LOCUS       NM_011148               3328 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus protein phosphatase, EF hand calcium-binding domain 2
            (Ppef2), mRNA.
ACCESSION   NM_011148 XM_006534817
VERSION     NM_011148.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3328)
  AUTHORS   Yang,Y., Jiang,X., Chen,J., Liu,L., Liu,G., Sun,K., Liu,W., Zhu,X.
            and Guan,Q.
  TITLE     The m6A reader YTHDC2 maintains visual function and retinal
            photoreceptor survival through modulating translation of PPEF2 and
            PDE6B
  JOURNAL   J Genet Genomics 51 (2), 208-221 (2024)
   PUBMED   38157933
  REMARK    GeneRIF: The m[6]A reader YTHDC2 maintains visual function and
            retinal photoreceptor survival through modulating translation of
            PPEF2 and PDE6B.
REFERENCE   2  (bases 1 to 3328)
  AUTHORS   Zwick,M., Ulas,T., Cho,Y.L., Ried,C., Grosse,L., Simon,C.,
            Bernhard,C., Busch,D.H., Schultze,J.L., Buchholz,V.R., Stutte,S.
            and Brocker,T.
  TITLE     Expression of the Phosphatase Ppef2 Controls Survival and Function
            of CD8+ Dendritic Cells
  JOURNAL   Front Immunol 10, 222 (2019)
   PUBMED   30809231
  REMARK    GeneRIF: Expression of the Phosphatase Ppef2 Controls Survival and
            Function of CD8(+) Dendritic Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3328)
  AUTHORS   Ramulu,P., Kennedy,M., Xiong,W.H., Williams,J., Cowan,M., Blesh,D.,
            Yau,K.W., Hurley,J.B. and Nathans,J.
  TITLE     Normal light response, photoreceptor integrity, and rhodopsin
            dephosphorylation in mice lacking both protein phosphatases with EF
            hands (PPEF-1 and PPEF-2)
  JOURNAL   Mol Cell Biol 21 (24), 8605-8614 (2001)
   PUBMED   11713293
REFERENCE   4  (bases 1 to 3328)
  AUTHORS   Brunner,B., Todt,T., Lenzner,S., Stout,K., Schulz,U., Ropers,H.H.
            and Kalscheuer,V.M.
  TITLE     Genomic structure and comparative analysis of nine Fugu genes:
            conservation of synteny with human chromosome Xp22.2-p22.1
  JOURNAL   Genome Res 9 (5), 437-448 (1999)
   PUBMED   10330123
REFERENCE   5  (bases 1 to 3328)
  AUTHORS   Sherman,P.M., Sun,H., Macke,J.P., Williams,J., Smallwood,P.M. and
            Nathans,J.
  TITLE     Identification and characterization of a conserved family of
            protein serine/threonine phosphatases homologous to Drosophila
            retinal degeneration C
  JOURNAL   Proc Natl Acad Sci U S A 94 (21), 11639-11644 (1997)
   PUBMED   9326663
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125542.4.
            
            On Mar 23, 2022 this sequence version replaced NM_011148.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027049.1, SRR17784651.605409.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AC125542.4         174372-174628       c
            258-385             AC125542.4         171434-171561       c
            386-513             AC125542.4         168804-168931       c
            514-571             AC125542.4         168618-168675       c
            572-747             AC125542.4         167427-167602       c
            748-862             AC125542.4         166087-166201       c
            863-909             AC125542.4         165064-165110       c
            910-1076            AC125542.4         163712-163878       c
            1077-1113           AC125542.4         163158-163194       c
            1114-1263           AC125542.4         162933-163082       c
            1264-1662           AC125542.4         157074-157472       c
            1663-1848           AC125542.4         154061-154246       c
            1849-1991           AC125542.4         152503-152645       c
            1992-2098           AC125542.4         150049-150155       c
