LOCUS       NM_001356427             778 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus pancreatic progenitor cell differentiation and
            proliferation factor (Ppdpf), transcript variant 2, mRNA.
ACCESSION   NM_001356427 XM_006500703
VERSION     NM_001356427.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 778)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 778)
  AUTHORS   Wang,Y.K., Ma,N., Xu,S., Huang,J.Y., Ni,Q.Z., Cao,H.J., Zheng,Q.W.,
            Zhu,B., Xia,J., Zhang,F.K., Ding,X.F., Qiu,X.S., Chen,T.W.,
            Wang,K., Chen,W., Li,Z.G., Cheng,S.Q., Xie,D. and Li,J.J.
  TITLE     PPDPF suppresses the development of hepatocellular carcinoma
            through TRIM21-mediated ubiquitination of RIPK1
  JOURNAL   Cell Rep 42 (4), 112340 (2023)
   PUBMED   37027301
  REMARK    GeneRIF: PPDPF suppresses the development of hepatocellular
            carcinoma through TRIM21-mediated ubiquitination of RIPK1.
REFERENCE   3  (bases 1 to 778)
  AUTHORS   Ni,Q.Z., Zhu,B., Ji,Y., Zheng,Q.W., Liang,X., Ma,N., Jiang,H.,
            Zhang,F.K., Shang,Y.R., Wang,Y.K., Xu,S., Zhang,E.B., Yuan,Y.M.,
            Chen,T.W., Yin,F.F., Cao,H.J., Huang,J.Y., Xia,J., Ding,X.F.,
            Qiu,X.S., Ding,K., Song,C., Zhou,W.T., Wu,M., Wang,K., Lui,R.,
            Lin,Q., Chen,W., Li,Z.G., Cheng,S.Q., Wang,X.F., Xie,D. and Li,J.J.
  TITLE     PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic
            Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1
  JOURNAL   Adv Sci (Weinh) 10 (2), e2202448 (2023)
   PUBMED   36453576
  REMARK    GeneRIF: PPDPF Promotes the Development of Mutant KRAS-Driven
            Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of
            SOS1.
REFERENCE   4  (bases 1 to 778)
  AUTHORS   Zheng,Q.W., Ni,Q.Z., Zhu,B., Liang,X., Ma,N., Wang,Y.K., Xu,S.,
            Cao,H.J., Xia,J., Zhang,F.K., Zhang,E.B., Qiu,X.S., Ding,X.F.,
            Qiu,L., Zhang,X.L., Dong,Z.H., Li,Z.G., Zhang,X.L., Xie,D. and
            Li,J.J.
  TITLE     PPDPF promotes lung adenocarcinoma progression via inhibiting
            apoptosis and NK cell-mediated cytotoxicity through STAT3
  JOURNAL   Oncogene 41 (36), 4244-4256 (2022)
   PUBMED   35906391
  REMARK    Erratum:[Oncogene. 2023 Aug;42(35):2655-2656. PMID: 37491607]
REFERENCE   5  (bases 1 to 778)
  AUTHORS   Ma,N., Wang,Y.K., Xu,S., Ni,Q.Z., Zheng,Q.W., Zhu,B., Cao,H.J.,
            Jiang,H., Zhang,F.K., Yuan,Y.M., Zhang,E.B., Chen,T.W., Xia,J.,
            Ding,X.F., Chen,Z.H., Zhang,X.P., Wang,K., Cheng,S.Q., Qiu,L.,
            Li,Z.G., Yu,Y.C., Wang,X.F., Zhou,B., Li,J.J. and Xie,D.
  TITLE     PPDPF alleviates hepatic steatosis through inhibition of mTOR
            signaling
  JOURNAL   Nat Commun 12 (1), 3059 (2021)
   PUBMED   34031390
  REMARK    GeneRIF: PPDPF alleviates hepatic steatosis through inhibition of
            mTOR signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 778)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   7  (bases 1 to 778)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   8  (bases 1 to 778)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450341.10 and CB202960.1.
