LOCUS       NM_001407463            6124 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus peptidyl-prolyl isomerase G (cyclophilin G) (Ppig),
            transcript variant 4, mRNA.
ACCESSION   NM_001407463 XM_006499184
VERSION     NM_001407463.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6124)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845261.17.
            
            On Jun 2, 2022 this sequence version replaced XM_006499184.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.9378.1,
                                           SRR10223971.2043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AL845261.17        39670-39819
            151-218             AL845261.17        48608-48675
            219-296             AL845261.17        49059-49136
            297-371             AL845261.17        49242-49316
            372-479             AL845261.17        49680-49787
            480-524             AL845261.17        50051-50095
            525-612             AL845261.17        51153-51240
            613-642             AL845261.17        52730-52759
            643-782             AL845261.17        52851-52990
            783-990             AL845261.17        58348-58555
            991-1158            AL845261.17        60475-60642
            1159-1246           AL845261.17        62890-62977
            1247-1383           AL845261.17        65823-65959
            1384-6124           AL845261.17        66134-70874
FEATURES             Location/Qualifiers
     source          1..6124
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 40.95 cM"
     gene            1..6124
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="peptidyl-prolyl isomerase G (cyclophilin G)"
                     /db_xref="GeneID:228005"
                     /db_xref="MGI:MGI:2445173"
     exon            1..150
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            151..218
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            219..296
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..2494
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 4;
                     peptidylprolyl isomerase G; peptidyl-prolyl cis-trans
                     isomerase G; PPIase G; rotamase G; cyclophilin G"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase G isoform 1"
                     /protein_id="NP_001394392.1"
                     /db_xref="GeneID:228005"
                     /db_xref="MGI:MGI:2445173"
                     /translation="MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLC
                     TGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAV
                     KHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTD
                     AASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSDSDSSSDSQSSSESSDSE
                     SASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEAENVDAQPQSTVRPEEIP
                     PIPENRFLMRKSPPKADDKERKNRERERERECNPPNSQPASYQRRFLVTRSGRKIKGR
                     GPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKEN
                     QRSPVRVKEKKITDHRHMSESPNRKVEKEKKAKDHKSESKERDIRRNSEKDDKYNKNK
                     VKKRGKSKSRSKSKERSKSKERDSKHSRHEDKRVRSRSKERDHETTKEKEKPLDPKGK
                     DQERSRSKENSKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSYNSRTRERSR
                     SRDRSRRVRSRSHDRDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRRRRR
                     DSRSSEREESQSRNKDKYRSQESKSSHRKENSEGEKRTYSKSRDHNSSSNNREKKADR
                     EQSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDH
                     ESSPGTDEDKSG"
     exon            297..371
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            372..479
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            480..524
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            525..612
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            613..642
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            643..782
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            783..990
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1158
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1246
