LOCUS       NP_084017               1194 aa            linear   ROD 09-FEB-2025
DEFINITION  liprin-alpha-3 [Mus musculus].
ACCESSION   NP_084017 XP_485929
VERSION     NP_084017.2
DBSOURCE    REFSEQ: accession NM_029741.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1194)
  AUTHORS   Emperador-Melero,J., Andersen,J.W., Metzbower,S.R., Levy,A.D.,
            Dharmasri,P.A., de Nola,G., Blanpied,T.A. and Kaeser,P.S.
  TITLE     Distinct active zone protein machineries mediate Ca2+ channel
            clustering and vesicle priming at hippocampal synapses
  JOURNAL   Nat Neurosci 27 (9), 1680-1694 (2024)
   PUBMED   39160372
REFERENCE   2  (residues 1 to 1194)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 1194)
  AUTHORS   Banerjee,A., Imig,C., Balakrishnan,K., Kershberg,L., Lipstein,N.,
            Uronen,R.L., Wang,J., Cai,X., Benseler,F., Rhee,J.S., Cooper,B.H.,
            Liu,C., Wojcik,S.M., Brose,N. and Kaeser,P.S.
  TITLE     Molecular and functional architecture of striatal dopamine release
            sites
  JOURNAL   Neuron 110 (2), 248-265 (2022)
   PUBMED   34767769
REFERENCE   4  (residues 1 to 1194)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1194)
  AUTHORS   Emperador-Melero,J., Wong,M.Y., Wang,S.S.H., de Nola,G.,
            Nyitrai,H., Kirchhausen,T. and Kaeser,P.S.
  TITLE     PKC-phosphorylation of Liprin-alpha3 triggers phase separation and
            controls presynaptic active zone structure
  JOURNAL   Nat Commun 12 (1), 3057 (2021)
   PUBMED   34031393
  REMARK    GeneRIF: PKC-phosphorylation of Liprin-alpha3 triggers phase
            separation and controls presynaptic active zone structure.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1194)
  AUTHORS   Joshi,C.S., Suryawanshi,A.R., Khan,S.A., Balasinor,N.H. and
            Khole,V.V.
  TITLE     Liprin alpha3: a putative estrogen regulated acrosomal protein
  JOURNAL   Histochem Cell Biol 139 (4), 535-548 (2013)
   PUBMED   23124857
REFERENCE   7  (residues 1 to 1194)
  AUTHORS   Zurner,M., Mittelstaedt,T., tom Dieck,S., Becker,A. and Schoch,S.
  TITLE     Analyses of the spatiotemporal expression and subcellular
            localization of liprin-alpha proteins
  JOURNAL   J Comp Neurol 519 (15), 3019-3039 (2011)
   PUBMED   21618221
REFERENCE   8  (residues 1 to 1194)
  AUTHORS   Zurner,M. and Schoch,S.
  TITLE     The mouse and human Liprin-alpha family of scaffolding proteins:
            genomic organization, expression profiling and regulation by
            alternative splicing
  JOURNAL   Genomics 93 (3), 243-253 (2009)
   PUBMED   19013515
REFERENCE   9  (residues 1 to 1194)
  AUTHORS   Masuda,T., Kai,N., Sakuma,C., Kobayashi,K., Koga,H. and Yaginuma,H.
  TITLE     Laser capture microdissection and cDNA array analysis for
            identification of mouse KIAA/FLJ genes differentially expressed in
            the embryonic dorsal spinal cord
  JOURNAL   Brain Res 1249, 61-67 (2009)
   PUBMED   19026994
REFERENCE   10 (residues 1 to 1194)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147645.1, BC058404.1, AK010782.1 and AW060329.1.
