bases 1 to 2789)
  AUTHORS   Khim,K.W., Choi,S.S., Jang,H.J., Lee,Y.H., Lee,E., Hyun,J.M.,
            Eom,H.J., Yoon,S., Choi,J.W., Park,T.E., Nam,D. and Choi,J.H.
  TITLE     PPM1A Controls Diabetic Gene Programming through Directly
            Dephosphorylating PPARgamma at Ser273
  JOURNAL   Cells 9 (2), 343 (2020)
   PUBMED   32024237
  REMARK    GeneRIF: PPM1A Controls Diabetic Gene Programming through Directly
            Dephosphorylating PPARgamma at Ser273.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2789)
  AUTHORS   Komaki,K., Katsura,K., Ohnishi,M., Guang Li,M., Sasaki,M.,
            Watanabe,M., Kobayashi,T. and Tamura,S.
  TITLE     Molecular cloning of PP2Ceta, a novel member of the protein
            phosphatase 2C family
  JOURNAL   Biochim Biophys Acta 1630 (2-3), 130-137 (2003)
   PUBMED   14654243
REFERENCE   7  (bases 1 to 2789)
  AUTHORS   Lauren,J., Airaksinen,M.S., Saarma,M. and Timmusk,T.
  TITLE     Two novel mammalian Nogo receptor homologs differentially expressed
            in the central and peripheral nervous systems
  JOURNAL   Mol Cell Neurosci 24 (3), 581-594 (2003)
   PUBMED   14664809
REFERENCE   8  (bases 1 to 2789)
  AUTHORS   Weston,W.M., Freeman,A.B., Haberecht,C., Hackmiller,R.C., Ma,L.,
            Nugent,P., Warr,E., Pisano,M.M. and Greene,R.M.
  TITLE     Phosphatase regulation of gene expression during development of the
            palate
  JOURNAL   Life Sci 71 (16), 1849-1862 (2002)
   PUBMED   12175701
REFERENCE   9  (bases 1 to 2789)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 2789)
  AUTHORS   Kato,S., Kobayashi,T., Terasawa,T., Ohnishi,M., Sasahara,Y.,
            Kanamaru,R. and Tamura,S.
  TITLE     The cDNA sequence encoding mouse Mg2+ -dependent protein
            phosphatase alpha
  JOURNAL   Gene 145 (2), 311-312 (1994)
   PUBMED   8056349
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY739448.1, AK076054.1, D28117.1, BE861326.1, AV307012.2 and
            BM932496.1.
            
            On Aug 11, 2009 this sequence version replaced NM_008910.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008595.1, SRR7652917.131269.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               BY739448.1         2-105
            105-324             AK076054.1         2-221
            325-1711            D28117.1           1-1387
            1712-2296           BE861326.1         1-585               c
            2297-2783           AV307012.2         184-670
            2784-2789           BM932496.1         473-478
FEATURES             Location/Qualifiers
     source          1..2789
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 30.26 cM"
     gene            1..2789
                     /gene="Ppm1a"
                     /gene_synonym="2310003C21Rik; 2900017D14Rik; MMPa-2;
                     MPPa-1"
                     /note="protein phosphatase 1A, magnesium dependent, alpha
                     isoform"
                     /db_xref="GeneID:19042"
                     /db_xref="MGI:MGI:99878"
     exon            1..421
                     /gene="Ppm1a"
                     /gene_synonym="2310003C21Rik; 2900017D14Rik; MMPa-2;
                     MPPa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..1275
                     /gene="Ppm1a"
                     /gene_synonym="2310003C21Rik; 2900017D14Rik; MMPa-2;
