LOCUS       NM_008909               6277 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus periplakin (Ppl), mRNA.
ACCESSION   NM_008909 XM_358905
VERSION     NM_008909.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6277)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6277)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   3  (bases 1 to 6277)
  AUTHORS   Cottle,D.L., Ursino,G.M.A., Jones,L.K., Tham,M.S., Zylberberg,A.K.
            and Smyth,I.M.
  TITLE     Topical Aminosalicylic Acid Improves Keratinocyte Differentiation
            in an Inducible Mouse Model of Harlequin Ichthyosis
  JOURNAL   Cell Rep Med 1 (8), 100129 (2020)
   PUBMED   33294854
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6277)
  AUTHORS   Besnard,V., Dagher,R., Madjer,T., Joannes,A., Jaillet,M., Kolb,M.,
            Bonniaud,P., Murray,L.A., Sleeman,M.A. and Crestani,B.
  TITLE     Identification of periplakin as a major regulator of lung injury
            and repair in mice
  JOURNAL   JCI Insight 3 (5), 90163 (2018)
   PUBMED   29515024
  REMARK    GeneRIF: Study in a mouse model of lung fibrosis induced by
            bleomycin found that Ppl expression was downregulated in the whole
            lung and in alveolar epithelial cells (AECs) after
            bleomycin-induced injury. Deletion of Ppl reduced lung fibrosis
            after bleomycin injury by promoting antiinflammatory cytokine
            expression and profoundly altering cellular signaling in AECs,
            including STAT3 activation, and TGF-beta/smad pathway activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6277)
  AUTHORS   Natsuga,K. and Watt,F.M.
  TITLE     Galectin-6 is a novel skin anti-microbial peptide that is modulated
            by the skin barrier and microbiome
  JOURNAL   J Dermatol Sci 84 (1), 97-99 (2016)
   PUBMED   27427436
REFERENCE   6  (bases 1 to 6277)
  AUTHORS   Nakashima,H., Grahovac,M.J., Mazzarella,R., Fujiwara,H.,
            Kitchen,J.R., Threat,T.A. and Ko,M.S.
  TITLE     Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome
            17, and Nubp1, mapped to chromosome 16--establish a new gene family
            of nucleotide-binding proteins in eukaryotes
  JOURNAL   Genomics 60 (2), 152-160 (1999)
   PUBMED   10486206
REFERENCE   7  (bases 1 to 6277)
  AUTHORS   Yang,A., Kaghad,M., Wang,Y., Gillett,E., Fleming,M.D., Dotsch,V.,
            Andrews,N.C., Caput,D. and McKeon,F.
  TITLE     p63, a p53 homolog at 3q27-29, encodes multiple products with
            transactivating, death-inducing, and dominant-negative activities
  JOURNAL   Mol Cell 2 (3), 305-316 (1998)
   PUBMED   9774969
REFERENCE   8  (bases 1 to 6277)
  AUTHORS   Ruhrberg,C., Williamson,J.A., Maatta,A. and Watt,F.M.
  TITLE     The periplakin gene maps to 16p13.3 in human and 16A-B1 in mouse
  JOURNAL   Genomics 49 (1), 157-159 (1998)
   PUBMED   9570964
REFERENCE   9  (bases 1 to 6277)
  AUTHORS   Aho,S., McLean,W.H., Li,K. and Uitto,J.
  TITLE     cDNA cloning, mRNA expression, and chromosomal mapping of human and
            mouse periplakin genes
  JOURNAL   Genomics 48 (2), 242-247 (1998)
   PUBMED   9521878
REFERENCE   10 (bases 1 to 6277)
  AUTHORS   Ruhrberg,C., Hajibagheri,M.A., Parry,D.A. and Watt,F.M.
  TITLE     Periplakin, a novel component of cornified envelopes and desmosomes
            that belongs to the plakin family and forms complexes with
            envoplakin
  JOURNAL   J Cell Biol 139 (7), 1835-1849 (1997)
   PUBMED   9412476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ056283.1, AK142562.1, AF126834.1, AC163723.3 and AW553870.2.
