LOCUS       NM_001407473            6256 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus peptidyl-prolyl isomerase G (cyclophilin G) (Ppig),
            transcript variant 9, mRNA.
ACCESSION   NM_001407473
VERSION     NM_001407473.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6256)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845261.17.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5286963.47346.1,
                                           SRR17253013.538340.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849382,
                                           SAMN00849383 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AL845261.17        39941-40225
            286-353             AL845261.17        48608-48675
            354-431             AL845261.17        49059-49136
            432-506             AL845261.17        49242-49316
            507-614             AL845261.17        49680-49787
            615-659             AL845261.17        50051-50095
            660-747             AL845261.17        51153-51240
            748-777             AL845261.17        52730-52759
            778-917             AL845261.17        52851-52990
            918-1125            AL845261.17        58348-58555
            1126-1290           AL845261.17        60475-60639
            1291-1378           AL845261.17        62890-62977
            1379-1515           AL845261.17        65823-65959
            1516-6256           AL845261.17        66134-70874
FEATURES             Location/Qualifiers
     source          1..6256
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 40.95 cM"
     gene            1..6256
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="peptidyl-prolyl isomerase G (cyclophilin G)"
                     /db_xref="GeneID:228005"
                     /db_xref="MGI:MGI:2445173"
     exon            1..285
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            286..353
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            354..431
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..2626
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /EC_number="5.2.1.8"
                     /note="isoform 3 is encoded by transcript variant 9;
                     peptidylprolyl isomerase G; peptidyl-prolyl cis-trans
                     isomerase G; PPIase G; rotamase G; cyclophilin G"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase G isoform 3"
                     /protein_id="NP_001394402.1"
                     /db_xref="GeneID:228005"
                     /db_xref="MGI:MGI:2445173"
                     /translation="MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLC
                     TGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAV
                     KHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTD
                     AASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSDSDSSSDSQSSSESSDSE
                     SASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEAENVDAQPQSTVRPEEIP
                     PIPENRFLMRKSPPKADDKERKNRERERERDNPPNSQPASYQRRFLVTRSGRKIKGRG
                     PRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQ
                     RSPVRVKEKKITDHRHMSESPNRKVEKEKKAKDHKSESKERDIRRNSEKDDKYNKNKV
                     KKRGKSKSRSKSKERSKSKERDSKHSRHEDKRVRSRSKERDHETTKEKEKPLDPKGKD
                     QERSRSKENSKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSYNSRTRERSRS
                     RDRSRRVRSRSHDRDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRRRRRD
                     SRSSEREESQSRNKDKYRSQESKSSHRKENSEGEKRTYSKSRDHNSSSNNREKKADRE
                     QSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDHE
                     SSPGTDEDKSG"
     exon            432..506
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            507..614
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            615..659
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            660..747
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            748..777
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            778..917
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1125
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1290
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1378
