LOCUS       NM_001081086            6259 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus peptidyl-prolyl isomerase G (cyclophilin G) (Ppig),
            transcript variant 1, mRNA.
ACCESSION   NM_001081086 XM_130275
VERSION     NM_001081086.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6259)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845261.17.
            
            On Jun 2, 2022 this sequence version replaced NM_001081086.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150694.1, SRR7652917.944934.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AL845261.17        39941-40225
            286-353             AL845261.17        48608-48675
            354-431             AL845261.17        49059-49136
            432-506             AL845261.17        49242-49316
            507-614             AL845261.17        49680-49787
            615-659             AL845261.17        50051-50095
            660-747             AL845261.17        51153-51240
            748-777             AL845261.17        52730-52759
            778-917             AL845261.17        52851-52990
            918-1125            AL845261.17        58348-58555
            1126-1293           AL845261.17        60475-60642
            1294-1381           AL845261.17        62890-62977
            1382-1518           AL845261.17        65823-65959
            1519-6259           AL845261.17        66134-70874
FEATURES             Location/Qualifiers
     source          1..6259
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 40.95 cM"
     gene            1..6259
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="peptidyl-prolyl isomerase G (cyclophilin G)"
                     /db_xref="GeneID:228005"
                     /db_xref="MGI:MGI:2445173"
     exon            1..285
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            286..353
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            354..431
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..2629
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peptidylprolyl isomerase G; peptidyl-prolyl cis-trans
                     isomerase G; PPIase G; rotamase G; cyclophilin G"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase G isoform 1"
                     /protein_id="NP_001074555.1"
                     /db_xref="CCDS:CCDS38137.1"
                     /db_xref="GeneID:228005"
                     /db_xref="MGI:MGI:2445173"
                     /translation="MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLC
                     TGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAV
                     KHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTD
                     AASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSDSDSSSDSQSSSESSDSE
                     SASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEAENVDAQPQSTVRPEEIP
                     PIPENRFLMRKSPPKADDKERKNRERERERECNPPNSQPASYQRRFLVTRSGRKIKGR
                     GPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKEN
                     QRSPVRVKEKKITDHRHMSESPNRKVEKEKKAKDHKSESKERDIRRNSEKDDKYNKNK
                     VKKRGKSKSRSKSKERSKSKERDSKHSRHEDKRVRSRSKERDHETTKEKEKPLDPKGK
                     DQERSRSKENSKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSYNSRTRERSR
                     SRDRSRRVRSRSHDRDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRRRRR
                     DSRSSEREESQSRNKDKYRSQESKSSHRKENSEGEKRTYSKSRDHNSSSNNREKKADR
                     EQSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDH
                     ESSPGTDEDKSG"
     exon            432..506
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            507..614
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            615..659
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            660..747
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            748..777
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            778..917
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1125
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1293
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1381
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1518
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..6259