            
            On Aug 17, 2006 this sequence version replaced NM_008909.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF126834.1, SRR10223969.16495.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CJ056283.1         1-5
            6-927               AK142562.1         1-922
            928-2081            AF126834.1         868-2021
            2082-2082           AC163723.3         147474-147474       c
            2083-2149           AF126834.1         2023-2089
            2150-2152           AC163723.3         146579-146581       c
            2153-4167           AF126834.1         2093-4107
            4168-4168           AC163723.3         138211-138211       c
            4169-5716           AF126834.1         4112-5659
            5717-6069           AC163723.3         136310-136662       c
            6070-6277           AW553870.2         1-208               c
FEATURES             Location/Qualifiers
     source          1..6277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.5 cM"
     gene            1..6277
                     /gene="Ppl"
                     /note="periplakin"
                     /db_xref="GeneID:19041"
                     /db_xref="MGI:MGI:1194898"
     exon            1..200
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..5403
                     /gene="Ppl"
                     /note="195kDa protein"
                     /codon_start=1
                     /product="periplakin"
                     /protein_id="NP_032935.2"
                     /db_xref="CCDS:CCDS27932.1"
                     /db_xref="GeneID:19041"
                     /db_xref="MGI:MGI:1194898"
                     /translation="MHSLFRKRNKGKYSPTVQTRSISNKELSDLIEQLQKNADQVERN
                     IVDTEAKMQSDLARMQEGQLPEHRDAALQNVSDSEKLLYVLEADSAIAKHMKHPQGDM
                     IAEDIRQLKERVTNLRGKHKQMYSLAVKEADPRVNWDTLVDEKLDKLSSQSFGTDLPL
                     VDSQVEQHNIFHNEVKAIGPHLAKDKEQNSELQAKYQKLLTASQARQQHLSSLQDYMQ
                     RCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHTEGD
                     QLLTAEHPGRNSIEAHMEAVHAEWKEYLNLLICEESHLKYMEDYHQFHKDMKDAQELL
                     RKVDSDLNQKYSPDFKDRYQIELLLRELDDQEKALDKYEDVVRGLQRRGQQVVPLKYR
                     RETPLKPIPVEALCDFESDQGLISRGYSYTLQKNNGESWELTDSTGKKLAAPAVCFII
                     PPTDPEALALADSLGSQYRSVRQKATGSKHALQQRHEVLRTENPGDASDLQGRQLLAG
                     LDKVASDLDRQEKAITGILRPPLEQGRAIEDSAERAKGLKNITNELLQIEPEKTQCTA
                     ECEAFVQALPASGTAPLLKTRVEDTNQKYERLVWLLEAAQEKVDVANRLENSLQRGRE
                     LLASYENRLIQDDTMPESGHVLDSKRQELEAMASELQAHKSLLGEVEQNLQVAKQCSS
                     SLASRFQEHCPDLERQEAEVHKLNQRFNNLSQQVERRAQSLQSARAAYDEYCSGYNRV
                     LQFLAKTPSYEPQETDSLGQMETKLKNQKNLLDELASREQEVQKVYADSQQYQQAVKD
                     YELEAEKLRSLLDLENGRNSHVNKRARLQSPAAKVKEEEAALAAKFTEVNAINRQRLQ
                     NLEFALNLLRQQPEAGVTHETLQGGKLSSGMEETWKIKKELEEEIERRQQLENEVKSA
                     QEEIQTLKDQGPQESLVRKEVLKKVPDPALEESFQQLQQTLAEEQHKNQLLQEELGAL
                     QLRLQALEQETRDGGQEYVVKEVLRIEPDRAQEDEVLQLREELEALRRQKGAREAEVL
                     LLQQRVAALAAEKSRVQEKVTEREVVKLQNDPQLEAEYRRLQEEHQREGTLREKQEEE
                     LSFLQAKLRRLEKERAMAEGKITVKEVLKVEKDAAVEREVNDLTRQYEDEAAKARSGQ
                     REKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKFRGAE
                     EQLKSYQSELEALRNRGPQVEVKEVTKEVIKYTTDPETEQELQRLREEIMDKTRLIER
                     CDLEIYQLKQEIQALKDTKPQVQTREVVQEILQFQEDPQTKKEVESLRIQLSEEQKKQ
