LOCUS       NM_001407462            6214 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus peptidyl-prolyl isomerase G (cyclophilin G) (Ppig),
            transcript variant 3, mRNA.
ACCESSION   NM_001407462 XM_006499185
VERSION     NM_001407462.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6214)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845261.17.
            
            On Jun 2, 2022 this sequence version replaced XM_006499185.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422591.437233.1,
                                           SRR17784646.1156323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AL845261.17        39670-39819
            151-240             AL845261.17        48353-48442
            241-308             AL845261.17        48608-48675
            309-386             AL845261.17        49059-49136
            387-461             AL845261.17        49242-49316
            462-569             AL845261.17        49680-49787
            570-614             AL845261.17        50051-50095
            615-702             AL845261.17        51153-51240
            703-732             AL845261.17        52730-52759
            733-872             AL845261.17        52851-52990
            873-1080            AL845261.17        58348-58555
            1081-1248           AL845261.17        60475-60642
            1249-1336           AL845261.17        62890-62977
            1337-1473           AL845261.17        65823-65959
            1474-6214           AL845261.17        66134-70874
FEATURES             Location/Qualifiers
     source          1..6214
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 40.95 cM"
     gene            1..6214
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="peptidyl-prolyl isomerase G (cyclophilin G)"
                     /db_xref="GeneID:228005"
                     /db_xref="MGI:MGI:2445173"
     exon            1..150
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            151..240
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            241..308
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            309..386
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..2584
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 3;
                     peptidylprolyl isomerase G; peptidyl-prolyl cis-trans
                     isomerase G; PPIase G; rotamase G; cyclophilin G"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase G isoform 1"
                     /protein_id="NP_001394391.1"
                     /db_xref="GeneID:228005"
                     /db_xref="MGI:MGI:2445173"
                     /translation="MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLC
                     TGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAV
                     KHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTD
                     AASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSDSDSSSDSQSSSESSDSE
                     SASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEAENVDAQPQSTVRPEEIP
                     PIPENRFLMRKSPPKADDKERKNRERERERECNPPNSQPASYQRRFLVTRSGRKIKGR
                     GPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKEN
                     QRSPVRVKEKKITDHRHMSESPNRKVEKEKKAKDHKSESKERDIRRNSEKDDKYNKNK
                     VKKRGKSKSRSKSKERSKSKERDSKHSRHEDKRVRSRSKERDHETTKEKEKPLDPKGK
                     DQERSRSKENSKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSYNSRTRERSR
                     SRDRSRRVRSRSHDRDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRRRRR
                     DSRSSEREESQSRNKDKYRSQESKSSHRKENSEGEKRTYSKSRDHNSSSNNREKKADR
                     EQSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDH
                     ESSPGTDEDKSG"
     exon            387..461
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            462..569
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            570..614
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            615..702
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            703..732
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            733..872
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1080
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1248
