LOCUS       NM_001407476            6094 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus peptidyl-prolyl isomerase G (cyclophilin G) (Ppig),
            transcript variant 12, mRNA.
ACCESSION   NM_001407476
VERSION     NM_001407476.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6094)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845261.17.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662772.249553.1,
                                           SRR17253014.3115505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AL845261.17        39670-39819
            151-218             AL845261.17        48608-48675
            219-296             AL845261.17        49059-49136
            297-371             AL845261.17        49242-49316
            372-479             AL845261.17        49680-49787
            480-524             AL845261.17        50051-50095
            525-612             AL845261.17        51153-51240
            613-752             AL845261.17        52851-52990
            753-960             AL845261.17        58348-58555
            961-1128            AL845261.17        60475-60642
            1129-1216           AL845261.17        62890-62977
            1217-1353           AL845261.17        65823-65959
            1354-6094           AL845261.17        66134-70874
FEATURES             Location/Qualifiers
     source          1..6094
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 40.95 cM"
     gene            1..6094
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="peptidyl-prolyl isomerase G (cyclophilin G)"
                     /db_xref="GeneID:228005"
                     /db_xref="MGI:MGI:2445173"
     exon            1..150
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            151..218
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            219..296
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..2464
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /EC_number="5.2.1.8"
                     /note="isoform 5 is encoded by transcript variant 12;
                     peptidylprolyl isomerase G; peptidyl-prolyl cis-trans
                     isomerase G; PPIase G; rotamase G; cyclophilin G"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase G isoform 5"
                     /protein_id="NP_001394405.1"
                     /db_xref="GeneID:228005"
                     /db_xref="MGI:MGI:2445173"
                     /translation="MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLC
                     TGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAV
                     KHNKEFLLSMANRGKDTNGSQFFMHHVVFGQVISGQEVVREIENQKTDAASKPFAEVR
                     ILSCGELIPKSKVKKEEKKRHKSSSSSSSSDSDSSSDSQSSSESSDSESASEEKSRKR
                     KKKHRKNSRKHKKEKKKRKKSKKSPSSESEAENVDAQPQSTVRPEEIPPIPENRFLMR
                     KSPPKADDKERKNRERERERECNPPNSQPASYQRRFLVTRSGRKIKGRGPRRYRTPSR
                     SRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKEK
                     KITDHRHMSESPNRKVEKEKKAKDHKSESKERDIRRNSEKDDKYNKNKVKKRGKSKSR
                     SKSKERSKSKERDSKHSRHEDKRVRSRSKERDHETTKEKEKPLDPKGKDQERSRSKEN
                     SKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSYNSRTRERSRSRDRSRRVRS
                     RSHDRDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRRRRRDSRSSEREES
                     QSRNKDKYRSQESKSSHRKENSEGEKRTYSKSRDHNSSSNNREKKADREQSPVSKTKQ
                     SSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDHESSPGTDEDK
                     SG"
     exon            297..371
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            372..479
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            480..524
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            525..612
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            613..752
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            753..960
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1128
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1216
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1353
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..6094
