LOCUS       NM_001357915            1478 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus phosphopantothenoylcysteine decarboxylase (Ppcdc),
            transcript variant 5, mRNA.
ACCESSION   NM_001357915 XM_006511366
VERSION     NM_001357915.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1478)
  AUTHORS   Bravo-Alonso,I., Morin,M., Arribas-Carreira,L., Alvarez,M.,
            Pedron-Giner,C., Soletto,L., Santolaria,C., Ramon-Maiques,S.,
            Ugarte,M., Rodriguez-Pombo,P., Arino,J., Moreno-Pelayo,M.A. and
            Perez,B.
  TITLE     Pathogenic variants of the coenzyme A biosynthesis-associated
            enzyme phosphopantothenoylcysteine decarboxylase cause
            autosomal-recessive dilated cardiomyopathy
  JOURNAL   J Inherit Metab Dis 46 (2), 261-272 (2023)
   PUBMED   36564894
REFERENCE   2  (bases 1 to 1478)
  AUTHORS   Strauss,E., Zhai,H., Brand,L.A., McLafferty,F.W. and Begley,T.P.
  TITLE     Mechanistic studies on phosphopantothenoylcysteine decarboxylase:
            trapping of an enethiolate intermediate with a mechanism-based
            inactivating agent
  JOURNAL   Biochemistry 43 (49), 15520-15533 (2004)
   PUBMED   15581364
REFERENCE   3  (bases 1 to 1478)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   4  (bases 1 to 1478)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125321.4 and CK388377.1.
            
            On Nov 10, 2017 this sequence version replaced XM_006511366.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR17253012.7371540.1, SRR17784649.366673.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC125321.4         138110-138126       c
            18-464              CK388377.1         1-447
            465-465             AC125321.4         132993-132993       c
            466-595             CK388377.1         449-578
            596-712             AC125321.4         113098-113214       c
            713-1478            AC125321.4         111973-112738       c
FEATURES             Location/Qualifiers
     source          1..1478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.04 cM"
     gene            1..1478
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /note="phosphopantothenoylcysteine decarboxylase"
                     /db_xref="GeneID:66812"
                     /db_xref="MGI:MGI:1914062"
     exon            1..45
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            46..294
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            295..360
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            361..543
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..798
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /EC_number="4.1.1.36"
                     /note="isoform c is encoded by transcript variant 5; coaC;
                     PPC-DC"
                     /codon_start=1
                     /product="phosphopantothenoylcysteine decarboxylase
                     isoform c"
                     /protein_id="NP_001344844.1"
                     /db_xref="GeneID:66812"
                     /db_xref="MGI:MGI:1914062"
                     /translation="MEPKAPCPAAVPSEERKFRVLVGVTGSVAALKLPLLVSKLLDVP
                     GTCVIRAWDLNKPLLFCPAMNTAMWEHPLTAQQVAQLKAFGYVEIPCVSKKLVCGDQG
                     LGAMAEVETIVAKVQAVLSQHGSIQQS"
     exon            544..712
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            713..1478
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1457..1462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1478
                     /gene="Ppcdc"
                     /gene_synonym="1810057I13Rik; 8430432M10Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaaaggcgcc tagataccgc gatacttgcg ggtatcctgg agctgcagct gggaaccagc
       61 aaggctgtga tgtatcttcc tgacacgtgt cctcaagagg tgtacagatg aaactgcagt
      121 aactttagag gcaaacatgc ctacttccgg tttgagacat ccattggaaa gccaaacatt
      181 ttggctgcaa ccagcattcc ttaggtgcag tgtggtcaca ctttcttggc tacagtcttg
      241 cccgtatcct gtggtcacat tttcttggct acattcttgc ccattctatt actggactct
      301 cctgttcttg ccacatttga ctgaagaagg acaacggggt caaggtttga ggactgacag
      361 attctagacc caggcttcct cagcccccag aaagccacca gacctcacat ggaaccaaag
      421 gccccatgcc cagccgccgt cccctcagag gagaggaagt tccgtgttct tgtgggcgtc
      481 actggcagcg tggccgctct gaagctgcct ctcctggtat ctaagctgtt ggacgttcct
      541 gggacctgtg tcatccgggc ctgggaccta aacaagcccc tactcttctg ccccgccatg
      601 aacactgcca tgtgggagca tcctctcacc gcacagcagg tagcccagct caaggccttt
      661 ggctacgtgg agattccctg tgtgagcaag aagctggtgt gtggagacca aggtctagga
      721 gccatggctg aagtggagac cattgtggct aaggtgcagg ccgtgctctc ccagcatggt
      781 agcatccagc agagttgacc tgggatttct gccgtgatgc ccctgcaccc agtgagttca
      841 gcctgagctg ttgaagaagg atatcagcac agtatgaagc gcttgtgctg gttgacgagg
      901 ggctagcctg aaccttcttg ggatttccct tcagtctaac cctcttcaag ctacacggaa
      961 ccacagaccc aggtcctacc ttctttcaac caagagatgc ctgcttcctg gaggccctcc
     1021 catttctttc tgggatagcc caaatagact aggcaagcac gctgctactg gaagggtaat
     1081 tgaatgactg agggacctcc tgcctgggaa ttgcttttag acacaccatg gatgaagctg
     1141 ggcatggagg ctcacatctg taatcctagc actcagaagg ctgaggcagg attgctacaa
     1201 ctttgaagtt ggcttgggtt acatagtaag ccaggccttt gagtgtgata gcctatatca
     1261 aaacaaaagc aacaagaaga aacaccatag ctcaagatcc ctgacatagc aggacacagc
     1321 aggctcctgg tcaggctgga agcatccagt ctttggtgcc caggtgtcgc acacagtcaa
     1381 gaagtctgtg aggtggccaa actcttcaga tttcccacag tctgtactga gagtaggggc
     1441 acgaacaggt ctgggaaata aagaaaagtg acctttta
//