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1336
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1473
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..6214
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2801..2806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATGAA"
     polyA_site      2819
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="major polyA site"
     regulatory      3907..3912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATAAA"
     polyA_site      3938
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
     regulatory      6191..6196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATAAA"
     polyA_site      6214
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="major polyA site"
ORIGIN      
        1 gtacttccgg cgcgacacct tccctccacg cctggcctgg gctgtggggg agggaggcgg
       61 ttagtgggct ttagcgcctt tcctgacggc ggtagatttg aagcgctttc caggaccggg
      121 ccgggagacg agaagcccgc ggcggggcag gtgtagtaac atgcacctgt catcccagca
      181 gcattcagga ggctgaggca gaaggattgc cataaattgt aggccagcct aggctataaa
      241 gagcaaaaca attggctcag tcattcttgg tggatttttg tttttttatt gtttccccca
      301 acttaaagac tgaagtgttg gaaccatggg gataaaggtc cagcgtcctc ggtgtttttt
      361 tgacattgcc attaataatc aacctgctgg aagagttgtc tttgaattat tttccgatgt
      421 atgtcccaaa acgtgtgaga actttcgctg cctttgcaca ggtgaaaaag ggacagggaa
      481 atcaactcag aagccattac attataagag ctgtctcttt catagagttg tcaaggattt
      541 catggttcag ggtggtgact tcagtgaagg gaatggaaga ggaggagaat ctatttatgg
      601 aggattcttt gaagatgaga gttttgctgt taaacacaac aaagagtttc tcttatcaat
      661 ggccaacaga gggaaggata caaatggctc tcagttcttt ataacaacaa aaccaactcc
      721 tcatttagat gggcatcatg ttgtttttgg gcaagtgatc tctggtcagg aagttgtgag
      781 agagattgaa aaccagaaaa cagatgccgc tagcaaacca tttgctgaag ttcggatact
      841 cagttgcgga gagctgattc caaagtctaa ggttaagaaa gaagaaaaga aaaggcataa
      901 gtcctcgtcc tcctcctcct ccagtgactc agacagctca agcgattctc agtcctcctc
      961 tgagtcttct gattctgaaa gcgcttccga agaaaaatcc agaaaaagga aaaagaaaca
     1021 taggaaaaat tcccgaaagc ataagaagga gaagaagaag cgaaagaaaa gcaagaaaag
     1081 cccatctagt gaaagtgaag cagaaaatgt tgatgcacag ccccagtcta ctgtccgtcc
     1141 agaagagatc cctcctatac cagaaaatag atttctaatg agaaaaagtc ctcctaaagc
     1201 cgatgacaag gagaggaaaa acagagagag agaaagagaa agagagtgta atccacctaa
     1261 ctcccagcct gcttcatacc agcgacgatt cttagttact aggtctggca ggaaaattaa
     1321 aggaagagga ccgaggcgtt atcgaactcc ttccagatcc agatcgaggg atcgattcag
     1381 acgaagtgag actcctccac attggagaca agagatgcag agagctcaga gaatgagggt
     1441 gtcaagtggt gaaagatgga tcaaagggga taagagtgag ttaaatgaaa taaaagaaaa
     1501 tcaaaggagc ccagttagag taaaagagaa aaaaataaca gatcacagac acatgtctga
     1561 gagtccaaac agaaaagtag aaaaggaaaa gaaagctaaa gaccataaat ctgaaagcaa
     1621 agagagagac atcagaagaa attcagaaaa agatgataaa tataacaaaa acaaagtgaa
     1681 gaaaaggggc aaatccaaga gtaggagcaa gagcaaggag agatccaaga gtaaggagcg
     1741 agactcgaag cacagcagac acgaagacaa gagggtgagg tcaagaagta aagaaaggga
     1801 tcatgagact actaaagaaa aagaaaaacc actggatcct aaagggaaag atcaggaaag
     1861 gagtagaagc aaagagaact ccaaacaggt agaatcaaaa agtaatgaac atgatcatag
     1921 caaaagtaaa gaaaaggata gacgtgcaca gtccaggagt agagaacggg atctgactaa
     1981 aagtaaacac agttacaaca gtagaacaag ggagcggagc agaagtaggg acaggagcag
     2041 aagagtgcgg tccagaagcc acgacagaga tcgcagcaga agcaaggagt accatagata
     2101 cagagaacag gagtatagga gaagaggaag gtcacgaagc cgggatcgaa gaacgccagg
     2161 acgatcgaga agtaaagata ggaggagaag aaggagggat tcccggagct cagagagaga
     2221 agaaagtcaa agtagaaaca aagataaata tagaagccaa gaaagtaaga gttcacacag
     2281 aaaagaaaat tctgagggtg agaaaagaac gtactctaaa agtcgtgatc ataatagctc
     2341 aagtaataac agggaaaaaa aggctgatag agagcaaagt ccagtgtcaa aaacaaagca
     2401 aagcagtcag gacaatgaag tgaagtcctc cacattaaaa aatcaagagg acgaaaagac
     2461 cagatccccg gtggaaaaag aaaaccaaaa atcaaagggt caagaaaatg accatgtaca
     2521 tgacaaaaat aaaaaatgtg atcatgaatc aagccctgga acagatgaag acaaaagtgg
     2581 atgagtgagt tgtgtactct taattccttc ctgtctcaaa ttttcagttt ttaagactta
     2641 ctgttgaacc tccctttttt attgttttca ttgttttgga gttgtttatg tttgtctccc
     2701 cccaccccct tttttttttt aaatgtggac ttcattgagt tgatcttttg ataatctgct
     2761 acctggataa tttgtactgc taaagtttta ataaacttga aatgaaaaga aaaacaacac