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2681..2686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATGAA"
     polyA_site      2699
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="major polyA site"
     regulatory      3787..3792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATAAA"
     polyA_site      3818
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
     regulatory      6071..6076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATAAA"
     polyA_site      6094
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="major polyA site"
ORIGIN      
        1 gtacttccgg cgcgacacct tccctccacg cctggcctgg gctgtggggg agggaggcgg
       61 ttagtgggct ttagcgcctt tcctgacggc ggtagatttg aagcgctttc caggaccggg
      121 ccgggagacg agaagcccgc ggcggggcag gagcaaaaca attggctcag tcattcttgg
      181 tggatttttg tttttttatt gtttccccca acttaaagac tgaagtgttg gaaccatggg
      241 gataaaggtc cagcgtcctc ggtgtttttt tgacattgcc attaataatc aacctgctgg
      301 aagagttgtc tttgaattat tttccgatgt atgtcccaaa acgtgtgaga actttcgctg
      361 cctttgcaca ggtgaaaaag ggacagggaa atcaactcag aagccattac attataagag
      421 ctgtctcttt catagagttg tcaaggattt catggttcag ggtggtgact tcagtgaagg
      481 gaatggaaga ggaggagaat ctatttatgg aggattcttt gaagatgaga gttttgctgt
      541 taaacacaac aaagagtttc tcttatcaat ggccaacaga gggaaggata caaatggctc
      601 tcagttcttt atgcatcatg ttgtttttgg gcaagtgatc tctggtcagg aagttgtgag
      661 agagattgaa aaccagaaaa cagatgccgc tagcaaacca tttgctgaag ttcggatact
      721 cagttgcgga gagctgattc caaagtctaa ggttaagaaa gaagaaaaga aaaggcataa
      781 gtcctcgtcc tcctcctcct ccagtgactc agacagctca agcgattctc agtcctcctc
      841 tgagtcttct gattctgaaa gcgcttccga agaaaaatcc agaaaaagga aaaagaaaca
      901 taggaaaaat tcccgaaagc ataagaagga gaagaagaag cgaaagaaaa gcaagaaaag
      961 cccatctagt gaaagtgaag cagaaaatgt tgatgcacag ccccagtcta ctgtccgtcc
     1021 agaagagatc cctcctatac cagaaaatag atttctaatg agaaaaagtc ctcctaaagc
     1081 cgatgacaag gagaggaaaa acagagagag agaaagagaa agagagtgta atccacctaa
     1141 ctcccagcct gcttcatacc agcgacgatt cttagttact aggtctggca ggaaaattaa
     1201 aggaagagga ccgaggcgtt atcgaactcc ttccagatcc agatcgaggg atcgattcag
     1261 acgaagtgag actcctccac attggagaca agagatgcag agagctcaga gaatgagggt
     1321 gtcaagtggt gaaagatgga tcaaagggga taagagtgag ttaaatgaaa taaaagaaaa
     1381 tcaaaggagc ccagttagag taaaagagaa aaaaataaca gatcacagac acatgtctga
     1441 gagtccaaac agaaaagtag aaaaggaaaa gaaagctaaa gaccataaat ctgaaagcaa
     1501 agagagagac atcagaagaa attcagaaaa agatgataaa tataacaaaa acaaagtgaa
     1561 gaaaaggggc aaatccaaga gtaggagcaa gagcaaggag agatccaaga gtaaggagcg
     1621 agactcgaag cacagcagac acgaagacaa gagggtgagg tcaagaagta aagaaaggga
     1681 tcatgagact actaaagaaa aagaaaaacc actggatcct aaagggaaag atcaggaaag
     1741 gagtagaagc aaagagaact ccaaacaggt agaatcaaaa agtaatgaac atgatcatag
     1801 caaaagtaaa gaaaaggata gacgtgcaca gtccaggagt agagaacggg atctgactaa
     1861 aagtaaacac agttacaaca gtagaacaag ggagcggagc agaagtaggg acaggagcag
     1921 aagagtgcgg tccagaagcc acgacagaga tcgcagcaga agcaaggagt accatagata
     1981 cagagaacag gagtatagga gaagaggaag gtcacgaagc cgggatcgaa gaacgccagg
     2041 acgatcgaga agtaaagata ggaggagaag aaggagggat tcccggagct cagagagaga
     2101 agaaagtcaa agtagaaaca aagataaata tagaagccaa gaaagtaaga gttcacacag
     2161 aaaagaaaat tctgagggtg agaaaagaac gtactctaaa agtcgtgatc ataatagctc
     2221 aagtaataac agggaaaaaa aggctgatag agagcaaagt ccagtgtcaa aaacaaagca
     2281 aagcagtcag gacaatgaag tgaagtcctc cacattaaaa aatcaagagg acgaaaagac
     2341 cagatccccg gtggaaaaag aaaaccaaaa atcaaagggt caagaaaatg accatgtaca
     2401 tgacaaaaat aaaaaatgtg atcatgaatc aagccctgga acagatgaag acaaaagtgg
     2461 atgagtgagt tgtgtactct taattccttc ctgtctcaaa ttttcagttt ttaagactta
     2521 ctgttgaacc tccctttttt attgttttca ttgttttgga gttgtttatg tttgtctccc
     2581 cccaccccct tttttttttt aaatgtggac ttcattgagt tgatcttttg ataatctgct
     2641 acctggataa tttgtactgc taaagtttta ataaacttga aatgaaaaga aaaacaacac
     2701 tttggtgtaa tactgtgtgc tatgttaaat tcttatgtat tcatttttgt gttgcaaccg
     2761 tcaatagcag cctactttgc ttaatcagcc atttggaaac aagcttaact gttggttgca
