LOCUS       NM_001252444            2328 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus peptidylprolyl isomerase (cyclophilin)-like 2 (Ppil2),
            transcript variant 1, mRNA.
ACCESSION   NM_001252444
VERSION     NM_001252444.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2328)
  AUTHORS   Engdahl,C., Naslund,J., Lindgren,L., Ahlm,C. and Bucht,G.
  TITLE     The Rift Valley Fever virus protein NSm and putative cellular
            protein interactions
  JOURNAL   Virol J 9, 139 (2012)
   PUBMED   22838834
  REMARK    GeneRIF: Cpsf2,Ppil2, and SNAP-25 are the most promising targets
            for the NSm protein of the virus during an infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2328)
  AUTHORS   Orr,S.L., Gese,E. and Hood,L.
  TITLE     A new approach to understanding T cell development: the isolation
            and characterization of immature CD4-, CD8-, CD3- T cell cDNAs by
            subtraction cloning
  JOURNAL   Mol Biol Cell 3 (7), 761-773 (1992)
   PUBMED   1387565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY033661.1, BY145175.1, AK012472.1 and AI837084.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012472.1, SRR13862062.172145.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BY033661.1         2-4
            4-93                BY145175.1         1-90
            94-2325             AK012472.1         75-2306
            2326-2328           AI837084.1         15-17               c
FEATURES             Location/Qualifiers
     source          1..2328
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.59 cM"
     gene            1..2328
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /note="peptidylprolyl isomerase (cyclophilin)-like 2"
                     /db_xref="GeneID:66053"
                     /db_xref="MGI:MGI:2447857"
     exon            1..110
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1644
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peptidyl-prolyl cis-trans isomerase-like 2; PPIase;
                     cyclophilin-60; cyclophilin-like protein Cyp-60; rotamase
                     PPIL2; RING-type E3 ubiquitin transferase isomerase-like
                     2; probable inactive peptidyl-prolyl cis-trans
                     isomerase-like 2; RING-type E3 ubiquitin-protein ligase
                     PPIL2"
                     /codon_start=1
                     /product="RING-type E3 ubiquitin-protein ligase PPIL2
                     isoform 1"
                     /protein_id="NP_001239373.1"
                     /db_xref="CCDS:CCDS27993.1"
                     /db_xref="GeneID:66053"
                     /db_xref="MGI:MGI:2447857"
                     /translation="MGKRQHQKDKMYITCAEYTHFYGGRKPDISQTSFRRLPFDHCSL
                     SLQPFVYPVCTPEGVVFDLLNIVPWLKKYGTNPSTGEKLDGKSLIKLNFAKNSEGQYH
                     CPVLYSVFTDNTHIVAIRTTGNVYTYEAVEQLNIKAKNLRDLLTDEPFSRQDIITLQD
                     PTNLDKFNVSNFFHVKNNMRIIDPDEEKAKQDPSYYLKNTNSETRETLQELYKEFKGD
                     EILAATMRPPEKKKVDQLNAAHYSTGKVSASFTSTAMVPETTHEAAVIDEDVLRYQFV
                     KKKGYVRLHTNKGDLNLELHCDLTPKTCENFIKLCKKQYYDGTIFHRSIRNFVIQGGD
                     PTGTGTGGESFWGKPFKDEFRPNLSHTGRGVLSMANSGPNTNKSQFFITFRSCAYLDK
                     KHTIFGRVVGGFDTLTAMENVESDPKTDRPKEEVLICTTTVFVDPYEEADAQIAQERK
                     KTQHQVDPEAKVKMSQPQPGNQGPQTYRQGVGKYIHPAATKRSAEEEPSTSTATPTAK
                     KRPSRGFGDFSSW"
     exon            111..160
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            161..206
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            207..269
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            270..321
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            322..373
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            374..465
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            466..555
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            556..631