            
            [WARNING] On Jul 18, 2024 this sequence was replaced by
            NM_001356427.2.
            
            On Oct 4, 2017 this sequence version replaced XM_006500703.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100439.1, CK791036.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AL450341.10        186384-186446
            64-777              CB202960.1         1-714
            778-778             AL450341.10        187641-187641
FEATURES             Location/Qualifiers
     source          1..778
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.62 cM"
     gene            1..778
                     /gene="Ppdpf"
                     /gene_synonym="0610012G23Rik; 2610317A05Rik;
                     2700038C09Rik; 3110053G12Rik"
                     /note="pancreatic progenitor cell differentiation and
                     proliferation factor"
                     /db_xref="GeneID:66496"
                     /db_xref="MGI:MGI:1913746"
     exon            1..208
                     /gene="Ppdpf"
                     /gene_synonym="0610012G23Rik; 2610317A05Rik;
                     2700038C09Rik; 3110053G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            209..280
                     /gene="Ppdpf"
                     /gene_synonym="0610012G23Rik; 2610317A05Rik;
                     2700038C09Rik; 3110053G12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..573
                     /gene="Ppdpf"
                     /gene_synonym="0610012G23Rik; 2610317A05Rik;
                     2700038C09Rik; 3110053G12Rik"
                     /note="isoform a is encoded by transcript variant 2;
                     exocrine differentiation and proliferation factor"
                     /codon_start=1
                     /product="pancreatic progenitor cell differentiation and
                     proliferation factor isoform a"
                     /protein_id="NP_001343356.1"
                     /db_xref="CCDS:CCDS17202.1"
                     /db_xref="GeneID:66496"
                     /db_xref="MGI:MGI:1913746"
                     /translation="MAAIPSSGSLVATHDYYRRRLGSSSSSSSGGSAEYPGDAVLQSP
                     GLPKADPGHWWASFFFGKSTLPFMTTVLESPERSAESPQVSRSPMTCGLTPETMKQQP
                     VIHSGQTNPRDLS"
     exon            281..358
                     /gene="Ppdpf"
                     /gene_synonym="0610012G23Rik; 2610317A05Rik;
                     2700038C09Rik; 3110053G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            359..455
                     /gene="Ppdpf"
                     /gene_synonym="0610012G23Rik; 2610317A05Rik;
                     2700038C09Rik; 3110053G12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            456..778
                     /gene="Ppdpf"
                     /gene_synonym="0610012G23Rik; 2610317A05Rik;
                     2700038C09Rik; 3110053G12Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtgaagc gggaggggct ttgacgcgcg ccccgcctcc cagtggtgcg tcttttgcgg
       61 tgcaggaaag ctactaagta cgcgcgtgcg catagcgcgc gtgggtccta aagtggtgtt
      121 tcgtgggtta tctttgcaaa tgggctccgc ggcctagcgc cctggtggcc taaaaacgaa
      181 gcctgcaagg aaggggttct ccgccgagcg cctcggtcct gaagcatggc agccatccct
      241 tccagcggct cgctcgtggc tacccatgac tactatcggc gacgcctggg ctcctcgtcc
      301 agcagcagct ccggcggaag tgccgagtac cctggggacg ccgtgctcca gtccccgggt
      361 cttcccaaag ccgacccggg ccactggtgg gccagcttct ttttcgggaa atccacactc
      421 ccgttcatga ctacagtgtt ggagtctcct gagcgctcgg cagaatcccc ccaggtctcc
      481 agaagcccga tgacctgtgg cctgactcct gaaaccatga agcagcagcc agtcatccat
      541 tctggccaga ccaaccccag ggacctttcc tgacctatca gaatctgcag cctgcccaag
      601 ctgaagtggt gctaggccag tgcctaccct ctcgaccctc cctgtaaact aggaaggctg
      661 aacaagagaa accagtagaa gctggagaga gccccctctt ggttcacagc actgaacttt
      721 cctgacccca taactgtgtc ttggcacaaa gcagaaaata aactcacagc agccaccc
//