                     VDLEGERASQEEKIKRKEEELAQGKERVVRQEVVQYEDEPDLRAEVTAFTNSIDAELR
                     QIDKLHVELRRLQHRRAELERQLEELERERQARRAAELEVQRLQQRLAALEQEEAKTG
                     EKVTHTQKVVLQQDPQQTREHALLRAQLEEERHRRQLLEGELEPLRRKLAALEKAEIK
                     EKVVFSESVQVEKGDTEQEIQRLKKSLEEESQSKRELDSEVTRLEAKLSELEFYNSKS
                     SKELDFLREENHKLQLERQNLQLETRRLQSEIEMAATETRDLKNITTIDSGTHLNSRL
                     WSLEKELDDLKKMSKDKDLEIDELQRRLGSVAVKREQRENHLRRSIVVIDPDTGRELS
                     PEEAHRAGLIDWKMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEDALQSG
                     RLTAAQYDRYVNKDMSIQELAVLVSGQK"
     exon            201..300
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            301..455
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            456..576
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            577..696
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            697..738
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            739..900
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1008
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1104
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1227
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1374
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1526
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1624
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1782
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1961
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2100
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2294
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2445
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2529
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2646
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2739
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..6277
                     /gene="Ppl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6093..6098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppl"
                     /note="hexamer: AATAAA"
     polyA_site      6119
                     /gene="Ppl"
                     /note="major polyA site"
     regulatory      6232..6237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppl"
                     /note="hexamer: AATAAA"
     regulatory      6246..6251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppl"
                     /note="hexamer: AATAAA"
     polyA_site      6252
                     /gene="Ppl"
     polyA_site      6269
                     /gene="Ppl"
ORIGIN      
        1 tccgcacacg gggctctgcg cgccgctgcc gctgccgcct ccgcctccgc cgccttcttt
       61 cacctgcgcc cgccgcccgc tttcggtgcg cgccgggtcc gtcgccgcgt tccaggtccc
      121 tctgtcccaa gcgccaccat gcactcgctc ttcaggaaga gaaacaaagg caaatacagc
      181 ccaacggtgc agacgcggag catctccaac aaggaactct cagatctgat tgagcagctg
      241 cagaagaatg cagaccaggt ggaaaggaac attgtggaca ccgaggccaa gatgcagagc
      301 gacttggccc ggatgcaaga ggggcagctc cctgagcacc gggacgcggc cctgcagaac
      361 gtgtctgact cagaaaagct gctgtacgtg ctggaggcag attcggccat cgccaagcac
      421 atgaagcacc cacaggggga catgatcgcc gaggacatcc gccagctgaa agagcgcgtg
      481 accaacctgc gggggaaaca caagcagatg tacagcctgg cagtgaaaga ggccgacccg
      541 agagtcaact gggacacact ggtggacgag aagctggaca agctgagcag ccagagcttt
      601 gggactgacc ttcctctggt ggatagccag gtggagcaac acaacatctt ccacaatgaa
      661 gtcaaagcca tcgggcccca cctggccaag gacaaggagc agaacagtga actccaagcc