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2846..2851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATGAA"
     polyA_site      2864
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="major polyA site"
     regulatory      3952..3957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATAAA"
     polyA_site      3983
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
     regulatory      6236..6241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="hexamer: AATAAA"
     polyA_site      6259
                     /gene="Ppig"
                     /gene_synonym="B230312B02Rik; CYP; SRCyp"
                     /note="major polyA site"
ORIGIN      
        1 ctttccgtcg aggtctctgg gctgctcggg ctcggagggg tggccccggg gaccgcggcg
       61 cggcctgggg ccccgtggtg gcccggcggc ttgcagccga gccccggggc gaaggaagcg
      121 gctcttcctc tccagccccc gccctcccgg ctcgggcgca cacctcctcc ctgacgcatt
      181 ttgccgcaca agctgtaata tggcggcagc gacggcagcc tcggctcccg ggagctaggt
      241 tcgttttgga ggcttcagaa ccgggagacg gagcgctgcg gcgtggagca aaacaattgg
      301 ctcagtcatt cttggtggat ttttgttttt ttattgtttc ccccaactta aagactgaag
      361 tgttggaacc atggggataa aggtccagcg tcctcggtgt ttttttgaca ttgccattaa
      421 taatcaacct gctggaagag ttgtctttga attattttcc gatgtatgtc ccaaaacgtg
      481 tgagaacttt cgctgccttt gcacaggtga aaaagggaca gggaaatcaa ctcagaagcc
      541 attacattat aagagctgtc tctttcatag agttgtcaag gatttcatgg ttcagggtgg
      601 tgacttcagt gaagggaatg gaagaggagg agaatctatt tatggaggat tctttgaaga
      661 tgagagtttt gctgttaaac acaacaaaga gtttctctta tcaatggcca acagagggaa
      721 ggatacaaat ggctctcagt tctttataac aacaaaacca actcctcatt tagatgggca
      781 tcatgttgtt tttgggcaag tgatctctgg tcaggaagtt gtgagagaga ttgaaaacca
      841 gaaaacagat gccgctagca aaccatttgc tgaagttcgg atactcagtt gcggagagct
      901 gattccaaag tctaaggtta agaaagaaga aaagaaaagg cataagtcct cgtcctcctc
      961 ctcctccagt gactcagaca gctcaagcga ttctcagtcc tcctctgagt cttctgattc
     1021 tgaaagcgct tccgaagaaa aatccagaaa aaggaaaaag aaacatagga aaaattcccg
     1081 aaagcataag aaggagaaga agaagcgaaa gaaaagcaag aaaagcccat ctagtgaaag
     1141 tgaagcagaa aatgttgatg cacagcccca gtctactgtc cgtccagaag agatccctcc
     1201 tataccagaa aatagatttc taatgagaaa aagtcctcct aaagccgatg acaaggagag
     1261 gaaaaacaga gagagagaaa gagaaagaga gtgtaatcca cctaactccc agcctgcttc
     1321 ataccagcga cgattcttag ttactaggtc tggcaggaaa attaaaggaa gaggaccgag
     1381 gcgttatcga actccttcca gatccagatc gagggatcga ttcagacgaa gtgagactcc
     1441 tccacattgg agacaagaga tgcagagagc tcagagaatg agggtgtcaa gtggtgaaag
     1501 atggatcaaa ggggataaga gtgagttaaa tgaaataaaa gaaaatcaaa ggagcccagt
     1561 tagagtaaaa gagaaaaaaa taacagatca cagacacatg tctgagagtc caaacagaaa
     1621 agtagaaaag gaaaagaaag ctaaagacca taaatctgaa agcaaagaga gagacatcag
     1681 aagaaattca gaaaaagatg ataaatataa caaaaacaaa gtgaagaaaa ggggcaaatc
     1741 caagagtagg agcaagagca aggagagatc caagagtaag gagcgagact cgaagcacag
     1801 cagacacgaa gacaagaggg tgaggtcaag aagtaaagaa agggatcatg agactactaa
     1861 agaaaaagaa aaaccactgg atcctaaagg gaaagatcag gaaaggagta gaagcaaaga
     1921 gaactccaaa caggtagaat caaaaagtaa tgaacatgat catagcaaaa gtaaagaaaa
     1981 ggatagacgt gcacagtcca ggagtagaga acgggatctg actaaaagta aacacagtta
     2041 caacagtaga acaagggagc ggagcagaag tagggacagg agcagaagag tgcggtccag
     2101 aagccacgac agagatcgca gcagaagcaa ggagtaccat agatacagag aacaggagta
     2161 taggagaaga ggaaggtcac gaagccggga tcgaagaacg ccaggacgat cgagaagtaa
     2221 agataggagg agaagaagga gggattcccg gagctcagag agagaagaaa gtcaaagtag
     2281 aaacaaagat aaatatagaa gccaagaaag taagagttca cacagaaaag aaaattctga
     2341 gggtgagaaa agaacgtact ctaaaagtcg tgatcataat agctcaagta ataacaggga
     2401 aaaaaaggct gatagagagc aaagtccagt gtcaaaaaca aagcaaagca gtcaggacaa
     2461 tgaagtgaag tcctccacat taaaaaatca agaggacgaa aagaccagat ccccggtgga
     2521 aaaagaaaac caaaaatcaa agggtcaaga aaatgaccat gtacatgaca aaaataaaaa
     2581 atgtgatcat gaatcaagcc ctggaacaga tgaagacaaa agtggatgag tgagttgtgt
     2641 actcttaatt ccttcctgtc tcaaattttc agtttttaag acttactgtt gaacctccct
     2701 tttttattgt tttcattgtt ttggagttgt ttatgtttgt ctccccccac cccctttttt
     2761 tttttaaatg tggacttcat tgagttgatc ttttgataat ctgctacctg gataatttgt
     2821 actgctaaag ttttaataaa cttgaaatga aaagaaaaac aacactttgg tgtaatactg
