LOCUS       NM_008907                746 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus peptidylprolyl isomerase A (Ppia), mRNA.
ACCESSION   NM_008907 XR_105433 XR_106634
VERSION     NM_008907.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 746)
  AUTHORS   Cao,M., Zhao,Q., Xia,H., Lyu,S., Luo,J., Fu,K., Chen,R. and Yuan,W.
  TITLE     Intracellular and extracellular Cyclophilin a promote cardiac
            fibrosis through TGF-beta signaling in response to angiotensin
  JOURNAL   Biochem Pharmacol 225, 116271 (2024)
   PUBMED   38723722
  REMARK    GeneRIF: Intracellular and extracellular Cyclophilin a promote
            cardiac fibrosis through TGF-beta signaling in response to
            angiotensin .
REFERENCE   2  (bases 1 to 746)
  AUTHORS   Wang,Y., Wang,C., Yang,X., Ni,K., Jiang,L., Xu,L., Liu,Q., Xu,X.,
            Gu,X., Liu,Y. and Ma,Z.
  TITLE     Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway Alleviates
            the Development of Neuropathic Pain by Promoting Repair of the
            Blood-Spinal Cord Barrier
  JOURNAL   Anesth Analg 138 (6), 1313-1323 (2024)
   PUBMED   38009963
  REMARK    GeneRIF: Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway
            Alleviates the Development of Neuropathic Pain by Promoting Repair
            of the Blood-Spinal Cord Barrier.
REFERENCE   3  (bases 1 to 746)
  AUTHORS   Cui,D., Yamamoto,K. and Ikeda,E.
  TITLE     High-Mannose-Type Glycan of Basigin in Endothelial Cells Is
            Essential for the Opening of the Blood-Brain Barrier Induced by
            Hypoxia, Cyclophilin A, or Tumor Necrosis Factor-alpha
  JOURNAL   Am J Pathol 194 (4), 612-625 (2024)
   PUBMED   38040091
  REMARK    GeneRIF: High-Mannose-Type Glycan of Basigin in Endothelial Cells
            Is Essential for the Opening of the Blood-Brain Barrier Induced by
            Hypoxia, Cyclophilin A, or Tumor Necrosis Factor-alpha.
REFERENCE   4  (bases 1 to 746)
  AUTHORS   Stauffer,W.T., Goodman,A.Z., Bobardt,M., Ure,D.R., Foster,R.T. and
            Gallay,P.
  TITLE     Mice lacking cyclophilin B, but not cyclophilin A, are protected
            from the development of NASH in a diet and chemical-induced model
  JOURNAL   PLoS One 19 (3), e0298211 (2024)
   PUBMED   38427624
  REMARK    GeneRIF: Mice lacking cyclophilin B, but not cyclophilin A, are
            protected from the development of NASH in a diet and
            chemical-induced model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 746)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 746)
  AUTHORS   Varmuza,S. and Tate,P.
  TITLE     Isolation of epiblast-specific cDNA clones by differential
            hybridization with polymerase chain reaction-amplified probes
            derived from single embryos
  JOURNAL   Mol Reprod Dev 32 (4), 339-348 (1992)
   PUBMED   1497882
REFERENCE   7  (bases 1 to 746)
  AUTHORS   Walsh,C.T., Zydowsky,L.D. and McKeon,F.D.
  TITLE     Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases,
            and blockade of T cell signal transduction
  JOURNAL   J Biol Chem 267 (19), 13115-13118 (1992)
   PUBMED   1618811
  REMARK    Review article
REFERENCE   8  (bases 1 to 746)
  AUTHORS   Sherry,B., Yarlett,N., Strupp,A. and Cerami,A.
  TITLE     Identification of cyclophilin as a proinflammatory secretory
            product of lipopolysaccharide-activated macrophages
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3511-3515 (1992)
   PUBMED   1565646
REFERENCE   9  (bases 1 to 746)
  AUTHORS   Hasel,K.W. and Sutcliffe,J.G.
  TITLE     Nucleotide sequence of a cDNA coding for mouse cyclophilin
  JOURNAL   Nucleic Acids Res 18 (13), 4019 (1990)
   PUBMED   2197604
REFERENCE   10 (bases 1 to 746)
  AUTHORS   Fischer,G., Wittmann-Liebold,B., Lang,K., Kiefhaber,T. and
            Schmid,F.X.
  TITLE     Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably
            identical proteins
  JOURNAL   Nature 337 (6206), 476-478 (1989)
   PUBMED   2492638
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK160780.1.
            
            On Jul 6, 2018 this sequence version replaced NM_008907.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160780.1, AK007981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-746               AK160780.1         29-774
FEATURES             Location/Qualifiers
     source          1..746
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.97 cM"
     gene            1..746
                     /gene="Ppia"
                     /gene_synonym="Cphn; CyP-18; CypA; SP18"
                     /note="peptidylprolyl isomerase A"
                     /db_xref="GeneID:268373"
                     /db_xref="MGI:MGI:97749"
     exon            1..113
                     /gene="Ppia"
                     /gene_synonym="Cphn; CyP-18; CypA; SP18"
                     /inference="alignment:Splign:2.1.0"
     exon            114..144
                     /gene="Ppia"
                     /gene_synonym="Cphn; CyP-18; CypA; SP18"
                     /inference="alignment:Splign:2.1.0"
     exon            145..233
                     /gene="Ppia"
                     /gene_synonym="Cphn; CyP-18; CypA; SP18"
                     /inference="alignment:Splign:2.1.0"
     exon            234..406
                     /gene="Ppia"
                     /gene_synonym="Cphn; CyP-18; CypA; SP18"
                     /inference="alignment:Splign:2.1.0"
     exon            407..746
                     /gene="Ppia"
                     /gene_synonym="Cphn; CyP-18; CypA; SP18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      723..728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppia"
                     /gene_synonym="Cphn; CyP-18; CypA; SP18"
                     /note="hexamer: AATAAA"
     polyA_site      746
                     /gene="Ppia"
                     /gene_synonym="Cphn; CyP-18; CypA; SP18"
                     /note="major polyA site"
ORIGIN      
        1 cgctttgcag acgccactgt cgcttttcgc cgcttgctgc agccatggtc aaccccaccg
       61 tgttcttcga catcacggcc gatgacgagc ccttgggccg cgtctccttc gagctgtttg
      121 cagacaaagt tccaaagaca gcagaaaact ttcgagctct gagcactgga gagaaaggat
      181 ttggctataa gggttcctcc tttcacagaa ttattccagg attcatgtgc cagggtggtg
      241 actttacacg ccataatggc actggcggca ggtccatcta cggagagaaa tttgaggatg
      301 agaacttcat cctaaagcat acaggtcctg gcatcttgtc catggcaaat gctggaccaa
      361 acacaaacgg ttcccagttt tttatctgca ctgccaagac tgaatggctg gatggcaagc
      421 atgtggtctt tgggaaggtg aaagaaggca tgaacattgt ggaagccatg gagcgttttg
      481 ggtccaggaa tggcaagacc agcaagaaga tcaccatttc cgactgtgga cagctctaat
      541 ttcttttgac ttgcgggcat tttacccatc aaaccattcc ttctgtagct caggagagcg
      601 tccctacccc atctgctcgc aatgtcctgt aatctctgct ctcactgaag ttctttgggt
      661 tccatatttt cctcattccc cttcaagtct agctggattg caaagttaag tttatgatta
      721 tgaataaaaa ctaaataaga actgtt
//