                     MPPa-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..1590
                     /gene="Ppm1a"
                     /gene_synonym="2310003C21Rik; 2900017D14Rik; MMPa-2;
                     MPPa-1"
                     /EC_number="3.1.3.16"
                     /note="PP2C-alpha; protein phosphatase IA; Mpp alpha"
                     /codon_start=1
                     /product="protein phosphatase 1A"
                     /protein_id="NP_032936.1"
                     /db_xref="CCDS:CCDS25970.1"
                     /db_xref="GeneID:19042"
                     /db_xref="MGI:MGI:99878"
                     /translation="MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVI
                     GLPSGLETWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFRGSAGAPSVENVKNGIR
                     TGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFF
                     TQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPE
                     PEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCL
                     YKGSRDNMSVILICFPSAPKVSAEAVKKEAELDKYLESRVEEIIKKQVEGVPDLVHVM
                     RTLASENIPSLPPGGELASKRNVIEAVYNRLNPYKNDDTDSASTDDMW"
     exon            1276..1393
                     /gene="Ppm1a"
                     /gene_synonym="2310003C21Rik; 2900017D14Rik; MMPa-2;
                     MPPa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1502
                     /gene="Ppm1a"
                     /gene_synonym="2310003C21Rik; 2900017D14Rik; MMPa-2;
                     MPPa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1560
                     /gene="Ppm1a"
                     /gene_synonym="2310003C21Rik; 2900017D14Rik; MMPa-2;
                     MPPa-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..2789
                     /gene="Ppm1a"
                     /gene_synonym="2310003C21Rik; 2900017D14Rik; MMPa-2;
                     MPPa-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2386..2391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1a"
                     /gene_synonym="2310003C21Rik; 2900017D14Rik; MMPa-2;
                     MPPa-1"
                     /note="hexamer: AATAAA"
     polyA_site      2409
                     /gene="Ppm1a"
                     /gene_synonym="2310003C21Rik; 2900017D14Rik; MMPa-2;
                     MPPa-1"
                     /note="major polyA site"
     regulatory      2635..2640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1a"
                     /gene_synonym="2310003C21Rik; 2900017D14Rik; MMPa-2;
                     MPPa-1"
                     /note="hexamer: ATTAAA"
     polyA_site      2667
                     /gene="Ppm1a"
                     /gene_synonym="2310003C21Rik; 2900017D14Rik; MMPa-2;
                     MPPa-1"
     regulatory      2769..2774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppm1a"
                     /gene_synonym="2310003C21Rik; 2900017D14Rik; MMPa-2;
                     MPPa-1"
                     /note="hexamer: AATAAA"
     polyA_site      2789
                     /gene="Ppm1a"
                     /gene_synonym="2310003C21Rik; 2900017D14Rik; MMPa-2;
                     MPPa-1"
ORIGIN      
        1 gggcgagggg cagcggtgtc gagagcgcgc gtgcgcgggg ccgcgctaga ggcggcggcg
       61 gtggcggcgc taggggcggg agcgcgcgca ggagctagaa cgccgtggtc tccgcgccgg
