LOCUS       NM_026352               1940 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus peptidylprolyl isomerase D (cyclophilin D) (Ppid),
            transcript variant 1, mRNA.
ACCESSION   NM_026352 XM_975458 XM_975500 XM_975538
VERSION     NM_026352.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1940)
  AUTHORS   Beutner,G., Burris,J.R., Collins,M.P., Kulkarni,C.A.,
            Nadtochiy,S.M., de Mesy Bentley,K.L., Cohen,E.D., Brookes,P.S. and
            Porter,G.A. Jr.
  TITLE     Coordinated metabolic responses to cyclophilin D deletion in the
            developing heart
  JOURNAL   iScience 27 (3), 109157 (2024)
   PUBMED   38414851
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1940)
  AUTHORS   Rodrigues,I.S., Pereira,L.M.G., Lisboa,J., Pereira,C., Oliveira,P.,
            Dos Santos,N.M.S. and do Vale,A.
  TITLE     Involvement of Hsp90 and cyclophilins in intoxication by AIP56, a
            metalloprotease toxin from Photobacterium damselae subsp. piscicida
  JOURNAL   Sci Rep 9 (1), 9019 (2019)
   PUBMED   31227743
  REMARK    GeneRIF: Involvement of Hsp90 and cyclophilins in intoxication by
            AIP56, a metalloprotease toxin from Photobacterium damselae subsp.
            piscicida.
            Erratum:[Sci Rep. 2020 Jan 22;10(1):1266. PMID: 31965037]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1940)
  AUTHORS   Gunduz-Cinar,O., Brockway,E., Lederle,L., Wilcox,T., Halladay,L.R.,
            Ding,Y., Oh,H., Busch,E.F., Kaugars,K., Flynn,S., Limoges,A.,
            Bukalo,O., MacPherson,K.P., Masneuf,S., Pinard,C., Sibille,E.,
            Chesler,E.J. and Holmes,A.
  TITLE     Identification of a novel gene regulating amygdala-mediated fear
            extinction
  JOURNAL   Mol Psychiatry 24 (4), 601-612 (2019)
   PUBMED   29311651
REFERENCE   4  (bases 1 to 1940)
  AUTHORS   Klawitter,J., Pennington,A., Klawitter,J., Thurman,J.M. and
            Christians,U.
  TITLE     Mitochondrial cyclophilin D ablation is associated with the
            activation of Akt/p70S6K pathway in the mouse kidney
  JOURNAL   Sci Rep 7 (1), 10540 (2017)
   PUBMED   28874678
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1940)
  AUTHORS   Bourke,C.H., Raees,M.Q., Malviya,S., Bradburn,C.A., Binder,E.B. and
            Neigh,G.N.
  TITLE     Glucocorticoid sensitizers Bag1 and Ppid are regulated by
            adolescent stress in a sex-dependent manner
  JOURNAL   Psychoneuroendocrinology 38 (1), 84-93 (2013)
   PUBMED   22647578
REFERENCE   6  (bases 1 to 1940)
  AUTHORS   Yokoi,H., Shimizu,Y., Anazawa,H., Lefebvre,C.A., Korneluk,R.G. and
            Ikeda,J.E.
  TITLE     The structure and complete nucleotide sequence of the human
            cyclophilin 40 (PPID) gene
  JOURNAL   Genomics 35 (3), 448-455 (1996)
   PUBMED   8812478
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113945.26.
            
            [WARNING] On Jul 12, 2024 this sequence was replaced by
            NM_026352.5.
