LOCUS       NM_176831               1454 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus phosphopantothenoylcysteine decarboxylase (Ppcdc),
            transcript variant 1, mRNA.
ACCESSION   NM_176831
VERSION     NM_176831.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1454)
  AUTHORS   Bravo-Alonso,I., Morin,M., Arribas-Carreira,L., Alvarez,M.,
            Pedron-Giner,C., Soletto,L., Santolaria,C., Ramon-Maiques,S.,
            Ugarte,M., Rodriguez-Pombo,P., Arino,J., Moreno-Pelayo,M.A. and
            Perez,B.
  TITLE     Pathogenic variants of the coenzyme A biosynthesis-associated
            enzyme phosphopantothenoylcysteine decarboxylase cause
            autosomal-recessive dilated cardiomyopathy
  JOURNAL   J Inherit Metab Dis 46 (2), 261-272 (2023)
   PUBMED   36564894
REFERENCE   2  (bases 1 to 1454)
  AUTHORS   Strauss,E., Zhai,H., Brand,L.A., McLafferty,F.W. and Begley,T.P.
  TITLE     Mechanistic studies on phosphopantothenoylcysteine decarboxylase:
            trapping of an enethiolate intermediate with a mechanism-based
            inactivating agent
  JOURNAL   Biochemistry 43 (49), 15520-15533 (2004)
   PUBMED   15581364
REFERENCE   3  (bases 1 to 1454)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   4  (bases 1 to 1454)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125321.4 and BC089351.1.
            
            On Nov 10, 2017 this sequence version replaced NM_176831.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Variants 1, 2, and 3 all encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036042.1, BC089351.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC125321.4         138091-138126       c
            37-1004             BC089351.1         1-968
            1005-1005           AC125321.4         112422-112422       c
            1006-1454           BC089351.1         969-1417
FEATURES             Location/Qualifiers
     source          1..1454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.04 cM"
     gene            1..1454
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /note="phosphopantothenoylcysteine decarboxylase"
                     /db_xref="GeneID:66812"
                     /db_xref="MGI:MGI:1914062"
     exon            1..45
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            46..111
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            112..294
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            295..390
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            391..519
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            520..688
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            689..1454
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1433..1438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1454
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaaaggcgcc tagataccgc gatacttgcg ggtatcctgg agctggactc tcctgttctt
       61 gccacatttg actgaagaag gacaacgggg tcaaggtttg aggactgaca gattctagac
      121 ccaggcttcc tcagccccca gaaagccacc agacctcaca tggaaccaaa ggccccatgc
      181 ccagccgccg tcccctcaga ggagaggaag ttccgtgttc ttgtgggcgt cactggcagc
      241 gtggccgctc tgaagctgcc tctcctggta tctaagctgt tggacgttcc tgggctggaa
      301 gtcacagtgg taacaacaga gagagccaaa catttctaca gccctcagga tgtccccgtc
      361 accctctaca gtgacgctga tgaatgggag atgtggaagc gccgttctga cccggttctc
      421 cacattgacc tgcggaggtg ggctgacctc atgctagtgg ctcccctcga tgccaacact
      481 ctggggaagg tggccagtgg catctgtgac aatttgctta cctgtgtcat ccgggcctgg
      541 gacctaaaca agcccctact cttctgcccc gccatgaaca ctgccatgtg ggagcatcct
      601 ctcaccgcac agcaggtagc ccagctcaag gcctttggct acgtggagat tccctgtgtg
      661 agcaagaagc tggtgtgtgg agaccaaggt ctaggagcca tggctgaagt ggagaccatt
      721 gtggctaagg tgcaggccgt gctctcccag catggtagca tccagcagag ttgacctggg
      781 atttctgccg tgatgcccct gcacccagtg agttcagcct gagctgttga agaaggatat
      841 cagcacagta tgaagcgctt gtgctggttg acgaggggct agcctgaacc ttcttgggat
      901 ttcccttcag tctaaccctc ttcaagctac acggaaccac agacccaggt cctaccttct
      961 ttcaaccaag agatgcctgc ttcctggagg ccctcccatt tctttctggg atagcccaaa
     1021 tagactaggc aagcacgctg ctactggaag ggtaattgaa tgactgaggg acctcctgcc
     1081 tgggaattgc ttttagacac accatggatg aagctgggca tggaggctca catctgtaat
     1141 cctagcactc agaaggctga ggcaggattg ctacaacttt gaagttggct tgggttacat
     1201 agtaagccag gcctttgagt gtgatagcct atatcaaaac aaaagcaaca agaagaaaca
     1261 ccatagctca agatccctga catagcagga cacagcaggc tcctggtcag gctggaagca
     1321 tccagtcttt ggtgcccagg tgtcgcacac agtcaagaag tctgtgaggt ggccaaactc
     1381 ttcagatttc ccacagtctg tactgagagt aggggcacga acaggtctgg gaaataaaga
     1441 aaagtgacct ttta
//