      721 aagtatcaga agttgctgac agcatcacag gcacggcagc agcacctgag ctcgctgcag
      781 gattacatgc agcgctgcac caatgagctg tactggctgg accagcaagc caagggccgc
      841 atgcagtatg actggagcga ccgcaacctc gactacccca gccgccgccg ccagtacgag
      901 aatttcatca accggaacct ggaggccaaa gaagaaagaa tcaacaaact gcacactgaa
      961 ggtgaccaac tgctgacagc tgagcaccca gggaggaact ccattgaggc acacatggag
     1021 gctgtgcatg ctgagtggaa ggagtacctg aacctgctca tctgtgagga gagccatctg
     1081 aaatacatgg aagactacca ccaatttcac aaagacatga aggatgctca ggagctgcta
     1141 cgcaaggtgg actcagactt gaaccagaaa tatagccctg acttcaaaga ccggtatcag
     1201 atagagctgt tgcttcggga actggatgac caggagaagg ctctggacaa gtatgaggat
     1261 gtggtgcgag ggctgcagag gcgagggcag caagtggtgc cactcaagta ccgccgcgag
     1321 acgccgctca agcccatccc tgtggaggct ctctgtgact ttgagagtga ccagggcctc
     1381 atctcgcggg gctatagcta cacactgcag aagaacaacg gggagagctg ggagctgaca
     1441 gacagcactg ggaagaagct ggctgcccca gccgtctgct tcatcattcc ccccaccgac
     1501 cccgaggcct tggctcttgc tgacagcctg ggcagccagt accgaagtgt gaggcagaag
     1561 gcgactggga gcaaacatgc actccagcag cggcatgagg tgctaaggac ggagaaccct
     1621 ggagatgcct ctgatcttca gggacgacag ctgctggctg gcttggacaa agtggccagt
     1681 gacctggacc ggcaggaaaa ggctatcaca gggatcctac ggccaccact tgagcaggga
     1741 cgggcaattg aggatagtgc ggagcgggcc aagggtctca agaacattac caatgagctg
     1801 ctacagattg agccagagaa gacgcagtgc acagccgagt gtgaagcctt tgtgcaggcc
     1861 ctcccggcca gcggcaccgc acccttgctg aagacccggg tagaagacac caaccagaaa
     1921 tatgagcgac tagtatggtt gctagaggca gcccaggaga aggtggacgt ggccaaccgc
     1981 ctggagaaca gtctgcagcg gggcagggag ctgctggcct catacgagaa caggctgatt
     2041 caggacgaca caatgcctga aagtggtcat gtgttggaca gcaagaggca ggagctggag
     2101 gccatggctt ctgagctgca ggcccacaag tccctcctgg gtgaggtgga acagaaccta
     2161 caggtggcca agcagtgttc cagctcactg gccagccgct tccaagagca ctgccctgac
     2221 ctggagcggc aggaggccga ggtgcacaag ctcaaccaac gtttcaacaa cctcagccag
     2281 caggtggaac ggagggccca gagcctgcag agtgccaggg ctgcctacga tgaatactgc
     2341 agtggttaca accgtgtgct ccagtttttg gccaagactc ccagttatga gccccaggag
     2401 acagacagcc tcggccagat ggagaccaag ctcaagaacc agaagaactt gcttgatgag
     2461 ctagcaagca gggaacagga ggtgcagaag gtctatgcag attcccagca gtaccagcaa
     2521 gcggtgaagg actatgaact tgaagcagag aagctaaggt ccttgctgga cctggagaat
     2581 ggacggaaca gccatgtgaa caagagagcc aggctgcagt ctcctgctgc caaagtgaag
     2641 gaagaggaag ctgctcttgc tgccaagttc acagaggtta atgccatcaa cagacagagg
     2701 ctacagaatt tggagtttgc actgaatctc ttgagacagc aaccagaagc aggagtgacc
     2761 catgagaccc tacaaggggg aaagctaagc tctggcatgg aggaaacatg gaagattaag
     2821 aaggaactgg aggaggagat agagcgaagg caacagctgg aaaatgaggt caagagtgcc
     2881 caggaggaaa tccagaccct gaaggatcag gggcctcagg agtcattggt gaggaaggag
     2941 gtgctgaaga aggtgccaga ccctgccctg gaggagagct tccagcagct gcagcagacg
     3001 ctggctgagg aacagcacaa gaaccagcta ttgcaggagg agctgggagc actgcagctc
     3061 cggctgcagg ctctagagca ggagaccagg gatgggggac aggagtatgt ggtcaaggag
     3121 gtcttgcgca ttgagccaga cagagcccag gaggatgagg tcttgcagct tcgggaggag
     3181 ctggaggcac tgcggcgcca gaaaggcgcc cgagaggctg aagtgctact cttacagcag
     3241 cgtgtagcag ccctggctgc tgagaagagc agggtgcagg aaaaggtcac tgagagagag
     3301 gtggtaaagc tacagaatga cccccaactg gaggcagaat accggaggct gcaggaggag
     3361 caccagcggg agggcacact cagggagaag caggaggagg agctgagttt cctacaggct
     3421 aagctcagga gactggagaa agaacgagcc atggcagaag gcaagatcac tgtcaaagag