            
            On Sep 29, 2017 this sequence version replaced NM_026352.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019778.1, AK003402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AC113945.26        25831-26051         c
            222-362             AC113945.26        23638-23778         c
            363-469             AC113945.26        22080-22186         c
            470-658             AC113945.26        19515-19703         c
            659-781             AC113945.26        18474-18596         c
            782-888             AC113945.26        18230-18336         c
            889-1030            AC113945.26        16989-17130         c
            1031-1117           AC113945.26        15030-15116         c
            1118-1160           AC113945.26        14903-14945         c
            1161-1940           AC113945.26        13578-14357         c
FEATURES             Location/Qualifiers
     source          1..1940
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 34.91 cM"
     gene            1..1940
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /note="peptidylprolyl isomerase D (cyclophilin D)"
                     /db_xref="GeneID:67738"
                     /db_xref="MGI:MGI:1914988"
     exon            1..221
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /inference="alignment:Splign:2.1.0"
     exon            222..362
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /inference="alignment:Splign:2.1.0"
     exon            363..469
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /inference="alignment:Splign:2.1.0"
     exon            470..658
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /inference="alignment:Splign:2.1.0"
     exon            659..781
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /inference="alignment:Splign:2.1.0"
     exon            782..888
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1030
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1117
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1160
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1940
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1387..1392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /note="hexamer: AATAAA"
     polyA_site      1405
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /note="major polyA site"
     regulatory      1757..1762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /note="hexamer: AATAAA"
     polyA_site      1780
                     /gene="Ppid"
                     /gene_synonym="4930564J03Rik; CYP-40; Ppidl"
                     /note="major polyA site"
ORIGIN      
        1 agagtacagc ttccggcggt gcgcaggaag taactcttcc gcgcgttgcc aggttataac
       61 gtagaggggc agtagagttt gctccggtct cgcgcacgag gtgctcgtgt cccgctgccc
      121 agtgcccgca gtgaagatgt cccacgcatc cccggcagcc aagccctcca actccaagaa
      181 cccgcgagtc ttctttgacg tggacatcgg cggggagcga gttggccgaa ttgttttaga
      241 attgtttgca gatattgttc ccaaaactgc agaaaatttt cgtgcgttgt gtacaggaga
      301 aaaaggaact gggtccacga ccgggaagcc tctccatttt aaaggatgcc ctttccaccg
      361 aattattaag aaatttatga ttcagggtgg agacttctca aatcagaatg ggacaggtgg
      421 cgaaagtatt tatggtgaaa aatttgaaga tgaaaatttt cattataagc atgatcggga
      481 gggtttgctg agcatggcaa atgcaggccc caatacgaat ggctctcagt tctttatcac
      541 aacagttccg actcctcatc tggacgggaa acatgtggta tttggtcagg tcataaaagg
      601 actaggtgtg gcaaggacgc ttgaaaatgt agaggtgaat ggtgaaaaac ctgccaaact
      661 ctgtgttatt gcagaatgtg gagaattgaa agaaggggat gactggggaa tcttccccaa
      721 agatggctct ggtgacagtc atccagactt ccctgaggat gcagatatag atttaaaaga
      781 tgtagataaa attttattaa tatctgaaga cttaaaaaac attggaaata cttttttcaa
      841 gtctcagaac tgggagatgg ctattaaaaa atatgcgaag gttttaaggt atgtggatag
      901 ttcaaaggct gttattgaga aagcagatag atccagactg caacctatag ccttaagttg
      961 tgtgctgaat attggtgctt gtaagctgaa gatgtcaaat tggcaggggg caattgacag
     1021 ttgcttagag gctcttgaaa tggacccttc aaatactaaa gcactatacc gaaaagcgca
     1081 aggatggcaa ggattgaaag aatatgatca agcattggct gatcttaaga aggcacagga
     1141 gatagcccca ggagataaag ctatccaggc agaattgctt aaagtcaaac aaatgataaa
     1201 ggcacagaaa gataaagaga aggccgtgta tgcaaaaatg tttgcttaat aatgattaaa
     1261 ctctctttaa ctattataca ttgattatat aaaggacaag gtatattact gtctacatgc
     1321 tccctgttgt gtttcccttg atctctgtca ttgtttacat agcagtgctg acacaggttc
     1381 cttcttaata aagagttaaa aaatacagtg aatctcattt taaaatgttt gtctgcattt
     1441 tcaccaagag tgtatctggc caatgtttaa actctaactc tcactaaatt ttcggctttg
     1501 tggatggtct agcccagcag ttcttaacct gatggtccac tgaaaaacat agatattttt
     1561 acagtatggt tcagagcagt agcaaaatta cagttgtgaa gtagcaacaa aaataaattt
     1621 atgtttgggg gtcaccacat gaagaactgt actaaaaggt tgcagcacta gtaaggttgg
     1681 gaaccactga tgtaactgtc acgtttatgt gtattaacca gctatgtgta taaaccatcg
     1741 ggcatggctg tgtttcaata aatcggtttt taagtgttca tctctggatg tcctttcctg
     1801 gtgtagacca cacatttgtt tttatacttg gagattttaa gttttgcaag acaaatatat
     1861 tgtagaagcc ttgtagtaca cgtttctgct ggtactggaa ggacttgaaa ggtaaataaa
     1921 taaatgctct cgtttattta
//