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            632..792
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            793..868
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            869..975
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1065
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1099
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1217
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1274
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1347
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1410
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1547
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1669
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..2328
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2305..2310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /note="hexamer: AATAAA"
     polyA_site      2328
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /note="major polyA site"
ORIGIN      
        1 gtcgatctcc ggaagtagtt gagaaagcgg aggcgccata gtcagtgtct gctgtggtct
       61 cttcggtttg ttgccaccat ggggaagcga cagcaccaga aggacaagat gtatatcact
      121 tgtgctgagt acactcattt ctatggtggc aggaagccag atatctcaca gacaagtttt
      181 cgccgcttac cttttgacca ctgcagtctc tctctccagc cttttgtcta cccagtctgc
      241 accccagaag gtgtcgtctt tgacttgctg aacattgttc cctggcttaa gaagtatggg
      301 acgaatccca gcactggaga gaaacttgat gggaagtcct tgatcaagct gaacttcgca
      361 aagaacagcg aagggcagta ccactgtcca gtgctgtatt ccgtgttcac tgacaacacc
      421 catattgtgg ccatcaggac aactggcaat gtctacacct atgaggcagt ggagcagcta
      481 aacatcaagg ccaagaactt gcgggatctg ttgactgatg agcccttttc caggcaagac
      541 atcatcaccc tgcaggaccc caccaatttg gacaaattca atgttagcaa cttcttccat
      601 gtgaagaata acatgagaat aatagaccca gatgaggaaa aggccaaaca agacccatct
      661 tattatttga aaaacacaaa ttcggagacg agagagacgc tacaggagct ctacaaagag
      721 ttcaaaggag atgagatttt agcagctacc atgaggccac ctgagaagaa gaaggtggac
      781 caactgaatg cggcccacta ctccacaggg aaggtcagtg catccttcac ctctactgcc
      841 atggtgcccg agaccacgca tgaagcagct gtcattgatg aagatgtact gcgctaccag
      901 tttgtgaaga aaaagggcta tgtaaggctt cacaccaaca agggcgacct taacttagag
      961 ctgcactgtg acctgacacc aaaaacctgt gaaaacttca tcaagctctg caagaaacag
     1021 tattatgatg gtaccatctt tcacaggtcc atcaggaact ttgtgatcca gggcggtgac
     1081 cccacaggta caggcacagg tggagagtca ttctggggca agcctttcaa agatgagttc
     1141 cgtcccaacc tttcacacac gggccgtggg gtgctcagca tggccaattc ggggcccaac
     1201 accaacaaat ctcagttctt catcacattc cgatcctgcg cttacctgga taagaagcat
     1261 accatctttg gacgggttgt tgggggcttt gacacgctga cagccatgga gaatgtggag
     1321 agtgacccta aaactgaccg tcctaaggag gaagtgctca tatgtacaac cacagtgttt
     1381 gtggacccct atgaggaggc tgatgcccag attgcccagg aacggaagaa gacacagcat
     1441 caggtggatc cagaggccaa ggtcaagatg agtcagcccc agcctggaaa ccagggaccc
     1501 cagacatacc gccagggggt gggcaagtac atccaccctg cggccacgaa acgatcagca
     1561 gaggaagaac catcgaccag cactgccacc cccacggcca agaaaaggcc cagtcggggc
     1621 tttggggact tcagctcctg gtagcagcag gctggcctca gggatcctgg ccactcacaa
     1681 gctactacaa ggtggtgtca gaagcatcag gaccccagaa gccctcggtt ctcagcgggc
     1741 tctgagaccc tgatcctttg ctcctagtgg atgctgcagg aacgaacgtg gctcgccgcc
     1801 gcccccacct ccacccccac cctgggaacc ttgctgtgtg acgacaggag ctttatttta
     1861 tacctcccac agacacgcca cagagggctg acagctttgg ctaggagaca gggaggccaa
     1921 ggcgctctgt ttgctcgagc ttgctggtcc tgctgttctt ggtgaactcc ctgtgggttc
     1981 cacagcactg cagtcagcct tgctcagcag ccgacacctg tccccagggc aggcagctgt
     2041 gtcctctcct gtcctccagc acagaggaca gaccaccagg gcttgcattt ccatgggtcg
     2101 gttgtctata gcttaaatgg tagtgtttta gacagtaaag acacttggat tttgaaaact
     2161 gcctgatgag ctcatcagaa aataaaggac ttttgagggg aaaaaaaatc tcatttctga
     2221 tctcttcaaa tacctgacag atgccatcaa gaataagcat taaggtataa aaatactatg
     2281 tatacagtaa caagacaaca aggaaataaa ccacatttct aaagcaaa
//
