LOCUS       NP_032935               1754 aa            linear   ROD 28-APR-2025
DEFINITION  periplakin [Mus musculus].
ACCESSION   NP_032935 XP_358905
VERSION     NP_032935.2
DBSOURCE    REFSEQ: accession NM_008909.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1754)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1754)
  AUTHORS   Ye,Q., Bhojwani,A. and Hu,J.K.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   3  (residues 1 to 1754)
  AUTHORS   Cottle,D.L., Ursino,G.M.A., Jones,L.K., Tham,M.S., Zylberberg,A.K.
            and Smyth,I.M.
  TITLE     Topical Aminosalicylic Acid Improves Keratinocyte Differentiation
            in an Inducible Mouse Model of Harlequin Ichthyosis
  JOURNAL   Cell Rep Med 1 (8), 100129 (2020)
   PUBMED   33294854
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1754)
  AUTHORS   Besnard,V., Dagher,R., Madjer,T., Joannes,A., Jaillet,M., Kolb,M.,
            Bonniaud,P., Murray,L.A., Sleeman,M.A. and Crestani,B.
  TITLE     Identification of periplakin as a major regulator of lung injury
            and repair in mice
  JOURNAL   JCI Insight 3 (5), 90163 (2018)
   PUBMED   29515024
  REMARK    GeneRIF: Study in a mouse model of lung fibrosis induced by
            bleomycin found that Ppl expression was downregulated in the whole
            lung and in alveolar epithelial cells (AECs) after
            bleomycin-induced injury. Deletion of Ppl reduced lung fibrosis
            after bleomycin injury by promoting antiinflammatory cytokine
            expression and profoundly altering cellular signaling in AECs,
            including STAT3 activation, and TGF-beta/smad pathway activation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1754)
  AUTHORS   Natsuga,K. and Watt,F.M.
  TITLE     Galectin-6 is a novel skin anti-microbial peptide that is modulated
            by the skin barrier and microbiome
  JOURNAL   J Dermatol Sci 84 (1), 97-99 (2016)
   PUBMED   27427436
REFERENCE   6  (residues 1 to 1754)
  AUTHORS   Nakashima,H., Grahovac,M.J., Mazzarella,R., Fujiwara,H.,
            Kitchen,J.R., Threat,T.A. and Ko,M.S.
  TITLE     Two novel mouse genes--Nubp2, mapped to the t-complex on chromosome
            17, and Nubp1, mapped to chromosome 16--establish a new gene family
            of nucleotide-binding proteins in eukaryotes
  JOURNAL   Genomics 60 (2), 152-160 (1999)
   PUBMED   10486206
REFERENCE   7  (residues 1 to 1754)
  AUTHORS   Yang,A., Kaghad,M., Wang,Y., Gillett,E., Fleming,M.D., Dotsch,V.,
            Andrews,N.C., Caput,D. and McKeon,F.
  TITLE     p63, a p53 homolog at 3q27-29, encodes multiple products with
            transactivating, death-inducing, and dominant-negative activities
  JOURNAL   Mol Cell 2 (3), 305-316 (1998)
   PUBMED   9774969
REFERENCE   8  (residues 1 to 1754)
  AUTHORS   Ruhrberg,C., Williamson,J.A., Maatta,A. and Watt,F.M.
  TITLE     The periplakin gene maps to 16p13.3 in human and 16A-B1 in mouse
  JOURNAL   Genomics 49 (1), 157-159 (1998)
   PUBMED   9570964
REFERENCE   9  (residues 1 to 1754)
  AUTHORS   Aho,S., McLean,W.H., Li,K. and Uitto,J.
  TITLE     cDNA cloning, mRNA expression, and chromosomal mapping of human and
            mouse periplakin genes
  JOURNAL   Genomics 48 (2), 242-247 (1998)
   PUBMED   9521878
REFERENCE   10 (residues 1 to 1754)
  AUTHORS   Ruhrberg,C., Hajibagheri,M.A., Parry,D.A. and Watt,F.M.
  TITLE     Periplakin, a novel component of cornified envelopes and desmosomes
            that belongs to the plakin family and forms complexes with
            envoplakin
  JOURNAL   J Cell Biol 139 (7), 1835-1849 (1997)
   PUBMED   9412476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ056283.1, AK142562.1, AF126834.1, AC163723.3 and AW553870.2.