     2821 gtacattgtt gtataggctt gtgtttcttt tgatacaaat ccctttagaa accacttgaa
     2881 gttttgtata gctttttggg ctttgatttt tcatttataa ttcatgggct tagagcagtt
     2941 tccttaacta acagaagcag gatccttatg tgatcttaaa ccttcatttg attttacagt
     3001 tatttgtact ttagttactt tttttgtgct ttatacctta tactttacaa ttccagctgt
     3061 agcttgtttc ttaatattgt ccacgttgct ctgcgagcta taaaaatgag gtgagtgctg
     3121 ttttcagttc atgtgctgat tgagcttgag ttgctgttat acagcatttg acagaaatta
     3181 gaccttggaa gaccagactg taattttcaa ttctttgttg cttttggtgt gaagagctga
     3241 aattgttgct ttttaagaac atgttattac ctttttctac aatttaaaaa atgcatttct
     3301 cattaaaaca tactacttgt gtagatcctt cttaagctag acagattcta aaaagcgtta
     3361 gtattggaaa taagatttcc ctattttggc tattagccta tatcacattg agtggtaatt
     3421 ctgcatgatt tgggtttgtt ttttgttttt ttttttttaa acttggacta acttctctga
     3481 ttctcatagc tgtgaatatg aaatgtcaag aagatgcatc tttctatata tgtaccatga
     3541 taggctgtgt agcatgtttg tgactctggt ttctttctat tcagatggct ttagaccagt
     3601 ttactgttaa cattatttta acttggcatg tataacattg ccatataaag tagaatagaa
     3661 agttgcaaaa tatgataccg tgcagagtta aacactaaac atatccaaag tccattcaga
     3721 attttgtgtg ttgtattttg ctattttttt gtgatgtgtg gccttttatt ctgtaatatc
     3781 cttctaaata aaacattgaa catccagcaa acacaaaacc tgcctcattt gagaaatatt
     3841 tcaaaaatcc aattaatagt agcctttagg acgtttttgt actctaatat ttgtcagtat
     3901 agtgtcagct cttaccaagg tagcttcttg gtaaacccac tagcttttca atgatatttg
     3961 tactgaataa agtgatgctt aatatacttc ccattattga ttactatggt aagatatatt
     4021 tggcattgta gctggtacag aatgaagagt gcagtgatta taaagctatt tggaacatcc
     4081 taaagcaaat acccacaatg gattctttac aaatagtttt tcttgatggg aatagttaat
     4141 atatacgtga tctgttacat gtcttaaaaa gttgattatg tcttaaattc agttgtgttt
     4201 taaaatatat cccaaactac ctgatcttta agaaaggaat ttcaacaaac attttaaaat
     4261 ccatactttt tttaagtaaa attacttttt ttttcttatc tagagctttt acttgttagc
     4321 atatacatta taaacaagaa ctttccagtt ctttaggaaa gtaaacatgg gagaaaattg
     4381 gtaatgtctg taatatcctc caagagagca gctcagagct gagcatttac gggctccccc
     4441 aactcctgct ttgttagttt gttatttttt tcaatatgac agataatggg gtaaatagtt
     4501 gagaaaagac aatctagatt tttttttcag aataaataat taacagcatt aattgtaccc
     4561 caagattcac agttatcaat tgcacaaagc ccaaattctt gttctagtag atttttagtt
     4621 atttgtacat catattccca aaactatttc ccatttcaat tttcccatca cattggcttt
     4681 ctaagaatat ctaaatttac agctaatgaa tagtttttaa taccccttga aagtactttc
     4741 acttgttttt attgcttgac tccaaagctg aggaaattat ttcagtatgt aagactttga
     4801 tgattattgt atgaattatt gttctggata agttgtttac cacagaaatt gacactacaa
     4861 agagatcgtt agagaaagta aagctactgt attgtactgc attgtagctg atacagaatg
     4921 gttacttgct gtaaagacaa gactgtctgg gaacagctat ccaacgttta aagtgctctt
     4981 tcacttaaaa gttatgctaa tctgctagct ttctttgccc cagtgtgatc cagctgctca
     5041 ctggctttgc ttgcatccag tggtaggtgt caaaccaaga acctttatgt tctggatagg
     5101 cacatgctgg ggttctggta ttttgggtaa tagtattaac tactgctcct actttatttt
     5161 ctagtgacta cttagagcag ttagtataat tgatcctttg ttccatgtgt taatagcttt
     5221 catcatggaa ccttttacag caaatttctg taaatttccc agaaaggact tagacttaac
     5281 tgattggtat aaaaaactaa atgagcattt ttcattcttt tgtttctatt tactgtaatt
     5341 attccctgta gggtttatgc atttacagtt gacaaactct ctgtgtagtt tgagaaactt
     5401 taattgtaag aatatatttt taaactaatt gtttttaaaa ataaagtatc ccaaggaaac
     5461 tgagtgttga ttgccattac tgcctgcagt gggcttctca atgtcttgaa gggattcacc
     5521 tgctgtgtga caaataaaca acaaatcaca ttcatttaaa aaaaaaaaaa aggccgcaca
     5581 ggccaaagag gaagaagtgt taaggtttta ctcatttgct ctccctgact cacccctagt
     5641 actggaggat ggaagggcat tcattggttt gtatttctgt ctggttttgg ttttctttta
     5701 tagacaattc catgttacta aaagcacatt ctctgtattt ctgccccacc ctctttgtgt
     5761 gtttatagta tttttgaaag attgacacat aaattgggta tttctatgga atcttgaggt
     5821 gtggctgctc tctgtggaag gggaaagcat aattaggtta atgcacttct tttcctagct
     5881 ccacagtcac tgtgatgtat atttttttaa tggaatttag aaaacttgtt ttctcaattg
     5941 taaaattagt ttaaagatgc tgcttctctt atcattagtc tagtaaatgt tgaactgttt
     6001 tctgcagatg gcattttaca aaatttaaac ttcaaaactg tattaacttt tatagttaaa
     6061 cattgtatta aataaagtat actacaataa acaa
//