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1515
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..6256
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2843..2848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATGAA"
     polyA_site      2861
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="major polyA site"
     regulatory      3949..3954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATAAA"
     polyA_site      3980
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
     regulatory      6233..6238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATAAA"
     polyA_site      6256
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="major polyA site"
ORIGIN      
        1 ctttccgtcg aggtctctgg gctgctcggg ctcggagggg tggccccggg gaccgcggcg
       61 cggcctgggg ccccgtggtg gcccggcggc ttgcagccga gccccggggc gaaggaagcg
      121 gctcttcctc tccagccccc gccctcccgg ctcgggcgca cacctcctcc ctgacgcatt
      181 ttgccgcaca agctgtaata tggcggcagc gacggcagcc tcggctcccg ggagctaggt
      241 tcgttttgga ggcttcagaa ccgggagacg gagcgctgcg gcgtggagca aaacaattgg
      301 ctcagtcatt cttggtggat ttttgttttt ttattgtttc ccccaactta aagactgaag
      361 tgttggaacc atggggataa aggtccagcg tcctcggtgt ttttttgaca ttgccattaa
      421 taatcaacct gctggaagag ttgtctttga attattttcc gatgtatgtc ccaaaacgtg
      481 tgagaacttt cgctgccttt gcacaggtga aaaagggaca gggaaatcaa ctcagaagcc
      541 attacattat aagagctgtc tctttcatag agttgtcaag gatttcatgg ttcagggtgg
      601 tgacttcagt gaagggaatg gaagaggagg agaatctatt tatggaggat tctttgaaga
      661 tgagagtttt gctgttaaac acaacaaaga gtttctctta tcaatggcca acagagggaa
      721 ggatacaaat ggctctcagt tctttataac aacaaaacca actcctcatt tagatgggca
      781 tcatgttgtt tttgggcaag tgatctctgg tcaggaagtt gtgagagaga ttgaaaacca
      841 gaaaacagat gccgctagca aaccatttgc tgaagttcgg atactcagtt gcggagagct
      901 gattccaaag tctaaggtta agaaagaaga aaagaaaagg cataagtcct cgtcctcctc
      961 ctcctccagt gactcagaca gctcaagcga ttctcagtcc tcctctgagt cttctgattc
     1021 tgaaagcgct tccgaagaaa aatccagaaa aaggaaaaag aaacatagga aaaattcccg
     1081 aaagcataag aaggagaaga agaagcgaaa gaaaagcaag aaaagcccat ctagtgaaag
     1141 tgaagcagaa aatgttgatg cacagcccca gtctactgtc cgtccagaag agatccctcc
     1201 tataccagaa aatagatttc taatgagaaa aagtcctcct aaagccgatg acaaggagag
     1261 gaaaaacaga gagagagaaa gagaaagaga taatccacct aactcccagc ctgcttcata
     1321 ccagcgacga ttcttagtta ctaggtctgg caggaaaatt aaaggaagag gaccgaggcg
     1381 ttatcgaact ccttccagat ccagatcgag ggatcgattc agacgaagtg agactcctcc
     1441 acattggaga caagagatgc agagagctca gagaatgagg gtgtcaagtg gtgaaagatg
     1501 gatcaaaggg gataagagtg agttaaatga aataaaagaa aatcaaagga gcccagttag
     1561 agtaaaagag aaaaaaataa cagatcacag acacatgtct gagagtccaa acagaaaagt
     1621 agaaaaggaa aagaaagcta aagaccataa atctgaaagc aaagagagag acatcagaag
     1681 aaattcagaa aaagatgata aatataacaa aaacaaagtg aagaaaaggg gcaaatccaa
     1741 gagtaggagc aagagcaagg agagatccaa gagtaaggag cgagactcga agcacagcag
     1801 acacgaagac aagagggtga ggtcaagaag taaagaaagg gatcatgaga ctactaaaga
     1861 aaaagaaaaa ccactggatc ctaaagggaa agatcaggaa aggagtagaa gcaaagagaa
     1921 ctccaaacag gtagaatcaa aaagtaatga acatgatcat agcaaaagta aagaaaagga
     1981 tagacgtgca cagtccagga gtagagaacg ggatctgact aaaagtaaac acagttacaa
     2041 cagtagaaca agggagcgga gcagaagtag ggacaggagc agaagagtgc ggtccagaag
     2101 ccacgacaga gatcgcagca gaagcaagga gtaccataga tacagagaac aggagtatag
     2161 gagaagagga aggtcacgaa gccgggatcg aagaacgcca ggacgatcga gaagtaaaga
     2221 taggaggaga agaaggaggg attcccggag ctcagagaga gaagaaagtc aaagtagaaa
     2281 caaagataaa tatagaagcc aagaaagtaa gagttcacac agaaaagaaa attctgaggg
     2341 tgagaaaaga acgtactcta aaagtcgtga tcataatagc tcaagtaata acagggaaaa
     2401 aaaggctgat agagagcaaa gtccagtgtc aaaaacaaag caaagcagtc aggacaatga
     2461 agtgaagtcc tccacattaa aaaatcaaga ggacgaaaag accagatccc cggtggaaaa
     2521 agaaaaccaa aaatcaaagg gtcaagaaaa tgaccatgta catgacaaaa ataaaaaatg
     2581 tgatcatgaa tcaagccctg gaacagatga agacaaaagt ggatgagtga gttgtgtact
     2641 cttaattcct tcctgtctca aattttcagt ttttaagact tactgttgaa cctccctttt
     2701 ttattgtttt cattgttttg gagttgttta tgtttgtctc cccccacccc cttttttttt
     2761 ttaaatgtgg acttcattga gttgatcttt tgataatctg ctacctggat aatttgtact