            
            On Aug 17, 2006 this sequence version replaced NP_032935.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF126834.1, SRR10223969.16495.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1754
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.5 cM"
     Protein         1..1754
                     /product="periplakin"
                     /note="195kDa protein"
                     /calculated_mol_wt=203649
     Region          1..20
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R269.1)"
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O60437; propagated from
                     UniProtKB/Swiss-Prot (Q9R269.1)"
     Region          213..387
                     /region_name="SPEC"
                     /note="Spectrin repeats, found in several proteins
                     involved in cytoskeletal structure; family members include
                     spectrin, alpha-actinin and dystrophin; the spectrin
                     repeat forms a three helix bundle with the second helix
                     interrupted by proline in some sequences; cd00176"
                     /db_xref="CDD:238103"
     Region          214..315
                     /region_name="Spectrin 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R269.1)"
     Site            317..322
                     /site_type="active"
                     /note="linker region [active]"
                     /db_xref="CDD:238103"
     Region          321..483
                     /region_name="Spectrin 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R269.1)"
     Region          388..451
                     /region_name="SH3_10"
                     /note="SH3 domain; pfam17902"
                     /db_xref="CDD:407754"
     Site            463
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O60437; propagated from
                     UniProtKB/Swiss-Prot (Q9R269.1)"
     Region          <467..1217
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          503..610
                     /region_name="Spectrin 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R269.1)"
     Site            885
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O60437; propagated from
                     UniProtKB/Swiss-Prot (Q9R269.1)"
     Region          903..1638
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Site            947
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O60437; propagated from
                     UniProtKB/Swiss-Prot (Q9R269.1)"
     Region          1555..1754
                     /region_name="Interacts with BFSP2 and VIM.
                     /evidence=ECO:0000269|PubMed:19029034"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R269.1)"
     Site            1582
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O60437; propagated from
                     UniProtKB/Swiss-Prot (Q9R269.1)"
     Region          <1655..1683
                     /region_name="PLEC"
                     /note="Plectin repeat; smart00250"
                     /db_xref="CDD:197605"
     Site            1655
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9R269.1)"
     CDS             1..1754
                     /gene="Ppl"
                     /coded_by="NM_008909.2:139..5403"
                     /db_xref="CCDS:CCDS27932.1"
                     /db_xref="GeneID:19041"
                     /db_xref="MGI:MGI:1194898"
ORIGIN      
        1 mhslfrkrnk gkysptvqtr sisnkelsdl ieqlqknadq vernivdtea kmqsdlarmq
       61 egqlpehrda alqnvsdsek llyvleadsa iakhmkhpqg dmiaedirql kervtnlrgk
      121 hkqmyslavk eadprvnwdt lvdekldkls sqsfgtdlpl vdsqveqhni fhnevkaigp
      181 hlakdkeqns elqakyqkll tasqarqqhl sslqdymqrc tnelywldqq akgrmqydws
      241 drnldypsrr rqyenfinrn leakeerink lhtegdqllt aehpgrnsie ahmeavhaew
      301 keylnllice eshlkymedy hqfhkdmkda qellrkvdsd lnqkyspdfk dryqielllr
      361 elddqekald kyedvvrglq rrgqqvvplk yrretplkpi pvealcdfes dqglisrgys
      421 ytlqknnges weltdstgkk laapavcfii pptdpealal adslgsqyrs vrqkatgskh
      481 alqqrhevlr tenpgdasdl qgrqllagld kvasdldrqe kaitgilrpp leqgraieds
      541 aerakglkni tnellqiepe ktqctaecea fvqalpasgt apllktrved tnqkyerlvw
      601 lleaaqekvd vanrlenslq rgrellasye nrliqddtmp esghvldskr qeleamasel
      661 qahksllgev eqnlqvakqc ssslasrfqe hcpdlerqea evhklnqrfn nlsqqverra
      721 qslqsaraay deycsgynrv lqflaktpsy epqetdslgq metklknqkn lldelasreq
      781 evqkvyadsq qyqqavkdye leaeklrsll dlengrnshv nkrarlqspa akvkeeeaal
      841 aakftevnai nrqrlqnlef alnllrqqpe agvthetlqg gklssgmeet wkikkeleee
      901 ierrqqlene vksaqeeiqt lkdqgpqesl vrkevlkkvp dpaleesfqq lqqtlaeeqh
      961 knqllqeelg alqlrlqale qetrdggqey vvkevlriep draqedevlq lreelealrr
     1021 qkgareaevl llqqrvaala aeksrvqekv terevvklqn dpqleaeyrr lqeehqregt
     1081 lrekqeeels flqaklrrle keramaegki tvkevlkvek daaverevnd ltrqyedeaa
     1141 karsgqrekt ellrkiwale eenakvvvqe kvreivrpdp kaesevanlr lelveqerkf
     1201 rgaeeqlksy qselealrnr gpqvevkevt kevikyttdp eteqelqrlr eeimdktrli
     1261 ercdleiyql kqeiqalkdt kpqvqtrevv qeilqfqedp qtkkeveslr iqlseeqkkq
     1321 vdlegerasq eekikrkeee laqgkervvr qevvqyedep dlraevtaft nsidaelrqi
     1381 dklhvelrrl qhrraelerq leelererqa rraaelevqr lqqrlaaleq eeaktgekvt
     1441 htqkvvlqqd pqqtrehall raqleeerhr rqllegelep lrrklaalek aeikekvvfs
     1501 esvqvekgdt eqeiqrlkks leeesqskre ldsevtrlea klselefyns ksskeldflr
     1561 eenhklqler qnlqletrrl qseiemaate trdlknitti dsgthlnsrl wslekelddl
     1621 kkmskdkdle idelqrrlgs vavkreqren hlrrsivvid pdtgrelspe eahraglidw
     1681 kmfvklrsqe cdweeisvkg pngessvihd rksgkkfsie dalqsgrlta aqydryvnkd
     1741 msiqelavlv sgqk
//