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1383
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..6124
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2711..2716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATGAA"
     polyA_site      2729
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="major polyA site"
     regulatory      3817..3822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATAAA"
     polyA_site      3848
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
     regulatory      6101..6106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATAAA"
     polyA_site      6124
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="major polyA site"
ORIGIN      
        1 gtacttccgg cgcgacacct tccctccacg cctggcctgg gctgtggggg agggaggcgg
       61 ttagtgggct ttagcgcctt tcctgacggc ggtagatttg aagcgctttc caggaccggg
      121 ccgggagacg agaagcccgc ggcggggcag gagcaaaaca attggctcag tcattcttgg
      181 tggatttttg tttttttatt gtttccccca acttaaagac tgaagtgttg gaaccatggg
      241 gataaaggtc cagcgtcctc ggtgtttttt tgacattgcc attaataatc aacctgctgg
      301 aagagttgtc tttgaattat tttccgatgt atgtcccaaa acgtgtgaga actttcgctg
      361 cctttgcaca ggtgaaaaag ggacagggaa atcaactcag aagccattac attataagag
      421 ctgtctcttt catagagttg tcaaggattt catggttcag ggtggtgact tcagtgaagg
      481 gaatggaaga ggaggagaat ctatttatgg aggattcttt gaagatgaga gttttgctgt
      541 taaacacaac aaagagtttc tcttatcaat ggccaacaga gggaaggata caaatggctc
      601 tcagttcttt ataacaacaa aaccaactcc tcatttagat gggcatcatg ttgtttttgg
      661 gcaagtgatc tctggtcagg aagttgtgag agagattgaa aaccagaaaa cagatgccgc
      721 tagcaaacca tttgctgaag ttcggatact cagttgcgga gagctgattc caaagtctaa
      781 ggttaagaaa gaagaaaaga aaaggcataa gtcctcgtcc tcctcctcct ccagtgactc
      841 agacagctca agcgattctc agtcctcctc tgagtcttct gattctgaaa gcgcttccga
      901 agaaaaatcc agaaaaagga aaaagaaaca taggaaaaat tcccgaaagc ataagaagga
      961 gaagaagaag cgaaagaaaa gcaagaaaag cccatctagt gaaagtgaag cagaaaatgt
     1021 tgatgcacag ccccagtcta ctgtccgtcc agaagagatc cctcctatac cagaaaatag
     1081 atttctaatg agaaaaagtc ctcctaaagc cgatgacaag gagaggaaaa acagagagag
     1141 agaaagagaa agagagtgta atccacctaa ctcccagcct gcttcatacc agcgacgatt
     1201 cttagttact aggtctggca ggaaaattaa aggaagagga ccgaggcgtt atcgaactcc
     1261 ttccagatcc agatcgaggg atcgattcag acgaagtgag actcctccac attggagaca
     1321 agagatgcag agagctcaga gaatgagggt gtcaagtggt gaaagatgga tcaaagggga
     1381 taagagtgag ttaaatgaaa taaaagaaaa tcaaaggagc ccagttagag taaaagagaa
     1441 aaaaataaca gatcacagac acatgtctga gagtccaaac agaaaagtag aaaaggaaaa
     1501 gaaagctaaa gaccataaat ctgaaagcaa agagagagac atcagaagaa attcagaaaa
     1561 agatgataaa tataacaaaa acaaagtgaa gaaaaggggc aaatccaaga gtaggagcaa
     1621 gagcaaggag agatccaaga gtaaggagcg agactcgaag cacagcagac acgaagacaa
     1681 gagggtgagg tcaagaagta aagaaaggga tcatgagact actaaagaaa aagaaaaacc
     1741 actggatcct aaagggaaag atcaggaaag gagtagaagc aaagagaact ccaaacaggt
     1801 agaatcaaaa agtaatgaac atgatcatag caaaagtaaa gaaaaggata gacgtgcaca
     1861 gtccaggagt agagaacggg atctgactaa aagtaaacac agttacaaca gtagaacaag
     1921 ggagcggagc agaagtaggg acaggagcag aagagtgcgg tccagaagcc acgacagaga
     1981 tcgcagcaga agcaaggagt accatagata cagagaacag gagtatagga gaagaggaag
     2041 gtcacgaagc cgggatcgaa gaacgccagg acgatcgaga agtaaagata ggaggagaag
     2101 aaggagggat tcccggagct cagagagaga agaaagtcaa agtagaaaca aagataaata
     2161 tagaagccaa gaaagtaaga gttcacacag aaaagaaaat tctgagggtg agaaaagaac
     2221 gtactctaaa agtcgtgatc ataatagctc aagtaataac agggaaaaaa aggctgatag
     2281 agagcaaagt ccagtgtcaa aaacaaagca aagcagtcag gacaatgaag tgaagtcctc
     2341 cacattaaaa aatcaagagg acgaaaagac cagatccccg gtggaaaaag aaaaccaaaa
     2401 atcaaagggt caagaaaatg accatgtaca tgacaaaaat aaaaaatgtg atcatgaatc
     2461 aagccctgga acagatgaag acaaaagtgg atgagtgagt tgtgtactct taattccttc
     2521 ctgtctcaaa ttttcagttt ttaagactta ctgttgaacc tccctttttt attgttttca
     2581 ttgttttgga gttgtttatg tttgtctccc cccaccccct tttttttttt aaatgtggac
     2641 ttcattgagt tgatcttttg ataatctgct acctggataa tttgtactgc taaagtttta
     2701 ataaacttga aatgaaaaga aaaacaacac tttggtgtaa tactgtgtgc tatgttaaat
