LOCUS       NP_001239373             521 aa            linear   ROD 04-JUN-2024
DEFINITION  RING-type E3 ubiquitin-protein ligase PPIL2 isoform 1 [Mus
            musculus].
ACCESSION   NP_001239373
VERSION     NP_001239373.1
DBSOURCE    REFSEQ: accession NM_001252444.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 521)
  AUTHORS   Engdahl,C., Naslund,J., Lindgren,L., Ahlm,C. and Bucht,G.
  TITLE     The Rift Valley Fever virus protein NSm and putative cellular
            protein interactions
  JOURNAL   Virol J 9, 139 (2012)
   PUBMED   22838834
  REMARK    GeneRIF: Cpsf2,Ppil2, and SNAP-25 are the most promising targets
            for the NSm protein of the virus during an infection.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 521)
  AUTHORS   Orr,S.L., Gese,E. and Hood,L.
  TITLE     A new approach to understanding T cell development: the isolation
            and characterization of immature CD4-, CD8-, CD3- T cell cDNAs by
            subtraction cloning
  JOURNAL   Mol Biol Cell 3 (7), 761-773 (1992)
   PUBMED   1387565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY033661.1, BY145175.1, AK012472.1 and AI837084.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012472.1, SRR13862062.172145.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.59 cM"
     Protein         1..521
                     /product="RING-type E3 ubiquitin-protein ligase PPIL2
                     isoform 1"
                     /EC_number="2.3.2.27"
                     /note="peptidyl-prolyl cis-trans isomerase-like 2; PPIase;
                     cyclophilin-60; cyclophilin-like protein Cyp-60; rotamase
                     PPIL2; RING-type E3 ubiquitin transferase isomerase-like
                     2; probable inactive peptidyl-prolyl cis-trans
                     isomerase-like 2; RING-type E3 ubiquitin-protein ligase
                     PPIL2"
                     /calculated_mol_wt=58934
     Region          38..110
                     /region_name="RING-Ubox_PPIL2"
                     /note="U-box domain, a modified RING finger, found in
                     peptidyl-prolyl cis-trans isomerase-like 2 (PPIL2) and
                     similar proteins; cd16663"
                     /db_xref="CDD:438325"
     Region          101..159
                     /region_name="RING_Ubox"
                     /note="RING finger (Really Interesting New Gene) domain
                     and U-box domain superfamily; cl17238"
                     /db_xref="CDD:473075"
     Site            order(103,106,122,124,127,130,143,146)
                     /site_type="other"
                     /note="cross-brace motif"
                     /db_xref="CDD:438111"
     Region          281..440
                     /region_name="cyclophilin_RING"
                     /note="cyclophilin-type peptidylprolyl cis- trans
                     isomerases (cyclophilins) having a modified RING finger
                     domain. This group includes the nuclear proteins, Human
                     hCyP-60 and Caenorhabditis elegans MOG-6 which, compared
                     to the archetypal cyclophilin Human...; cd01923"
                     /db_xref="CDD:238904"
     Site            order(322..323,328,379,381,389)
                     /site_type="active"
                     /db_xref="CDD:238904"
     Region          447..521
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D787.2)"
     Site            483
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q13356; propagated from
                     UniProtKB/Swiss-Prot (Q9D787.2)"
     CDS             1..521
                     /gene="Ppil2"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     4921520K19Rik; 4930511F14Rik; C130078A06Rik; CYC4"
                     /coded_by="NM_001252444.1:79..1644"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS27993.1"
                     /db_xref="GeneID:66053"
                     /db_xref="MGI:MGI:2447857"
ORIGIN      
        1 mgkrqhqkdk myitcaeyth fyggrkpdis qtsfrrlpfd hcslslqpfv ypvctpegvv
       61 fdllnivpwl kkygtnpstg ekldgkslik lnfaknsegq yhcpvlysvf tdnthivair
      121 ttgnvytyea veqlnikakn lrdlltdepf srqdiitlqd ptnldkfnvs nffhvknnmr
      181 iidpdeekak qdpsyylknt nsetretlqe lykefkgdei laatmrppek kkvdqlnaah
      241 ystgkvsasf tstamvpett heaavidedv lryqfvkkkg yvrlhtnkgd lnlelhcdlt
      301 pktcenfikl ckkqyydgti fhrsirnfvi qggdptgtgt ggesfwgkpf kdefrpnlsh
      361 tgrgvlsman sgpntnksqf fitfrscayl dkkhtifgrv vggfdtltam envesdpktd
      421 rpkeevlict ttvfvdpyee adaqiaqerk ktqhqvdpea kvkmsqpqpg nqgpqtyrqg
      481 vgkyihpaat krsaeeepst statptakkr psrgfgdfss w
//