      121 ccgggtccgc agctcgggat cgggtggctg gggcgggggg aggggggccc aggcaggtgg
      181 ggcggaaagc gatgagtcct cggcgcctcc tccgcctccc gcgggccccg ctctctgcct
      241 cccgctccga cgcccggatg atctgagccg cgagggctcc gagagccggg ggcccggacc
      301 cagcccggct cctcccctcc tccgcccggg cccggccgcc gtcgcgggac cccgtgcccg
      361 gccgccgtcg ccaccgccgc cccggccgac cgagggaccc gcccgcccgc ggctgctccg
      421 gacctagagg atcaagtcat aatgggagca tttttagaca agccaaagat ggagaagcat
      481 aatgcccagg ggcaggggaa tgggttacga tacggcctaa gcagcatgca aggttggcga
      541 gttgaaatgg aggacgcaca cacggctgtg atcggtttgc caagtggact tgagacatgg
      601 tcattctttg ctgtatatga tgggcatgct ggttctcagg ttgccaaata ctgctgtgag
      661 cacttgttag atcacatcac caataaccag gatttcagag gatctgcagg agcaccttct
      721 gtggagaacg taaagaatgg aatcagaaca gggtttctgg agattgatga acacatgaga
      781 gttatgtcag agaagaaaca tggtgcagat agaagcgggt caacagctgt gggcgtctta
      841 atctctcccc aacatactta tttcattaac tgtggagact cgagaggttt actttgtagg
      901 aatagaaaag ttcacttctt cacacaagac cataaaccaa gtaacccgct ggaaaaagaa
      961 cgaattcaga atgcaggggg ctcggtgatg attcagcgtg tcaatggctc tctggctgta
     1021 tcgagggccc ttggggattt cgattacaaa tgtgtccatg gaaaaggtcc cacagagcag
     1081 cttgtctccc cagagcccga agtccatgat attgaaaggt ctgaagaaga tgaccagttc
     1141 atcatccttg catgcgatgg catctgggac gtcatgggga acgaagagct ctgtgacttt
     1201 gtgagatcca gacttgaagt cactgatgac cttgagaaag tttgcaatga agtagtcgac
     1261 acctgcttgt ataagggaag tcgagacaac atgagtgtga ttttgatctg ttttccaagt
     1321 gcacccaaag tctcggcaga ggcggtgaag aaggaggcgg agctggacaa gtacctggag
     1381 agcagagtag aagaaatcat aaagaagcag gtggaaggcg tccctgactt agtccacgtg
     1441 atgcgcacgt tagccagtga gaacatcccc agcctcccac cagggggtga attggcaagc
     1501 aagcggaatg taattgaagc cgtttacaat agactgaacc cttacaaaaa tgacgacact
     1561 gattctgcgt caaccgatga tatgtggtaa agccgctcac ccagccgtgg actcaccttc
     1621 gcctgcaaag gggaagccag ctcatccttg ccgagccttt accatccatc accgacttca
     1681 caggagggtc tgacacgggt gaggactgca gcttcagcga tggaacagct agcccagaat
     1741 ggattttctt tttttattgt aaatttgaga cttatgtaag cgtgatttca aaccgtaatt
     1801 catgttgtaa atcagactcc agcaattttt gttgtatgat tttggttttt gtaaagtgta
     1861 attgtccttg tacaaagtgc tcatatttaa ttatgaactg ctttaaaatc actatcagtg
     1921 aatgataaag gaaatttggc ttgttgtgtg acacaacaga catagtcatg ctgtgtctgg
     1981 actcggttgg gatagggaaa gcggcagcca catagctgca tgctacgtgc acacgattag
     2041 gaagaattcc aaaagcttac acagctgtca cccaggctca tggaaactgt ctctgttccg
     2101 gcgaggactg gctcactgat acagccatcg ctctcacctg tctctaggat gtcctctcct
     2161 cgtagccaag atattgcagc tgatcctgta tattcatgag agtatctatc aattttgggc
     2221 taacatgcct tgattctctt gcacctcttt atgagttctt acatttaatt actaattggt
     2281 aagcagcagc ttcctacaca gtaggagact gccacatttt tttcctatca tgactggctg
     2341 ggcctgctgc tgttcctagt aagatattcc gaattccatt ttatcaataa agcttggttt
     2401 aacaaacaag acatgtaatc atgtatgcgt gattcctcgg tcaccccggc ttcagacccc
     2461 actcggggag agaaagatgt catgtttcct taaactggat gatggtgtta gcatccaggt
     2521 gcaggtggat cggaagattg acgtctgctg tctcctaatc tgttttaatt gcgtttcttc
     2581 caggctgctt acttctcatt aagatgtgtg tcagcttgac tttacctact gttaattaaa
     2641 gtaattgtca aagtttgaca accctaaccc tgtgatagat gtgtgtgtgt tgaatgtgtg
     2701 tttgcctgta acttttaatt gacccacgtc tttagaatct aagaggttaa gatacatttg
     2761 tgatttgaaa taaaagcatg ttgataata
//