            2099-2262           AC125542.4         148732-148895       c
            2263-2350           AC125542.4         146976-147063       c
            2351-3328           AC125542.4         144579-145556       c
FEATURES             Location/Qualifiers
     source          1..3328
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 46.28 cM"
     gene            1..3328
                     /gene="Ppef2"
                     /note="protein phosphatase, EF hand calcium-binding domain
                     2"
                     /db_xref="GeneID:19023"
                     /db_xref="MGI:MGI:1342304"
     exon            1..257
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            258..385
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..2604
                     /gene="Ppef2"
                     /EC_number="3.1.3.16"
                     /codon_start=1
                     /product="serine/threonine-protein phosphatase with
                     EF-hands 2"
                     /protein_id="NP_035278.1"
                     /db_xref="CCDS:CCDS39151.1"
                     /db_xref="GeneID:19023"
                     /db_xref="MGI:MGI:1342304"
                     /translation="MGSSSSTQHHFAFQNAEKAFKAAALIQRWYRRYMARLEMRRRCT
                     WNIFQSIEYAGQQDQVKLHEFFSYLVDHFTPSSHHERDFLNRMFTEERFAQDVETEEG
                     GDFESIEVPDSYTGPRLSFPLLPDHATALVEAFRLRQQLHARYVLNLLYETRKHLAQL
                     PNINRVSTCYSEEVTVCGDLHGQLDDLIFIFYKNGLPSPERAYVFNGDFVDRGKDSVE
                     VLMVLFAFMLVYPKEFHLNRGNHEDHLVNLRYGFTKEVMHKYKIHGKKILRTLQDVFC
                     WLPLATLVDEKVLVLHGGVSDKTDLELLAKLDRHKIVSTMRCKTRKESENREEQKRKD
                     NQTSSGQKPTPWFLPQSRSLPSSPFHLGSGFKAYKAGRSCSIPCGSPNSKELSRRGQV
                     RRSVDLELEQCRQQAGFLGIREKGESLPLAPDADCVADGGGVLEPTPEEWKQVVDILW
                     SDPAAQEGCKANAVRGGGCYFGPDVTERLMEKYKLQLLIRSHECKPEGYEFCHNRKVL
                     TIFSASNYYEVGSNRGAYVKLGPALTPHIVQYQANKATHRLTMRQRISRVEESALRAL
                     RQKLFAHSSDLLVEFRKRDPDESGVITLSDWATAVESVLHLGLPWRMLRPQLVNSSAD
                     NVLEYRSWLDSLAKEQLSRENIQSSLLEKLYRNRSNLETIFRIIDSDHSGFISLDEFR
                     QTWKLFSSHMSIDITDDGICDLARSIDFNKDGHIDINEFLEAFRLVEQSCLEGHASAC
                     LQSTDTAESGHSSPGPC"
     exon            386..513
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            514..571
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            572..747
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            748..862
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..909
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1076
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1113
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1263
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1662
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1848
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1991
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2098
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2262
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2350
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..3328
                     /gene="Ppef2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3307..3312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppef2"
                     /note="hexamer: AATAAA"
     polyA_site      3328
                     /gene="Ppef2"
                     /note="major polyA site"
ORIGIN      
        1 agtccccggg cctcctttga cccagggtgt tgctgcccac ggcttgaagg tggacattgt
       61 gattgtcaca tggcacttga aatgcattgc cagggtagtc ggtgtcatcc tgctccctga
      121 gaagacaaca tcagacaaag gttagacctg accccatcag gcagttccat ccaccaaccg
      181 tgaagaaaga tggtgatcag acacatgggt taggtgcctg cctcctcgtg tctcagagtc
      241 agctaagctc ctggaagcaa acccctccgt tccctcggat cgggatccgc cactgccgtc
