LOCUS       NM_001416223            4499 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus periphilin 1 (Pphln1), transcript variant 10, mRNA.
ACCESSION   NM_001416223
VERSION     NM_001416223.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4499)
  AUTHORS   Gresakova,V., Novosadova,V., Prochazkova,M., Prochazka,J. and
            Sedlacek,R.
  TITLE     Dual role of Fam208a during zygotic cleavage and early embryonic
            development
  JOURNAL   Exp Cell Res 406 (2), 112723 (2021)
   PUBMED   34216590
REFERENCE   2  (bases 1 to 4499)
  AUTHORS   Mrowiec,K., Chadalski,M., Paszek,A., Vydra,N., Janus,P.,
            Pietrowska,M., Toma-Jonik,A., Gramatyka,M. and Widlak,W.
  TITLE     The periphilin 1-like BFAR isoform 3 is highly expressed in
            transcriptionally silent oocytes and involved in RNA metabolism
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (10), 119086 (2021)
   PUBMED   34175335
REFERENCE   3  (bases 1 to 4499)
  AUTHORS   Soehn,A.S., Franck,T., Biskup,S., Giaime,E., Melle,C., Rott,R.,
            Cebo,D., Kalbacher,H., Ott,E., Pahnke,J., Meitinger,T., Kruger,R.,
            Gasser,T., Berg,D., von Eggeling,F., Engelender,S., da Costa,C.A.
            and Riess,O.
  TITLE     Periphilin is a novel interactor of synphilin-1, a protein
            implicated in Parkinson's disease
  JOURNAL   Neurogenetics 11 (2), 203-215 (2010)
   PUBMED   19730898
REFERENCE   4  (bases 1 to 4499)
  AUTHORS   Soehn,A.S., Pham,T.T., Schaeferhoff,K., Floss,T., Weisenhorn,D.M.,
            Wurst,W., Bonin,M. and Riess,O.
  TITLE     Periphilin is strongly expressed in the murine nervous system and
            is indispensable for murine development
  JOURNAL   Genesis 47 (10), 697-707 (2009)
   PUBMED   19621438
  REMARK    GeneRIF: results point to an indispensable function of periphilin
            during murine development and an important role in the nervous
            system, reflected by a strong and tightly regulated expression in
            the murine brain.
REFERENCE   5  (bases 1 to 4499)
  AUTHORS   Kurita,M., Suzuki,H., Kawano,Y., Aiso,S. and Matsuoka,M.
  TITLE     CR/periphilin is a transcriptional co-repressor involved in cell
            cycle progression
  JOURNAL   Biochem Biophys Res Commun 364 (4), 930-936 (2007)
   PUBMED   17963697
REFERENCE   6  (bases 1 to 4499)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 4499)
  AUTHORS   Kurita,M., Suzuki,H., Masai,H., Mizumoto,K., Ogata,E.,
            Nishimoto,I., Aiso,S. and Matsuoka,M.
  TITLE     Overexpression of CR/periphilin downregulates Cdc7 expression and
            induces S-phase arrest
  JOURNAL   Biochem Biophys Res Commun 324 (2), 554-561 (2004)
   PUBMED   15474462
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126556.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.5252867.1,
                                           SRR13422601.2366002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC126556.4         40898-40997
            101-588             AC126556.4         41542-42029
            589-680             AC126556.4         53228-53319
            681-887             AC126556.4         62820-63026
            888-949             AC126556.4         66550-66611
            950-1161            AC126556.4         84037-84248
            1162-1218           AC126556.4         94653-94709
            1219-1298           AC126556.4         97987-98066
            1299-1418           AC126556.4         102208-102327
            1419-1559           AC126556.4         107641-107781
            1560-4499           AC126556.4         131510-134449
FEATURES             Location/Qualifiers
     source          1..4499
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 47.55 cM"
     gene            1..4499
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /note="periphilin 1"
                     /db_xref="GeneID:223828"
                     /db_xref="MGI:MGI:1917029"