     2761 tcttatgtat tcatttttgt gttgcaaccg tcaatagcag cctactttgc ttaatcagcc
     2821 atttggaaac aagcttaact gttggttgca gtacattgtt gtataggctt gtgtttcttt
     2881 tgatacaaat ccctttagaa accacttgaa gttttgtata gctttttggg ctttgatttt
     2941 tcatttataa ttcatgggct tagagcagtt tccttaacta acagaagcag gatccttatg
     3001 tgatcttaaa ccttcatttg attttacagt tatttgtact ttagttactt tttttgtgct
     3061 ttatacctta tactttacaa ttccagctgt agcttgtttc ttaatattgt ccacgttgct
     3121 ctgcgagcta taaaaatgag gtgagtgctg ttttcagttc atgtgctgat tgagcttgag
     3181 ttgctgttat acagcatttg acagaaatta gaccttggaa gaccagactg taattttcaa
     3241 ttctttgttg cttttggtgt gaagagctga aattgttgct ttttaagaac atgttattac
     3301 ctttttctac aatttaaaaa atgcatttct cattaaaaca tactacttgt gtagatcctt
     3361 cttaagctag acagattcta aaaagcgtta gtattggaaa taagatttcc ctattttggc
     3421 tattagccta tatcacattg agtggtaatt ctgcatgatt tgggtttgtt ttttgttttt
     3481 ttttttttaa acttggacta acttctctga ttctcatagc tgtgaatatg aaatgtcaag
     3541 aagatgcatc tttctatata tgtaccatga taggctgtgt agcatgtttg tgactctggt
     3601 ttctttctat tcagatggct ttagaccagt ttactgttaa cattatttta acttggcatg
     3661 tataacattg ccatataaag tagaatagaa agttgcaaaa tatgataccg tgcagagtta
     3721 aacactaaac atatccaaag tccattcaga attttgtgtg ttgtattttg ctattttttt
     3781 gtgatgtgtg gccttttatt ctgtaatatc cttctaaata aaacattgaa catccagcaa
     3841 acacaaaacc tgcctcattt gagaaatatt tcaaaaatcc aattaatagt agcctttagg
     3901 acgtttttgt actctaatat ttgtcagtat agtgtcagct cttaccaagg tagcttcttg
     3961 gtaaacccac tagcttttca atgatatttg tactgaataa agtgatgctt aatatacttc
     4021 ccattattga ttactatggt aagatatatt tggcattgta gctggtacag aatgaagagt
     4081 gcagtgatta taaagctatt tggaacatcc taaagcaaat acccacaatg gattctttac
     4141 aaatagtttt tcttgatggg aatagttaat atatacgtga tctgttacat gtcttaaaaa
     4201 gttgattatg tcttaaattc agttgtgttt taaaatatat cccaaactac ctgatcttta
     4261 agaaaggaat ttcaacaaac attttaaaat ccatactttt tttaagtaaa attacttttt
     4321 ttttcttatc tagagctttt acttgttagc atatacatta taaacaagaa ctttccagtt
     4381 ctttaggaaa gtaaacatgg gagaaaattg gtaatgtctg taatatcctc caagagagca
     4441 gctcagagct gagcatttac gggctccccc aactcctgct ttgttagttt gttatttttt
     4501 tcaatatgac agataatggg gtaaatagtt gagaaaagac aatctagatt tttttttcag
     4561 aataaataat taacagcatt aattgtaccc caagattcac agttatcaat tgcacaaagc
     4621 ccaaattctt gttctagtag atttttagtt atttgtacat catattccca aaactatttc
     4681 ccatttcaat tttcccatca cattggcttt ctaagaatat ctaaatttac agctaatgaa
     4741 tagtttttaa taccccttga aagtactttc acttgttttt attgcttgac tccaaagctg
     4801 aggaaattat ttcagtatgt aagactttga tgattattgt atgaattatt gttctggata
     4861 agttgtttac cacagaaatt gacactacaa agagatcgtt agagaaagta aagctactgt
     4921 attgtactgc attgtagctg atacagaatg gttacttgct gtaaagacaa gactgtctgg
     4981 gaacagctat ccaacgttta aagtgctctt tcacttaaaa gttatgctaa tctgctagct
     5041 ttctttgccc cagtgtgatc cagctgctca ctggctttgc ttgcatccag tggtaggtgt
     5101 caaaccaaga acctttatgt tctggatagg cacatgctgg ggttctggta ttttgggtaa
     5161 tagtattaac tactgctcct actttatttt ctagtgacta cttagagcag ttagtataat
     5221 tgatcctttg ttccatgtgt taatagcttt catcatggaa ccttttacag caaatttctg
     5281 taaatttccc agaaaggact tagacttaac tgattggtat aaaaaactaa atgagcattt
     5341 ttcattcttt tgtttctatt tactgtaatt attccctgta gggtttatgc atttacagtt
     5401 gacaaactct ctgtgtagtt tgagaaactt taattgtaag aatatatttt taaactaatt
     5461 gtttttaaaa ataaagtatc ccaaggaaac tgagtgttga ttgccattac tgcctgcagt
     5521 gggcttctca atgtcttgaa gggattcacc tgctgtgtga caaataaaca acaaatcaca
     5581 ttcatttaaa aaaaaaaaaa aggccgcaca ggccaaagag gaagaagtgt taaggtttta
     5641 ctcatttgct ctccctgact cacccctagt actggaggat ggaagggcat tcattggttt
     5701 gtatttctgt ctggttttgg ttttctttta tagacaattc catgttacta aaagcacatt
     5761 ctctgtattt ctgccccacc ctctttgtgt gtttatagta tttttgaaag attgacacat
     5821 aaattgggta tttctatgga atcttgaggt gtggctgctc tctgtggaag gggaaagcat
     5881 aattaggtta atgcacttct tttcctagct ccacagtcac tgtgatgtat atttttttaa
     5941 tggaatttag aaaacttgtt ttctcaattg taaaattagt ttaaagatgc tgcttctctt
     6001 atcattagtc tagtaaatgt tgaactgttt tctgcagatg gcattttaca aaatttaaac
     6061 ttcaaaactg tattaacttt tatagttaaa cattgtatta aataaagtat actacaataa
     6121 acaa
//