            
            On Nov 24, 2007 this sequence version replaced NP_084017.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB516303.1, SRR7974084.1772.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1194
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.26 cM"
     Protein         1..1194
                     /product="liprin-alpha-3"
                     /note="PTPRF-interacting protein alpha-3; protein tyrosine
                     phosphatase receptor type f polypeptide-interacting
                     protein alpha-3; Liprin-alpha3"
                     /calculated_mol_wt=133296
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P60469.2)"
     Site            17
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     Region          39..>635
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Site            142
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75145; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     Region          201..233
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P60469.2)"
     Site            207
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75145; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     Site            431
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13136; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     Site            508
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     Region          522..588
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P60469.2)"
     Region          535..>747
                     /region_name="PRK13729"
                     /note="conjugal transfer pilus assembly protein TraB;
                     Provisional"
                     /db_xref="CDD:184281"
     Region          624..817
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P60469.2)"
     Site            640
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13136; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     Site            645
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:16452087,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     Site            668
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13136; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     Site            683
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75145; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     Site            714
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     Site            737
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13136; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     Site            792
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q91Z79; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     Site            794
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q91Z79; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     Region          835..905
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat1"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     1; cd09562"
                     /db_xref="CDD:188961"
     Region          952..1017
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat2"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     2; cd09565"
                     /db_xref="CDD:188964"
     Region          1037..1108
                     /region_name="SAM_liprin-alpha1,2,3,4_repeat3"
                     /note="SAM domain of liprin-alpha1,2,3,4 proteins repeat
                     3; cd09568"
                     /db_xref="CDD:188967"
     Site            1123
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q13136; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     Region          1157..1194
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P60469.2)"
     Site            1164
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O75145; propagated from
                     UniProtKB/Swiss-Prot (P60469.2)"
     CDS             1..1194
                     /gene="Ppfia3"
                     /gene_synonym="2410127E16Rik"
                     /coded_by="NM_029741.2:377..3961"
                     /db_xref="CCDS:CCDS52246.1"
                     /db_xref="GeneID:76787"
                     /db_xref="MGI:MGI:1924037"
ORIGIN      
        1 mmcevmptis edgrrgsalg pdeaggeler lmvtmltere rlletlreaq dglataqlrl
       61 relghekdsl qrqlsialpq efaaltkeln lcreqllere eeiaelkaer nntrlllehl
      121 eclvsrhers lrmtvvkrqa qspggvssev evlkalkslf ehhkaldekv rerlrmaler
      181 vavleeelel snqealnlrd qlsrrrsgle epgkdgdgqt langlgpvge snrrtaelee
      241 alerqraevc qlrerlavlc rqmsqleeel gtahrelgka eeansklqrd lkealaqred
      301 meerittlek rylsaqreat slhdandkle nelaskesly rqseeksrql aewlddakqk
      361 lqqtlqkaet lpeieaqlaq rvaalnkaee rhgnfeerlr qleaqleekn qelqrarqre
      421 kmnddhnkrl setvdkllse snerlqlhlk ermgaleekn slseeianmk klqdelllnk
      481 eqllaemerm qmeidqlrgr ppssysrslp gsalelrysq aptlpsgapl dpygagsgra
      541 gkrgrwsgak desskdwdrs apagsipppf pgeldgsdee eaegmfgael lspsgqadvq
      601 tlaimlqeql eainkeikli qeeketteqr aeelesrvss sgldslgryr sscslppslt
      661 tstlaspspp ssghstprla ppsparegtd ktnhvskeea gvprgegpav pgdtppptpr
      721 sarlermaqa lalqagsped gapprgsest pdslhkapkr ksikssigrl fgkkekgrmg
      781 ppgresvsla gtpsdetlat dplglakltg pgdkdrrnkr khelleeacr qglpfaawdg
      841 ptvvswlelw vgmpawyvaa cranvksgai manlsdteiq reigisnplh rlklrlaiqe
      901 mvsltspsap assrtptgnv wmtheemesl taatkpetke isweqilayg dmnhewvgnd
      961 wlpslglpqy rsyfmeslvd armldhlnkk elrgqlkmvd sfhrvslhyg imclkrlnyd
     1021 rkdlerrree sqtqirdvmv wsnervmgwv sglglkefat nltesgvhga llaldetfdy
     1081 sdlalllqip tqnaqarqll ekefsnlisl gtdrrldeds aksfsrspsw rkmfrekdlr
     1141 gvtpdsaeml ppnfrsaaag algspglplr klqpegqtsg ssradgvsvr tysc
//