     exon            1..100
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /inference="alignment:Splign:2.1.0"
     exon            101..588
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /inference="alignment:Splign:2.1.0"
     CDS             519..1754
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /note="isoform 8 is encoded by transcript variant 10;
                     gastric cancer antigen Ga50"
                     /codon_start=1
                     /product="periphilin-1 isoform 8"
                     /protein_id="NP_001403152.1"
                     /db_xref="GeneID:223828"
                     /db_xref="MGI:MGI:1917029"
                     /translation="MANLWPAQTPRLHIPVVLGYRPRLASTRDEMWSEGRYDYDRLPR
                     ERVPPRSHPSDGYHRVVNVVPKRPPLLDKRPPLLDKRPPLLARPDEGGYSRYYSHVDC
                     RVCDEGRSFSHDRRSGPSHSGDESGYRWLRDDHSTSRQPDYRDMRDGFRRKSFYSSHY
                     SRDRSPHKRDAPFFRESPVGRKDSPHSRSGSSVSSRSYSPERSRTHSFHQSQHRKSSR
                     VGASYKRQNEAIRGRGKERSIQSVKTSRDASPSSSSAVASSKALDKPSRLTEKELAEA
                     ESKWANETLEKSDESNLAEMNEFEAGSTAPLFIDQTEEPESNTVDGTELYEDSQLSNR
                     SKAIASKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSVQFALRQNLHEIGERCVEE
                     LKRFITEYDNSAQDFGDPF"
     exon            589..680
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /inference="alignment:Splign:2.1.0"
     exon            681..887
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /inference="alignment:Splign:2.1.0"
     exon            888..949
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1161
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1218
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1298
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1418
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1559
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..4499
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4472..4477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /note="hexamer: AATAAA"
     polyA_site      4499
                     /gene="Pphln1"
                     /gene_synonym="CR; HSPC206; HSPC232"
                     /note="major polyA site"
ORIGIN      
        1 agggcgagcg gacgtctggc ttcgcgggtt tcaccggcgg ctgaggcggc ggcgacagag
       61 gcggcggcga cagaggcgga ggctcagcag tgggacgtag ggtttctctg tgtagccctg
      121 gctgtcctgg aactcgctct gtagaccagg ctggcctcga actcagagat cccgcccgcc
      181 tcgcctccag agtgcaggga ttaaaggcgt gcaccatcac cgcccggcta cactgattat
      241 tctttaagag ctcgtcgttt ctacagagaa atccgaatgc ttattttgcc cggtagttta
      301 aacttaactt ctacccacca gcacgtacag accaggcctg taactactcc ctgggaacct
      361 gcgtgtcagc agcccggagc ccagagcctg tcgtggagcc tgcacaatca atcctgactg
      421 aagcggaggg acgaagtgca atccacccag ggcgccgctg agttttgaga ggcattaatt
      481 ccttggcgtc caccaaggga ccactgggac taattctcat ggcaaacttg tggccagccc
      541 aaactcccag gcttcacatc ccggttgtgc ttggttatcg cccacgattg gcttccacaa
      601 gagatgaaat gtggtctgag ggacgctatg actacgaccg acttccgaga gaacgcgtgc
      661 ctccccggag ccatcccagt gatggctacc atagagtagt taatgttgtg ccaaagagac
      721 cacctctgct agacaagaga ccacctctgc tagacaagag accacctctg ctagccagac
      781 ctgatgaagg aggctacagt agatattaca gtcatgttga ttgccgagta tgtgacgagg
      841 gccgcagttt ttctcatgat cgaagaagtg gcccatctca cagtggagat gaatctggct
      901 acagatggct aagagatgat cattccacaa gccggcagcc tgactacagg gacatgagag
      961 acggcttcag aagaaagagt ttctactctt cacattattc gagagatcgg tctccccata
     1021 aaagggacgc tcccttcttc agagaatccc ctgtcggccg gaaggactcc ccacacagca
     1081 gatccggctc cagtgtcagc agcagaagct attctccaga gcgaagcagg actcactcct
     1141 tccatcagtc tcagcataga aagtcctcgc gtgtcggtgc ttcctacaaa cgacagaatg
     1201 aagcaattcg tggaagaggt aaagagagat ccatccagtc agtgaaaacc tcgagagatg
     1261 cgtcaccctc aagttcctca gcagttgctt catccaaggc gttagacaaa cccagcaggc
     1321 taactgagaa ggaacttgct gaggctgaaa gcaagtgggc taatgaaaca ctagagaagt