     3481 gtgctcaagg tagagaaaga tgcagctgtg gagagagaag tcaatgacct cacccgccag
     3541 tatgaggacg aggctgccaa ggcacgctct ggccagcggg agaagacaga acttctcaga
     3601 aagatatggg ccctggaaga ggaaaatgct aaggtggtgg tacaggagaa ggtccgagag
     3661 atcgtgcggc cagatcccaa ggcagagagt gaagtggcca acctccgcct ggagctggtg
     3721 gagcaggagc gcaaattcag gggtgctgag gagcagctga agagctacca gagtgagctg
     3781 gaggccctac ggaaccgtgg accacaggta gaagtcaaag aggtgaccaa agaggtcatt
     3841 aaatatacaa ctgacccaga gacagagcag gaactccaga ggctcaggga ggagatcatg
     3901 gacaagacca ggttaataga aaggtgtgac ctagagattt accagctgaa gcaggagatc
     3961 caggccctta aggacaccaa gccacaggtg cagactagag aggtagtcca ggagatcctg
     4021 cagttccagg aagaccccca aaccaagaag gaggtagagt ctctgcgtat acagctgtca
     4081 gaagaacaga agaaacaggt ggacctggaa ggggagcggg catcccagga agagaagatc
     4141 aaacgcaagg aggaagagct ggcacagggg aaggaaaggg ttgtacgcca ggaggtagta
     4201 cagtatgaag atgagccaga tttgcgagct gaggtgactg ccttcacaaa cagcattgat
     4261 gctgagctgc ggcagattga taaactgcat gtggagctac ggcggttaca gcatcgccga
     4321 gcagagctgg agaggcagtt ggaggagctg gagcgggaga ggcaggcacg tagggcagcc
     4381 gagctggagg tacagaggct gcaacagcgg ctggctgcat tggagcagga ggaggccaag
     4441 actggtgaga aggtgaccca cacacaaaag gtggtgctgc agcaggaccc acagcagacc
     4501 agggagcatg ccctgctccg agcccagctg gaggaagagc ggcaccggag gcagctactg
     4561 gagggtgagc ttgagccgct gcgtagaaag ttggctgccc tggagaaggc agagatcaaa
     4621 gaaaaggtgg tcttctctga gagtgtccag gtagaaaaag gtgacactga gcaagagatc
     4681 cagcgcctca agaagagcct ggaagaggag agccagagca agagggagct ggattcagag
     4741 gtgacccggc tagaagccaa gttatctgag ctagaattct ataattccaa gtcatccaag
     4801 gaactggact tcctgagaga agaaaaccac aagctacagc tagagcggca aaacctgcag
     4861 ctagagaccc ggagactcca atcagagatt gagatggcag caacagaaac tcgagatctg
     4921 aagaacataa ccacgataga ctctgggacc cacctaaact ctaggctgtg gtccctagag
     4981 aaggaactgg atgacctcaa gaagatgtcc aaggacaagg atctggagat cgatgaacta
     5041 cagaggcgcc tgggctctgt ggctgtcaag agagagcaga gggagaacca cctgaggcgc
     5101 tccatagtgg tcatagaccc tgacacaggt cgtgagctgt ccccagagga ggctcaccgg
     5161 gctgggctta tcgactggaa aatgtttgtg aagctcagaa gccaggagtg cgactgggag
     5221 gagatatcag tgaaaggtcc taatggggag tcatcagtaa ttcatgacag gaagtcaggc
     5281 aagaagttct ccattgagga cgctcttcag agtggcaggc taaccgctgc tcaatatgac
     5341 cgctatgtca acaaggatat gtccattcag gagctggcag tcttggtgtc tgggcagaag
     5401 taggcccagc ccttcttcct ggcttttctt ggagctggat tatcttaaag atggagatgg
     5461 ttaactcatt ctcagcaact tcctgggtgt cttctgctcc cgagccttca tatagacttc
     5521 tgagctaagt gttttatcca cattgtatca ggctgcttac agtgcagcta ctgtaatacc
     5581 agcagacact agctgggtag catctctcag ctcagcctca tccagtctga gtgagtgacc
     5641 tgctcccacc tctgatgact taataacctt tctgcctctt tcaactcaac aagactggtc
     5701 cactggggct gctgaccttc cttcttgcca ttccattttt ctgactggga tcaaactatc
     5761 aacagtgcct gctcagtagt gacttttctc attgaacagg gctctacact agaacatgtg
     5821 tccagaatcc acaatgcctg gctcttggtg ctagaataac tagccaggat gtgccagaaa
     5881 gacaggcacc aacaacagtt tgctagttct gaaaagatct tagtaatgga tggtgtgcta
     5941 gccttacttt cagtgcctta gaagtcttca tcattatcgc attggcattt agatatacaa
     6001 aagttgattg ttcaccaaac aaatttctgc ttctctgtat ttcatgtatt atgtaagaaa
     6061 atgggaagtg atagggaact ttatggcatg aaaataaaaa tctggtggct tgactctaac
     6121 tcacagcaag tatgactcct ttacatatga gcctgaacct tggctctcag ccacaatggg
     6181 cgggcattcc atgaacacca gggctcctat gtactgaaga ataataaaat aaataaaata
     6241 ttgcaaataa aatagtaatg aaaaaatgag gaaagac
//
