LOCUS       NM_001285827            1086 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus peptidylprolyl isomerase (cyclophilin)-like 3 (Ppil3),
            transcript variant 4, mRNA.
ACCESSION   NM_001285827
VERSION     NM_001285827.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1086)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1086)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1086)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK010207.1, CJ166559.1 and BB687332.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            compared to variant 3. Variants 1, 3, and 4 encode the same isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF315803.1, AV496278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AK010207.1         5-103
            100-528             CJ166559.1         44-472
            529-1082            AK010207.1         347-900
            1083-1086           BB687332.1         388-391
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 29.1 cM"
     gene            1..1086
                     /gene="Ppil3"
                     /gene_synonym="2310076N22Rik; 2510026K04Rik; Cyp10l"
                     /note="peptidylprolyl isomerase (cyclophilin)-like 3"
                     /db_xref="GeneID:70225"
                     /db_xref="MGI:MGI:1917475"
     exon            1..341
                     /gene="Ppil3"
                     /gene_synonym="2310076N22Rik; 2510026K04Rik; Cyp10l"
                     /inference="alignment:Splign:2.1.0"
     exon            342..392
                     /gene="Ppil3"
                     /gene_synonym="2310076N22Rik; 2510026K04Rik; Cyp10l"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..875
                     /gene="Ppil3"
                     /gene_synonym="2310076N22Rik; 2510026K04Rik; Cyp10l"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 4;
                     cyclophilin-like 3; peptidyl-prolyl cis-trans
                     isomerase-like 3; PPIase; cyclophilin-like protein PPIL3;
                     rotamase PPIL3"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase-like 3
                     isoform 1"
                     /protein_id="NP_001272756.1"
                     /db_xref="CCDS:CCDS35579.1"
                     /db_xref="GeneID:70225"
                     /db_xref="MGI:MGI:1917475"
                     /translation="MSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCVFHR
                     NIKGFMVQTGDPTGTGRGGSSIWAKKFEDEYSEYLKHNVRGVVSMANNGPNTNGSQFF
                     ITYGKQPHLDMKYTVFGKVIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFA
                     Q"
     exon            393..467
                     /gene="Ppil3"
                     /gene_synonym="2310076N22Rik; 2510026K04Rik; Cyp10l"
                     /inference="alignment:Splign:2.1.0"
     exon            468..561
                     /gene="Ppil3"
                     /gene_synonym="2310076N22Rik; 2510026K04Rik; Cyp10l"
                     /inference="alignment:Splign:2.1.0"
     exon            562..629
                     /gene="Ppil3"
                     /gene_synonym="2310076N22Rik; 2510026K04Rik; Cyp10l"
                     /inference="alignment:Splign:2.1.0"
     exon            630..748
                     /gene="Ppil3"
                     /gene_synonym="2310076N22Rik; 2510026K04Rik; Cyp10l"
                     /inference="alignment:Splign:2.1.0"
     exon            749..1086
                     /gene="Ppil3"
                     /gene_synonym="2310076N22Rik; 2510026K04Rik; Cyp10l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1053..1058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppil3"
                     /gene_synonym="2310076N22Rik; 2510026K04Rik; Cyp10l"
                     /note="hexamer: AATAGA"
     polyA_site      1085
                     /gene="Ppil3"
                     /gene_synonym="2310076N22Rik; 2510026K04Rik; Cyp10l"
                     /note="major polyA site"
ORIGIN      
        1 ctgcttccga ctccaggccg ctgtgtgaag ttgggcggaa ttggtcctgt gcgttctgct
       61 tcccactcca ggccgctgta tgaagttgct gggcgacagc gggttctgct tcttagtgag
      121 gttgtgggta gagctctcag gggccgaggg gtgaggtgcg tggtcctccg agtcctagtc
      181 ggtgtgatga ggagagactg acgggagagt agggcgtccc ctgcggaggg ctccgggctt
      241 cacttctgtg gcgcacagac acgcctttgg aacccgcagg catgccggcc cttgtagttg
      301 aggcttttcc gttcccgcag cagtggtgct gagcgcagtg ggagatttga aaaattaaac
      361 agtgcttcct agaaccatca agaaggaaaa tgtctgtgac actgcataca gatgtgggag
      421 atatcaagat agaagtcttc tgtgagagaa cacccaaaac atgtgagaat ttcttggctc
      481 tttgtgccag taattactac aacggctgtg tgtttcatag aaatatcaag ggcttcatgg
      541 ttcaaacagg agatccaaca ggtactggaa gaggaggtag cagcatctgg gccaaaaagt
      601 ttgaggatga atacagtgaa tatctgaagc acaatgttcg aggtgttgta tctatggcta
      661 ataatggccc aaataccaat ggatctcagt tcttcatcac ctatggcaag cagccacact
      721 tggacatgaa atatacagtg tttggaaagg taatagatgg tctggagact ttggatgagt
      781 tggagaagtt accagtaaat gagaagacat acagacctct taatgatgta cacattaagg
      841 acataactat tcatgccaac ccatttgctc agtagctgtc atggacctgg acagatactt
      901 ggtgaacact tcactggaac acgcccattg tggtttaacc agttctcctt ctcctggtgt
      961 ttgcaggaat gggctccatg taggagccct gtagcttccc tcccatctga gcatattctc
     1021 tgccactgct gttgttcagt gtgttcactt taaatagaaa gccatgcctt ttttttttta
     1081 tcacat
//