     1381 cagacgaaag taacttggct gaaatgaatg agtttgaggc gggatccacg gcacccttat
     1441 ttattgacca gacagaagaa cccgagtcaa acacagtaga tggtacagaa ctgtatgaag
     1501 acagccagct cagcaaccgc tctaaagcca ttgcctcgaa aaccaaagag attgagcagg
     1561 tttaccgaca agactgcgag actttcggga tggtggtgaa aatgctgatt gaaaaagatc
     1621 cctcattaga aaagtctgtc cagtttgcac tgaggcagaa cttacacgag ataggtgagc
     1681 gctgcgtgga agagctcaag cgtttcatta ctgagtatga caactctgct caggactttg
     1741 gagacccctt ttagaagaag aagtacccag gtcaaaaggt tttcttagat tgtttttttc
     1801 tccttggatt gtgtaaatcc ttactatttt gtgatgaaga gaaatacttt atgatagcta
     1861 agcacatttc tagtactaaa taaacatcta caatagctta aagtatctta attagaatgt
     1921 ttcccctatg tgtagaatat tctactctat cttcatacat ttcctccctc caaaaataat
     1981 attcagttac tttaatgttc aaaagaaaaa agcagctctg gagagcagct ccctgtattt
     2041 aacccatgtt tcatagtctt ccatgacgtc tatggtcatc tttttgcata ccgtgtaaag
     2101 gttgtctttt ttattttgtt ttgtgttttt tgtctttttg ttcttttttt tcgagacagg
     2161 gtttctctgt gtatccctgg ctgtcctgga acccactctg tagaccaggc tggcctctaa
     2221 ctcagaaatc cgcctgcctc tgcctcccaa gtgctgggat taaaggcgtg cgccaccact
     2281 gctgtattca gatgttgatt tccagctgaa tactctttgg tattgttatt tgaattgcta
     2341 agcaccttca ttgtagtttg taaactctcc tctccaccac cttctgattg gtaaacactg
     2401 agggcctgta ggtcaggaaa ggaaaggcag ggcagggcag ggcatcacaa aaggaagtct
     2461 gactttcagg gactgaaaga taacgggcca tgtggcaaac atggaccaaa ataaatggat
     2521 tagttaagcc ataggagcta gttgggaaga agcctaagat ataaggcctt ggcattcata
     2581 aataataaaa agtctctgtg ttattgttgg gagtcagggg tcgaaacagt ctaacagtag
     2641 tgatcatttg gtctcaggag tttaatttgt agttaagatc attccagatt gcatacaatt
     2701 agtggtaccg ttagcatttt gagttggtga tgtcaaaata tgctgtctta atgagttaga
     2761 actttgctat cattcaatat ttgctttgag aataattctt attcaatata caaaaaaatg
     2821 cacttgaaaa tctgtaagga tctgttagaa caaaatcttc tcccaagtca gtaaacttgg
     2881 ttcatctctt ctatgaagtg ctcttaaggc ttctacctgc tctctctaga caatattatg
     2941 gactaacagg agaggtaatc tgagatgcaa gatgaatatt aagttgagat ggtctcagaa
     3001 acccatctca tgggtataat aaaaaaatta gaatatacag agcacttaag ttatgtttta
     3061 ggcccacatt atatcaaaaa cgggacctga catggcactc atgcttggga ttaagctata
     3121 gattactctg tccatctccg tgatctcagt tctgtgggcg tagaggggct cactgctcac
     3181 aagtgtcctc agaacacact gaggccagca cagctgccag caggtcctga gtgagccact
     3241 gaatcagtga agagacactt aggatctctt gctcacttcc tggtccctgg ttcactgagg
     3301 caaaatacta aatttgtgac attaggcacc ttaaaaaaaa tcactgccca atcaaattat
     3361 ctaccttttt ttgggggggg gcgagggggg tcagggtctt acagtatagt cctagctagc
     3421 ctgaaaatct ctgtgtagac taggatagcc ttaaactcac agacatctcc ccacccctac
     3481 ctcttacatg ctggcgttaa gcccacgggc caccctgctc agcatccttt tgtttgtttt
     3541 cattttcatt ttttttctgt ccttattact ttttgattcg agacagggtt ttgctgtgtg
     3601 tcctaggctg gcttcaaact taactgctct ggcctttagc tttcgggatt cctgcctcag
     3661 ctttcctgag ccccaatgct tgccgtgacc attgagtggc ctctatgatc ctgtctgcgg
     3721 atatccctaa accacataca gattatactt aagtagaaat agaagaatgg ttaattttaa
     3781 tgagccctaa aatagatgtg tgaagatttg tattatgcca ttttgaaaat ttaaaactaa
     3841 ttgacgacat gttttttgtt ttgtttgttt tcttaaattc cccaagtgag aacacttgta
     3901 cgttttggca ttgagtcttt ccatcccttt tctgcgcaca ctccccttct gagcgtgtgc
     3961 tgcgcaatgc cggtcacttc agtaatacca caagcgattt tccttcttcc cttccactaa
     4021 ttctcagctc tttaaatcaa gttattaaca agcatacgta taaaatttga ggagcttcca
     4081 aggcaaaaaa aaaaaatgtt cacttggtag aaacattcat ttaaaaagag aatcttactg
     4141 ataaattatt taagtgaagg cccagccagt catcctcttc cttccactca cactgggcct
     4201 tcgaagctgt gtccagcttg ccgtccgcgc tgttctgcca ggctccacag tgttaaatgt
     4261 ttccttcatc tttgtttttt tttaaatgcc ttttgacatc taaaattcat gtgtactaga
     4321 gtatgtttta taaaatgttt ttgattctac ggagacatgt ttgtaagtta tccattgttt
     4381 ttcaatagac ctgattcata tgataagttc tcattgcctc accataaggc cttgatgatc
     4441 aatatgggga aagcagatac tgtaaatgca aaataaagca tccgatacta agtaataaa
//
