LOCUS       NM_134084               1560 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus peptidylprolyl isomerase F (cyclophilin F) (Ppif),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_134084
VERSION     NM_134084.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1560)
  AUTHORS   Sautchuk,R. Jr., Martinez,J., Catheline,S.E. and Eliseev,R.A.
  TITLE     Cyclophilin D, regulator of the mitochondrial permeability
            transition, impacts bone development and fracture repair
  JOURNAL   Bone 189, 117258 (2024)
   PUBMED   39299628
  REMARK    GeneRIF: Cyclophilin D, regulator of the mitochondrial permeability
            transition, impacts bone development and fracture repair.
REFERENCE   2  (bases 1 to 1560)
  AUTHORS   Ballard-Kordeliski,A., Lee,R.H., O'Shaughnessy,E.C., Kim,P.Y.,
            Jones,S.R., Pawlinski,R., Flick,M.J., Paul,D.S., Mackman,N.,
            Adalsteinsson,D.A. and Bergmeier,W.
  TITLE     4D intravital imaging studies identify platelets as the predominant
            cellular procoagulant surface in a mouse hemostasis model
  JOURNAL   Blood 144 (10), 1116-1126 (2024)
   PUBMED   38820498
REFERENCE   3  (bases 1 to 1560)
  AUTHORS   Koga,J.I., Umezu,R., Kondo,Y., Shirouzu,T., Orkhonselenge,N.,
            Ueno,H., Katsuki,S., Matoba,T., Nishimura,Y. and Kataoka,M.
  TITLE     Cyclophilin D induces necrotic core formation by mediating
            mitochondria-associated macrophage death in advanced
            atherosclerotic lesions
  JOURNAL   Atherosclerosis 396, 118524 (2024)
   PUBMED   38972156
REFERENCE   4  (bases 1 to 1560)
  AUTHORS   Dikalova,A., Fehrenbach,D., Mayorov,V., Panov,A., Ao,M.,
            Lantier,L., Amarnath,V., Lopez,M.G., Billings,F.T. 4th, Sack,M.N.
            and Dikalov,S.
  TITLE     Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and
            Hypertension
  JOURNAL   Circ Res 134 (11), 1451-1464 (2024)
   PUBMED   38639088
  REMARK    GeneRIF: Mitochondrial CypD Acetylation Promotes Endothelial
            Dysfunction and Hypertension.
REFERENCE   5  (bases 1 to 1560)
  AUTHORS   Stauffer,W.T., Bobardt,M., Ure,D.R., Foster,R.T. and Gallay,P.
  TITLE     Cyclophilin D knockout significantly prevents HCC development in a
            streptozotocin-induced mouse model of diabetes-linked NASH
  JOURNAL   PLoS One 19 (4), e0301711 (2024)
   PUBMED   38573968
  REMARK    GeneRIF: Cyclophilin D knockout significantly prevents HCC
            development in a streptozotocin-induced mouse model of
            diabetes-linked NASH.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1560)
  AUTHORS   Schneider,M.D.
  TITLE     Cyclophilin D: knocking on death's door
  JOURNAL   Sci STKE 2005 (287), pe26 (2005)
   PUBMED   15942033
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1560)
  AUTHORS   Basso,E., Fante,L., Fowlkes,J., Petronilli,V., Forte,M.A. and
            Bernardi,P.
  TITLE     Properties of the permeability transition pore in mitochondria
            devoid of Cyclophilin D
  JOURNAL   J Biol Chem 280 (19), 18558-18561 (2005)
   PUBMED   15792954
  REMARK    GeneRIF: the permeability transition pore can form and open in the
            absence of CyP-D, which is the target for PTP inhibition by
            Cyclosporin A
REFERENCE   8  (bases 1 to 1560)
  AUTHORS   Baines,C.P., Kaiser,R.A., Purcell,N.H., Blair,N.S., Osinska,H.,
            Hambleton,M.A., Brunskill,E.W., Sayen,M.R., Gottlieb,R.A.,
            Dorn,G.W., Robbins,J. and Molkentin,J.D.
  TITLE     Loss of cyclophilin D reveals a critical role for mitochondrial
            permeability transition in cell death
  JOURNAL   Nature 434 (7033), 658-662 (2005)
   PUBMED   15800627
  REMARK    GeneRIF: cyclophilin D and the mitochondrial permeability
            transition are required for mediating Ca2+- and oxidative
            damage-induced cell death, but not Bcl-2 family member-regulated
            death
REFERENCE   9  (bases 1 to 1560)
  AUTHORS   Nakagawa,T., Shimizu,S., Watanabe,T., Yamaguchi,O., Otsu,K.,
            Yamagata,H., Inohara,H., Kubo,T. and Tsujimoto,Y.