      301 catgtcctgc aggagcgctg tccctcagcc atgggaagca gctcatccac ccagcaccac
      361 tttgcgtttc agaacgctga gaaagccttc aaggcagcgg ccctgatcca gagatggtac
      421 cggcgctaca tggcccgcct agagatgagg aggcgatgta cctggaacat cttccagtct
      481 atagagtatg ctggacagca agaccaggtc aagctccatg aattcttcag ctaccttgtg
      541 gaccatttca ctcccagcag ccaccatgag agagatttcc tgaaccgcat gttcaccgaa
      601 gagagattcg cccaggacgt ggagacagag gagggtggag attttgaatc catagaggtg
      661 ccagacagct acacggggcc acgcctctcc ttcccccttc ttcctgacca tgccactgcc
      721 ctggtggaag ctttcaggct gcgacaacag ctccatgctc gatacgtctt gaatcttctg
      781 tacgagacca gaaaacacct ggcccagctg cccaacatca accgagtctc cacctgctac
      841 agcgaggagg tcacagtgtg tggagatcta catggccagt tggatgattt aatatttata
      901 ttttataaga acggtctacc atcaccagag agagcatacg tgttcaatgg tgactttgtg
      961 gatcgaggca aggactctgt agaggtcctg atggttctct ttgccttcat gttggtatac
     1021 cccaaggagt tccatcttaa cagaggaaac catgaggacc atctagtgaa cctacgatat
     1081 ggcttcacca aggaagtgat gcataaatac aagatacatg ggaagaaaat cctaaggaca
     1141 cttcaggatg tcttctgctg gcttccgttg gccactctgg ttgatgagaa agtccttgtt
     1201 cttcatggtg gagtctcaga caagacagac ctggaacttc tggctaaact agacaggcac
     1261 aagattgttt ctaccatgag gtgcaaaaca agaaaggaaa gtgagaatcg agaggagcag
     1321 aagagaaaag ataaccagac aagctctgga cagaaaccta ctccgtggtt tcttcctcaa
     1381 agccgctctc tgccctcttc gccttttcac ctgggctctg gctttaaggc ctacaaagcc
     1441 ggcaggtcct gcagcatccc ctgtggctcc cctaacagca aggagctatc ccggcggggg
     1501 caggtgcggc gctcagtgga cctggaactg gaacagtgcc ggcagcaagc cggcttcctg
     1561 gggatcagag agaaggggga gtccttgcct ttggccccag atgctgactg tgttgctgat
     1621 gggggagggg tgctggaacc cacccccgag gagtggaagc aggttgtaga tattctgtgg
     1681 agtgatcccg cggctcagga gggctgcaag gccaacgctg tccgaggagg aggctgttac
     1741 tttgggcctg acgtgacaga acggttgatg gaaaaataca agctgcaact cctgatccgt
     1801 tcgcatgagt gcaaacccga gggctatgag ttctgtcaca accgcaaggt gttaaccatc
     1861 ttttctgcct ccaactacta tgaagttggc agcaacagag gagcctacgt caagctgggg
     1921 ccagccctga ctccacatat cgtgcagtat caagctaaca aggcgaccca caggctaacc
     1981 atgaggcaaa ggatcagcag ggtggaggag tcggccctca gagcccttcg acagaaatta
     2041 tttgctcatt cgtcggacct gcttgttgag tttaggaagc gcgacccgga tgagagcggt
     2101 gtcatcaccc tgagtgattg ggcgactgcc gtggagtctg tgctgcacct gggactgccc
     2161 tggcggatgc tgcggccaca actggtgaat agttcagcgg ataacgtgtt ggaatacagg
     2221 tcctggttgg acagtttggc caaagaacag ctgagccgag agaatattca gtcgagtttg
     2281 ctggaaaagc tctatcgaaa ccgatccaac ttggagacca tttttaggat catagacagc
     2341 gatcattcag gattcatctc cctggatgag ttcaggcaga cttggaagct cttcagctca
     2401 catatgagca tcgacatcac agatgacggc atctgtgacc tcgccagaag catcgacttc
     2461 aacaaggatg gccacatcga catcaatgag ttcctggagg ccttccgcct cgtggagcag
     2521 tcctgcttag agggccacgc ctctgcttgc ctgcagtcca cagacactgc tgagagtggc
     2581 catagcagtc caggcccatg ctgaggatag actggtctat tactcaaagt gcctaaggcg
     2641 atgctgagtt tatgactcca catggacttg gactttatcc tgaaaatttg ccaccacaaa
     2701 gcattcaaat caagagttac ctgtttggac tggagagatg gttcagtggt taagagcact
     2761 gactgctctt ccagaggtcc tgagttcaat tcccggcaac cacattgtgg ttcatagtgg
     2821 atctgtcagc ctcttctggt gtgtatgaag acagctacag tgaaatcata tacataaaat
     2881 aaataattta aaaaaaaaag aattacctgt gtgtttgcta gtgggtggat gtgcatgcgt
     2941 gtgtgtgtgt gtgtgtgtga gtgtgtgtgt gtgagtgtat gtgtgtgtgt gtgtgtgtgt
     3001 ctgtgtgtgt gtgtgtgtgt ctgtgtgtgt gaatgaatag atagtggtcc caacctcatt
     3061 ttagaatctt tacaaagtag aactcaggtg tagaaatgtt taaattctca aatctactct
     3121 agttatcact gataatttaa cacccttatg attttatttc atatatttta ttttgattca
     3181 tattattttg ttttaaaatg tcatcagtaa aagaaaattt taattgtata taatcctatg
     3241 acccaaatat atagtttttt cattatgtac ttatagcact tctctgattt tatgtcctca
     3301 tttttaaata aatttacact taattata
//