     2821 gctaaagttt taataaactt gaaatgaaaa gaaaaacaac actttggtgt aatactgtgt
     2881 gctatgttaa attcttatgt attcattttt gtgttgcaac cgtcaatagc agcctacttt
     2941 gcttaatcag ccatttggaa acaagcttaa ctgttggttg cagtacattg ttgtataggc
     3001 ttgtgtttct tttgatacaa atccctttag aaaccacttg aagttttgta tagctttttg
     3061 ggctttgatt tttcatttat aattcatggg cttagagcag tttccttaac taacagaagc
     3121 aggatcctta tgtgatctta aaccttcatt tgattttaca gttatttgta ctttagttac
     3181 tttttttgtg ctttatacct tatactttac aattccagct gtagcttgtt tcttaatatt
     3241 gtccacgttg ctctgcgagc tataaaaatg aggtgagtgc tgttttcagt tcatgtgctg
     3301 attgagcttg agttgctgtt atacagcatt tgacagaaat tagaccttgg aagaccagac
     3361 tgtaattttc aattctttgt tgcttttggt gtgaagagct gaaattgttg ctttttaaga
     3421 acatgttatt acctttttct acaatttaaa aaatgcattt ctcattaaaa catactactt
     3481 gtgtagatcc ttcttaagct agacagattc taaaaagcgt tagtattgga aataagattt
     3541 ccctattttg gctattagcc tatatcacat tgagtggtaa ttctgcatga tttgggtttg
     3601 ttttttgttt tttttttttt aaacttggac taacttctct gattctcata gctgtgaata
     3661 tgaaatgtca agaagatgca tctttctata tatgtaccat gataggctgt gtagcatgtt
     3721 tgtgactctg gtttctttct attcagatgg ctttagacca gtttactgtt aacattattt
     3781 taacttggca tgtataacat tgccatataa agtagaatag aaagttgcaa aatatgatac
     3841 cgtgcagagt taaacactaa acatatccaa agtccattca gaattttgtg tgttgtattt
     3901 tgctattttt ttgtgatgtg tggcctttta ttctgtaata tccttctaaa taaaacattg
     3961 aacatccagc aaacacaaaa cctgcctcat ttgagaaata tttcaaaaat ccaattaata
     4021 gtagccttta ggacgttttt gtactctaat atttgtcagt atagtgtcag ctcttaccaa
     4081 ggtagcttct tggtaaaccc actagctttt caatgatatt tgtactgaat aaagtgatgc
     4141 ttaatatact tcccattatt gattactatg gtaagatata tttggcattg tagctggtac
     4201 agaatgaaga gtgcagtgat tataaagcta tttggaacat cctaaagcaa atacccacaa
     4261 tggattcttt acaaatagtt tttcttgatg ggaatagtta atatatacgt gatctgttac
     4321 atgtcttaaa aagttgatta tgtcttaaat tcagttgtgt tttaaaatat atcccaaact
     4381 acctgatctt taagaaagga atttcaacaa acattttaaa atccatactt tttttaagta
     4441 aaattacttt ttttttctta tctagagctt ttacttgtta gcatatacat tataaacaag
     4501 aactttccag ttctttagga aagtaaacat gggagaaaat tggtaatgtc tgtaatatcc
     4561 tccaagagag cagctcagag ctgagcattt acgggctccc ccaactcctg ctttgttagt
     4621 ttgttatttt tttcaatatg acagataatg gggtaaatag ttgagaaaag acaatctaga
     4681 tttttttttc agaataaata attaacagca ttaattgtac cccaagattc acagttatca
     4741 attgcacaaa gcccaaattc ttgttctagt agatttttag ttatttgtac atcatattcc
     4801 caaaactatt tcccatttca attttcccat cacattggct ttctaagaat atctaaattt
     4861 acagctaatg aatagttttt aatacccctt gaaagtactt tcacttgttt ttattgcttg
     4921 actccaaagc tgaggaaatt atttcagtat gtaagacttt gatgattatt gtatgaatta
     4981 ttgttctgga taagttgttt accacagaaa ttgacactac aaagagatcg ttagagaaag
     5041 taaagctact gtattgtact gcattgtagc tgatacagaa tggttacttg ctgtaaagac
     5101 aagactgtct gggaacagct atccaacgtt taaagtgctc tttcacttaa aagttatgct
     5161 aatctgctag ctttctttgc cccagtgtga tccagctgct cactggcttt gcttgcatcc
     5221 agtggtaggt gtcaaaccaa gaacctttat gttctggata ggcacatgct ggggttctgg
     5281 tattttgggt aatagtatta actactgctc ctactttatt ttctagtgac tacttagagc
     5341 agttagtata attgatcctt tgttccatgt gttaatagct ttcatcatgg aaccttttac
     5401 agcaaatttc tgtaaatttc ccagaaagga cttagactta actgattggt ataaaaaact
     5461 aaatgagcat ttttcattct tttgtttcta tttactgtaa ttattccctg tagggtttat
     5521 gcatttacag ttgacaaact ctctgtgtag tttgagaaac tttaattgta agaatatatt
     5581 tttaaactaa ttgtttttaa aaataaagta tcccaaggaa actgagtgtt gattgccatt
     5641 actgcctgca gtgggcttct caatgtcttg aagggattca cctgctgtgt gacaaataaa
     5701 caacaaatca cattcattta aaaaaaaaaa aaaggccgca caggccaaag aggaagaagt
     5761 gttaaggttt tactcatttg ctctccctga ctcaccccta gtactggagg atggaagggc
     5821 attcattggt ttgtatttct gtctggtttt ggttttcttt tatagacaat tccatgttac
     5881 taaaagcaca ttctctgtat ttctgcccca ccctctttgt gtgtttatag tatttttgaa
     5941 agattgacac ataaattggg tatttctatg gaatcttgag gtgtggctgc tctctgtgga
     6001 aggggaaagc ataattaggt taatgcactt cttttcctag ctccacagtc actgtgatgt
     6061 atattttttt aatggaattt agaaaacttg ttttctcaat tgtaaaatta gtttaaagat
     6121 gctgcttctc ttatcattag tctagtaaat gttgaactgt tttctgcaga tggcatttta
     6181 caaaatttaa acttcaaaac tgtattaact tttatagtta aacattgtat taaataaagt
     6241 atactacaat aaacaa
//