  TITLE     Cyclophilin D-dependent mitochondrial permeability transition
            regulates some necrotic but not apoptotic cell death
  JOURNAL   Nature 434 (7033), 652-658 (2005)
   PUBMED   15800626
  REMARK    GeneRIF: results indicate that the CypD-dependent mitochondrial
            permeability transition regulates some forms of necrotic death, but
            not apoptotic death
REFERENCE   10 (bases 1 to 1560)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC004041.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004041.1, BQ942760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1560
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 15.06 cM"
     gene            1..1560
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CyP-F; CypD; PPIase"
                     /note="peptidylprolyl isomerase F (cyclophilin F)"
                     /db_xref="GeneID:105675"
                     /db_xref="MGI:MGI:2145814"
     exon            1..254
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CyP-F; CypD; PPIase"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..683
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CyP-F; CypD; PPIase"
                     /EC_number="5.2.1.8"
                     /note="peptidyl-prolyl cis-trans isomerase, mitochondrial;
                     peptidyl-prolyl cis-trans isomerase F, mitochondrial;
                     cyclophilin D; cyclophilin F; PPIase F; rotamase F;
                     mitochondrial Cyclophilin D"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase F,
                     mitochondrial precursor"
                     /protein_id="NP_598845.1"
                     /db_xref="CCDS:CCDS26874.1"
                     /db_xref="GeneID:105675"
                     /db_xref="MGI:MGI:2145814"
                     /translation="MLALRCGPRLLGLLSGPRSAPLLLSATRTCSDGGARGANSSSGN
                     PLVYLDVGADGQPLGRVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPAFM
                     CQAGDFTNHNGTGGRSIYGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKT
                     DWLDGKHVVFGHVKEGMDVVKKIESFGSKSGKTSKKIVITDCGQLS"
     exon            255..285
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CyP-F; CypD; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            286..374
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CyP-F; CypD; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            375..471
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CyP-F; CypD; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            472..547
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CyP-F; CypD; PPIase"
                     /inference="alignment:Splign:2.1.0"
     exon            548..1549
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CyP-F; CypD; PPIase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1527..1532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CyP-F; CypD; PPIase"
                     /note="hexamer: AATAAA"
     polyA_site      1549
                     /gene="Ppif"
                     /gene_synonym="CyP-D; CyP-F; CypD; PPIase"
                     /note="major polyA site"
ORIGIN      
        1 tacgaccttg cctgtgtctg ctctgagttc ttccgcgcgc cctcgcccga cccgcgacag
       61 cgatgctagc gctgcgttgc ggcccccgcc tgctcggtct gctctccggc ccgcgctccg
      121 cgccgctgct cctctccgcg acccgtacct gcagcgacgg cggagcccgc ggcgcgaact
      181 cttcctccgg gaacccgctc gtgtacttgg acgtgggcgc cgatggacag ccgctcggcc
      241 gcgtggtgct ggagttaaag gcagatgtcg tgccaaagac tgcagagaac ttcagagccc
      301 tatgcactgg tgagaagggc tttggctaca aaggctccac cttccacagg gtgatcccag
      361 ccttcatgtg ccaggctggc gacttcacca accacaatgg cacaggaggg aggtccatct
      421 acggaagccg ctttcccgac gagaacttca cactgaagca tgtggggcca ggtgtcctgt
      481 ccatggcgaa cgcaggcccc aacaccaatg gctctcagtt ctttatctgc acgataaaga
      541 cagactggct agatggcaag catgtcgtgt tcggccatgt caaagagggc atggatgttg
      601 tgaagaaaat agaatctttc ggctcaaaaa gtgggaagac gtctaagaag attgtcatca
      661 cagactgtgg ccagttgagc taactcacag ccaaggtgct aggacagcag caggcatcca
      721 tgtcttgatt cacccaggtt ctccaaagaa cagtttgcac ccacttctat tgagtctgag
      781 gaaggccact caggcatggt cctcccagac caggctgctc tccactgtcc atcctgcctc
      841 agatcccgtt tctgggcatc agtatggcca tcgggccatg taccctcagc cgatgtcccc
      901 gtgattgcca tgtgcgtgtg ccttggacat tggcaatgct gaccagttag tcagggaagg
      961 ctcctgactc ttttccttga tcagtgggga tagcagttgc tatttaatgt tgtcttcctc
     1021 cttgcaataa tttaacatag aattcaagat ctcatcgaaa caaagctgtg acactcatgg
     1081 cactgtccgt gtgtgacctg tgttgctgtg acactcacgg cactgtccat gtgtgacctg
     1141 agttggcaca agccacagac acccccaacc cccccacctc ccagcctggc ttctgagaca
     1201 tcactcaggg ctcttgtgaa agtcccagcg tcaatgcctt ccctcctggt cactgtgaat
     1261 cctgctggct gctgctgtga tttttgaaag cctgtgaaat agaagcagca ggacctggga
     1321 acagacctgt gagcccggtc tttctgctca atgtgaattc ccgtggtgaa aacttacaga
     1381 cactgcctga cctcatgctg ttctcaagag ggaagtgtct tctggcaggc tttgcttttt
     1441 ctgtatgttg aataaatcca atctatcaat aatatatatg taaaagattt ctgggacagt
     1501 cctgtgtgtt catctcaaat gtgataaata aatcctattt tctataaaaa aaaaaaaaaa
//