     2821 tttggtgtaa tactgtgtgc tatgttaaat tcttatgtat tcatttttgt gttgcaaccg
     2881 tcaatagcag cctactttgc ttaatcagcc atttggaaac aagcttaact gttggttgca
     2941 gtacattgtt gtataggctt gtgtttcttt tgatacaaat ccctttagaa accacttgaa
     3001 gttttgtata gctttttggg ctttgatttt tcatttataa ttcatgggct tagagcagtt
     3061 tccttaacta acagaagcag gatccttatg tgatcttaaa ccttcatttg attttacagt
     3121 tatttgtact ttagttactt tttttgtgct ttatacctta tactttacaa ttccagctgt
     3181 agcttgtttc ttaatattgt ccacgttgct ctgcgagcta taaaaatgag gtgagtgctg
     3241 ttttcagttc atgtgctgat tgagcttgag ttgctgttat acagcatttg acagaaatta
     3301 gaccttggaa gaccagactg taattttcaa ttctttgttg cttttggtgt gaagagctga
     3361 aattgttgct ttttaagaac atgttattac ctttttctac aatttaaaaa atgcatttct
     3421 cattaaaaca tactacttgt gtagatcctt cttaagctag acagattcta aaaagcgtta
     3481 gtattggaaa taagatttcc ctattttggc tattagccta tatcacattg agtggtaatt
     3541 ctgcatgatt tgggtttgtt ttttgttttt ttttttttaa acttggacta acttctctga
     3601 ttctcatagc tgtgaatatg aaatgtcaag aagatgcatc tttctatata tgtaccatga
     3661 taggctgtgt agcatgtttg tgactctggt ttctttctat tcagatggct ttagaccagt
     3721 ttactgttaa cattatttta acttggcatg tataacattg ccatataaag tagaatagaa
     3781 agttgcaaaa tatgataccg tgcagagtta aacactaaac atatccaaag tccattcaga
     3841 attttgtgtg ttgtattttg ctattttttt gtgatgtgtg gccttttatt ctgtaatatc
     3901 cttctaaata aaacattgaa catccagcaa acacaaaacc tgcctcattt gagaaatatt
     3961 tcaaaaatcc aattaatagt agcctttagg acgtttttgt actctaatat ttgtcagtat
     4021 agtgtcagct cttaccaagg tagcttcttg gtaaacccac tagcttttca atgatatttg
     4081 tactgaataa agtgatgctt aatatacttc ccattattga ttactatggt aagatatatt
     4141 tggcattgta gctggtacag aatgaagagt gcagtgatta taaagctatt tggaacatcc
     4201 taaagcaaat acccacaatg gattctttac aaatagtttt tcttgatggg aatagttaat
     4261 atatacgtga tctgttacat gtcttaaaaa gttgattatg tcttaaattc agttgtgttt
     4321 taaaatatat cccaaactac ctgatcttta agaaaggaat ttcaacaaac attttaaaat
     4381 ccatactttt tttaagtaaa attacttttt ttttcttatc tagagctttt acttgttagc
     4441 atatacatta taaacaagaa ctttccagtt ctttaggaaa gtaaacatgg gagaaaattg
     4501 gtaatgtctg taatatcctc caagagagca gctcagagct gagcatttac gggctccccc
     4561 aactcctgct ttgttagttt gttatttttt tcaatatgac agataatggg gtaaatagtt
     4621 gagaaaagac aatctagatt tttttttcag aataaataat taacagcatt aattgtaccc
     4681 caagattcac agttatcaat tgcacaaagc ccaaattctt gttctagtag atttttagtt
     4741 atttgtacat catattccca aaactatttc ccatttcaat tttcccatca cattggcttt
     4801 ctaagaatat ctaaatttac agctaatgaa tagtttttaa taccccttga aagtactttc
     4861 acttgttttt attgcttgac tccaaagctg aggaaattat ttcagtatgt aagactttga
     4921 tgattattgt atgaattatt gttctggata agttgtttac cacagaaatt gacactacaa
     4981 agagatcgtt agagaaagta aagctactgt attgtactgc attgtagctg atacagaatg
     5041 gttacttgct gtaaagacaa gactgtctgg gaacagctat ccaacgttta aagtgctctt
     5101 tcacttaaaa gttatgctaa tctgctagct ttctttgccc cagtgtgatc cagctgctca
     5161 ctggctttgc ttgcatccag tggtaggtgt caaaccaaga acctttatgt tctggatagg
     5221 cacatgctgg ggttctggta ttttgggtaa tagtattaac tactgctcct actttatttt
     5281 ctagtgacta cttagagcag ttagtataat tgatcctttg ttccatgtgt taatagcttt
     5341 catcatggaa ccttttacag caaatttctg taaatttccc agaaaggact tagacttaac
     5401 tgattggtat aaaaaactaa atgagcattt ttcattcttt tgtttctatt tactgtaatt
     5461 attccctgta gggtttatgc atttacagtt gacaaactct ctgtgtagtt tgagaaactt
     5521 taattgtaag aatatatttt taaactaatt gtttttaaaa ataaagtatc ccaaggaaac
     5581 tgagtgttga ttgccattac tgcctgcagt gggcttctca atgtcttgaa gggattcacc
     5641 tgctgtgtga caaataaaca acaaatcaca ttcatttaaa aaaaaaaaaa aggccgcaca
     5701 ggccaaagag gaagaagtgt taaggtttta ctcatttgct ctccctgact cacccctagt
     5761 actggaggat ggaagggcat tcattggttt gtatttctgt ctggttttgg ttttctttta
     5821 tagacaattc catgttacta aaagcacatt ctctgtattt ctgccccacc ctctttgtgt
     5881 gtttatagta tttttgaaag attgacacat aaattgggta tttctatgga atcttgaggt
     5941 gtggctgctc tctgtggaag gggaaagcat aattaggtta atgcacttct tttcctagct
     6001 ccacagtcac tgtgatgtat atttttttaa tggaatttag aaaacttgtt ttctcaattg
     6061 taaaattagt ttaaagatgc tgcttctctt atcattagtc tagtaaatgt tgaactgttt
     6121 tctgcagatg gcattttaca aaatttaaac ttcaaaactg tattaacttt tatagttaaa
     6181 cattgtatta aataaagtat actacaataa acaa
//