     2881 tgtgctatgt taaattctta tgtattcatt tttgtgttgc aaccgtcaat agcagcctac
     2941 tttgcttaat cagccatttg gaaacaagct taactgttgg ttgcagtaca ttgttgtata
     3001 ggcttgtgtt tcttttgata caaatccctt tagaaaccac ttgaagtttt gtatagcttt
     3061 ttgggctttg atttttcatt tataattcat gggcttagag cagtttcctt aactaacaga
     3121 agcaggatcc ttatgtgatc ttaaaccttc atttgatttt acagttattt gtactttagt
     3181 tacttttttt gtgctttata ccttatactt tacaattcca gctgtagctt gtttcttaat
     3241 attgtccacg ttgctctgcg agctataaaa atgaggtgag tgctgttttc agttcatgtg
     3301 ctgattgagc ttgagttgct gttatacagc atttgacaga aattagacct tggaagacca
     3361 gactgtaatt ttcaattctt tgttgctttt ggtgtgaaga gctgaaattg ttgcttttta
     3421 agaacatgtt attacctttt tctacaattt aaaaaatgca tttctcatta aaacatacta
     3481 cttgtgtaga tccttcttaa gctagacaga ttctaaaaag cgttagtatt ggaaataaga
     3541 tttccctatt ttggctatta gcctatatca cattgagtgg taattctgca tgatttgggt
     3601 ttgttttttg tttttttttt tttaaacttg gactaacttc tctgattctc atagctgtga
     3661 atatgaaatg tcaagaagat gcatctttct atatatgtac catgataggc tgtgtagcat
     3721 gtttgtgact ctggtttctt tctattcaga tggctttaga ccagtttact gttaacatta
     3781 ttttaacttg gcatgtataa cattgccata taaagtagaa tagaaagttg caaaatatga
     3841 taccgtgcag agttaaacac taaacatatc caaagtccat tcagaatttt gtgtgttgta
     3901 ttttgctatt tttttgtgat gtgtggcctt ttattctgta atatccttct aaataaaaca
     3961 ttgaacatcc agcaaacaca aaacctgcct catttgagaa atatttcaaa aatccaatta
     4021 atagtagcct ttaggacgtt tttgtactct aatatttgtc agtatagtgt cagctcttac
     4081 caaggtagct tcttggtaaa cccactagct tttcaatgat atttgtactg aataaagtga
     4141 tgcttaatat acttcccatt attgattact atggtaagat atatttggca ttgtagctgg
     4201 tacagaatga agagtgcagt gattataaag ctatttggaa catcctaaag caaataccca
     4261 caatggattc tttacaaata gtttttcttg atgggaatag ttaatatata cgtgatctgt
     4321 tacatgtctt aaaaagttga ttatgtctta aattcagttg tgttttaaaa tatatcccaa
     4381 actacctgat ctttaagaaa ggaatttcaa caaacatttt aaaatccata ctttttttaa
     4441 gtaaaattac tttttttttc ttatctagag cttttacttg ttagcatata cattataaac
     4501 aagaactttc cagttcttta ggaaagtaaa catgggagaa aattggtaat gtctgtaata
     4561 tcctccaaga gagcagctca gagctgagca tttacgggct cccccaactc ctgctttgtt
     4621 agtttgttat ttttttcaat atgacagata atggggtaaa tagttgagaa aagacaatct
     4681 agattttttt ttcagaataa ataattaaca gcattaattg taccccaaga ttcacagtta
     4741 tcaattgcac aaagcccaaa ttcttgttct agtagatttt tagttatttg tacatcatat
     4801 tcccaaaact atttcccatt tcaattttcc catcacattg gctttctaag aatatctaaa
     4861 tttacagcta atgaatagtt tttaataccc cttgaaagta ctttcacttg tttttattgc
     4921 ttgactccaa agctgaggaa attatttcag tatgtaagac tttgatgatt attgtatgaa
     4981 ttattgttct ggataagttg tttaccacag aaattgacac tacaaagaga tcgttagaga
     5041 aagtaaagct actgtattgt actgcattgt agctgataca gaatggttac ttgctgtaaa
     5101 gacaagactg tctgggaaca gctatccaac gtttaaagtg ctctttcact taaaagttat
     5161 gctaatctgc tagctttctt tgccccagtg tgatccagct gctcactggc tttgcttgca
     5221 tccagtggta ggtgtcaaac caagaacctt tatgttctgg ataggcacat gctggggttc
     5281 tggtattttg ggtaatagta ttaactactg ctcctacttt attttctagt gactacttag
     5341 agcagttagt ataattgatc ctttgttcca tgtgttaata gctttcatca tggaaccttt
     5401 tacagcaaat ttctgtaaat ttcccagaaa ggacttagac ttaactgatt ggtataaaaa
     5461 actaaatgag catttttcat tcttttgttt ctatttactg taattattcc ctgtagggtt
     5521 tatgcattta cagttgacaa actctctgtg tagtttgaga aactttaatt gtaagaatat
     5581 atttttaaac taattgtttt taaaaataaa gtatcccaag gaaactgagt gttgattgcc
     5641 attactgcct gcagtgggct tctcaatgtc ttgaagggat tcacctgctg tgtgacaaat
     5701 aaacaacaaa tcacattcat ttaaaaaaaa aaaaaaggcc gcacaggcca aagaggaaga
     5761 agtgttaagg ttttactcat ttgctctccc tgactcaccc ctagtactgg aggatggaag
     5821 ggcattcatt ggtttgtatt tctgtctggt tttggttttc ttttatagac aattccatgt
     5881 tactaaaagc acattctctg tatttctgcc ccaccctctt tgtgtgttta tagtattttt
     5941 gaaagattga cacataaatt gggtatttct atggaatctt gaggtgtggc tgctctctgt
     6001 ggaaggggaa agcataatta ggttaatgca cttcttttcc tagctccaca gtcactgtga
     6061 tgtatatttt tttaatggaa tttagaaaac ttgttttctc aattgtaaaa ttagtttaaa
     6121 gatgctgctt ctcttatcat tagtctagta aatgttgaac tgttttctgc agatggcatt
     6181 ttacaaaatt taaacttcaa aactgtatta acttttatag ttaaacattg tattaaataa
     6241 agtatactac aataaacaa
//
